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Home > SCOP hierarchy > Proteasome activator superfamily

Proteasome activator superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All alpha proteins [ 46456] (284)
Fold:	Four-helical up-and-down bundle [ 47161] (28)
Superfamily:	Proteasome activator [ 47216]
Families:	Proteasome activator [ 47217] (2)

Superfamily statistics

	Genomes (234)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	497	1,576	3
Proteins	494	1,569	3

Functional annotation

General category	Processes_IC
Detailed category	Protein modification

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	tissue	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	embryo	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	trunk	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	tail	0	Informative	Direct
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	Least Informative	Direct
Xenopus DEvelopment stage (XDE)	climax stage	0	Moderately Informative	Direct
Xenopus DEvelopment stage (XDE)	NF stage 66	0	Informative	Direct

Document: XA annotation of SCOP domains

InterPro annotation

Cross references IPR009077 SSF47216 Protein matches

Abstract
The 20S proteasome is a multicatalytic complex that is responsible for the non-lysosomal degradation of intracellular proteins. The proteasome is composed of a catalytic core that is regulated by protein complexes, which bind to the ends of the cylindrical core structure. One of these regulatory complexes is the PA28 activator complex (also known as the 11S regulator, or REG), a ring-shaped hexameric structure that enhances the peptidase activity of the core enzyme. Three REG subunits have been isolated, REGalpha, REGbeta and REGgamma. REGalpha and REGbeta preferentially form a heteromeric complex with alternating alpha and beta subunits. The structure of the human REGalpha subunit reveals a heptameric barrel-shaped assembly containing a central channel [ PubMed 9403698]. The binding of REG is thought to create a pore through with substrates and products can pass.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Proteasome activator domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Proteasome activator superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Xenopus Anatomy (XA) · Internal database links ]