SUPERFAMILY 1.75 HMM library and genome assignments server

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Wiscott-Aldrich syndrome protein, WASP, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47911]
Superfamily:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47912]
Families:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47913]


Superfamily statistics
Genomes (184) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 479 1,395 1
Proteins 330 1,036 1


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR011026 SSF47912 Protein matches
Abstract

The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members [PubMed10724160]. Mutations in WASP lead to the Wiskott-Aldrich syndrome, a paediatric disorder characterised by actin cytoskeletal defects in haematopoietic cells, leading clinically to thrombocytopenia, eczema and immunodeficiency. The WASP proteins signal to the cytoskeleton through the Arp2/3 complex, an actin-nucleating assembly that regulates the structure and dynamics of actin filament networks at the leading edge of the cell.

WASP family members have unique N-terminal regions, followed by a central segment rich in proline, and a common C-terminal region. The C-terminal region contains the VCA region that binds the Arp2/3 complex and actin, while the distinct N-terminal region enables family members to activate Arp2/3 in response to different upstream signals.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Wiscott-Aldrich syndrome protein, WASP, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Wiscott-Aldrich syndrome protein, WASP, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]