Cyclin family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Cyclin-like [ 47953]
• Superfamily: Cyclin-like [ 47954] (3)
• Family: Cyclin [ 47955] (8)

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Family statistics

	Genomes (426)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,542	9,402	48
Proteins	2,749	7,345	25

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	retinal cancer	0.00000594	1.668	--	DIRECT
Disease Ontology (DO)	sensory system cancer	0.000006634	1.668	--	DIRECT
Disease Ontology (DO)	larynx cancer	0.0009129	1.911	--	DIRECT
Disease Ontology (DO)	disease of cellular proliferation	0.02961	0.2322	--	INHERITED FROM: sensory system cancer || larynx cancer || retinal cancer || retinal cell cancer || laryngeal carcinoma
Disease Ontology (DO)	respiratory system cancer	0.0545	1.434	--	INHERITED FROM: larynx cancer || laryngeal carcinoma
Disease Ontology (DO)	cancer	0.898	0.2555	--	INHERITED FROM: larynx cancer || retinal cancer || sensory system cancer || retinal cell cancer || laryngeal carcinoma
Disease Ontology (DO)	ocular cancer	1	1.668	--	INHERITED FROM: retinal cancer || retinal cell cancer
Disease Ontology (DO)	organ system cancer	0.008882	0.4879	Least Informative	INHERITED FROM: laryngeal carcinoma || retinal cell cancer || sensory system cancer || retinal cancer || larynx cancer
Disease Ontology (DO)	nervous system cancer	0.056	1.191	Moderately Informative	INHERITED FROM: retinal cell cancer || retinal cancer || sensory system cancer
Disease Ontology (DO)	retinal cell cancer	0.000005623	1.668	Informative	DIRECT
Disease Ontology (DO)	laryngeal carcinoma	0.00002637	1.911	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	absent Purkinje cell layer	0.000000001013	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased hematopoietic stem cell number	0.0000009776	2.603	--	DIRECT
Mammalian Phenotype (MP)	retina hypoplasia	0.000003088	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal common myeloid progenitor cell morphology	0.00002354	2.603	--	DIRECT
Mammalian Phenotype (MP)	ectopic Purkinje cell	0.00004516	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellar foliation	0.00006609	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellum lobule morphology	0.00009579	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased erythrocyte cell number	0.0001051	2.126	--	DIRECT
Mammalian Phenotype (MP)	small cerebellum	0.0002866	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal interventricular septum morphology	0.0006735	1.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.001103	1.072	--	INHERITED FROM: abnormal common myeloid progenitor cell morphology
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.001254	1.072	--	INHERITED FROM: abnormal common myeloid progenitor cell morphology
Mammalian Phenotype (MP)	abnormal cerebellar Purkinje cell layer	0.001848	2.603	--	INHERITED FROM: absent Purkinje cell layer || ectopic Purkinje cell
Mammalian Phenotype (MP)	abnormal cerebellar cortex morphology	0.006358	1.825	--	INHERITED FROM: abnormal cerebellum lobule morphology || ectopic Purkinje cell || abnormal cerebellar foliation || absent Purkinje cell layer
Mammalian Phenotype (MP)	abnormal cerebellum morphology	0.01329	1.7	--	INHERITED FROM: small cerebellum || absent Purkinje cell layer || ectopic Purkinje cell || abnormal cerebellum lobule morphology || abnormal cerebellar foliation
Mammalian Phenotype (MP)	abnormal myeloid cell number	0.01463	1.758	--	INHERITED FROM: decreased erythrocyte cell number
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0.0161	1.261	--	INHERITED FROM: abnormal interventricular septum morphology
Mammalian Phenotype (MP)	abnormal cerebellum development	0.01779	2.302	--	INHERITED FROM: abnormal cerebellar foliation
Mammalian Phenotype (MP)	abnormal Purkinje cell morphology	0.02441	2.603	--	INHERITED FROM: ectopic Purkinje cell
Mammalian Phenotype (MP)	abnormal erythroid lineage cell morphology	0.03779	1.457	--	INHERITED FROM: decreased erythrocyte cell number
Mammalian Phenotype (MP)	abnormal hindbrain morphology	0.05513	1.649	--	INHERITED FROM: abnormal cerebellar foliation || ectopic Purkinje cell || abnormal cerebellum lobule morphology || absent Purkinje cell layer || small cerebellum
Mammalian Phenotype (MP)	edema	0.07065	1.7	--	INHERITED FROM: hydrops fetalis
Mammalian Phenotype (MP)	abnormal retina morphology	0.1327	1.241	--	INHERITED FROM: retina hypoplasia
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.1353	1.241	--	INHERITED FROM: retina hypoplasia
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.1486	0.7167	--	INHERITED FROM: abnormal hematopoietic stem cell morphology || abnormal common myeloid progenitor cell morphology || decreased hematopoietic stem cell number || decreased erythrocyte cell number
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.1622	1.223	--	INHERITED FROM: retina hypoplasia
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.1915	0.5861	--	INHERITED FROM: ectopic Purkinje cell || small cerebellum || abnormal cerebellar foliation || abnormal cerebellum lobule morphology || absent Purkinje cell layer
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.2149	0.7902	--	INHERITED FROM: abnormal interventricular septum morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.2263	0.6686	--	INHERITED FROM: abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology || decreased erythrocyte cell number || decreased hematopoietic stem cell number
Mammalian Phenotype (MP)	vision/eye phenotype	0.5476	0.8789	--	INHERITED FROM: retina hypoplasia
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.5855	0.8473	--	INHERITED FROM: decreased hematopoietic stem cell number || decreased erythrocyte cell number
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.9603	0.3626	--	INHERITED FROM: hydrops fetalis
Mammalian Phenotype (MP)	mortality/aging	0.0001003	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.356	0.5945	Least Informative	INHERITED FROM: decreased erythrocyte cell number || decreased hematopoietic stem cell number || abnormal common myeloid progenitor cell morphology || abnormal hematopoietic stem cell morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.3739	0.4959	Least Informative	INHERITED FROM: ectopic Purkinje cell || small cerebellum || abnormal cerebellar foliation || absent Purkinje cell layer || abnormal cerebellum lobule morphology
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.419	0.6737	Least Informative	INHERITED FROM: abnormal interventricular septum morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.9548	0.4926	Least Informative	INHERITED FROM: hydrops fetalis
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.002735	1.059	Moderately Informative	INHERITED FROM: abnormal common myeloid progenitor cell morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.0344	0.9129	Moderately Informative	INHERITED FROM: decreased erythrocyte cell number || abnormal common myeloid progenitor cell morphology
Mammalian Phenotype (MP)	abnormal nervous system development	0.06827	1.112	Moderately Informative	INHERITED FROM: abnormal cerebellar foliation
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.1052	0.9904	Moderately Informative	INHERITED FROM: decreased erythrocyte cell number
Mammalian Phenotype (MP)	abnormal neuron morphology	0.2007	0.8323	Moderately Informative	INHERITED FROM: ectopic Purkinje cell
Mammalian Phenotype (MP)	abnormal heart morphology	0.2466	0.9597	Moderately Informative	INHERITED FROM: abnormal interventricular septum morphology
Mammalian Phenotype (MP)	abnormal brain morphology	0.2564	0.9799	Moderately Informative	INHERITED FROM: abnormal cerebellar foliation || ectopic Purkinje cell || abnormal cerebellum lobule morphology || absent Purkinje cell layer || small cerebellum
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.3444	1.072	Moderately Informative	INHERITED FROM: decreased erythrocyte cell number || decreased hematopoietic stem cell number
Mammalian Phenotype (MP)	abnormal eye morphology	0.4931	0.9129	Moderately Informative	INHERITED FROM: retina hypoplasia
Mammalian Phenotype (MP)	abnormal heart septum morphology	0.001266	1.427	Informative	INHERITED FROM: abnormal interventricular septum morphology
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.001719	1.7	Informative	INHERITED FROM: abnormal common myeloid progenitor cell morphology
Mammalian Phenotype (MP)	abnormal brain development	0.00685	1.524	Informative	INHERITED FROM: abnormal cerebellar foliation
Mammalian Phenotype (MP)	abnormal metencephalon morphology	0.01706	1.649	Informative	INHERITED FROM: ectopic Purkinje cell || abnormal cerebellum lobule morphology || abnormal cerebellar foliation || small cerebellum || absent Purkinje cell layer
Mammalian Phenotype (MP)	abnormal erythrocyte morphology	0.05378	1.524	Informative	INHERITED FROM: decreased erythrocyte cell number
Mammalian Phenotype (MP)	abnormal fluid regulation	0.189	1.373	Informative	INHERITED FROM: hydrops fetalis
Mammalian Phenotype (MP)	abnormal hematopoietic stem cell morphology	0.00004725	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	hydrops fetalis	0.0004858	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased myeloid cell number	0.001133	1.904	Highly Informative	INHERITED FROM: decreased erythrocyte cell number
Mammalian Phenotype (MP)	ectopic neuron	0.001348	1.904	Highly Informative	INHERITED FROM: ectopic Purkinje cell
Mammalian Phenotype (MP)	abnormal hindbrain development	0.003593	2.126	Highly Informative	INHERITED FROM: abnormal cerebellar foliation
Mammalian Phenotype (MP)	abnormal cerebellar layer morphology	0.004187	2.001	Highly Informative	INHERITED FROM: ectopic Purkinje cell || absent Purkinje cell layer
Mammalian Phenotype (MP)	abnormal erythrocyte cell number	0.00808	2.126	Highly Informative	INHERITED FROM: decreased erythrocyte cell number

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	pronuclear size defective early emb	0.000000009353	2.769	--	DIRECT
Worm Phenotype (WP)	excess maternal pronucleus early emb	0.000000009353	2.769	--	DIRECT
Worm Phenotype (WP)	excess pronucleus early emb	0.00000001712	2.769	--	DIRECT
Worm Phenotype (WP)	cell cycle progression variant	0.00000002466	2.769	--	DIRECT
Worm Phenotype (WP)	pronuclear morphology defective early emb	0.0000000293	2.769	--	DIRECT
Worm Phenotype (WP)	chromosome segregation variant karyomeres early emb	0.00000009524	2.769	--	DIRECT
Worm Phenotype (WP)	nuclear number variant	0.0000001462	1.866	--	DIRECT
Worm Phenotype (WP)	nuclear appearance number defective early emb	0.0000004437	2.292	--	DIRECT
Worm Phenotype (WP)	multiple cytoplasmic cavities early emb	0.000001125	2.292	--	DIRECT
Worm Phenotype (WP)	multiple nuclei early emb	0.000001207	2.292	--	DIRECT
Worm Phenotype (WP)	nuclear division variant	0.000007092	1.866	--	DIRECT
Worm Phenotype (WP)	pigmentation variant	0.00001006	1.924	--	DIRECT
Worm Phenotype (WP)	Aba ABp division axis defective early emb	0.00003231	2.769	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.00004208	1.371	--	DIRECT
Worm Phenotype (WP)	division axis defective	0.00007789	2.468	--	DIRECT
Worm Phenotype (WP)	slow development	0.0001835	2.167	--	DIRECT
Worm Phenotype (WP)	nuclear morphology variation early emb	0.0001988	2.769	--	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance variant	0.0002907	1.99	--	DIRECT
Worm Phenotype (WP)	male gonad development variant	0.0007326	1.924	--	DIRECT
Worm Phenotype (WP)	pronuclear number defective early emb	0.001408	2.769	--	INHERITED FROM: excess maternal pronucleus early emb || excess pronucleus early emb
Worm Phenotype (WP)	somatic gonad morphology variant	0.001433	1.866	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	embryonic cell physiology variant	0.002215	1.538	--	INHERITED FROM: embryonic cell organization biogenesis variant || nuclear appearance number defective early emb || pronuclear morphology defective early emb || excess pronucleus early emb || excess maternal pronucleus early emb || pronucleus centrosomes defective early emb || nucleus defective early emb || nuclear morphology variation early emb || pronuclear size defective early emb || multiple nuclei early emb
Worm Phenotype (WP)	organ system morphology variant	0.004909	0.7516	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	gametogenesis variant	0.008078	1.013	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	chromosome segregation variant	0.008214	1.814	--	INHERITED FROM: chromosome segregation variant karyomeres early emb
Worm Phenotype (WP)	no differentiated gametes	0.01713	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	gene expression variant	0.01836	0.6256	--	INHERITED FROM: level of transgene expression variant
Worm Phenotype (WP)	pronuclear nuclear appearance variant emb	0.0184	1.99	--	INHERITED FROM: pronuclear size defective early emb || pronuclear morphology defective early emb || pronucleus centrosomes defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb
Worm Phenotype (WP)	pronuclear nuclear appearance defective early emb	0.02001	1.99	--	INHERITED FROM: pronucleus centrosomes defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb || pronuclear size defective early emb || pronuclear morphology defective early emb
Worm Phenotype (WP)	cell component morphology variant	0.0223	0.8392	--	INHERITED FROM: excess maternal pronucleus early emb || pronuclear morphology defective early emb || nucleus defective early emb || nuclear morphology variation early emb || cytoplasmic appearance variant || pronuclear size defective early emb || multiple nuclei early emb || pronucleus centrosomes defective early emb || excess pronucleus early emb || multiple cytoplasmic cavities early emb || nuclear appearance number defective early emb || embryonic cell organization biogenesis variant || nuclear appearance variant
Worm Phenotype (WP)	no germ line	0.02582	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	nuclear number defective early emb	0.03564	2.292	--	INHERITED FROM: excess maternal pronucleus early emb || multiple nuclei early emb || excess pronucleus early emb
Worm Phenotype (WP)	cell morphology variant	0.06108	0.7558	--	INHERITED FROM: nuclear appearance variant || embryonic cell organization biogenesis variant || pronucleus centrosomes defective early emb || pronuclear size defective early emb || pronuclear morphology defective early emb || nuclear appearance number defective early emb || multiple cytoplasmic cavities early emb || embryonic cell morphology variant || excess pronucleus early emb || multiple nuclei early emb || cytoplasmic appearance variant || nuclear morphology variation early emb || nucleus defective early emb || excess maternal pronucleus early emb
Worm Phenotype (WP)	reproductive system development variant	0.1187	1.156	--	INHERITED FROM: male gonad development variant
Worm Phenotype (WP)	cytoplasmic morphology defective early emb	0.1714	2.167	--	INHERITED FROM: multiple cytoplasmic cavities early emb
Worm Phenotype (WP)	general pace of development variant	0.1726	0.4786	--	INHERITED FROM: slow development || slow embryonic development
Worm Phenotype (WP)	retarded heterochronic variations	0.1889	0.4548	--	INHERITED FROM: slow development || slow embryonic development
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1925	0.1444	--	INHERITED FROM: level of transgene expression variant
Worm Phenotype (WP)	developmental timing variant	0.1962	0.4548	--	INHERITED FROM: slow embryonic development || slow development
Worm Phenotype (WP)	organism physiology variant	0.2094	0.1342	--	INHERITED FROM: level of transgene expression variant
Worm Phenotype (WP)	gonad morphology variant	0.5142	1.306	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	transgene expression variant	0.6989	0.773	--	INHERITED FROM: level of transgene expression variant
Worm Phenotype (WP)	morphology variant	0.7452	0.046	--	INHERITED FROM: pronuclear size defective early emb || embryonic cell organization biogenesis variant || multiple nuclei early emb || nuclear appearance number defective early emb || embryonic cell morphology variant || multiple cytoplasmic cavities early emb || pigmentation variant || organism pigmentation variant || nuclear morphology variation early emb || nuclear appearance variant || pronucleus centrosomes defective early emb || gonad arm morphology variant || pronuclear morphology defective early emb || excess pronucleus early emb || excess maternal pronucleus early emb || cytoplasmic appearance variant || nucleus defective early emb
Worm Phenotype (WP)	reproductive system physiology variant	0.8316	0.05515	--	INHERITED FROM: male gonad development variant
Worm Phenotype (WP)	organ system physiology variant	0.8353	0.04518	--	INHERITED FROM: male gonad development variant
Worm Phenotype (WP)	embryonic development variant	0.8653	0.04518	--	INHERITED FROM: Aba ABp division axis defective early emb || nuclear morphology variation early emb || nucleus defective early emb || slow embryonic development || pronuclear morphology defective early emb || excess maternal pronucleus early emb || embryonic cell organization biogenesis variant || nuclear appearance number defective early emb || multiple cytoplasmic cavities early emb || excess pronucleus early emb || pronucleus centrosomes defective early emb || early embryonic lethal || chromosome segregation variant karyomeres early emb || pronuclear size defective early emb || multiple nuclei early emb
Worm Phenotype (WP)	embryonic lethal	0.876	0.046	--	INHERITED FROM: Aba ABp division axis defective early emb || excess pronucleus early emb || multiple cytoplasmic cavities early emb || pronucleus centrosomes defective early emb || early embryonic lethal || chromosome segregation variant karyomeres early emb || pronuclear morphology defective early emb || excess maternal pronucleus early emb || pronuclear size defective early emb
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: nuclear division variant || chromosome segregation variant karyomeres early emb || excess maternal pronucleus early emb || early embryonic lethal || no oocytes || embryonic cell organization biogenesis variant || nuclear appearance number defective early emb || lethal || excess pronucleus early emb || slow embryonic development || male gonad development variant || multiple cytoplasmic cavities early emb || cell homeostasis metabolism variant || development variant || pronucleus centrosomes defective early emb || cell cycle progression variant || pronuclear size defective early emb || nuclear morphology variation early emb || multiple nuclei early emb || cell number variant || pronuclear morphology defective early emb || slow development || nucleus defective early emb || division axis defective || nuclear number variant || organism development variant || level of transgene expression variant || Aba ABp division axis defective early emb
Worm Phenotype (WP)	cell physiology variant	0.002782	0.5955	Least Informative	INHERITED FROM: pronuclear size defective early emb || chromosome segregation variant karyomeres early emb || pronucleus centrosomes defective early emb || embryonic cell organization biogenesis variant || nuclear number variant || cell homeostasis metabolism variant || division axis defective || nuclear division variant || pronuclear morphology defective early emb || multiple nuclei early emb || excess pronucleus early emb || nuclear appearance number defective early emb || excess maternal pronucleus early emb || cell cycle progression variant || nuclear morphology variation early emb || nucleus defective early emb || Aba ABp division axis defective early emb
Worm Phenotype (WP)	cell development variant	0.03132	0.6752	Least Informative	INHERITED FROM: no oocytes
Worm Phenotype (WP)	organism metabolism processing variant	0.08045	0.4899	Least Informative	INHERITED FROM: level of transgene expression variant
Worm Phenotype (WP)	early embryonic lethal	0.000001296	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0004155	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0.0007226	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.001439	1.013	Moderately Informative	INHERITED FROM: no oocytes
Worm Phenotype (WP)	organ system development variant	0.001607	0.9113	Moderately Informative	INHERITED FROM: male gonad development variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.07639	1.135	Moderately Informative	INHERITED FROM: pronuclear morphology defective early emb || excess maternal pronucleus early emb || multiple nuclei early emb || pronuclear size defective early emb || embryonic cell organization biogenesis variant || cytoplasmic appearance variant || nuclear appearance number defective early emb || pronucleus centrosomes defective early emb || multiple cytoplasmic cavities early emb || excess pronucleus early emb || nuclear morphology variation early emb || nucleus defective early emb
Worm Phenotype (WP)	cell division variant	0.1315	1.036	Moderately Informative	INHERITED FROM: multiple nuclei early emb || division axis defective || Aba ABp division axis defective early emb
Worm Phenotype (WP)	cell cycle variant	0.2201	1.225	Moderately Informative	INHERITED FROM: cell cycle progression variant
Worm Phenotype (WP)	cell type morphology variant	0.232	0.8878	Moderately Informative	INHERITED FROM: multiple nuclei early emb || pronuclear size defective early emb || excess maternal pronucleus early emb || nuclear morphology variation early emb || excess pronucleus early emb || embryonic cell morphology variant || nuclear appearance number defective early emb
Worm Phenotype (WP)	germ cell differentiation variant	0.3059	1.167	Moderately Informative	INHERITED FROM: no oocytes
Worm Phenotype (WP)	reproductive system morphology variant	0.3565	1.078	Moderately Informative	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.00008439	1.538	Informative	DIRECT
Worm Phenotype (WP)	gonad development variant	0.2162	1.538	Informative	INHERITED FROM: male gonad development variant
Worm Phenotype (WP)	cell number increased	0.6984	1.446	Informative	INHERITED FROM: excess pronucleus early emb || excess maternal pronucleus early emb
Worm Phenotype (WP)	nucleus defective early emb	0.0000008845	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic cell morphology variant	0.000001286	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	organism pigmentation variant	0.000006892	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	pronucleus centrosomes defective early emb	0.00001067	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	slow embryonic development	0.00004655	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	nuclear appearance variant	0.00004984	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	no oocytes	0.0003142	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	gonad arm morphology variant	0.0009306	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance defective early emb	0.0191	1.99	Highly Informative	INHERITED FROM: multiple cytoplasmic cavities early emb
Worm Phenotype (WP)	multiple nuclei	0.3268	1.924	Highly Informative	INHERITED FROM: multiple nuclei early emb

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	sporulation efficiency	0.00009217	2.143	--	DIRECT
Yeast Phenotype (YP)	mitotic cell cycle	0.0007433	1.444	--	DIRECT
Yeast Phenotype (YP)	budding	0.01605	2.143	--	INHERITED FROM: budding index
Yeast Phenotype (YP)	cellular morphology	0.03327	1.24	--	INHERITED FROM: endomembrane system morphology
Yeast Phenotype (YP)	development	0.004554	1.143	Moderately Informative	INHERITED FROM: budding index || sporulation efficiency
Yeast Phenotype (YP)	morphology	0.09742	1.143	Moderately Informative	INHERITED FROM: endomembrane system morphology
Yeast Phenotype (YP)	cell cycle progression	0.0003556	1.444	Informative	DIRECT
Yeast Phenotype (YP)	subcellular morphology	0.002222	1.541	Informative	INHERITED FROM: endomembrane system morphology
Yeast Phenotype (YP)	sexual cycle	0.06265	1.745	Informative	INHERITED FROM: sporulation efficiency
Yeast Phenotype (YP)	endomembrane system morphology	0.0000007683	2.143	Highly Informative	DIRECT
Yeast Phenotype (YP)	budding index	0.00002656	2.143	Highly Informative	DIRECT
Yeast Phenotype (YP)	sporulation	0.001457	1.967	Highly Informative	INHERITED FROM: sporulation efficiency

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	increased cell size	0.0002243	2.386	--	DIRECT
Fly Phenotype (FP)	cell size defective	0.005554	1.784	--	INHERITED FROM: increased cell size

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	germarium	0.0009705	1.69	--	DIRECT
Fly Anatomy (FA)	ovary	0.08057	1.31	--	INHERITED FROM: germarium
Fly Anatomy (FA)	female reproductive system	0.08523	1.31	--	INHERITED FROM: germarium
Fly Anatomy (FA)	female organism	0.08966	1.213	--	INHERITED FROM: germarium
Fly Anatomy (FA)	reproductive system	0.1702	1.047	--	INHERITED FROM: germarium
Fly Anatomy (FA)	cell	0.5035	0.4069	--	INHERITED FROM: female germline cell
Fly Anatomy (FA)	organ system	0.6911	0.1823	--	INHERITED FROM: germarium
Fly Anatomy (FA)	organism	0.7099	0.06695	--	INHERITED FROM: germarium
Fly Anatomy (FA)	multicellular structure	0.8931	0.008955	--	INHERITED FROM: germarium || tagmatic subdivision of organ system
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: germarium || female germline cell || tagmatic subdivision of organ system
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: tagmatic subdivision of organ system || female germline cell || germarium
Fly Anatomy (FA)	organ system subdivision	0.3896	0.4301	Least Informative	INHERITED FROM: tagmatic subdivision of organ system
Fly Anatomy (FA)	multi-tissue structure	0.418	0.6038	Least Informative	INHERITED FROM: germarium
Fly Anatomy (FA)	female-specific anatomical entity	0.08966	1.213	Moderately Informative	INHERITED FROM: germarium
Fly Anatomy (FA)	gonad	0.158	1.047	Moderately Informative	INHERITED FROM: germarium
Fly Anatomy (FA)	germline cell	0.05643	1.389	Informative	INHERITED FROM: female germline cell
Fly Anatomy (FA)	ovariole	0.06599	1.31	Informative	INHERITED FROM: germarium
Fly Anatomy (FA)	female germline cell	0.0005314	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of organ system	0.0007472	2.088	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	postmigratory neural crest cell	0.00001833	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0.0000415	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.00006825	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0.0004995	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	migratory neural crest cell	0.0007872	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0.01085	0.6748	--	INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell
Xenopus ANatomical entity (XAN)	gamete	0.01131	1.202	--	INHERITED FROM: egg
Xenopus ANatomical entity (XAN)	neural crest	0.01591	1.689	--	INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: egg || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: postmigratory neural crest cell || genital system || animal hemisphere || egg || anatomical group || animal pole || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || germ cell || migratory neural crest cell || organism subdivision || cell
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.0005872	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0.003647	0.4777	Least Informative	INHERITED FROM: egg || genital system
Xenopus ANatomical entity (XAN)	tissue	0.009923	0.4672	Least Informative	INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell
Xenopus ANatomical entity (XAN)	germ cell	0.000007106	1.08	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0.2584	0.9357	Moderately Informative	INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell
Xenopus ANatomical entity (XAN)	animal hemisphere	0.0006072	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.0007307	1.347	Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0.04042	1.374	Informative	INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell
Xenopus ANatomical entity (XAN)	animal pole	0.00006038	2.166	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	primordium	0.003385	1.822	--	INHERITED FROM: phyllome primordium
Plant ANatomical entity (PAN)	portion of plant tissue	0.09612	0.1621	--	INHERITED FROM: phyllome primordium
Plant ANatomical entity (PAN)	shoot axis	0.4328	0.3985	--	INHERITED FROM: vegetative shoot apex || phyllome primordium
Plant ANatomical entity (PAN)	plant organ	0.4527	0.2391	--	INHERITED FROM: phyllome primordium || vegetative shoot apex
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.4856	0.2335	--	INHERITED FROM: phyllome primordium || vegetative shoot apex
Plant ANatomical entity (PAN)	plant axis	0.5199	0.3257	--	INHERITED FROM: vegetative shoot apex || phyllome primordium
Plant ANatomical entity (PAN)	shoot system	0.6596	0.05272	--	INHERITED FROM: vegetative shoot apex || phyllome primordium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || phyllome primordium || vegetative shoot apex || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: phyllome primordium || vegetative shoot apex
Plant ANatomical entity (PAN)	shoot apex	0.03121	0.481	Least Informative	INHERITED FROM: vegetative shoot apex || phyllome primordium
Plant ANatomical entity (PAN)	portion of meristem tissue	0.9367	0.5892	Least Informative	INHERITED FROM: phyllome primordium
Plant ANatomical entity (PAN)	vegetative shoot apex	0.0007057	2.123	Highly Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome primordium	0.0008161	2.123	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.639	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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