Pointed domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: SAM domain-like [ 47768] (16)
• Superfamily: SAM/Pointed domain [ 47769] (3)
• Family: Pointed domain [ 47770] (6)

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Family statistics

	Genomes (104)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	557	1,660	9
Proteins	557	1,660	9

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	breast cancer	0.0006823	1.283	--	DIRECT
Disease Ontology (DO)	thoracic cancer	0.006561	1.283	--	INHERITED FROM: breast cancer
Disease Ontology (DO)	cancer	0.9884	0.2555	--	INHERITED FROM: breast cancer
Disease Ontology (DO)	organ system cancer	0.01337	0.4879	Least Informative	INHERITED FROM: breast cancer

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal gland morphology	0	0.7519	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0	0.7055	--	DIRECT
Mammalian Phenotype (MP)	abnormal vascular development	0.00001104	1.223	--	DIRECT
Mammalian Phenotype (MP)	thrombocytopenia	0.0001384	2.302	--	DIRECT
Mammalian Phenotype (MP)	dilated vasculature	0.0001781	2.603	--	DIRECT
Mammalian Phenotype (MP)	edema	0.0001952	1.7	--	DIRECT
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.0002373	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.0004705	1.281	--	DIRECT
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.0005226	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.0005751	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal extraembryonic tissue morphology	0.0006107	1.348	--	DIRECT
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.0007087	1.156	--	DIRECT
Mammalian Phenotype (MP)	increased tumor incidence	0.000976	1.172	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.001021	0.9404	--	INHERITED FROM: abnormal mature B cell morphology || abnormal B cell differentiation || decreased thymocyte number || abnormal lymphocyte cell number || decreased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal blood circulation	0.001038	1.261	--	INHERITED FROM: hemorrhage
Mammalian Phenotype (MP)	abnormal tumor incidence	0.001619	1.141	--	INHERITED FROM: increased organ/body region tumor incidence || increased tumor incidence || abnormal organ/body region tumor incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.001728	1.141	--	INHERITED FROM: increased organ/body region tumor incidence || increased tumor incidence || abnormal organ/body region tumor incidence
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.002502	0.8473	--	INHERITED FROM: abnormal mature B cell morphology || abnormal B cell differentiation || abnormal lymphocyte cell number || decreased thymocyte number || decreased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.002779	0.9129	--	INHERITED FROM: decreased leukocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number || decreased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.002811	1.072	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.003038	1.072	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.004729	0.8108	--	INHERITED FROM: abnormal mature B cell morphology || abnormal B cell differentiation || decreased leukocyte cell number || decreased lymphocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.004901	0.8038	--	INHERITED FROM: decreased leukocyte cell number || abnormal B cell differentiation || abnormal mature B cell morphology || abnormal lymphocyte cell number || decreased thymocyte number || decreased lymphocyte cell number
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.004962	0.7902	--	INHERITED FROM: abnormal vascular development || abnormal blood vessel morphology || abnormal cardiovascular development || dilated vasculature
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.005157	0.8473	--	INHERITED FROM: decreased thymocyte number || abnormal lymphocyte cell number || decreased lymphocyte cell number || thrombocytopenia || decreased leukocyte cell number
Mammalian Phenotype (MP)	abnormal platelet cell number	0.008844	2.302	--	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.01515	0.7167	--	INHERITED FROM: abnormal lymphocyte cell number || decreased thymocyte number || decreased lymphocyte cell number || decreased leukocyte cell number || thrombocytopenia || abnormal mature B cell morphology || abnormal B cell differentiation
Mammalian Phenotype (MP)	embryo phenotype	0.01983	0.8708	--	INHERITED FROM: abnormal extraembryonic tissue morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.02407	0.6686	--	INHERITED FROM: abnormal mature B cell morphology || decreased leukocyte cell number || thrombocytopenia || decreased lymphocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number || abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.0321	1.156	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal myeloid cell number	0.04301	1.758	--	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.06904	1.205	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.149	0.3626	--	INHERITED FROM: edema
Mammalian Phenotype (MP)	abnormal immune system morphology	0.2615	0.7223	--	INHERITED FROM: decreased lymphocyte cell number || decreased thymocyte number || abnormal lymphocyte cell number || abnormal mature B cell morphology || decreased leukocyte cell number || abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal T cell number	0.6188	1.261	--	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0	0.6947	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.006507	0.5462	Least Informative	INHERITED FROM: abnormal B cell differentiation || decreased thymocyte number || abnormal mature B cell morphology || abnormal lymphocyte cell number || decreased lymphocyte cell number || decreased leukocyte cell number
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.01483	0.6737	Least Informative	INHERITED FROM: abnormal blood vessel physiology || hemorrhage || abnormal blood vessel morphology || abnormal vascular development || dilated vasculature || abnormal cardiovascular development
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.04172	0.5945	Least Informative	INHERITED FROM: abnormal B cell differentiation || abnormal mature B cell morphology || decreased leukocyte cell number || thrombocytopenia || decreased lymphocyte cell number || abnormal lymphocyte cell number || decreased thymocyte number
Mammalian Phenotype (MP)	abnormal homeostasis	0.6476	0.4926	Least Informative	INHERITED FROM: edema
Mammalian Phenotype (MP)	prenatal lethality	0	0.9129	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.00006739	1.059	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.0005412	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.0006902	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.001562	1.072	Moderately Informative	INHERITED FROM: decreased lymphocyte cell number || decreased leukocyte cell number || thrombocytopenia || decreased thymocyte number
Mammalian Phenotype (MP)	neoplasm	0.002529	1.035	Moderately Informative	INHERITED FROM: abnormal organ/body region tumor incidence || increased tumor incidence || increased organ/body region tumor incidence
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.044	1.059	Moderately Informative	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal B cell morphology	0.09202	1.156	Moderately Informative	INHERITED FROM: abnormal mature B cell morphology || abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.104	1.098	Moderately Informative	INHERITED FROM: abnormal mature B cell morphology
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.2311	0.9499	Moderately Informative	INHERITED FROM: abnormal blood vessel physiology || hemorrhage
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.3016	1.035	Moderately Informative	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.3281	0.9129	Moderately Informative	INHERITED FROM: abnormal B cell differentiation || thrombocytopenia
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.4064	1.112	Moderately Informative	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	abnormal endocrine gland morphology	0.5787	1.141	Moderately Informative	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.5916	0.9904	Moderately Informative	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal T cell morphology	0.6777	1.205	Moderately Informative	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.00004348	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel physiology	0.0001118	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	hemorrhage	0.0004275	1.348	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fluid regulation	0.001195	1.373	Informative	INHERITED FROM: edema
Mammalian Phenotype (MP)	abnormal thymus morphology	0.02305	1.399	Informative	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	lethality throughout fetal growth and development	0.05116	1.7	Informative	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	decreased T cell number	0.5055	1.427	Informative	INHERITED FROM: decreased thymocyte number
Mammalian Phenotype (MP)	decreased thymocyte number	0.0001096	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	lethality throughout fetal growth and development, complete penetrance	0.0008751	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal platelet morphology	0.004172	2.126	Highly Informative	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	decreased myeloid cell number	0.04435	1.904	Highly Informative	INHERITED FROM: thrombocytopenia

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	cell number defective	0.0003969	1.344	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	chorion	0.004054	2.088	--	INHERITED FROM: dorsal appendage
Fly Anatomy (FA)	chorionic specialization	0.005248	2.088	--	INHERITED FROM: dorsal appendage
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || somatic cell || cell || dorsal appendage || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || dorsal appendage || cell || somatic cell || organism
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	acellular anatomical structure	0.008177	1.134	Moderately Informative	INHERITED FROM: dorsal appendage
Fly Anatomy (FA)	egg	0.002764	1.69	Informative	INHERITED FROM: dorsal appendage
Fly Anatomy (FA)	dorsal appendage	0.0001888	2.088	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	hematological system	0	1.865	--	DIRECT
Xenopus ANatomical entity (XAN)	blood vessel	0	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk vasculature	0.000000007743	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: ventral blood island || blood vessel || cardiovascular system || circulatory system || trunk vasculature || hematological system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: intersomitic region || head region || circulatory system || ventral blood island || anatomical group || cavitated compound organ || multicellular anatomical structure || cardiovascular system || periocular region || blood vessel || mesoderm || compound organ || trunk || tissue || anatomical region || pharyngeal region || hematological system || trunk region || trunk vasculature || multi-tissue structure || organism subdivision || embryonic structure || head || primary germ layer || lateral plate mesoderm
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0	1.285	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.0006583	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	ventral blood island	0	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	circulatory system	0	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	periocular region	0.0000001756	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	intersomitic region	0.00002609	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	lateral plate mesoderm	0.0007672	1.824	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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