Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47004]
• Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47005]
• Families: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47006] (3)

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Superfamily statistics

	Genomes (2,619)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,601	46,403	7
Proteins	6,381	44,763	7

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Functional annotation

• General category: General
• Detailed category: General

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0	0.8117	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)tra	0.000000000005966	2.083	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autoimmune disease of urogenital tract	0	1.769	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction disease	0	0.827	--	DIRECT
Disease Ontology (DO)	immune system disease	0	0.78	--	DIRECT
Disease Ontology (DO)	hepatobiliary disease	0	1.468	--	DIRECT
Disease Ontology (DO)	liver cirrhosis	0	1.672	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2157	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0	0.8526	Moderately Informative	DIRECT
Disease Ontology (DO)	gastrointestinal system disease	0	0.8526	Moderately Informative	DIRECT
Disease Ontology (DO)	liver disease	0	1.468	Informative	DIRECT
Disease Ontology (DO)	primary biliary cirrhosis	0	1.769	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Muscular hypotonia	0	1.23	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.6284	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0	1.009	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of coordination	0	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.7631	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal homeostasis	0	0.7631	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.7731	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5315	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.5677	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	1.045	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0	1.128	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of central motor function	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8268	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.8502	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0	0.9916	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Intellectual disability	0	1.365	Informative	DIRECT
Phenotypic Abnormality (PA)	Acidosis	0	1.293	Informative	DIRECT
Phenotypic Abnormality (PA)	Ataxia	0	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Lactic acidosis	0	1.929	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	liver and biliary system	0	1.858	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.7237	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0	1.17	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0	1.17	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || alimentary system || liver and biliary system || liver || urogenital system || egg || genital system || male genitalia || gamete
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || liver || genital system || egg || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || ectoderm || compound organ || trunk || tissue || anatomical region || germ cell || liver and biliary system || solid compound organ || male genitalia || gamete || trunk region || anatomical cluster || viscus || male organism || organism subdivision || cell || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9688	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0	1.013	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.955	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.9618	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0	1.399	Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver	0	1.983	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7597	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	root	0	0.5579	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.5346	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.6838	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.7789	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.7615	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.586	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.119	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR004167 SSF47005 Protein matches
• Abstract: A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E-3 binding protein of eukaryotic pyruvate dehydrogenase.

InterPro database

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