Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
• Superfamily: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
• Families: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)

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Superfamily statistics

	Genomes (266)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,808	4,426	4
Proteins	1,797	4,402	4

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Functional annotation

• General category: General
• Detailed category: Protein interaction

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acce	0	1.281	Informative	DIRECT
Enzyme Commission (EC)	Adenylate kinase	0	1.958	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.7582	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.7582	Moderately Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	vestibuloauditory system	0	1.837	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical cluster || sensory system || anatomical group || whole organism || vestibuloauditory system || inner ear || compound organ || central nervous system || cavitated compound organ || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	central nervous system	0	1.008	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	sensory system	0	1.097	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.883	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	inner ear	0	1.962	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: head region || anatomical group || multicellular anatomical structure || anatomical region || organism subdivision || head
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Adenylate kinase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Nucleoside-diphosphate kinase	0.00006891	2.651	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acceptor	0	1.59	Informative	DIRECT

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InterPro annotation

• Cross references: IPR003117 SSF47391 Protein matches
• Abstract:

  In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

  Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).

InterPro database

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