Calponin-homology domain, CH-domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: CH domain-like [ 47575] (3)
• Superfamily: Calponin-homology domain, CH-domain [ 47576]
• Family: Calponin-homology domain, CH-domain [ 47577] (9)

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Family statistics

	Genomes (493)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	5,680	17,766	21
Proteins	5,657	17,716	21

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Pectus excavatum	0.0001551	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the upper limbs	0.00119	1.617	--	INHERITED FROM: Scapular winging
Phenotypic Abnormality (PA)	Abnormality of the scapula	0.01259	1.985	--	INHERITED FROM: Scapular winging
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system electrophysiology	0.01524	1.383	--	INHERITED FROM: Heart block
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.04035	0.9183	--	INHERITED FROM: Scapular winging
Phenotypic Abnormality (PA)	Abnormal tendon morphology	0.07655	1.462	--	INHERITED FROM: Abnormality of the Achilles tendon || Decreased cervical spine flexion due to contractures of posterior cervical muscles || Contractures of the joints of the lower limbs
Phenotypic Abnormality (PA)	Cardiac conduction abnormality	0.08781	1.86	--	INHERITED FROM: Heart block
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.09456	1.14	--	INHERITED FROM: Contractures of the joints of the lower limbs || Decreased cervical spine flexion due to contractures of posterior cervical muscles
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.09797	0.4712	--	INHERITED FROM: Contractures of the joints of the lower limbs || Abnormality of the Achilles tendon || Scapular winging || Pectus excavatum || Decreased cervical spine flexion due to contractures of posterior cervical muscles
Phenotypic Abnormality (PA)	Limb joint contracture	0.181	1.86	--	INHERITED FROM: Contractures of the joints of the lower limbs
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.3467	0.6771	--	INHERITED FROM: Scapular winging || Pectus excavatum
Phenotypic Abnormality (PA)	Abnormality of the foot	0.5205	1.082	--	INHERITED FROM: Abnormality of the Achilles tendon
Phenotypic Abnormality (PA)	Abnormality of the shoulder girdle musculature	0.5614	1.763	--	INHERITED FROM: Scapular winging
Phenotypic Abnormality (PA)	Abnormality of limbs	0.05021	0.6429	Least Informative	INHERITED FROM: Abnormality of the musculature of the lower limbs || Scapular winging || Abnormality of the Achilles tendon
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.07083	0.513	Least Informative	INHERITED FROM: Decreased cervical spine flexion due to contractures of posterior cervical muscles || Pectus excavatum || Abnormality of the Achilles tendon || Scapular winging || Contractures of the joints of the lower limbs
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.08534	0.5433	Least Informative	INHERITED FROM: Scapular winging || Contractures of the joints of the lower limbs || Decreased cervical spine flexion due to contractures of posterior cervical muscles || Abnormality of the musculature of the lower limbs
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1191	0.5179	Least Informative	INHERITED FROM: Heart block
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.02196	1.031	Moderately Informative	INHERITED FROM: Decreased cervical spine flexion due to contractures of posterior cervical muscles || Contractures of the joints of the lower limbs || Lipodystrophy
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.03812	0.9309	Moderately Informative	INHERITED FROM: Heart block
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.04159	0.9061	Moderately Informative	INHERITED FROM: Scapular winging || Contractures of the joints of the lower limbs || Abnormality of the musculature of the lower limbs || Decreased cervical spine flexion due to contractures of posterior cervical muscles
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.06642	0.9309	Moderately Informative	INHERITED FROM: Abnormality of the musculature of the lower limbs || Abnormality of the Achilles tendon
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.1961	1.207	Moderately Informative	INHERITED FROM: Scapular winging || Pectus excavatum
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.4911	1.101	Moderately Informative	INHERITED FROM: Contractures of the joints of the lower limbs || Decreased cervical spine flexion due to contractures of posterior cervical muscles
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.01486	1.421	Informative	INHERITED FROM: Abnormality of the musculature of the lower limbs || Scapular winging
Phenotypic Abnormality (PA)	Abnormal adipose tissue morphology	0.01764	1.684	Informative	INHERITED FROM: Lipodystrophy
Phenotypic Abnormality (PA)	Flexion contracture	0.08357	1.462	Informative	INHERITED FROM: Contractures of the joints of the lower limbs || Decreased cervical spine flexion due to contractures of posterior cervical muscles
Phenotypic Abnormality (PA)	Decreased cervical spine flexion due to contractures of posterior cervical muscles	0.00002532	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Lipodystrophy	0.0001637	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Scapular winging	0.0003314	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Contractures of the joints of the lower limbs	0.0004388	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature of the lower limbs	0.0005218	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the Achilles tendon	0.0008386	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Heart block	0.0009955	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the sternum	0.002264	2.161	Highly Informative	INHERITED FROM: Pectus excavatum

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased transitional stage T1 B cell number	0.000008789	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased transitional stage T2 B cell number	0.00005292	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage T1 B cell morphology	0.00006594	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage T2 B cell morphology	0.00008126	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal exercise endurance	0.00008337	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased transitional stage B cell number	0.0003796	2.126	--	DIRECT
Mammalian Phenotype (MP)	intestinal ulcer	0.0006523	2.126	--	DIRECT
Mammalian Phenotype (MP)	muscle phenotype	0.0008595	0.8473	--	DIRECT
Mammalian Phenotype (MP)	decreased transitional stage B cell number	0.001654	2.126	--	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal intestinal epithelium morphology	0.07846	1.758	--	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.08585	0.9404	--	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	abnormal B cell number	0.09395	1.348	--	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.09601	1.281	--	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal immature B cell morphology	0.1061	1.7	--	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal immature B cell number	0.1252	1.7	--	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1589	0.3626	--	INHERITED FROM: abnormal exercise endurance
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.1917	1.156	--	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	increased B cell number	0.2211	1.7	--	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.2987	1.156	--	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.3434	0.9129	--	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal cell physiology	0.3666	0.6209	--	INHERITED FROM: abnormal cell adhesion
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.3801	0.8473	--	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.4438	0.8473	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.4805	0.8108	--	INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.4912	0.8038	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.5591	1.205	--	INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.5954	0.7167	--	INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.6429	0.9404	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	increased leukocyte cell number	0.6476	1.241	--	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.6727	1.072	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.6884	1.072	--	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.7527	1.156	--	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.7747	0.6686	--	INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.988	0.7223	--	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology
Mammalian Phenotype (MP)	immune system phenotype	0.1111	0.5462	Least Informative	INHERITED FROM: abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	cellular phenotype	0.4769	0.5387	Least Informative	INHERITED FROM: abnormal cell adhesion
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.5268	0.5945	Least Informative	INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.02384	1.023	Moderately Informative	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	abnormal B cell morphology	0.1326	1.156	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.2237	1.072	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.2313	1.098	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.5414	1.023	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.5474	1.188	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.6836	0.9129	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.7803	1.059	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	decreased B cell number	0.03721	1.562	Informative	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal metabolism	0.08728	1.281	Informative	INHERITED FROM: abnormal exercise endurance
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.2853	1.373	Informative	INHERITED FROM: abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal intestine morphology	0.3093	1.457	Informative	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.6137	1.524	Informative	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal cell adhesion	0.0008154	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased immature B cell number	0.002977	2.126	Highly Informative	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal transitional stage B cell morphology	0.005007	2.001	Highly Informative	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	gastrointestinal ulcer	0.007196	2.126	Highly Informative	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	decreased immature B cell number	0.1186	2.001	Highly Informative	INHERITED FROM: decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal intestinal mucosa morphology	0.9208	1.904	Highly Informative	INHERITED FROM: intestinal ulcer

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	cleavage furrow initiation defective early emb	0.00000005833	2.769	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.00000008763	1.407	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.0000004764	0.7558	--	DIRECT
Worm Phenotype (WP)	reduced brood size	0.00000282	1.593	--	DIRECT
Worm Phenotype (WP)	cleavage furrow defective	0.000008857	2.07	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.00001587	1.407	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.00002897	1.623	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.00003269	1.306	--	DIRECT
Worm Phenotype (WP)	body wall muscle myosin organization defective	0.00004522	2.468	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.001242	0.7516	--	INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective || muscle system morphology variant
Worm Phenotype (WP)	neuronal outgrowth variant	0.003027	1.565	--	INHERITED FROM: axon guidance variant
Worm Phenotype (WP)	cytokinesis variant	0.003817	1.689	--	INHERITED FROM: cytokinesis variant emb || cleavage furrow defective || cleavage furrow defective early emb || cleavage furrow initiation defective early emb
Worm Phenotype (WP)	cytokinesis defective early emb	0.00645	1.866	--	INHERITED FROM: cleavage furrow defective early emb || cleavage furrow initiation defective early emb
Worm Phenotype (WP)	muscle cell morphology variant	0.007586	1.337	--	INHERITED FROM: body wall muscle myosin organization defective || striated muscle morphology variant
Worm Phenotype (WP)	mitochondria spacing variant	0.02269	1.623	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	neuron development variant	0.08785	1.321	--	INHERITED FROM: axon guidance variant
Worm Phenotype (WP)	body wall muscle thick filament variant	0.1104	2.292	--	INHERITED FROM: body wall muscle myosin organization defective
Worm Phenotype (WP)	organelle organization biogenesis variant	0.125	1.306	--	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	morphology variant	0.5848	0.046	--	INHERITED FROM: actin organization biogenesis variant || mitochondria alignment variant || cell morphology variant || muscle system morphology variant || body wall muscle myosin organization defective || striated muscle morphology variant
Worm Phenotype (WP)	hermaphrodite fertility variant	0.8842	0.0947	--	INHERITED FROM: reduced brood size || brood size variant
Worm Phenotype (WP)	cell component morphology variant	0.899	0.8392	--	INHERITED FROM: actin organization biogenesis variant || mitochondria alignment variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: reproductive system physiology variant || axon guidance variant || lethal || cytokinesis variant emb || muscle cell physiology variant || actin organization biogenesis variant || development variant || cleavage furrow defective early emb || exploded through vulva || cell physiology variant || reduced brood size || brood size variant || embryonic development variant || embryonic lethal || fertility variant || muscle system physiology variant || cleavage furrow initiation defective early emb || organ system physiology variant || cleavage furrow defective || organism development variant || fertility reduced
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle myosin organization defective
Worm Phenotype (WP)	cell physiology variant	0.0007016	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.1233	0.6752	Least Informative	INHERITED FROM: axon guidance variant
Worm Phenotype (WP)	early embryonic lethal	0.005464	1.178	Moderately Informative	INHERITED FROM: cleavage furrow defective early emb || cleavage furrow initiation defective early emb
Worm Phenotype (WP)	organ system development variant	0.006487	0.9113	Moderately Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	cell type morphology variant	0.01246	0.8878	Moderately Informative	INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective
Worm Phenotype (WP)	cell organization biogenesis variant	0.2298	1.135	Moderately Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	cell division variant	0.4273	1.036	Moderately Informative	INHERITED FROM: cleavage furrow defective || cleavage furrow defective early emb || cleavage furrow initiation defective early emb || cytokinesis variant emb
Worm Phenotype (WP)	brood size variant	0.000006972	1.538	Informative	DIRECT
Worm Phenotype (WP)	cytokinesis variant emb	0.0004076	1.689	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0.0005779	1.426	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.002613	1.565	Informative	INHERITED FROM: axon guidance variant
Worm Phenotype (WP)	mitochondria morphology variant	0.005952	1.513	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.01796	1.623	Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	epithelial system development variant	0.04458	1.655	Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	cell component localization variant	0.06443	1.388	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.6293	1.446	Informative	INHERITED FROM: body wall muscle myosin organization defective
Worm Phenotype (WP)	actin organization biogenesis variant	0.000006313	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	cleavage furrow defective early emb	0.000007926	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	axon guidance variant	0.0004382	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	exploded through vulva	0.0009154	1.99	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	indirect flight muscle	0.0004004	2.088	--	DIRECT
Fly Anatomy (FA)	skeletal muscle of mesothorax	0.001413	1.912	--	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	skeletal muscle of thorax	0.00146	1.912	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	somatic muscle	0.00276	1.544	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	abdominal nerve	0.003366	1.787	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	adult muscle system	0.004808	1.912	--	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	muscle system	0.006845	1.435	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	segmental nerve	0.007736	2.088	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	neuron projection bundle	0.01423	1.243	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	adult segment	0.06494	0.821	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	adult somatic muscle	0.08289	1.912	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	adult tagma	0.08764	0.6649	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	organism subdivision	0.1103	0.5027	--	INHERITED FROM: indirect flight muscle || abdominal segmental nerve || flight muscle
Fly Anatomy (FA)	embryonic/larval nervous system	0.1272	0.7171	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	larval abdomen	0.1275	1.389	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	cell	0.2242	0.4069	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	mesothoracic segment	0.2391	0.9578	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	organ system	0.2423	0.1823	--	INHERITED FROM: indirect flight muscle || flight muscle || abdominal segmental nerve
Fly Anatomy (FA)	abdominal segment	0.4851	1.243	--	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	adult thorax	0.5002	0.942	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	thorax	0.6495	0.912	--	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	adult thoracic segment	0.6867	0.942	--	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	organism	0.7443	0.06695	--	INHERITED FROM: flight muscle || abdominal segmental nerve || indirect flight muscle
Fly Anatomy (FA)	thoracic segment	0.9006	0.912	--	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: abdominal segmental nerve || flight muscle || indirect flight muscle || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || indirect flight muscle || flight muscle || abdominal segmental nerve
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: abdominal segmental nerve || indirect flight muscle || flight muscle
Fly Anatomy (FA)	tagma	0.09367	0.5027	Least Informative	INHERITED FROM: indirect flight muscle || abdominal segmental nerve || flight muscle
Fly Anatomy (FA)	adult	0.1134	0.4496	Least Informative	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	segment	0.1202	0.6568	Least Informative	INHERITED FROM: abdominal segmental nerve || indirect flight muscle || flight muscle
Fly Anatomy (FA)	somatic cell	0.128	0.4861	Least Informative	INHERITED FROM: indirect flight muscle || flight muscle
Fly Anatomy (FA)	nervous system	0.3157	0.6333	Least Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	organ system subdivision	0.3274	0.4301	Least Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	larva	0.6815	0.3763	Least Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	multi-cell-component structure	0.01212	1.088	Moderately Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	peripheral nervous system	0.08898	0.8978	Moderately Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	adult mesothoracic segment	0.1665	0.9912	Moderately Informative	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	larval segment	0.2982	1.243	Moderately Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	larval tagma	0.5127	1.159	Moderately Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	abdomen	0.5927	1.185	Moderately Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	syncytium	0.004059	1.544	Informative	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	muscle cell	0.008124	1.486	Informative	INHERITED FROM: flight muscle || indirect flight muscle
Fly Anatomy (FA)	larval abdominal segment	0.08048	1.486	Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	embryonic/larval peripheral nervous system	0.08508	1.544	Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	nerve	0.1067	1.389	Informative	INHERITED FROM: abdominal segmental nerve
Fly Anatomy (FA)	flight muscle	0.0007025	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	abdominal segmental nerve	0.0008909	2.088	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	F-actin monooxygenase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.000000000000004716	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.514	Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0	2.026	Highly Informative	DIRECT

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