C-terminal domain of alpha and beta subunits of F1 ATP synthase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Left-handed superhelix [ 47916] (4)
• Superfamily: C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47917]
• Family: C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47918] (2)

---

Family statistics

	Genomes (2,875)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,172	62,468	12
Proteins	6,171	62,462	12

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.7283	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; catalyzing transmembran	0	1.662	Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0	1.727	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0	1.237	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0	0.8392	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0	1.156	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0	1.263	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0	1.321	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0	1.727	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0	1.156	--	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	0	1.655	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0	1.689	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0	1.354	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0	1.013	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0	1.078	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || somatic gonad development variant || protein protein interaction variant || vesicle morphology variant || reproductive system physiology variant || transgene expression variant || diplotene progression during oogenesis variant || gene expression variant || organ system development variant || oogenesis variant || organism homeostasis metabolism variant || apoptosis variant || lethal || larval development variant || diplotene region organization variant || protein interaction variant || organism physiology variant || transgene subcellular localization variant || meiosis variant || germ cell development variant || germ cell differentiation variant || slow growth || cell division variant || oocyte septum formation variant || development variant || developmental timing variant || reproductive system development variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || growth variant || hermaphrodite fertility reduced || cell death variant || embryonic development variant || embryonic lethal || larval growth variant || vesicle organization variant || general pace of development variant || fertility variant || behavior variant || pattern of transgene expression variant || protein aggregation variant || gametogenesis variant || recycling endosome morphology variant || cell cycle variant || meiotic progression prophase variant || postembryonic development variant || gonad development variant || larval arrest || organ system physiology variant || organism behavior variant || maternal sterile || endosome morphology variant || organism development variant || programmed cell death variant || fertility reduced || cell development variant
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	gonad development variant	0	1.538	Informative	DIRECT
Worm Phenotype (WP)	diplotene progression during oogenesis variant	0	1.655	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0	1.655	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0	1.292	Informative	DIRECT
Worm Phenotype (WP)	lysosome-related organelle morphology variant	0	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	0	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	diplotene region organization variant	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte septum formation variant	0	1.99	Highly Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular morphology	0	1.24	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	utilization of carbon source	0	1.33	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	chronological lifespan	0	1.666	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT
Yeast Phenotype (YP)	development	0	1.143	Moderately Informative	DIRECT
Yeast Phenotype (YP)	morphology	0	1.143	Moderately Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.24	Moderately Informative	DIRECT
Yeast Phenotype (YP)	nutrient utilization	0	1.189	Moderately Informative	DIRECT
Yeast Phenotype (YP)	vegetative growth	0	1.24	Moderately Informative	DIRECT
Yeast Phenotype (YP)	lifespan	0	1.403	Informative	DIRECT
Yeast Phenotype (YP)	respiratory metabolism	0	1.599	Informative	DIRECT
Yeast Phenotype (YP)	desiccation resistance	0	1.666	Informative	DIRECT
Yeast Phenotype (YP)	respiratory growth	0	1.842	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	sterile	0	1.687	Informative	DIRECT
Fly Phenotype (FP)	short lived	0	1.908	Highly Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	skin	0	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	oocyte	0	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || surface structure || head region || genital system || brain || intestine || nervous system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || ectoderm || compound organ || trunk || tissue || anatomical region || germ cell || limb || central nervous system || dermal system || oocyte || male genitalia || trunk region || skin || anatomical cluster || viscus || male organism || endomesoderm || organism subdivision || cell || head || primary germ layer
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || alimentary system || urogenital system || intestine || nervous system || brain || genital system || male genitalia || central nervous system || dermal system || skin
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0	1.08	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb	0	1.635	Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0	1.418	Informative	DIRECT
Xenopus ANatomical entity (XAN)	dermal system	0	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endomesoderm	0	1.263	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || collective plant structure || phyllome || pollen sac || multi-tissue plant structure || microsporophyll || guard cell || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || whole plant || epidermis || microsporangium || epidermal cell || shoot epidermal cell || pollen || plant cell || shoot epidermis || microgametophyte
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: sporophyll || phyllome || guard cell || pollen || microsporophyll || pollen sac || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0	1.304	Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0	1.832	--	DIRECT
Enzyme Commission (EC)	Hydron translocation linked to the hydrolysis of a nucleoside triphosphate	0	2.385	--	DIRECT
Enzyme Commission (EC)	H(+)-transporting two-sector ATPase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Na(+)-transporting two-sector ATPase	0.00000000003631	2.753	--	DIRECT
Enzyme Commission (EC)	Linked to the hydrolysis of a nucleoside triphosphate	0.2456	2.275	--	INHERITED FROM: Na(+)-transporting two-sector ATPase
Enzyme Commission (EC)	Translocases	0	1.628	Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of inorganic cations	1	2.116	Highly Informative	INHERITED FROM: Na(+)-transporting two-sector ATPase

---