SUPERFAMILY 1.75 HMM library and genome assignments server

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S100 proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Family:   S100 proteins [ 47478]

Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 409 756 26
Proteins 409 755 26

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0004907Least InformativeDirect
Disease Ontology (DO)cell type cancer0.00005537Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0006975Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.02055Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2423Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease0.00003195InformativeDirect
Disease Ontology (DO)lung carcinoma0.00006087InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.0001877InformativeDirect
Disease Ontology (DO)psoriatic arthritis0.00000563Highly InformativeDirect

Document: DO annotation of SCOP domains

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Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 174 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EF-hand domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Internal database links ]