P4 origin-binding domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DNA/RNA-binding 3-helical bundle [ 46688] (14)
• Superfamily: "Winged helix" DNA-binding domain [ 46785] (84)
• Family: P4 origin-binding domain-like [ 46856] (2)

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Family statistics

	Genomes (185)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	397	1,559	2
Proteins	397	1,558	2

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Growth abnormality	0	0.7903	--	DIRECT
Phenotypic Abnormality (PA)	Abdominal symptom	0	1.161	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0	1.184	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0	1.184	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical cluster || anatomical group || whole organism || compound organ
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	otic placode	0.000000078	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	anterior branchial crest	0.000005439	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	hyoid crest	0.00005282	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial crest	0.000112	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	visual system	0.0007307	1.321	--	DIRECT
Xenopus ANatomical entity (XAN)	cranial placode	0.0009262	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	neural crest	0.006234	1.689	--	INHERITED FROM: branchial crest || anterior branchial crest || hyoid crest
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: neural tube || nervous system || brain || optic vesicle || otic placode || central nervous system || visual system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || brain || nervous system || neural tube || anatomical group || cavitated compound organ || multicellular anatomical structure || ectoderm || compound organ || trunk || tissue || anatomical region || cranial placode || central nervous system || visual system || anterior branchial crest || trunk region || branchial crest || otic placode || neuroectoderm || neurogenic placode || organism subdivision || optic vesicle || head || hyoid crest || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0.001729	1.158	Moderately Informative	INHERITED FROM: optic vesicle || otic placode || visual system
Xenopus ANatomical entity (XAN)	embryonic structure	0.0057	1.149	Moderately Informative	INHERITED FROM: neural tube || otic placode || optic vesicle || cranial placode || neurogenic placode
Xenopus ANatomical entity (XAN)	neuroectoderm	0.0009167	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	vestibuloauditory system	0.07493	1.543	Informative	INHERITED FROM: otic placode
Xenopus ANatomical entity (XAN)	optic vesicle	0.00000006607	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neurogenic placode	0.00001442	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neural tube	0.0000283	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	cranial neural crest	0.001738	1.824	Highly Informative	INHERITED FROM: branchial crest || hyoid crest || anterior branchial crest
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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