Zf-UBP family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: RING/U-box [ 57849]
• Superfamily: RING/U-box [ 57850] (6)
• Family: Zf-UBP [ 161204] (3)

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Family statistics

	Genomes (310)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	601	2,116	3
Proteins	601	2,114	3

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Omega peptidases	0	1.294	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.379	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	some die during P-stage	0.002265	1.784	--	INHERITED FROM: some die during pupal stage
Fly Phenotype (FP)	increased mortality during development	0.3168	0.6148	--	INHERITED FROM: some die during pupal stage
Fly Phenotype (FP)	increased mortality	0.6442	0.5343	Least Informative	INHERITED FROM: some die during pupal stage
Fly Phenotype (FP)	some die during pupal stage	0.0006704	1.908	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || somatic cell || cell || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || cell || larva || somatic cell || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	ethmoid cartilage	0.000005808	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	chondrocranium	0.00003451	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	Meckel's cartilage	0.0002318	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	serous membrane	0.001221	2.17	--	INHERITED FROM: pericardium
Zebrafish Anatomy (ZA)	oral region	0.00218	2.17	--	INHERITED FROM: ventral mandibular arch || Meckel's cartilage
Zebrafish Anatomy (ZA)	cranial cartilage	0.002221	1.994	--	INHERITED FROM: ethmoid cartilage || chondrocranium cartilage || Meckel's cartilage
Zebrafish Anatomy (ZA)	cartilage element	0.002916	1.994	--	INHERITED FROM: ethmoid cartilage || chondrocranium cartilage || Meckel's cartilage
Zebrafish Anatomy (ZA)	pharyngeal arch 1	0.004142	2.17	--	INHERITED FROM: ventral mandibular arch || Meckel's cartilage
Zebrafish Anatomy (ZA)	mandibular arch skeleton	0.004899	2.17	--	INHERITED FROM: Meckel's cartilage || ventral mandibular arch
Zebrafish Anatomy (ZA)	skeletal element	0.007715	1.693	--	INHERITED FROM: chondrocranium cartilage || ethmoid cartilage || Meckel's cartilage
Zebrafish Anatomy (ZA)	splanchnocranium	0.01122	1.869	--	INHERITED FROM: Meckel's cartilage || ventral mandibular arch
Zebrafish Anatomy (ZA)	cranium	0.04522	1.693	--	INHERITED FROM: olfactory region || chondrocranium cartilage || ventral mandibular arch || chondrocranium || neurocranium || ethmoid cartilage || Meckel's cartilage
Zebrafish Anatomy (ZA)	compound organ	0.231	0.4299	--	INHERITED FROM: chondrocranium cartilage || Meckel's cartilage || ethmoid cartilage
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: ethmoid cartilage || anatomical system || chondrocranium cartilage || olfactory region || Meckel's cartilage || anatomical group || chondrocranium || whole organism || organism subdivision || pericardium || central nervous system || neurocranium || ventral mandibular arch || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.7079	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0.08981	0.5848	Least Informative	INHERITED FROM: pericardium || ventral mandibular arch || Meckel's cartilage
Zebrafish Anatomy (ZA)	anatomical cluster	0.2875	0.7389	Least Informative	INHERITED FROM: ethmoid cartilage || chondrocranium cartilage || olfactory region || pericardium || chondrocranium || Meckel's cartilage || neurocranium || ventral mandibular arch
Zebrafish Anatomy (ZA)	central nervous system	0	1.04	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0.3643	0.9398	Moderately Informative	INHERITED FROM: ethmoid cartilage || neurocranium || Meckel's cartilage || ventral mandibular arch || chondrocranium cartilage || olfactory region || chondrocranium
Zebrafish Anatomy (ZA)	pericardial region	0.008359	1.568	Informative	INHERITED FROM: pericardium
Zebrafish Anatomy (ZA)	skeletal system	0.02775	1.517	Informative	INHERITED FROM: ventral mandibular arch || neurocranium || Meckel's cartilage || chondrocranium || ethmoid cartilage || olfactory region || chondrocranium cartilage
Zebrafish Anatomy (ZA)	pharyngeal arch	0.03731	1.693	Informative	INHERITED FROM: Meckel's cartilage || ventral mandibular arch
Zebrafish Anatomy (ZA)	chondrocranium cartilage	0.00001821	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	olfactory region	0.00001885	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	neurocranium	0.00006451	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	pericardium	0.0004455	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	ventral mandibular arch	0.0008486	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	pharyngeal arch cartilage	0.001099	1.994	Highly Informative	INHERITED FROM: Meckel's cartilage

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || urogenital system || genital system || male genitalia
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || genital system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || anatomical region || male genitalia || trunk region || male organism || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Omega peptidases	0	1.753	--	DIRECT
Enzyme Commission (EC)	Histone deacetylase	0.00000002443	2.929	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	1	1.213	Moderately Informative	INHERITED FROM: Histone deacetylase
Enzyme Commission (EC)	In linear amides	0.03882	1.539	Informative	INHERITED FROM: Histone deacetylase
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.849	Highly Informative	DIRECT

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