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Chemotaxis receptor methyltransferase CheR, N-terminal domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Transferases |
Document: Function annotation of SCOP domain superfamilies
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
InterPro annotation
| Cross references | IPR000780 SSF47757 Protein matches |
| Abstract | Flagellated bacteria swim towards favourable chemicals and away from deleterious ones. Sensing of
chemoeffector gradients involves chemotaxis receptors, transmembrane (TM) proteins that detect
stimuli through their periplasmic domains and transduce the signals via their cytoplasmic domains
[,  9115443]. Signalling outputs from these
receptors are influenced both by the binding of the chemoeffector ligand to their periplasmic
domains and by methylation of specific glutamate residues on their cytoplasmic domains. Methylation
is catalysed by CheR, an S-adenosylmethionine-dependent methyltransferase [9115443], which
reversibly methylates specific glutamate residues within a coiled coil region, to form gamma-glutamyl methyl ester residues [9115443, 9628482]. The structure of the Salmonella typhimurium chemotaxis receptor methyltransferase CheR, bound to S-adenosylhomocysteine, has been determined
to a resolution of 2.0 A [9115443]. The structure reveals CheR to be a two-domain protein, with
a smaller N-terminal helical domain linked via a single polypeptide connection to a larger
C-terminal alpha/beta domain. The C-terminal domain has the characteristics of a nucleotide-binding
fold, with an insertion of a small anti-parallel beta-sheet subdomain. The S-adenosylhomocysteine-binding site is formed mainly by the large domain, with contributions from residues within the
N-terminal domain and the linker region [9115443]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Chemotaxis receptor methyltransferase CheR, N-terminal domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 1 hidden Markov models representing the Chemotaxis receptor methyltransferase CheR, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]
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