Chaperone J-domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Long alpha-hairpin [ 46556] (20)
• Superfamily: Chaperone J-domain [ 46565]
• Family: Chaperone J-domain [ 46566] (7)

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Family statistics

	Genomes (1,916)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,157	17,232	13
Proteins	3,156	17,230	13

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Parkinsonism	0.0001076	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of extrapyramidal motor function	0.007938	2.462	--	INHERITED FROM: Parkinsonism
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2319	0.2371	--	INHERITED FROM: Parkinsonism
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.1385	0.3869	Least Informative	INHERITED FROM: Parkinsonism
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.2394	1.047	Moderately Informative	INHERITED FROM: Parkinsonism

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal liver glycogen level	0.0008561	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal glucose homeostasis	0.02408	1.261	--	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	abnormal glycogen homeostasis	0.06847	2.126	--	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	abnormal liver morphology	0.268	1.156	--	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0.3251	1.098	--	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.5143	0.3626	--	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	abnormal homeostasis	0.2838	0.4926	Least Informative	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.4116	1.012	Moderately Informative	INHERITED FROM: abnormal liver glycogen level
Mammalian Phenotype (MP)	abnormal glycogen level	0.007518	2.126	Highly Informative	INHERITED FROM: abnormal liver glycogen level

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0	1.053	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.000000000000008126	1.087	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.000000000239	1.078	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.0000001266	0.773	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.04377	0.6256	--	INHERITED FROM: transgene expression variant || pattern of transgene expression variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: developmental growth variant || organism metabolism processing variant || protein protein interaction variant || reproductive system physiology variant || transgene expression variant || organism homeostasis metabolism variant || movement variant || lethal || larval development variant || protein interaction variant || organism physiology variant || development variant || growth variant || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || behavior variant || pattern of transgene expression variant || protein aggregation variant || postembryonic development variant || larval arrest || organ system physiology variant || organism behavior variant || organism development variant || locomotion variant || fertility reduced
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.0001322	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	movement variant	0	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.00000000000001374	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0.0005706	0.9833	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || compound organ || anatomical region || organism subdivision

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0.000003075	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0.000003106	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0.000003438	0.227	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0.00001079	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0.00001261	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0.00004086	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0.0002842	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0.0008621	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0.0008678	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0.0009154	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0.01392	0.2152	--	INHERITED FROM: guard cell || shoot epidermal cell
Plant ANatomical entity (PAN)	shoot system	0.2213	0.05272	--	INHERITED FROM: inflorescence axis || shoot epidermis || branch || inflorescence branch || stomatal complex || pedicel || shoot epidermal cell || guard cell
Plant ANatomical entity (PAN)	shoot axis	0.4837	0.3985	--	INHERITED FROM: branch || pedicel || inflorescence axis || inflorescence branch
Plant ANatomical entity (PAN)	plant axis	0.6984	0.3257	--	INHERITED FROM: branch || inflorescence branch || pedicel || inflorescence axis
Plant ANatomical entity (PAN)	reproductive shoot system	0.8207	0.3304	--	INHERITED FROM: pedicel || inflorescence branch || inflorescence axis
Plant ANatomical entity (PAN)	plant organ	0.9154	0.2391	--	INHERITED FROM: inflorescence axis || branch || inflorescence branch || pedicel
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.9548	0.2335	--	INHERITED FROM: inflorescence axis || branch || pedicel || inflorescence branch
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: inflorescence axis || collective plant structure || guard cell || branch || inflorescence branch || portion of plant tissue || stomatal complex || epidermis || shoot epidermal cell || plant cell || shoot epidermis || pedicel
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || guard cell || shoot epidermal cell || pedicel || stomatal complex || inflorescence branch || branch || shoot epidermis
Plant ANatomical entity (PAN)	branch	0.0008678	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0.02007	0.4859	Least Informative	INHERITED FROM: pedicel || inflorescence axis || inflorescence branch
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	pollen development stage	0.0002069	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0.0008102	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: pollen development stage || floral organ differentiation stage || floral organ formation stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || pollen development stage || plant organ development stage || androecium development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0000008289	1.639	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.006664	0.7021	--	INHERITED FROM: Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Hydrolases	0.02077	0.4043	Least Informative	INHERITED FROM: Phosphoric monoester hydrolases || Acting on ester bonds || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Transferases	0.1361	0.3972	Least Informative	INHERITED FROM: Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Acting on ester bonds	0.0002027	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.000001616	1.338	Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000003068	1.437	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.000000001052	1.868	Highly Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Chaperone	0	1.431	Informative	DIRECT

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