Prefoldin family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Long alpha-hairpin [ 46556] (20)
• Superfamily: Prefoldin [ 46579]
• Family: Prefoldin [ 46580] (2)

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Family statistics

	Genomes (46)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	56	253	3
Proteins	56	253	3

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.5703	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	embryonic cell physiology variant	0.00000005168	1.538	--	DIRECT
Worm Phenotype (WP)	pronuclear migration defective early emb	0.0000004847	2.292	--	DIRECT
Worm Phenotype (WP)	mitotic spindle defective early emb	0.00001885	1.814	--	DIRECT
Worm Phenotype (WP)	spindle variant	0.00003258	1.727	--	DIRECT
Worm Phenotype (WP)	microtubule organization biogenesis variant	0.00004567	1.727	--	DIRECT
Worm Phenotype (WP)	protruding vulva	0.0001379	1.623	--	DIRECT
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.0002478	1.426	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0006172	0.8392	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.001837	0.7516	--	INHERITED FROM: hermaphrodite reproductive system morphology variant || vulva morphology variant || protruding vulva
Worm Phenotype (WP)	cell morphology variant	0.002014	0.7558	--	INHERITED FROM: embryonic cell organization biogenesis variant || pronucleus centrosomes defective early emb || cytoskeleton organization biogenesis variant || spindle variant || microtubule organization biogenesis variant || cell organization biogenesis variant || mitotic spindle defective early emb || cell component morphology variant || pronuclear migration defective early emb
Worm Phenotype (WP)	pronuclear nuclear appearance defective early emb	0.007742	1.99	--	INHERITED FROM: pronuclear migration defective early emb || pronucleus centrosomes defective early emb
Worm Phenotype (WP)	spindle defective early emb	0.03501	1.727	--	INHERITED FROM: mitotic spindle defective early emb
Worm Phenotype (WP)	pronuclear nuclear appearance variant emb	0.1338	1.99	--	INHERITED FROM: pronuclear migration defective early emb || pronucleus centrosomes defective early emb
Worm Phenotype (WP)	organelle organization biogenesis variant	0.7113	1.306	--	INHERITED FROM: mitotic spindle defective early emb || cytoskeleton organization biogenesis variant || spindle variant || microtubule organization biogenesis variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: spindle variant || reproductive system physiology variant || early embryonic lethal || embryonic cell organization biogenesis variant || lethal || embryonic cell physiology variant || mitotic spindle defective early emb || development variant || pronucleus centrosomes defective early emb || pronuclear migration defective early emb || embryonic development variant || embryonic lethal || fertility variant || microtubule organization biogenesis variant || organ system physiology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	cell physiology variant	0.007176	0.5955	Least Informative	INHERITED FROM: pronucleus centrosomes defective early emb || embryonic cell organization biogenesis variant || pronuclear migration defective early emb || embryonic cell physiology variant || mitotic spindle defective early emb || spindle variant
Worm Phenotype (WP)	early embryonic lethal	0.000007228	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.000008464	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.122	1.036	Moderately Informative	INHERITED FROM: mitotic spindle defective early emb || spindle variant
Worm Phenotype (WP)	reproductive system morphology variant	0.1349	1.078	Moderately Informative	INHERITED FROM: protruding vulva || hermaphrodite reproductive system morphology variant || vulva morphology variant
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.0000000568	1.538	Informative	DIRECT
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.00009809	1.623	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.0002441	1.426	Informative	DIRECT
Worm Phenotype (WP)	pronucleus centrosomes defective early emb	0.000003526	1.99	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	temperature sensitive growth	0	1.444	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	cold sensitivity	0.000001355	2.444	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0.002783	1.24	--	INHERITED FROM: cell size
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.24	Moderately Informative	DIRECT
Yeast Phenotype (YP)	vegetative growth	0	1.24	Moderately Informative	DIRECT
Yeast Phenotype (YP)	morphology	0.008199	1.143	Moderately Informative	INHERITED FROM: cell size
Yeast Phenotype (YP)	intracellular transport	0.0001491	1.666	Informative	DIRECT
Yeast Phenotype (YP)	endocytosis	0.000005473	2.143	Highly Informative	DIRECT
Yeast Phenotype (YP)	cell size	0.00003452	2.143	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	neuroblast	0	1.611	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	somatic precursor cell	0	1.185	--	DIRECT
Fly Anatomy (FA)	stem cell	0	1.31	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: neuroblast || type II neuroblast || somatic stem cell || somatic cell || somatic precursor cell || cell || stem cell || type I neuroblast
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: developing material anatomical entity || type I neuroblast || stem cell || cell || somatic precursor cell || somatic cell || type II neuroblast || neuroblast || somatic stem cell
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	somatic stem cell	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	type I neuroblast	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	type II neuroblast	0	1.912	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || anatomical group || multicellular anatomical structure || ectoderm || tissue || anatomical region || organism subdivision || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.00048	1.347	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.10 ten leaves visible stage || LP.04 four leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || LP.10 ten leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT

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