SUPERFAMILY 1.75 HMM library and genome assignments server

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Long-chain cytokines family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Family:   Long-chain cytokines [ 47267] (9)

Family statistics
Genomes (64) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 636 2,385 26
Proteins 636 2,382 26

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04468Least InformativeInherited
Disease Ontology (DO)nervous system disease0.05311Least InformativeInherited
Disease Ontology (DO)artery disease0.0001489Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0007126Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000911Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.002512Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.01722Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.06356Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.2411Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.000004988InformativeDirect
Disease Ontology (DO)multiple sclerosis0.00004123InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.00007288InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.0001861InformativeDirect
Disease Ontology (DO)periodontal disease0.000475InformativeDirect
Disease Ontology (DO)overnutrition0.0009499InformativeDirect
Disease Ontology (DO)upper respiratory tract disease0.004181InformativeInherited
Disease Ontology (DO)celiac disease0.0001273Highly InformativeDirect
Disease Ontology (DO)kidney failure0.0003741Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal homeostasis0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.03347Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.09865Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.106Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2046Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7563Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8044Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.001694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.01054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.02634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.03301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.1034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2456Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3028Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0001463InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.000195InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.000727InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000727InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton development0.02912InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.04697InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland development0.00008001Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to experimental autoimmune encephalomyelitis0.0002955Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sleep behavior0.0004006Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)pleuroperitoneal region0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]