Bromodomain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Bromodomain-like [ 47363] (15)
• Superfamily: Bromodomain [ 47370]
• Family: Bromodomain [ 47371] (4)

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Family statistics

	Genomes (415)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,306	4,151	8
Proteins	1,180	3,724	7

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyltransferases	0.000000000004852	0.8778	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000000001391	0	--	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.6062	0.72	Least Informative	INHERITED FROM: Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	1.001	Moderately Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.005645	0.8169	Moderately Informative	INHERITED FROM: Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Histone acetyltransferase	0	1.627	Informative	DIRECT
Enzyme Commission (EC)	Histone-lysine N-methyltransferase	0.00000000001965	1.595	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	viral infectious disease	0.4914	1.212	--	INHERITED FROM: progressive multifocal leukoencephalopathy
Disease Ontology (DO)	disease by infectious agent	0.4203	0.8142	Moderately Informative	INHERITED FROM: progressive multifocal leukoencephalopathy
Disease Ontology (DO)	progressive multifocal leukoencephalopathy	0.0004982	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Long eyelashes	0.0000002961	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal fear/anxiety-related behavior	0.000003428	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal aggressive, impulsive or violent behavior	0.00001238	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Nasolacrimal duct obstruction	0.00001433	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Phonophobia	0.00001433	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Low anterior hairline	0.00003072	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of mouth size	0.0001298	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal patella morphology	0.000134	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Sound sensitivity	0.0002783	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Single transverse palmar crease	0.0006255	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Strabismus	0.0007969	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal testis morphology	0.000904	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Sacral dimple	0.0009512	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Sacrococcygeal pilonidal abnormality	0.0009512	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal eyebrow morphology	0.001059	1.763	--	INHERITED FROM: Thick eyebrow
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.001179	1.232	--	INHERITED FROM: Long eyelashes
Phenotypic Abnormality (PA)	Spina bifida	0.001377	1.86	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of the palmar creases	0.001489	2.161	--	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormality of upper lip	0.001539	1.684	--	INHERITED FROM: Abnormality of the philtrum
Phenotypic Abnormality (PA)	Spinal dysraphism	0.001861	1.763	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0.002594	1.184	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Congenital abnormal hair pattern	0.002878	1.985	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Increased body weight	0.003927	1.684	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.004269	1.082	--	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction
Phenotypic Abnormality (PA)	Abnormal neural tube morphology	0.004647	1.763	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Skin dimple	0.005835	2.462	--	INHERITED FROM: Sacral dimple
Phenotypic Abnormality (PA)	Abnormal nasolacrimal system morphology	0.006451	2.161	--	INHERITED FROM: Nasolacrimal duct obstruction || Abnormal lacrimal duct morphology
Phenotypic Abnormality (PA)	Abnormality of the scalp	0.008429	1.86	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of skeletal maturation	0.009909	1.985	--	INHERITED FROM: Delayed skeletal maturation
Phenotypic Abnormality (PA)	Abnormality of the frontal hairline	0.01209	2.161	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.01655	0.9309	--	INHERITED FROM: Abnormal testis morphology || Cryptorchidism
Phenotypic Abnormality (PA)	Abnormality of the head	0.01943	0.4538	--	INHERITED FROM: Abnormal facial shape || Nasolacrimal duct obstruction || Long eyelashes || Abnormal lacrimal duct morphology || Low anterior hairline || Thick eyebrow || Abnormality of the philtrum || Abnormality of mouth size || Microcephaly
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.02097	0.4454	--	INHERITED FROM: Abnormal facial shape || Long eyelashes || Nasolacrimal duct obstruction || Abnormal lacrimal duct morphology || Low anterior hairline || Thick eyebrow || Abnormality of mouth size || Abnormality of the philtrum || Microcephaly
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.02121	0.7381	--	INHERITED FROM: Abnormality of the philtrum || Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.02336	0.9572	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the scalp hair	0.02404	1.86	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormal sacrum morphology	0.02687	2.462	--	INHERITED FROM: Sacral dimple || Sacrococcygeal pilonidal abnormality
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.02915	0.6771	--	INHERITED FROM: Microcephaly || Sacral dimple || Sacrococcygeal pilonidal abnormality
Phenotypic Abnormality (PA)	Abnormality of the spinal cord	0.03376	1.763	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.03834	0.2371	--	INHERITED FROM: Microcephaly || Phonophobia || Abnormal aggressive, impulsive or violent behavior || Hyperactivity || Sound sensitivity || Intellectual disability || Spina bifida occulta || Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.04041	1.082	--	INHERITED FROM: Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction || Long eyelashes || Thick eyebrow
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0.04085	0.7381	--	INHERITED FROM: Intellectual disability
Phenotypic Abnormality (PA)	Abnormal hair pattern	0.04561	1.985	--	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of eye movement	0.04955	1.286	--	INHERITED FROM: Strabismus
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.06097	1.348	--	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.06701	0.8826	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Growth abnormality	0.09559	0.7903	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.1193	0.533	--	INHERITED FROM: Microcephaly || Spina bifida occulta
Phenotypic Abnormality (PA)	Decreased head circumference	0.1455	1.348	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1459	0.4712	--	INHERITED FROM: Joint hypermobility || Abnormal patella morphology || Sacrococcygeal pilonidal abnormality || Sacral dimple || Microcephaly || Delayed skeletal maturation
Phenotypic Abnormality (PA)	Abnormal palmar dermatoglyphics	0.1613	2.161	--	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.2208	1.14	--	INHERITED FROM: Joint hypermobility
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.2492	0.7065	--	INHERITED FROM: Abnormality of mouth size || Abnormality of the philtrum
Phenotypic Abnormality (PA)	Abnormality of the skin	0.2552	0.722	--	INHERITED FROM: Single transverse palmar crease || Sacral dimple || Abnormal dermatoglyphics
Phenotypic Abnormality (PA)	Abnormality of the skin of the palm	0.3096	1.763	--	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormal external genitalia	0.419	1.421	--	INHERITED FROM: Cryptorchidism || Abnormal testis morphology
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.4229	1.207	--	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal hair quantity || Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the male genitalia	0.4393	1.421	--	INHERITED FROM: Abnormal testis morphology || Cryptorchidism
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.4454	0.6631	--	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.453	0.9183	--	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.467	1.047	--	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.5825	0.7722	--	INHERITED FROM: Sacral dimple || Abnormal dermatoglyphics || Single transverse palmar crease
Phenotypic Abnormality (PA)	Neural tube defect	1	1.763	--	INHERITED FROM: Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormality of limbs	0.02536	0.6429	Least Informative	INHERITED FROM: Abnormal patella morphology || Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.03684	0.6051	Least Informative	INHERITED FROM: Abnormal testis morphology || Cryptorchidism
Phenotypic Abnormality (PA)	Abnormality of the integument	0.1086	0.6235	Least Informative	INHERITED FROM: Abnormal dermatoglyphics || Long eyelashes || Sacral dimple || Thick eyebrow || Single transverse palmar crease || Low anterior hairline || Abnormal hair quantity
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.1138	0.513	Least Informative	INHERITED FROM: Microcephaly || Sacral dimple || Sacrococcygeal pilonidal abnormality || Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormality of the eye	0.3963	0.5703	Least Informative	INHERITED FROM: Strabismus
Phenotypic Abnormality (PA)	Abnormality of the face	0.4264	0.533	Least Informative	INHERITED FROM: Thick eyebrow || Abnormal facial shape || Long eyelashes || Nasolacrimal duct obstruction || Abnormality of mouth size || Abnormal lacrimal duct morphology || Abnormality of the philtrum || Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.4568	0.3869	Least Informative	INHERITED FROM: Phonophobia || Abnormal aggressive, impulsive or violent behavior || Hyperactivity || Abnormal fear/anxiety-related behavior || Sound sensitivity || Intellectual disability
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.5959	0.4756	Least Informative	INHERITED FROM: Microcephaly || Spina bifida occulta
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.001037	1.031	Moderately Informative	INHERITED FROM: Abnormal testis morphology || Cryptorchidism
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.003772	1.082	Moderately Informative	INHERITED FROM: Thick eyebrow || Long eyelashes || Abnormal lacrimal duct morphology || Nasolacrimal duct obstruction
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.0154	1.047	Moderately Informative	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.02086	0.971	Moderately Informative	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of skull size	0.02748	1.101	Moderately Informative	INHERITED FROM: Microcephaly
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.02854	1.184	Moderately Informative	INHERITED FROM: Abnormal hair quantity || Thick eyebrow || Low anterior hairline || Long eyelashes
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.03702	0.8092	Moderately Informative	INHERITED FROM: Intellectual disability
Phenotypic Abnormality (PA)	Abnormality of the hand	0.04256	1.031	Moderately Informative	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.0542	1.101	Moderately Informative	INHERITED FROM: Delayed skeletal maturation || Joint hypermobility
Phenotypic Abnormality (PA)	Behavioral abnormality	0.06157	1.082	Moderately Informative	INHERITED FROM: Phonophobia || Sound sensitivity || Abnormal aggressive, impulsive or violent behavior || Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormality of the ear	0.07257	0.9572	Moderately Informative	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.1006	0.9309	Moderately Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.1117	1.101	Moderately Informative	INHERITED FROM: Abnormal patella morphology
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.1423	0.7903	Moderately Informative	INHERITED FROM: Strabismus
Phenotypic Abnormality (PA)	Abnormality of body weight	0.1506	1.12	Moderately Informative	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Localized skin lesion	0.1524	1.161	Moderately Informative	INHERITED FROM: Sacral dimple
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.253	1.031	Moderately Informative	INHERITED FROM: Sacral dimple || Sacrococcygeal pilonidal abnormality
Phenotypic Abnormality (PA)	Abnormality of movement	0.7082	1.064	Moderately Informative	INHERITED FROM: Hyperactivity
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Abnormality of mouth size || Abnormality of the philtrum
Phenotypic Abnormality (PA)	Obesity	0.0003423	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Intellectual disability	0.0004297	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal hair quantity	0.0004483	1.559	Informative	DIRECT
Phenotypic Abnormality (PA)	Joint hypermobility	0.0004517	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal facial shape	0.0005002	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Microcephaly	0.0005565	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal conjugate eye movement	0.00109	1.617	Informative	INHERITED FROM: Strabismus
Phenotypic Abnormality (PA)	Abnormality of the outer ear	0.002662	1.617	Informative	INHERITED FROM: Abnormality of the pinna
Phenotypic Abnormality (PA)	Abnormality of male external genitalia	0.002928	1.462	Informative	INHERITED FROM: Cryptorchidism || Abnormal testis morphology
Phenotypic Abnormality (PA)	Impairment in personality functioning	0.004915	1.508	Informative	INHERITED FROM: Abnormal fear/anxiety-related behavior
Phenotypic Abnormality (PA)	Abnormality of the forehead	0.009574	1.684	Informative	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Regional abnormality of skin	0.0117	1.508	Informative	INHERITED FROM: Single transverse palmar crease || Abnormal dermatoglyphics
Phenotypic Abnormality (PA)	Abnormality of the palm	0.02307	1.617	Informative	INHERITED FROM: Single transverse palmar crease
Phenotypic Abnormality (PA)	Abnormal lip morphology	0.07631	1.508	Informative	INHERITED FROM: Abnormality of the philtrum
Phenotypic Abnormality (PA)	Abnormal lacrimal duct morphology	0.00005332	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the pinna	0.00007175	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Spina bifida occulta	0.0001148	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cryptorchidism	0.0001222	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Thick eyebrow	0.0001642	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the philtrum	0.0002104	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hyperactivity	0.0003179	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Delayed skeletal maturation	0.0004605	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal dermatoglyphics	0.0005815	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal eyelash morphology	0.001519	1.86	Highly Informative	INHERITED FROM: Long eyelashes
Phenotypic Abnormality (PA)	Abnormal emotion/affect behavior	0.008934	1.86	Highly Informative	INHERITED FROM: Abnormal aggressive, impulsive or violent behavior
Phenotypic Abnormality (PA)	Abnormality of the hairline	0.1922	1.985	Highly Informative	INHERITED FROM: Low anterior hairline
Phenotypic Abnormality (PA)	Abnormality of the knee	0.3057	1.86	Highly Informative	INHERITED FROM: Abnormal patella morphology

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	embryo phenotype	0.00006792	0.8708	--	DIRECT
Mammalian Phenotype (MP)	short nasal bone	0.00008517	2.603	--	DIRECT
Mammalian Phenotype (MP)	small nasal bone	0.000358	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased vertebrae number	0.0008465	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal nasal bone morphology	0.003606	2.302	--	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal vertebrae morphology	0.007176	1.603	--	INHERITED FROM: decreased vertebrae number
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.02371	0.8323	--	INHERITED FROM: short nasal bone || decreased vertebrae number || small nasal bone
Mammalian Phenotype (MP)	craniofacial phenotype	0.02964	1.047	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	skeleton phenotype	0.03566	0.8038	--	INHERITED FROM: decreased vertebrae number || small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal vertebrae number	0.04941	2.603	--	INHERITED FROM: decreased vertebrae number
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.07485	1.399	--	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal cranium morphology	0.155	1.205	--	INHERITED FROM: short nasal bone || small nasal bone
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.155	1.281	--	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.3844	0.5861	--	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.8122	1.205	--	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.0003012	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0.6504	0.4959	Least Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal nervous system development	0.02283	1.112	Moderately Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.02911	1.047	Moderately Informative	INHERITED FROM: small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal embryo morphology	0.0663	1.112	Moderately Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.1198	1.001	Moderately Informative	INHERITED FROM: decreased vertebrae number || small nasal bone || short nasal bone
Mammalian Phenotype (MP)	abnormal neural tube morphology	0.164	1.7	Informative	INHERITED FROM: abnormal neural tube closure
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.5201	1.399	Informative	INHERITED FROM: decreased vertebrae number
Mammalian Phenotype (MP)	abnormal neural tube closure	0.0003451	2.126	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	acute functional tolerance to alcohol defective	0.000000006708	2.769	--	DIRECT
Worm Phenotype (WP)	organism UV hypersensitive	0.00000000898	2.07	--	DIRECT
Worm Phenotype (WP)	drug adaptation variant	0.0000000614	2.769	--	DIRECT
Worm Phenotype (WP)	ethanol resistant	0.000000104	2.769	--	DIRECT
Worm Phenotype (WP)	vulval cell induction variant	0.0000002122	1.727	--	DIRECT
Worm Phenotype (WP)	anesthetic resistant	0.0000003645	2.769	--	DIRECT
Worm Phenotype (WP)	distal tip cell development variant	0.000001391	2.468	--	DIRECT
Worm Phenotype (WP)	vulvaless	0.00001112	2.468	--	DIRECT
Worm Phenotype (WP)	light response variant	0.00001158	1.99	--	DIRECT
Worm Phenotype (WP)	extra distal tip cells	0.00001691	2.468	--	DIRECT
Worm Phenotype (WP)	amphid phasmid sensillum morphology variant	0.00001727	1.924	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.00003878	0.6859	--	DIRECT
Worm Phenotype (WP)	anesthetic response variant	0.0001727	1.769	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.0002415	0.6256	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.001441	1.371	--	INHERITED FROM: cell number increased || extra distal tip cells
Worm Phenotype (WP)	reproductive system development variant	0.003831	1.156	--	INHERITED FROM: vulvaless || extra distal tip cells || distal tip cell development variant || vulval cell induction variant || multivulva
Worm Phenotype (WP)	organ system morphology variant	0.004847	0.7516	--	INHERITED FROM: amphid phasmid sensillum morphology variant || sensillum morphology variant
Worm Phenotype (WP)	vulva cell fate specification variant	0.03327	1.689	--	INHERITED FROM: multivulva || vulvaless || vulval cell induction variant
Worm Phenotype (WP)	nervous system morphology variant	0.04314	1.321	--	INHERITED FROM: amphid phasmid sensillum morphology variant || sensillum morphology variant
Worm Phenotype (WP)	vulval cell induction reduced	0.1324	2.468	--	INHERITED FROM: vulvaless
Worm Phenotype (WP)	drug response variant	0.1946	1.135	--	INHERITED FROM: acute functional tolerance to alcohol defective || anesthetic resistant || anesthetic response variant || drug adaptation variant || ethanol resistant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.261	0.1444	--	INHERITED FROM: gene expression variant || anesthetic resistant || organism UV response variant || acute functional tolerance to alcohol defective || sick || ethanol resistant || drug adaptation variant || organism UV hypersensitive || anesthetic response variant
Worm Phenotype (WP)	organism physiology variant	0.2793	0.1342	--	INHERITED FROM: anesthetic resistant || gene expression variant || organism UV response variant || acute functional tolerance to alcohol defective || sick || anesthetic response variant || ethanol resistant || drug adaptation variant || organism UV hypersensitive
Worm Phenotype (WP)	vulval cell induction increased	0.4569	1.866	--	INHERITED FROM: multivulva
Worm Phenotype (WP)	growth variant	0.5869	0.3438	--	INHERITED FROM: sick
Worm Phenotype (WP)	somatic gonad development variant	0.9061	1.655	--	INHERITED FROM: distal tip cell development variant || extra distal tip cells
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || extra distal tip cells || reproductive system physiology variant || cell fate specification variant || gene expression variant || vulvaless || organ system development variant || distal tip cell development variant || lethal || anesthetic resistant || acute functional tolerance to alcohol defective || organism UV hypersensitive || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || multivulva || sick || embryonic development variant || embryonic lethal || fertility variant || light response variant || behavior variant || cell number increased || vulval cell induction variant || drug adaptation variant || ethanol resistant || anesthetic response variant || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || organism UV response variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism behavior variant	0.00003691	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.001215	0.4899	Least Informative	INHERITED FROM: gene expression variant
Worm Phenotype (WP)	cell development variant	0.02835	0.6752	Least Informative	INHERITED FROM: vulvaless || vulval cell induction variant || cell fate specification variant || multivulva
Worm Phenotype (WP)	organism environmental stimulus response variant	0.07839	0.6614	Least Informative	INHERITED FROM: anesthetic resistant || organism UV hypersensitive || drug adaptation variant || ethanol resistant || anesthetic response variant || acute functional tolerance to alcohol defective || organism UV response variant
Worm Phenotype (WP)	organ system development variant	0.000000182	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.04798	0.9693	Moderately Informative	INHERITED FROM: organism UV response variant || organism UV hypersensitive
Worm Phenotype (WP)	chemical response variant	0.4659	0.9053	Moderately Informative	INHERITED FROM: anesthetic response variant || drug adaptation variant || ethanol resistant || anesthetic resistant || acute functional tolerance to alcohol defective
Worm Phenotype (WP)	cell fate specification variant	0.00003472	1.513	Informative	DIRECT
Worm Phenotype (WP)	sensillum morphology variant	0.00009853	1.593	Informative	DIRECT
Worm Phenotype (WP)	sick	0.0003011	1.727	Informative	DIRECT
Worm Phenotype (WP)	cell number increased	0.0004414	1.446	Informative	DIRECT
Worm Phenotype (WP)	drug resistant	0.00886	1.689	Informative	INHERITED FROM: anesthetic resistant || ethanol resistant
Worm Phenotype (WP)	vulva development variant	0.01986	1.655	Informative	INHERITED FROM: multivulva || vulval cell induction variant || vulvaless
Worm Phenotype (WP)	chemical resistant	0.03602	1.593	Informative	INHERITED FROM: ethanol resistant
Worm Phenotype (WP)	gonad development variant	0.5851	1.538	Informative	INHERITED FROM: distal tip cell development variant || extra distal tip cells
Worm Phenotype (WP)	organism UV response variant	0.0000004155	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	multivulva	0.00000158	1.866	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	chronological lifespan	0.0008595	1.666	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	development	0.002858	1.143	Moderately Informative	INHERITED FROM: chronological lifespan
Yeast Phenotype (YP)	chromosome/plasmid maintenance	0.0001938	1.444	Informative	DIRECT
Yeast Phenotype (YP)	lifespan	0.2146	1.403	Informative	INHERITED FROM: chronological lifespan
Yeast Phenotype (YP)	radiation resistance	0.0005092	1.967	Highly Informative	DIRECT
Yeast Phenotype (YP)	ionic stress resistance	0.0006442	2.143	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	modifier of variegation	0.0001573	1.687	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	portion of organism substance	0.0003242	1.869	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0.4221	0.1857	--	INHERITED FROM: blood || hematopoietic system
Zebrafish Anatomy (ZA)	anatomical group	0.4623	0.1532	--	INHERITED FROM: blood || hematopoietic system
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: portion of organism substance || blood || hematopoietic cell || whole organism || hematopoietic system
Zebrafish Anatomy (ZA)	cell	0.3575	0.6388	Least Informative	INHERITED FROM: hematopoietic cell
Zebrafish Anatomy (ZA)	hematopoietic system	0.000352	1.626	Informative	DIRECT
Zebrafish Anatomy (ZA)	hematopoietic cell	0.0009907	1.471	Informative	DIRECT
Zebrafish Anatomy (ZA)	blood	0.00003685	1.994	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || tissue || organism subdivision
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.0001058	0.5979	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Adenosinetriphosphatase	0.000000001444	2.531	--	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.00000000522	1.617	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0.0000004202	1.767	--	DIRECT
Enzyme Commission (EC)	Diamine N-acetyltransferase	0.000002578	2.929	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0004533	1.639	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Protein-tyrosine kinases || Non-specific protein-tyrosine kinase || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Transferases	0.000000000001023	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.8663	0.4043	Least Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Acyltransferases	0	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.001422	1.133	Moderately Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.002137	1.437	Informative	INHERITED FROM: Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.06524	1.321	Informative	INHERITED FROM: Histone acetyltransferase || Diamine N-acetyltransferase
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.1842	1.452	Informative	INHERITED FROM: Adenosinetriphosphatase
Enzyme Commission (EC)	Aminoacyltransferases	0.5898	1.391	Informative	INHERITED FROM: RING-type E3 ubiquitin transferase
Enzyme Commission (EC)	Histone acetyltransferase	0	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0.000000005311	2.084	Highly Informative	DIRECT

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