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Home > SCOP hierarchy > Kix domain of CBP (creb binding protein) superfamily

Kix domain of CBP (creb binding protein) superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All alpha proteins [ 46456] (284)
Fold:	Kix domain of CBP (creb binding protein) [ 47039]
Superfamily:	Kix domain of CBP (creb binding protein) [ 47040]
Families:	Kix domain of CBP (creb binding protein) [ 47041]

Superfamily statistics

	Genomes (198)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	553	1,666	2
Proteins	531	1,598	2

Functional annotation

General category	Regulation
Detailed category	DNA-binding

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Histone acetyltransferase	0	Informative	Direct

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Histone acetyltransferase	0	Informative	Direct

Document: EC annotation of SCOP domains

InterPro annotation

Cross references IPR003101 SSF47040 Protein matches

Abstract
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner [ PubMed 9413984]. This provides a model for activator:coactivator interactions. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Kix domain of CBP (creb binding protein) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Kix domain of CBP (creb binding protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · Internal database links ]