Interferon regulatory factor family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DNA/RNA-binding 3-helical bundle [ 46688] (14)
• Superfamily: "Winged helix" DNA-binding domain [ 46785] (84)
• Family: Interferon regulatory factor [ 46877] (3)

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Family statistics

	Genomes (83)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	296	878	6
Proteins	296	878	6

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	skin disease	0.01466	1.022	--	INHERITED FROM: psoriasis
Disease Ontology (DO)	disease by infectious agent	0.0001562	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	integumentary system disease	0.07576	0.9817	Moderately Informative	INHERITED FROM: psoriasis
Disease Ontology (DO)	psoriasis	0.0005552	1.735	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal response to infection	0.000000001898	1.112	--	DIRECT
Mammalian Phenotype (MP)	abnormal interferon secretion	0.0000001342	1.373	--	DIRECT
Mammalian Phenotype (MP)	decreased interferon-beta secretion	0.0000001994	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal plasmacytoid dendritic cell morphology	0.0000003573	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased plasmacytoid dendritic cell number	0.00000129	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal plasmacytoid dendritic cell number	0.000005072	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.000007849	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.0000365	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0.0001156	0.6789	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.0002021	1.112	--	DIRECT
Mammalian Phenotype (MP)	abnormal interferon-alpha secretion	0.0003285	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell number	0.0009092	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymph node size	0.001311	1.7	--	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	abnormal dendritic cell number	0.001319	2.001	--	INHERITED FROM: decreased plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell number || decreased dendritic cell number
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.001565	1.156	--	INHERITED FROM: decreased T cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.001632	0.8789	--	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.001846	1.281	--	INHERITED FROM: decreased mature B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal dendritic cell morphology	0.001938	2.001	--	INHERITED FROM: decreased dendritic cell number || abnormal plasmacytoid dendritic cell morphology || decreased plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	increased leukocyte cell number	0.002084	1.241	--	INHERITED FROM: increased lymphocyte cell number
Mammalian Phenotype (MP)	altered susceptibility to viral infection	0.002101	2.126	--	INHERITED FROM: increased susceptibility to viral infection
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.002257	0.8789	--	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.004319	1.156	--	INHERITED FROM: decreased T cell number || decreased plasmacytoid dendritic cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal interferon-beta secretion	0.004929	2.603	--	INHERITED FROM: decreased interferon-beta secretion
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.006012	0.9404	--	INHERITED FROM: abnormal mature B cell number || abnormal T cell number || decreased mature B cell number || decreased T cell number || increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal circulating protein level	0.008562	1.205	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.01338	0.8473	--	INHERITED FROM: abnormal mature B cell number || decreased T cell number || decreased mature B cell number || abnormal T cell number || increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.01464	0.9129	--	INHERITED FROM: abnormal mature B cell number || decreased T cell number || abnormal plasmacytoid dendritic cell number || decreased mature B cell number || abnormal T cell number || decreased dendritic cell number || decreased plasmacytoid dendritic cell number || increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.02335	0.8108	--	INHERITED FROM: abnormal plasmacytoid dendritic cell number || decreased T cell number || abnormal plasmacytoid dendritic cell morphology || decreased mature B cell number || abnormal T cell number || abnormal mature B cell number || decreased dendritic cell number || decreased plasmacytoid dendritic cell number || increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.02405	0.8038	--	INHERITED FROM: abnormal mature B cell number || abnormal plasmacytoid dendritic cell number || decreased T cell number || abnormal plasmacytoid dendritic cell morphology || abnormal T cell number || decreased mature B cell number || decreased dendritic cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.02513	0.8473	--	INHERITED FROM: decreased plasmacytoid dendritic cell number || increased lymphocyte cell number || decreased dendritic cell number || abnormal mature B cell number || decreased mature B cell number || abnormal T cell number || abnormal plasmacytoid dendritic cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.03009	0.6893	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.06397	0.7167	--	INHERITED FROM: decreased dendritic cell number || decreased T cell number || decreased mature B cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number || abnormal mature B cell number || abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || abnormal T cell number
Mammalian Phenotype (MP)	abnormal B cell number	0.07592	1.348	--	INHERITED FROM: abnormal mature B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal cytokine level	0.1281	1.348	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1931	0.3626	--	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.2381	1.085	--	INHERITED FROM: abnormal interferon-alpha secretion || decreased interferon-beta secretion || abnormal interferon secretion
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.2694	0.9219	--	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.277	0.9219	--	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.294	0.9219	--	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.5803	0.6686	--	INHERITED FROM: decreased T cell number || decreased mature B cell number || decreased dendritic cell number || abnormal plasmacytoid dendritic cell number || abnormal T cell number || abnormal plasmacytoid dendritic cell morphology || abnormal mature B cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	abnormal immune system morphology	0.7198	0.7223	--	INHERITED FROM: decreased dendritic cell number || enlarged lymph nodes || decreased mature B cell number || decreased T cell number || increased lymphocyte cell number || decreased plasmacytoid dendritic cell number || abnormal T cell number || abnormal plasmacytoid dendritic cell morphology || abnormal plasmacytoid dendritic cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	immune system phenotype	0.001332	0.5462	Least Informative	INHERITED FROM: abnormal circulating cytokine level || abnormal interferon-alpha secretion || increased lymphocyte cell number || abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || enlarged lymph nodes || decreased dendritic cell number || decreased T cell number || decreased interferon-beta secretion || abnormal interferon secretion || increased susceptibility to viral infection || abnormal immune system physiology || decreased plasmacytoid dendritic cell number || abnormal mature B cell number || abnormal T cell number || abnormal lymphocyte physiology || abnormal response to infection || abnormal immune serum protein physiology || decreased mature B cell number
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.04993	0.5945	Least Informative	INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal plasmacytoid dendritic cell morphology || abnormal T cell number || abnormal mature B cell number || decreased plasmacytoid dendritic cell number || increased lymphocyte cell number || decreased T cell number || decreased mature B cell number || decreased dendritic cell number || abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal homeostasis	0.117	0.4926	Least Informative	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.0000003206	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.001037	0.9219	Moderately Informative	INHERITED FROM: abnormal lymphocyte physiology
Mammalian Phenotype (MP)	abnormal T cell morphology	0.001353	1.205	Moderately Informative	INHERITED FROM: abnormal T cell number || decreased T cell number
Mammalian Phenotype (MP)	abnormal protein level	0.003915	1.112	Moderately Informative	INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.004057	1.188	Moderately Informative	INHERITED FROM: increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.004221	1.023	Moderately Informative	INHERITED FROM: decreased T cell number || abnormal T cell number || decreased mature B cell number || abnormal mature B cell number || increased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.004799	1.112	Moderately Informative	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.008842	1.072	Moderately Informative	INHERITED FROM: decreased T cell number || decreased dendritic cell number || decreased plasmacytoid dendritic cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal B cell morphology	0.09202	1.156	Moderately Informative	INHERITED FROM: abnormal mature B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.104	1.098	Moderately Informative	INHERITED FROM: decreased dendritic cell number || abnormal plasmacytoid dendritic cell number || decreased mature B cell number || abnormal plasmacytoid dendritic cell morphology || decreased plasmacytoid dendritic cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	altered susceptibility to infection	0.7029	1.112	Moderately Informative	INHERITED FROM: increased susceptibility to viral infection
Mammalian Phenotype (MP)	abnormal mature B cell number	0.0002245	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	decreased T cell number	0.000294	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.0003656	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	decreased B cell number	0.05541	1.562	Informative	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.1031	1.603	Informative	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	increased susceptibility to infection	0.4073	1.324	Informative	INHERITED FROM: increased susceptibility to viral infection
Mammalian Phenotype (MP)	abnormal lymph organ size	0.7604	1.399	Informative	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	increased susceptibility to viral infection	0.0000000003103	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased mature B cell number	0.0000743	1.758	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased dendritic cell number	0.0004644	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged lymph nodes	0.0005836	1.904	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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