Bromodomain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Bromodomain-like [ 47363] (15)
• Superfamily: Bromodomain [ 47370]
• Families: Bromodomain [ 47371] (4)

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Superfamily statistics

	Genomes (504)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	13,754	41,549	8
Proteins	10,751	31,319	7

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Functional annotation

• General category: Regulation
• Detailed category: DNA-binding

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0.00000000000488	0.8117	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000000007605	0	--	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.7336	0.7211	Least Informative	INHERITED FROM: Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.01673	0.8609	Moderately Informative	INHERITED FROM: Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Histone acetyltransferase	0	1.481	Informative	DIRECT
Enzyme Commission (EC)	Histone-lysine N-methyltransferase	0.00000000006826	1.384	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease by infectious agent	0.4214	0.8029	Moderately Informative	INHERITED FROM: progressive multifocal leukoencephalopathy
Disease Ontology (DO)	viral infectious disease	0.5261	1.257	Informative	INHERITED FROM: progressive multifocal leukoencephalopathy
Disease Ontology (DO)	progressive multifocal leukoencephalopathy	0.0006419	1.894	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.01931	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Phonophobia	0.00001642	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Nasolacrimal duct obstruction	0.00002691	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Spina bifida occulta	0.000143	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Cryptorchidism	0.0002273	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of mouth size	0.0002716	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Sound sensitivity	0.000305	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Obesity	0.0005221	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Hyperactivity	0.0005322	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Spina bifida	0.001979	2.106	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormal eyebrow morphology	0.002156	1.804	--	INHERITED FROM: Thick eyebrow
Phenotypic Abnormality (PA)	Abnormal eyelash morphology	0.002608	1.804	--	INHERITED FROM: Long eyelashes
Phenotypic Abnormality (PA)	Abnormality of upper lip	0.002707	1.804	--	INHERITED FROM: Abnormality of the philtrum
Phenotypic Abnormality (PA)	Abnormality of male external genitalia	0.004485	1.293	--	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Increased body weight	0.005547	2.407	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Abnormal neural tube morphology	0.005923	1.929	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.008246	1.176	--	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction
Phenotypic Abnormality (PA)	Abnormal nasolacrimal system morphology	0.008414	2.106	--	INHERITED FROM: Nasolacrimal duct obstruction || Abnormal lacrimal duct morphology
Phenotypic Abnormality (PA)	Abnormal emotion/affect behavior	0.01114	1.804	--	INHERITED FROM: Abnormal aggressive, impulsive or violent behavior
Phenotypic Abnormality (PA)	Abnormality of the scalp	0.01238	1.804	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of skeletal maturation	0.01386	2.106	--	INHERITED FROM: Delayed skeletal maturation
Phenotypic Abnormality (PA)	Abnormality of the forehead	0.01401	1.804	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the frontal hairline	0.01887	2.106	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.02377	0.8625	--	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.02784	0.8625	--	INHERITED FROM: Abnormality of the philtrum || Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.03085	0.472	--	INHERITED FROM: Abnormal facial shape || Long eyelashes || Nasolacrimal duct obstruction || Abnormal lacrimal duct morphology || Low anterior hairline || Thick eyebrow || Abnormality of mouth size || Abnormality of the philtrum
Phenotypic Abnormality (PA)	Abnormality of the scalp hair	0.03301	1.804	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the spinal cord	0.03722	1.929	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.0525	0.2543	--	INHERITED FROM: Phonophobia || Abnormal aggressive, impulsive or violent behavior || Hyperactivity || Sound sensitivity || Intellectual disability || Spina bifida occulta || Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormal hair pattern	0.05424	1.708	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.06285	1.176	--	INHERITED FROM: Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction || Long eyelashes || Thick eyebrow
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.1539	0.6284	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of body weight	0.1791	1.452	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.18	0.4621	--	INHERITED FROM: Joint hypermobility || Abnormal patella morphology || Delayed skeletal maturation
Phenotypic Abnormality (PA)	Abnormality of the hairline	0.2108	1.804	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.2618	1.202	--	INHERITED FROM: Joint hypermobility
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.2724	0.8383	--	INHERITED FROM: Abnormality of mouth size || Abnormality of the philtrum
Phenotypic Abnormality (PA)	Abnormality of the knee	0.3188	1.804	--	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormality of the face	0.4437	0.5614	--	INHERITED FROM: Thick eyebrow || Abnormal facial shape || Long eyelashes || Nasolacrimal duct obstruction || Abnormality of mouth size || Abnormal lacrimal duct morphology || Abnormality of the philtrum || Low anterior hairline
Phenotypic Abnormality (PA)	Abnormal external genitalia	0.4652	1.23	--	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormality of the male genitalia	0.4773	1.26	--	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.4805	1.26	--	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal hair quantity || Low anterior hairline
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.4926	1.23	--	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Neural tube defect	1	1.929	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of the head	0.02873	0.4771	Least Informative	INHERITED FROM: Abnormal facial shape || Nasolacrimal duct obstruction || Long eyelashes || Abnormal lacrimal duct morphology || Low anterior hairline || Thick eyebrow || Abnormality of the philtrum || Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of limbs	0.0395	0.6431	Least Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.04646	0.5432	Least Informative	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormality of the integument	0.125	0.7253	Least Informative	INHERITED FROM: Long eyelashes || Thick eyebrow || Low anterior hairline || Abnormal hair quantity
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.1447	0.472	Least Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.5041	0.4022	Least Informative	INHERITED FROM: Phonophobia || Abnormal aggressive, impulsive or violent behavior || Hyperactivity || Abnormal fear/anxiety-related behavior || Sound sensitivity || Intellectual disability
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.6464	0.5677	Least Informative	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.001637	0.9594	Moderately Informative	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.00734	1.176	Moderately Informative	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.04158	1.202	Moderately Informative	INHERITED FROM: Abnormal hair quantity || Thick eyebrow || Low anterior hairline || Long eyelashes
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.0501	0.8268	Moderately Informative	INHERITED FROM: Intellectual disability
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.06245	1.176	Moderately Informative	INHERITED FROM: Delayed skeletal maturation || Joint hypermobility
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0.0625	0.8502	Moderately Informative	INHERITED FROM: Intellectual disability
Phenotypic Abnormality (PA)	Behavioral abnormality	0.07621	1.176	Moderately Informative	INHERITED FROM: Phonophobia || Sound sensitivity || Abnormal aggressive, impulsive or violent behavior || Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormality of the ear	0.09681	1.176	Moderately Informative	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Growth abnormality	0.1102	0.9441	Moderately Informative	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.1119	0.9152	Moderately Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.1242	1.128	Moderately Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormality of movement	0.7646	1.045	Moderately Informative	INHERITED FROM: Hyperactivity
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.9594	Moderately Informative	INHERITED FROM: Abnormality of mouth size || Abnormality of the philtrum
Phenotypic Abnormality (PA)	Joint hypermobility	0.0006223	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal hair quantity	0.0008288	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal facial shape	0.0008326	1.628	Informative	DIRECT
Phenotypic Abnormality (PA)	Intellectual disability	0.0008861	1.365	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal testis morphology	0.001555	1.452	Informative	INHERITED FROM: Cryptorchidism
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.002407	1.407	Informative	INHERITED FROM: Long eyelashes
Phenotypic Abnormality (PA)	Congenital abnormal hair pattern	0.004218	1.708	Informative	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the outer ear	0.004826	1.628	Informative	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Impairment in personality functioning	0.008763	1.628	Informative	INHERITED FROM: Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.0742	1.407	Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormal lip morphology	0.1013	1.708	Informative	INHERITED FROM: Abnormality of the philtrum
Phenotypic Abnormality (PA)	Long eyelashes	0.000000705	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal fear/anxiety-related behavior	0.000006453	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal aggressive, impulsive or violent behavior	0.00002107	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Low anterior hairline	0.00007533	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal lacrimal duct morphology	0.00009927	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal patella morphology	0.0001541	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the pinna	0.0001698	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Thick eyebrow	0.0002039	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the philtrum	0.000428	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Delayed skeletal maturation	0.0007776	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Spinal dysraphism	0.002631	1.929	Highly Informative	INHERITED FROM: Spina bifida occulta

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	short nasal bone	0.0001576	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal nasal bone morphology	0.006137	2.207	--	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	craniofacial phenotype	0.03366	1.207	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	skeleton phenotype	0.04211	0.8451	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal embryo morphology	0.07772	1.146	--	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.1366	1.128	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal cranium morphology	0.1693	1.304	--	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.1782	1.277	--	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.3876	0.627	--	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.832	1.304	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.000379	0.7017	Least Informative	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0.6471	0.5166	Least Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	embryo phenotype	0.00009938	0.9058	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system development	0.02655	1.229	Moderately Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.02928	0.8951	Moderately Informative	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.03318	1.207	Moderately Informative	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.08399	1.663	Informative	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal neural tube morphology	0.2	1.663	Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal neural tube closure	0.000463	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	small nasal bone	0.0005436	2.207	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	acute functional tolerance to alcohol defective	0.000000002233	2.708	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.00000003272	0.8099	--	DIRECT
Worm Phenotype (WP)	drug adaptation variant	0.00000003468	2.708	--	DIRECT
Worm Phenotype (WP)	ethanol resistant	0.00000004404	2.708	--	DIRECT
Worm Phenotype (WP)	vulval cell induction variant	0.00000006876	1.666	--	DIRECT
Worm Phenotype (WP)	anesthetic resistant	0.0000001447	2.708	--	DIRECT
Worm Phenotype (WP)	organism UV response variant	0.0000004243	1.862	--	DIRECT
Worm Phenotype (WP)	multivulva	0.0000006485	1.708	--	DIRECT
Worm Phenotype (WP)	distal tip cell development variant	0.0000006666	2.407	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.000005837	0.632	--	DIRECT
Worm Phenotype (WP)	amphid phasmid sensillum morphology variant	0.000008479	1.708	--	DIRECT
Worm Phenotype (WP)	extra distal tip cells	0.00001149	2.407	--	DIRECT
Worm Phenotype (WP)	light response variant	0.00001284	1.862	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.00004687	0.6038	--	DIRECT
Worm Phenotype (WP)	intestinal development variant	0.0006848	1.753	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.0008331	1.327	--	DIRECT
Worm Phenotype (WP)	vulva cell fate specification variant	0.04018	1.628	--	INHERITED FROM: multivulva || vulvaless || vulval cell induction variant
Worm Phenotype (WP)	vulval cell induction reduced	0.1176	2.23	--	INHERITED FROM: vulvaless
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.2397	0.1501	--	INHERITED FROM: gene expression variant || anesthetic resistant || organism UV response variant || acute functional tolerance to alcohol defective || sick || ethanol resistant || drug adaptation variant || organism UV hypersensitive || anesthetic response variant || organism metabolism processing variant
Worm Phenotype (WP)	organism physiology variant	0.2544	0.1405	--	INHERITED FROM: anesthetic resistant || gene expression variant || organism UV response variant || acute functional tolerance to alcohol defective || sick || anesthetic response variant || ethanol resistant || drug adaptation variant || organism UV hypersensitive || organism metabolism processing variant
Worm Phenotype (WP)	chemical response variant	0.4737	0.8045	--	INHERITED FROM: anesthetic response variant || drug adaptation variant || ethanol resistant || anesthetic resistant || acute functional tolerance to alcohol defective
Worm Phenotype (WP)	vulval cell induction increased	0.4986	1.708	--	INHERITED FROM: multivulva
Worm Phenotype (WP)	gonad development variant	0.5965	1.407	--	INHERITED FROM: distal tip cell development variant || extra distal tip cells
Worm Phenotype (WP)	growth variant	0.6675	0.4022	--	INHERITED FROM: sick
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || extra distal tip cells || reproductive system physiology variant || cell fate specification variant || gene expression variant || vulvaless || organ system development variant || distal tip cell development variant || lethal || anesthetic resistant || acute functional tolerance to alcohol defective || intestinal development variant || organism UV hypersensitive || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || multivulva || sick || embryonic development variant || embryonic lethal || cell number variant || fertility variant || light response variant || behavior variant || cell number increased || vulval cell induction variant || drug adaptation variant || ethanol resistant || anesthetic response variant || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || organism UV response variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism behavior variant	0.000005343	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.000256	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.001802	0.7119	Least Informative	INHERITED FROM: amphid phasmid sensillum morphology variant || sensillum morphology variant
Worm Phenotype (WP)	cell development variant	0.01516	0.632	Least Informative	INHERITED FROM: vulvaless || vulval cell induction variant || cell fate specification variant || multivulva
Worm Phenotype (WP)	organism environmental stimulus response variant	0.03969	0.5677	Least Informative	INHERITED FROM: anesthetic resistant || organism UV hypersensitive || drug adaptation variant || ethanol resistant || anesthetic response variant || acute functional tolerance to alcohol defective || organism UV response variant
Worm Phenotype (WP)	reproductive system development variant	0.004946	1.026	Moderately Informative	INHERITED FROM: vulvaless || extra distal tip cells || distal tip cell development variant || vulval cell induction variant || multivulva
Worm Phenotype (WP)	nervous system morphology variant	0.0474	1.216	Moderately Informative	INHERITED FROM: amphid phasmid sensillum morphology variant || sensillum morphology variant
Worm Phenotype (WP)	organism stress response variant	0.05978	0.8325	Moderately Informative	INHERITED FROM: organism UV response variant || organism UV hypersensitive
Worm Phenotype (WP)	drug response variant	0.2057	1.017	Moderately Informative	INHERITED FROM: acute functional tolerance to alcohol defective || anesthetic resistant || anesthetic response variant || drug adaptation variant || ethanol resistant
Worm Phenotype (WP)	cell fate specification variant	0.00003264	1.407	Informative	DIRECT
Worm Phenotype (WP)	sensillum morphology variant	0.00004385	1.477	Informative	DIRECT
Worm Phenotype (WP)	anesthetic response variant	0.00007732	1.628	Informative	DIRECT
Worm Phenotype (WP)	sick	0.0001719	1.561	Informative	DIRECT
Worm Phenotype (WP)	cell number increased	0.0002525	1.477	Informative	DIRECT
Worm Phenotype (WP)	drug resistant	0.005559	1.503	Informative	INHERITED FROM: anesthetic resistant || ethanol resistant
Worm Phenotype (WP)	vulva development variant	0.02359	1.531	Informative	INHERITED FROM: multivulva || vulval cell induction variant || vulvaless
Worm Phenotype (WP)	chemical resistant	0.04041	1.477	Informative	INHERITED FROM: ethanol resistant
Worm Phenotype (WP)	alimentary system development variant	0.317	1.666	Informative	INHERITED FROM: intestinal development variant
Worm Phenotype (WP)	somatic gonad development variant	0.9166	1.531	Informative	INHERITED FROM: distal tip cell development variant || extra distal tip cells
Worm Phenotype (WP)	organism UV hypersensitive	0.000000003446	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	vulvaless	0.00000495	2.23	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	development	0.002652	1.267	--	INHERITED FROM: chronological lifespan
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT
Yeast Phenotype (YP)	chromosome/plasmid maintenance	0.0002343	1.392	Informative	DIRECT
Yeast Phenotype (YP)	lifespan	0.2361	1.517	Informative	INHERITED FROM: chronological lifespan
Yeast Phenotype (YP)	radiation resistance	0.0006273	1.994	Highly Informative	DIRECT
Yeast Phenotype (YP)	chronological lifespan	0.0007173	1.869	Highly Informative	DIRECT
Yeast Phenotype (YP)	ionic stress resistance	0.0007785	1.994	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT
Fly Phenotype (FP)	modifier of variegation	0.0002322	1.525	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	portion of organism substance	0.0004229	1.837	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0.4486	0.2245	--	INHERITED FROM: blood || hematopoietic system
Zebrafish Anatomy (ZA)	anatomical group	0.4845	0.1889	--	INHERITED FROM: blood || hematopoietic system
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: portion of organism substance || blood || whole organism || hematopoietic system
Zebrafish Anatomy (ZA)	hematopoietic system	0.0003919	1.536	Informative	DIRECT
Zebrafish Anatomy (ZA)	blood	0.00004496	1.962	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || multicellular anatomical structure || tissue || organism subdivision
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.0000946	0.6341	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Transferases	0.00000000001264	0.3035	--	DIRECT
Enzyme Commission (EC)	Diamine N-acetyltransferase	0.000003076	2.651	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.9085	0.3541	Least Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.5453	Least Informative	INHERITED FROM: Protein-tyrosine kinases || Non-specific protein-tyrosine kinase || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.001914	1.181	Moderately Informative	INHERITED FROM: Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Acting on acid anhydrides	0.002075	0.9562	Moderately Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.06214	1.119	Moderately Informative	INHERITED FROM: Histone acetyltransferase || Diamine N-acetyltransferase
Enzyme Commission (EC)	Aminoacyltransferases	0.7537	1.166	Moderately Informative	INHERITED FROM: RING-type E3 ubiquitin transferase
Enzyme Commission (EC)	Histone acetyltransferase	0	1.721	Informative	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.0000000288	1.384	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0.0000003601	1.537	Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0004375	1.42	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.215	1.28	Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Adenosinetriphosphatase	0.000000004016	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0.000000004754	1.873	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR001487 SSF47370 Protein matches
• Abstract: Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [1350857]. Bromodomains can interact with acetylated lysine [9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

  The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [7580139].

InterPro database

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