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Homeodomain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Family:   Homeodomain [ 46690] (40)

Family statistics
Genomes (186) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,632 12,364 56
Proteins 4,623 12,337 56

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.0004572InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0005196Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.02256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2044Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2425Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4268Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4881Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.765Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9658Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.004964Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2702Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.3342Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.409Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4263Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.5542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.7909Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.8068Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.9465Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.002113InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fontanelles or cranial sutures0.01431InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.01604InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.03327InformativeInherited
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.1259InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.1358InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.1659InformativeInherited
Phenotypic Abnormality (PA)Short stature0.4055InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the extremities0.4888InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.5121InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.5428InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5785InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7194InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.000003502Highly InformativeDirect
Phenotypic Abnormality (PA)Agenesis of corpus callosum0.00007015Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of periauricular region0.0002376Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal 2nd finger morphology0.001687Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.005148Highly InformativeInherited
Phenotypic Abnormality (PA)Midline defect of the nose0.006876Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ureter physiology0.1013Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.1617Highly InformativeInherited
Phenotypic Abnormality (PA)Cleft palate0.3889Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of fingers0.6139Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.7419Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000000000002318Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.000000365Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000001607Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.000002331Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.05571Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.417Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6728Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000000000000007869Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0000000000006016Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.00000001056Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0000004414Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.000000634Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.0000008718Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000001762Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.001174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.004297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.03996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0476Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.06413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.06681Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1253Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2914Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.5644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.8135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.8381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.959Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.9615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.00000000009834InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.00002933InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.00007515InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00007576InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.00008462InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.0001461InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0005736InformativeDirect
Mammalian Phenotype (MP)abnormal neuron differentiation0.0007531InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.001364InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.004701InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01147InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.02341InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.02791InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.04718InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.08177InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.08443InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.1015InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1084InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.1274InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1509InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.2068InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.2083InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2435InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.258InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.4028InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.4895InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.511InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.5966InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.6206InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.6329InformativeInherited
Mammalian Phenotype (MP)abnormal ovary morphology0.7669InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.8268InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.8593InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.9845InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology1InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.0000000007587Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.00000000105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal middle ear morphology0.000000006259Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0000002554Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib joint0.000002082Highly InformativeDirect
Mammalian Phenotype (MP)distended abdomen0.000003958Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuroendocrine gland morphology0.000005701Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00009807Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diencephalon morphology0.0001319Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas development0.0003503Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.0005405Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0005826Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0008151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vas deferens morphology0.0008485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.002282Highly InformativeInherited
Mammalian Phenotype (MP)abnormal urinary system development0.005305Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain development0.0101Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.01134Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid gland morphology0.01182Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic aorta morphology0.01639Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.01974Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.02714Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.03072Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.05379Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.06266Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.1009Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.112Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mandible morphology0.1739Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.4466Highly InformativeInherited
Mammalian Phenotype (MP)abnormal secondary palate morphology0.538Highly InformativeInherited
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.8535Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal telencephalic commissure morphology0.8829Highly InformativeInherited
Mammalian Phenotype (MP)abnormal femur morphology0.9768Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000000002362Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000002368Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000000437Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.04218Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3529Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4102Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000000003189Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000000003492Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00000003749Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.000003612Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.6731Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.6888Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.7898Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.000000001183InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.000004307InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.05561InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.06642InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.07454InformativeInherited
Worm Phenotype (WP)body posture variant0.1608InformativeInherited
Worm Phenotype (WP)vulva development variant0.3658InformativeInherited
Worm Phenotype (WP)locomotion reduced0.5909InformativeInherited
Worm Phenotype (WP)cell number increased1InformativeInherited
Worm Phenotype (WP)sexually dimorphic development variant0.000001105Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.000003072Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00001635Highly InformativeDirect
Worm Phenotype (WP)tail morphology variant0.00003057Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00003533Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00007129Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00009452Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.0001462Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.0001513Highly InformativeDirect
Worm Phenotype (WP)body region development variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.0004894Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0005828Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.007756Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.03084Least InformativeInherited
Fly Phenotype (FP)visible0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.07451Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.00000002207InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.000000001558Highly InformativeDirect
Fly Phenotype (FP)pair rule phenotype0.000000033Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00000008768Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0001435Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0000000000006665Least InformativeDirect
Fly Anatomy (FA)tagma0.000000000001891Least InformativeDirect
Fly Anatomy (FA)adult0.0000000002057Least InformativeDirect
Fly Anatomy (FA)segment0.000000535Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0001076Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.001713Least InformativeInherited
Fly Anatomy (FA)nervous system0.04047Least InformativeInherited
Fly Anatomy (FA)larva0.06964Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1454Least InformativeInherited
Fly Anatomy (FA)larval segment0.0000000000003644Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0.000000001873Moderately InformativeDirect
Fly Anatomy (FA)appendage0.00000002868Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.00000007913Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.000007678Moderately InformativeDirect
Fly Anatomy (FA)abdomen0.0001667Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0.0005986Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0007861Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0.00171Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.001977Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.002266Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.01942Moderately InformativeInherited
Fly Anatomy (FA)neuron0.03054Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.2338Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.7927Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.8097Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.8101Moderately InformativeInherited
Fly Anatomy (FA)adult head0.8872Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.0000002763InformativeDirect
Fly Anatomy (FA)central brain0.00001051InformativeDirect
Fly Anatomy (FA)extended germ band embryo0.00005244InformativeDirect
Fly Anatomy (FA)embryonic/larval neuron0.00007476InformativeDirect
Fly Anatomy (FA)appendage segment0.00009997InformativeDirect
Fly Anatomy (FA)primordium0.000108InformativeDirect
Fly Anatomy (FA)antennal segment0.0002104InformativeDirect
Fly Anatomy (FA)adult external head0.0003881InformativeDirect
Fly Anatomy (FA)anatomical cluster0.001429InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.001639InformativeInherited
Fly Anatomy (FA)syncytium0.001652InformativeInherited
Fly Anatomy (FA)muscle cell0.002186InformativeInherited
Fly Anatomy (FA)nerve0.003625InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.006603InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.008896InformativeInherited
Fly Anatomy (FA)chemosensory system0.0169InformativeInherited
Fly Anatomy (FA)neuromere0.01978InformativeInherited
Fly Anatomy (FA)cuticular specialization0.09747InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.1006InformativeInherited
Fly Anatomy (FA)tract0.1061InformativeInherited
Fly Anatomy (FA)adult brain0.176InformativeInherited
Fly Anatomy (FA)somatic stem cell0.1803InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.1945InformativeInherited
Fly Anatomy (FA)leg0.2902InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.2973InformativeInherited
Fly Anatomy (FA)sensory organ cell0.3784InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.549InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.6443InformativeInherited
Fly Anatomy (FA)wing blade0.7629InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.7815InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.8139InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.8291InformativeInherited
Fly Anatomy (FA)chaeta0.868InformativeInherited
Fly Anatomy (FA)anatomical space0.8799InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.9077InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.9447InformativeInherited
Fly Anatomy (FA)labral segment0.9523InformativeInherited
Fly Anatomy (FA)ommatidium0.9877InformativeInherited
Fly Anatomy (FA)larval neuromere0.000001853Highly InformativeDirect
Fly Anatomy (FA)commissure0.000002213Highly InformativeDirect
Fly Anatomy (FA)head bristle0.00001406Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval sensillum0.00004244Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004981Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0000692Highly InformativeDirect
Fly Anatomy (FA)EL neuron0.00009227Highly InformativeDirect
Fly Anatomy (FA)metathoracic segment0.0001313Highly InformativeDirect
Fly Anatomy (FA)mesothoracic tergum0.000158Highly InformativeDirect
Fly Anatomy (FA)maxillary palp olfactory receptor neuron0.0002362Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0002492Highly InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of organ system0.0003031Highly InformativeDirect
Fly Anatomy (FA)prothoracic segment0.01088Highly InformativeInherited
Fly Anatomy (FA)germ layer derivative0.0218Highly InformativeInherited
Fly Anatomy (FA)adult abdomen0.02254Highly InformativeInherited
Fly Anatomy (FA)dorsal vessel primordium0.03482Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval head sense organ0.03773Highly InformativeInherited
Fly Anatomy (FA)trichome field0.06365Highly InformativeInherited
Fly Anatomy (FA)extrinsic neuron0.06817Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval hypodermal muscle0.1501Highly InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.159Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.2221Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval motor neuron0.3023Highly InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus0.3064Highly InformativeInherited
Fly Anatomy (FA)sensory cluster0.4069Highly InformativeInherited
Fly Anatomy (FA)adult antennal lobe0.5245Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0007628Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.141Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1531Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.4229Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.9435Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0006749Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.2853Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.0001273InformativeDirect
Zebrafish Anatomy (ZA)endocrine system0.01107InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.07484InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.201InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.9344InformativeInherited
Zebrafish Anatomy (ZA)telencephalon0.06285Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00000000008853Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0002637Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.002834Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.3895Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.006731Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.00773Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1335Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.7744Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000000000009037InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00000000001753InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00000002225InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0000002895InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.000003046InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00004627InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.02549InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.04401InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.6859InformativeInherited
Xenopus ANatomical entity (XAN)tail0.9217InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system1InformativeInherited
Xenopus ANatomical entity (XAN)limb1InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ1InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000000000000001113Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.000000000000001113Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00000000000004003Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000000000005239Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.000000000001289Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.000000000004754Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.000000000007103Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00000000001304Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.00000000006529Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.000000000238Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0000000003588Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00000000817Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin0.0000000183Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindgut0.00000002126Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0000004411Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0000004715Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0000007016Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000001131Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001267Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.000003529Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000005409Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.000008219Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.00004058Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00006815Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001831Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0006347Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0009286Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.01245Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.03069Highly InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode0.6962Highly InformativeInherited
Xenopus ANatomical entity (XAN)pelvic appendage0.7131Highly InformativeInherited
Xenopus ANatomical entity (XAN)splanchnocranium0.8974Highly InformativeInherited
Xenopus ANatomical entity (XAN)skeletal tissue1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000000000000001108Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage1InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0000009512Highly InformativeDirect
Xenopus DEvelopment stage (XDE)neurula stage0.00002547Highly InformativeDirect
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.005134Highly InformativeInherited
Xenopus DEvelopment stage (XDE)gastrula stage0.06033Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0.06058Least InformativeInherited
Plant ANatomical entity (PAN)seed0.06646Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.3056Least InformativeInherited
Plant ANatomical entity (PAN)vascular leaf0.339Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6493Least InformativeInherited
Plant ANatomical entity (PAN)root1Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)androecium1Least InformativeInherited
Plant ANatomical entity (PAN)gynoecium1Least InformativeInherited
Plant ANatomical entity (PAN)stalk1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000000000985InformativeDirect
Plant ANatomical entity (PAN)root tip0.00000000172InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00000005718InformativeDirect
Plant ANatomical entity (PAN)vascular system0.00004436InformativeDirect
Plant ANatomical entity (PAN)shoot meristem0Highly InformativeDirect
Plant ANatomical entity (PAN)apical meristem0Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.0000000000005581Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.00000000001989Highly InformativeDirect
Plant ANatomical entity (PAN)plant ovule0.0000000001787Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.000000009909Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0000008839Highly InformativeDirect
Plant ANatomical entity (PAN)filament0.0002885Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.000415Highly InformativeDirect
Plant ANatomical entity (PAN)stele0.001098Highly InformativeInherited
Plant ANatomical entity (PAN)cortex0.291Highly InformativeInherited
Plant structure DEvelopment stage (PDE)seedling development stage0.000003301InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect

Document: EC annotation of SCOP domains

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.
   
Superfamily level     Family level

Alignments of sequences to 187 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Homeodomain-like domain.
   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.