SUPERFAMILY 1.75 HMM library and genome assignments server

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Short-chain cytokines family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Family:   Short-chain cytokines [ 47286] (13)


Family statistics
Genomes (52) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 541 1,345 27
Proteins 541 1,345 27


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.00000000000209Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.000000008689Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00000005242Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000005973Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.000178Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.000989Moderately InformativeDirect
Disease Ontology (DO)artery disease0.004055Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4272Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.4511Moderately InformativeInherited
Disease Ontology (DO)asthma0.000000001294InformativeDirect
Disease Ontology (DO)parasitic infectious disease0.0000001025InformativeDirect
Disease Ontology (DO)periodontal disease0.000002202InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00005781InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0001091InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0002825InformativeDirect
Disease Ontology (DO)hypertension0.0003265InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.003179InformativeInherited
Disease Ontology (DO)interstitial lung disease0.2061InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.2274InformativeInherited
Disease Ontology (DO)arthritis0.794InformativeInherited
Disease Ontology (DO)atopic dermatitis0.00000006465Highly InformativeDirect
Disease Ontology (DO)rheumatoid arthritis0.0001539Highly InformativeDirect
Disease Ontology (DO)celiac disease0.0002397Highly InformativeDirect
Disease Ontology (DO)anemia0.7761Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.0003433Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.007019Least InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.00000000466Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00000004386Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.0000001168Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.000004107Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.000009376Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004235Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003562Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.009838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01274Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.01539Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.08853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.3319Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.4737Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.5485Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.000002552InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.00001049InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0004915InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.000584InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.008192InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.01552InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.01899InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.02766InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.06271InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.07425InformativeInherited
Mammalian Phenotype (MP)abnormal ovary morphology0.3775InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.5757InformativeInherited
Mammalian Phenotype (MP)lung inflammation0.00001278Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.00006294Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.0002158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology0.0002224Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.0002513Highly InformativeDirect
Mammalian Phenotype (MP)increased granulocyte number0.0006409Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0009356Highly InformativeDirect
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.002502Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.01157Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.03903Highly InformativeInherited
Mammalian Phenotype (MP)decreased acute inflammation0.3095Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1645Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.253Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.01705InformativeInherited
Zebrafish Anatomy (ZA)integument0.000755Highly InformativeDirect

Document: ZA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Internal database links ]