Myb/SANT domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DNA/RNA-binding 3-helical bundle [ 46688] (14)
• Superfamily: Homeodomain-like [ 46689] (19)
• Family: Myb/SANT domain [ 46739] (15)

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Family statistics

	Genomes (131)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	620	1,514	10
Proteins	620	1,514	10

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal common lymphocyte progenitor cell morphology	0.00004313	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased megakaryocyte cell number	0.00006178	2.603	--	DIRECT
Mammalian Phenotype (MP)	arrested B cell differentiation	0.0002068	2.302	--	DIRECT
Mammalian Phenotype (MP)	trunk curl	0.0007295	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal posture	0.001394	2.603	--	INHERITED FROM: trunk curl
Mammalian Phenotype (MP)	abnormal bone marrow hematopoietic cell morphology	0.006032	2.126	--	INHERITED FROM: increased megakaryocyte cell number || abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.01208	0.7167	--	INHERITED FROM: abnormal common lymphocyte progenitor cell morphology || increased megakaryocyte cell number || abnormal megakaryocyte morphology || arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal megakaryocyte progenitor cell morphology	0.01551	2.126	--	INHERITED FROM: increased megakaryocyte cell number || abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.03416	0.8473	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.04992	1.156	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.06516	0.8038	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.1011	1.072	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.1744	1.205	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0.2376	1.205	--	INHERITED FROM: trunk curl
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.3611	0.8178	--	INHERITED FROM: trunk curl
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.3659	0.6686	--	INHERITED FROM: abnormal megakaryocyte morphology || increased megakaryocyte cell number || abnormal common lymphocyte progenitor cell morphology || arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3771	0.7223	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.3998	0.9404	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.6912	0.8108	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.9223	1.072	--	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.02093	0.5945	Least Informative	INHERITED FROM: arrested B cell differentiation || abnormal megakaryocyte morphology || increased megakaryocyte cell number || abnormal common lymphocyte progenitor cell morphology
Mammalian Phenotype (MP)	immune system phenotype	0.1363	0.5462	Least Informative	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.05297	1.059	Moderately Informative	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal B cell morphology	0.05601	1.156	Moderately Informative	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.1056	0.9129	Moderately Informative	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.2106	0.9904	Moderately Informative	INHERITED FROM: increased megakaryocyte cell number || abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: trunk curl
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.008861	1.7	Informative	INHERITED FROM: increased megakaryocyte cell number || abnormal megakaryocyte morphology || abnormal common lymphocyte progenitor cell morphology
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.2853	1.373	Informative	INHERITED FROM: arrested B cell differentiation
Mammalian Phenotype (MP)	abnormal megakaryocyte morphology	0.0007161	2.126	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	growth variant	0.3599	0.3438	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.5196	0.1444	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	organism physiology variant	0.538	0.1342	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || cell fate specification variant || growth rate variant || lethal || development variant || exploded through vulva || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || organism development variant || fertility reduced
Worm Phenotype (WP)	cell development variant	0.1667	0.6752	Least Informative	INHERITED FROM: cell fate specification variant
Worm Phenotype (WP)	organ system development variant	0.04457	0.9113	Moderately Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	cell fate specification variant	0.0008114	1.513	Informative	DIRECT
Worm Phenotype (WP)	epithelial system development variant	0.001158	1.655	Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	growth rate variant	0.00007771	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	exploded through vulva	0.000769	1.99	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	wing vein	0.0009972	1.611	--	DIRECT
Fly Anatomy (FA)	cuticle	0.1656	1.31	--	INHERITED FROM: wing vein
Fly Anatomy (FA)	wing	0.5378	1.243	--	INHERITED FROM: wing vein
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult external thorax || organism || mesothoracic segment || adult mesothoracic segment || adult || wing vein || segment || thoracic segment || somatic cell || tagmatic subdivision of integument || portion of tissue || cell || adult thorax || region of integument || multi-tissue structure || adult tagma || adult segment || tagma || organ system subdivision || thorax || adult integumentary system || adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure || thorax || adult integumentary system || adult tagma || adult segment || tagma || organ system subdivision || adult thorax || cell || region of integument || multi-tissue structure || tagmatic subdivision of integument || portion of tissue || segment || thoracic segment || somatic cell || adult mesothoracic segment || adult || wing vein || adult external thorax || organism || mesothoracic segment
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: mesothoracic segment || adult external thorax || adult thorax || tagma || adult segment || wing vein || adult tagma || adult mesothoracic segment || thorax || thoracic segment || segment || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	acellular anatomical structure	0.02258	1.134	Moderately Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	appendage	0.1032	1.047	Moderately Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	cuticular specialization	0.005786	1.486	Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	wing blade	0.007628	1.486	Informative	INHERITED FROM: wing vein

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	neutrophil	0.00003824	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	portion of organism substance	0.000704	1.869	--	DIRECT
Zebrafish Anatomy (ZA)	leukocyte	0.06061	1.772	--	INHERITED FROM: neutrophil || granulocyte
Zebrafish Anatomy (ZA)	myeloid leukocyte	0.08821	2.17	--	INHERITED FROM: neutrophil || granulocyte
Zebrafish Anatomy (ZA)	myeloid cell	0.2106	2.17	--	INHERITED FROM: granulocyte || neutrophil
Zebrafish Anatomy (ZA)	anatomical system	0.3916	0.1857	--	INHERITED FROM: granulocyte || neutrophil
Zebrafish Anatomy (ZA)	anatomical group	0.4309	0.1532	--	INHERITED FROM: neutrophil || granulocyte
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: granulocyte || portion of organism substance || hematopoietic cell || neutrophil || whole organism
Zebrafish Anatomy (ZA)	cell	0.04145	0.6388	Least Informative	INHERITED FROM: hematopoietic cell || granulocyte || neutrophil
Zebrafish Anatomy (ZA)	hematopoietic cell	0.0001307	1.471	Informative	DIRECT
Zebrafish Anatomy (ZA)	motile cell	0.001388	1.626	Informative	INHERITED FROM: neutrophil || granulocyte
Zebrafish Anatomy (ZA)	immune system	0.001928	1.693	Informative	INHERITED FROM: granulocyte || neutrophil
Zebrafish Anatomy (ZA)	granulocyte	0.0001022	2.17	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group || multicellular anatomical structure
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.0009903	1.347	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	protoxylem	0.000000000003161	2.901	--	DIRECT
Plant ANatomical entity (PAN)	xylem	0.00000000346	2.424	--	DIRECT
Plant ANatomical entity (PAN)	portion of vascular tissue	0.0000103	1.646	--	DIRECT
Plant ANatomical entity (PAN)	anther wall tapetum	0.00008804	2.901	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium tapetum	0.00008804	2.901	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium wall	0.0001181	2.901	--	DIRECT
Plant ANatomical entity (PAN)	sporangium wall	0.0002013	2.901	--	DIRECT
Plant ANatomical entity (PAN)	leaf trichome	0.0008014	2.299	--	DIRECT
Plant ANatomical entity (PAN)	leaf epidermis	0.002751	2.299	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	phyllome epidermis	0.003132	2.299	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	tapetum	0.009074	2.901	--	INHERITED FROM: anther wall tapetum || microsporangium tapetum
Plant ANatomical entity (PAN)	anther wall	0.01303	2.901	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	plant organ	0.03713	0.2391	--	INHERITED FROM: microsporangium wall || lateral root || sporangium wall || leaf trichome || anther wall tapetum || microsporangium tapetum
Plant ANatomical entity (PAN)	phyllome trichome	0.05014	2.299	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.05169	0.2335	--	INHERITED FROM: microsporangium wall || lateral root || sporangium wall || anther wall tapetum || leaf trichome || microsporangium tapetum
Plant ANatomical entity (PAN)	primary xylem	0.09286	2.901	--	INHERITED FROM: protoxylem
Plant ANatomical entity (PAN)	flower	0.9917	0.3446	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	whole plant	1	0.3507	--	INHERITED FROM: portion of vascular tissue || xylem || protoxylem || vascular system
Plant ANatomical entity (PAN)	epidermis	1	0.2046	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	phyllome	1	0.3234	--	INHERITED FROM: leaf trichome || anther wall tapetum
Plant ANatomical entity (PAN)	shoot epidermis	1	0.2224	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	shoot system	1	0.05272	--	INHERITED FROM: leaf trichome || anther wall tapetum
Plant ANatomical entity (PAN)	portion of plant tissue	1	0.1621	--	INHERITED FROM: xylem || vascular system || portion of vascular tissue || protoxylem || microsporangium tapetum || anther wall tapetum || leaf trichome
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: xylem || vascular system || microsporangium wall || protoxylem || lateral root || portion of vascular tissue || sporangium wall || leaf trichome || anther wall tapetum || microsporangium tapetum
Plant ANatomical entity (PAN)	sporophyll	1	0.3985	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	stamen	1	0.5171	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	cardinal organ part	1	0.4385	--	INHERITED FROM: microsporangium wall || microsporangium tapetum || anther wall tapetum || sporangium wall
Plant ANatomical entity (PAN)	plant axis	1	0.3257	--	INHERITED FROM: lateral root
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: lateral root || anther wall tapetum || leaf trichome
Plant ANatomical entity (PAN)	collective phyllome structure	1	0.3837	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	root system	1	0.4584	--	INHERITED FROM: lateral root
Plant ANatomical entity (PAN)	leaf	1	0.4282	--	INHERITED FROM: leaf trichome
Plant ANatomical entity (PAN)	reproductive shoot system	1	0.3304	--	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	microsporangium	1	0.6705	--	INHERITED FROM: microsporangium wall || microsporangium tapetum || anther wall tapetum
Plant ANatomical entity (PAN)	collective plant structure	1	0.01555	--	INHERITED FROM: leaf trichome || anther wall tapetum || lateral root
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	1	0.437	--	INHERITED FROM: sporangium wall || anther wall tapetum || microsporangium wall || microsporangium tapetum
Plant ANatomical entity (PAN)	root	1	0.4679	Least Informative	INHERITED FROM: lateral root
Plant ANatomical entity (PAN)	microsporophyll	1	0.4415	Least Informative	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	androecium	1	0.5153	Least Informative	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	sporangium	1	0.6679	Least Informative	INHERITED FROM: anther wall tapetum || microsporangium tapetum || sporangium wall || microsporangium wall
Plant ANatomical entity (PAN)	vascular system	0.000001166	1.41	Informative	DIRECT
Plant ANatomical entity (PAN)	portion of ground tissue	0.00297	1.579	Informative	INHERITED FROM: microsporangium tapetum || anther wall tapetum
Plant ANatomical entity (PAN)	lateral root	0.0002173	2.123	Highly Informative	DIRECT
Plant ANatomical entity (PAN)	anther	0.002107	2.123	Highly Informative	INHERITED FROM: anther wall tapetum
Plant ANatomical entity (PAN)	trichome	0.004065	1.947	Highly Informative	INHERITED FROM: leaf trichome

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