C-terminal domain of alpha and beta subunits of F1 ATP synthase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Left-handed superhelix [ 47916] (4)
• Superfamily: C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47917]
• Families: C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47918] (2)

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Superfamily statistics

	Genomes (3,130)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,064	75,372	12
Proteins	8,057	75,344	12

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Functional annotation

• General category: Metabolism
• Detailed category: Energy

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.6408	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; catalyzing transmembran	0	1.481	Informative	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	1.861	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	endosome morphology variant	0	1.628	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6038	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0	1.189	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.632	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	0.9594	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	gonad development variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0	1.23	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0	0.7833	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0	1.327	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0	1.245	--	DIRECT
Worm Phenotype (WP)	cell death variant	0	0.9441	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.7938	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0	1.293	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0	1.666	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0	0.8099	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	diplotene region organization variant	0	2.407	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0	1.176	--	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0	1.064	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0	1.074	--	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8211	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0	1.31	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0	1.594	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0	0.9517	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || somatic gonad development variant || protein protein interaction variant || vesicle morphology variant || reproductive system physiology variant || transgene expression variant || diplotene progression during oogenesis variant || gene expression variant || organ system development variant || oogenesis variant || organism homeostasis metabolism variant || apoptosis variant || lethal || larval development variant || diplotene region organization variant || protein interaction variant || organism physiology variant || transgene subcellular localization variant || meiosis variant || germ cell development variant || germ cell differentiation variant || slow growth || cell division variant || oocyte septum formation variant || development variant || developmental timing variant || reproductive system development variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || growth variant || hermaphrodite fertility reduced || cell death variant || embryonic development variant || embryonic lethal || larval growth variant || vesicle organization variant || general pace of development variant || fertility variant || behavior variant || pattern of transgene expression variant || protein aggregation variant || gametogenesis variant || recycling endosome morphology variant || cell cycle variant || meiotic progression prophase variant || postembryonic development variant || gonad development variant || larval arrest || organ system physiology variant || organism behavior variant || maternal sterile || endosome morphology variant || organism development variant || programmed cell death variant || fertility reduced || cell development variant
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	1.017	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0	1.128	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0	1.064	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0	1.026	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0	1.017	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0	0.9752	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0	1.164	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0	1	Moderately Informative	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein interaction variant	0	1.035	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0	1.106	Moderately Informative	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	0	1.531	Informative	DIRECT
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0	1.666	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0	1.276	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0	1.531	Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	0	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	lysosome-related organelle morphology variant	0	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte septum formation variant	0	2.009	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	development	0	1.267	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0	1.216	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	utilization of carbon source	0	1.357	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0	1.11	Moderately Informative	DIRECT
Yeast Phenotype (YP)	nutrient utilization	0	1.149	Moderately Informative	DIRECT
Yeast Phenotype (YP)	lifespan	0	1.517	Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.295	Informative	DIRECT
Yeast Phenotype (YP)	respiratory metabolism	0	1.626	Informative	DIRECT
Yeast Phenotype (YP)	vegetative growth	0	1.392	Informative	DIRECT
Yeast Phenotype (YP)	subcellular morphology	0.2558	1.392	Informative	INHERITED FROM: mitochondrial morphology
Yeast Phenotype (YP)	respiratory growth	0	1.772	Highly Informative	DIRECT
Yeast Phenotype (YP)	chronological lifespan	0	1.869	Highly Informative	DIRECT
Yeast Phenotype (YP)	desiccation resistance	0	1.772	Highly Informative	DIRECT
Yeast Phenotype (YP)	alkaline pH resistance	0.00000371	1.869	Highly Informative	DIRECT
Yeast Phenotype (YP)	mitochondrial morphology	0.00002675	1.994	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT
Fly Phenotype (FP)	viable	0	0.735	Least Informative	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5628	Least Informative	DIRECT
Fly Phenotype (FP)	sterile	0	1.604	Informative	DIRECT
Fly Phenotype (FP)	short lived	0	1.826	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	oocyte	0	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	skin	0	1.72	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.7237	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || surface structure || head region || genital system || brain || intestine || nervous system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || ectoderm || compound organ || trunk || tissue || anatomical region || germ cell || limb || central nervous system || dermal system || oocyte || male genitalia || trunk region || skin || anatomical cluster || viscus || male organism || endomesoderm || organism subdivision || cell || head || primary germ layer
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || alimentary system || urogenital system || intestine || nervous system || brain || genital system || male genitalia || central nervous system || dermal system || skin
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9688	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.955	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.9618	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.8635	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0	1.013	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb	0	1.615	Informative	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.363	Informative	DIRECT
Xenopus ANatomical entity (XAN)	dermal system	0	1.647	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endomesoderm	0	1.256	Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0	1.419	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7597	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || collective plant structure || phyllome || pollen sac || multi-tissue plant structure || microsporophyll || guard cell || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || microsporangium || epidermal cell || shoot epidermal cell || pollen || plant cell || shoot epidermis || microgametophyte
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: sporophyll || phyllome || guard cell || pollen || microsporophyll || pollen sac || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0	1.256	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Translocases	0	1.339	--	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	2.253	--	DIRECT
Enzyme Commission (EC)	Na(+)-transporting two-sector ATPase	0.00000000003005	2.475	--	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	1	1.776	--	INHERITED FROM: Na(+)-transporting two-sector ATPase
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0	1.505	Informative	DIRECT
Enzyme Commission (EC)	Hydron translocation linked to the hydrolysis of a nucleoside triphosphate	0	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Linked to the hydrolysis of a nucleoside triphosphate	0.2169	1.998	Highly Informative	INHERITED FROM: Na(+)-transporting two-sector ATPase

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InterPro annotation

• Cross references: IPR000793 SSF47917 Protein matches
• Abstract:

  This entry represents the alpha and beta subunits found in the F1, V1, and A1 complexes of F-, V- and A-ATPases, respectively (sometimes called the A and B subunits in V- and A-ATPases). The F-ATPases (or F1F0-ATPases), V-ATPases (or V1V0-ATPases) and A-ATPases (or A1A0-ATPases) are composed of two linked complexes: the F1, V1 or A1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0, V0 or A0 complex that forms the membrane-spanning pore. The F-, V- and A-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [11309608, 15629643].

  In F-ATPases, there are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex, while the remaining F1 subunits (gamma, delta, epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits, those on the beta subunits being catalytic, while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP, which are induced by the rotation of the gamma subunit, itself is driven by the movement of protons through the F0 complex C subunit [12745923].

  In V- and A-ATPases, the alpha/A and beta/B subunits of the V1 or A1 complex are homologous to the alpha and beta subunits in the F1 complex of F-ATPases, except that the alpha subunit is catalytic and the beta subunit is regulatory.

  The alpha/A and beta/B subunits can each be divided into three regions, or domains, centred around the ATP-binding pocket, and based on structure and function, where the central region is the nucleotide-binding domain [12885621]. This entry represents the C-terminal domain of the alpha/A/beta/B subunits, which forms a left-handed superhelix composed of 4-5 individual helices. The C-terminal domain can vary between the alpha and beta subunits, and between different ATPases [11309608].

  More information about this protein can be found at Protein of the Month: ATP Synthases.

InterPro database

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