Ypt/Rab-GAP domain of gyp1p family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Left-handed superhelix [ 47916] (4)
• Superfamily: Ypt/Rab-GAP domain of gyp1p [ 47923]
• Family: Ypt/Rab-GAP domain of gyp1p [ 47924]

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Family statistics

	Genomes (474)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,182	3,632	4
Proteins	643	1,953	2

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the corpus callosum	0.002231	1.684	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormal corpus callosum morphology	0.003052	1.617	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of the cerebral white matter	0.00467	1.617	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0.02	1.184	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.04912	0.9572	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.1157	0.6631	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.154	0.533	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.4435	0.2371	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.2023	0.4756	Least Informative	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.03391	1.047	Moderately Informative	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0468	0.971	Moderately Informative	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of the cerebral subcortex	0.006643	1.508	Informative	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Hypoplasia of the corpus callosum	0.0004239	1.763	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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