SUPERFAMILY 1.75 HMM library and genome assignments server

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Cyclin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Family:   Cyclin [ 47955] (8)

Family statistics
Genomes (426) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,542 9,402 48
Proteins 2,749 7,345 25

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.008882Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.056Moderately InformativeInherited
Disease Ontology (DO)retinal cell cancer0.000005623InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.00002637Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0001003Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.356Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3739Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.419Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9548Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.002735Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.0344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.06827Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2564Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.3444Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4931Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.001266InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.001719InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.00685InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.01706InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.05378InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.189InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.00004725Highly InformativeDirect
Mammalian Phenotype (MP)hydrops fetalis0.0004858Highly InformativeDirect
Mammalian Phenotype (MP)decreased myeloid cell number0.001133Highly InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.001348Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain development0.003593Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.004187Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte cell number0.00808Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002782Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03132Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.08045Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000001296Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0004155Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.0007226Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.001439Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.001607Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.07639Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1315Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.2201Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.232Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.3059Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.3565Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00008439InformativeDirect
Worm Phenotype (WP)gonad development variant0.2162InformativeInherited
Worm Phenotype (WP)cell number increased0.6984InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.0000008845Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.000001286Highly InformativeDirect
Worm Phenotype (WP)organism pigmentation variant0.000006892Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.00001067Highly InformativeDirect
Worm Phenotype (WP)slow embryonic development0.00004655Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.00004984Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.0003142Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0009306Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.0191Highly InformativeInherited
Worm Phenotype (WP)multiple nuclei0.3268Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)development0.004554Moderately InformativeInherited
Yeast Phenotype (YP)morphology0.09742Moderately InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.0003556InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.002222InformativeInherited
Yeast Phenotype (YP)sexual cycle0.06265InformativeInherited
Yeast Phenotype (YP)endomembrane system morphology0.0000007683Highly InformativeDirect
Yeast Phenotype (YP)budding index0.00002656Highly InformativeDirect
Yeast Phenotype (YP)sporulation0.001457Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.3896Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.418Least InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.08966Moderately InformativeInherited
Fly Anatomy (FA)gonad0.158Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.05643InformativeInherited
Fly Anatomy (FA)ovariole0.06599InformativeInherited
Fly Anatomy (FA)female germline cell0.0005314Highly InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of organ system0.0007472Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0005872Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0.003647Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.009923Least InformativeInherited
Xenopus ANatomical entity (XAN)germ cell0.000007106Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.2584Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.0006072InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0007307InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.04042InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.00006038Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0.03121Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.9367Least InformativeInherited
Plant ANatomical entity (PAN)vegetative shoot apex0.0007057Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.0008161Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]