SUPERFAMILY 1.75 HMM library and genome assignments server

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Interferon regulatory factor family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   Interferon regulatory factor [ 46877] (3)

Family statistics
Genomes (83) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 296 878 6
Proteins 296 878 6

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0001562Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.07576Moderately InformativeInherited
Disease Ontology (DO)psoriasis0.0005552InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.001332Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04993Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.117Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000003206Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.001037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.001353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.003915Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.004057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.004221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.004799Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.008842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.09202Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.104Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.7029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell number0.0002245InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.000294InformativeDirect
Mammalian Phenotype (MP)increased lymphocyte cell number0.0003656InformativeDirect
Mammalian Phenotype (MP)decreased B cell number0.05541InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1031InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4073InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.7604InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to viral infection0.0000000003103Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0000743Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0004644Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0005836Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]