DBL homology domain (DH-domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DBL homology domain (DH-domain) [ 48064]
• Superfamily: DBL homology domain (DH-domain) [ 48065]
• Family: DBL homology domain (DH-domain) [ 48066] (10)

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Family statistics

	Genomes (289)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,844	15,876	16
Proteins	4,666	15,301	16

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.279	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased transitional stage T1 B cell number	0.0000001797	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased transitional stage T2 B cell number	0.000001917	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage T1 B cell morphology	0.000002554	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage T2 B cell morphology	0.000003359	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased transitional stage B cell number	0.00002597	2.126	--	DIRECT
Mammalian Phenotype (MP)	decreased transitional stage B cell number	0.0001837	2.126	--	DIRECT
Mammalian Phenotype (MP)	anterior iris synechia	0.0002094	2.603	--	DIRECT
Mammalian Phenotype (MP)	iris synechia	0.0002821	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal vascular endothelial cell migration	0.0006518	2.603	--	DIRECT
Mammalian Phenotype (MP)	intestinal ulcer	0.0008145	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal enterocyte morphology	0.0009884	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.004247	1.758	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal vascular endothelial cell development	0.007679	2.302	--	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	increased B cell number	0.009921	1.7	--	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.01583	0.9219	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.01675	0.9219	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal B cell activation	0.017	1.562	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal iris morphology	0.01746	2.126	--	INHERITED FROM: anterior iris synechia || iris synechia
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.01883	0.9219	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.02583	0.8789	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.04005	0.8789	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.04823	1.156	--	INHERITED FROM: decreased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal immature B cell morphology	0.04956	1.7	--	INHERITED FROM: abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number || decreased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal uvea morphology	0.05062	1.758	--	INHERITED FROM: iris synechia || anterior iris synechia
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.05749	1.281	--	INHERITED FROM: increased transitional stage T1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal immature B cell number	0.06142	1.7	--	INHERITED FROM: increased transitional stage T1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal vascular development	0.1034	1.223	--	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	abnormal B cell number	0.1091	1.348	--	INHERITED FROM: decreased transitional stage T2 B cell number || increased transitional stage B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.132	0.9129	--	INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	increased leukocyte cell number	0.1348	1.241	--	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.1604	1.156	--	INHERITED FROM: decreased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1852	0.6789	--	INHERITED FROM: decreased interleukin-2 secretion || decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal intestinal epithelium morphology	0.1856	1.758	--	INHERITED FROM: intestinal ulcer || abnormal enterocyte morphology
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.2248	1.188	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.2345	0.9404	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || abnormal transitional stage B cell morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.2358	0.8038	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.2566	0.7167	--	INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage B cell morphology
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.2704	1.072	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.3143	1.072	--	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.3275	1.085	--	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.3791	0.8108	--	INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.4326	0.8473	--	INHERITED FROM: increased transitional stage T1 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	abnormal B cell physiology	0.4328	1.172	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.4357	1.205	--	INHERITED FROM: abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage B cell number || decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage B cell morphology
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.4577	0.7902	--	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.4652	0.6686	--	INHERITED FROM: decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.488	0.7223	--	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number || decreased transitional stage B cell number || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage B cell morphology
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.5042	1.156	--	INHERITED FROM: increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology || increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.5744	1.112	--	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal cell physiology	0.5981	0.6209	--	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.615	0.8473	--	INHERITED FROM: abnormal transitional stage T2 B cell morphology || decreased transitional stage T2 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	vision/eye phenotype	0.7863	0.8789	--	INHERITED FROM: iris synechia || anterior iris synechia
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.829	0.9404	--	INHERITED FROM: abnormal enterocyte morphology || intestinal ulcer
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.4319	0.5945	Least Informative	INHERITED FROM: abnormal transitional stage B cell morphology || decreased B cell proliferation || decreased transitional stage T2 B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	immune system phenotype	0.5769	0.5462	Least Informative	INHERITED FROM: decreased B cell proliferation || abnormal transitional stage B cell morphology || decreased interleukin-2 secretion || abnormal transitional stage T2 B cell morphology || abnormal transitional stage T1 B cell morphology || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number || decreased transitional stage T2 B cell number
Mammalian Phenotype (MP)	cellular phenotype	0.711	0.5387	Least Informative	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.7857	0.6737	Least Informative	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.01355	0.9219	Moderately Informative	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.07097	1.059	Moderately Informative	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.1178	1.072	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.1218	1.023	Moderately Informative	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	abnormal B cell morphology	0.1389	1.156	Moderately Informative	INHERITED FROM: decreased transitional stage B cell number || decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage B cell morphology || abnormal transitional stage T1 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T2 B cell morphology
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.1791	1.001	Moderately Informative	INHERITED FROM: decreased interleukin-2 secretion
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.2136	1.188	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.2975	1.098	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.3569	1.023	Moderately Informative	INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number || increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.4606	1.059	Moderately Informative	INHERITED FROM: abnormal transitional stage B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number || decreased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.5488	1.098	Moderately Informative	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.6426	1.023	Moderately Informative	INHERITED FROM: abnormal enterocyte morphology || intestinal ulcer
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.6576	0.9129	Moderately Informative	INHERITED FROM: increased transitional stage B cell number || decreased transitional stage T2 B cell number || decreased transitional stage B cell number || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number || abnormal transitional stage T1 B cell morphology || abnormal transitional stage T2 B cell morphology
Mammalian Phenotype (MP)	abnormal eye morphology	0.7181	0.9129	Moderately Informative	INHERITED FROM: iris synechia || anterior iris synechia
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.003429	1.562	Informative	INHERITED FROM: decreased B cell proliferation
Mammalian Phenotype (MP)	abnormal cell migration	0.08267	1.399	Informative	INHERITED FROM: abnormal vascular endothelial cell migration
Mammalian Phenotype (MP)	decreased B cell number	0.189	1.562	Informative	INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal intestine morphology	0.2294	1.457	Informative	INHERITED FROM: intestinal ulcer || abnormal enterocyte morphology
Mammalian Phenotype (MP)	abnormal anterior eye segment morphology	0.2381	1.489	Informative	INHERITED FROM: iris synechia || anterior iris synechia
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.2768	1.373	Informative	INHERITED FROM: decreased transitional stage B cell number || abnormal transitional stage T1 B cell morphology || decreased transitional stage T2 B cell number || increased transitional stage B cell number || abnormal transitional stage T2 B cell morphology || abnormal transitional stage B cell morphology || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.5103	1.524	Informative	INHERITED FROM: increased transitional stage T1 B cell number || increased transitional stage B cell number
Mammalian Phenotype (MP)	decreased interleukin-2 secretion	0.0001194	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased B cell proliferation	0.0004311	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal transitional stage B cell morphology	0.0007769	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	gastrointestinal ulcer	0.001407	2.126	Highly Informative	INHERITED FROM: intestinal ulcer
Mammalian Phenotype (MP)	increased immature B cell number	0.005493	2.126	Highly Informative	INHERITED FROM: increased transitional stage B cell number || increased transitional stage T1 B cell number
Mammalian Phenotype (MP)	abnormal anterior uvea morphology	0.02249	1.904	Highly Informative	INHERITED FROM: iris synechia || anterior iris synechia
Mammalian Phenotype (MP)	decreased immature B cell number	0.02704	2.001	Highly Informative	INHERITED FROM: decreased transitional stage T2 B cell number || decreased transitional stage B cell number
Mammalian Phenotype (MP)	abnormal cornea morphology	0.07151	1.758	Highly Informative	INHERITED FROM: anterior iris synechia
Mammalian Phenotype (MP)	abnormal intestinal mucosa morphology	0.09766	1.904	Highly Informative	INHERITED FROM: intestinal ulcer

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	pathogen resistance increased	0	2.292	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	bacterially unswollen	0	2.468	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.0000003568	1.426	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.0002552	1.407	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.0006004	1.623	--	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.0006412	1.655	--	DIRECT
Worm Phenotype (WP)	clear	0.0009067	2.769	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.00299	1.306	--	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	body size variant	0.004409	1.189	--	INHERITED FROM: short
Worm Phenotype (WP)	muscle cell morphology variant	0.005598	1.337	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	organ system morphology variant	0.005988	0.7516	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	muscle system morphology variant	0.007634	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
Worm Phenotype (WP)	pigmentation variant	0.01129	1.924	--	INHERITED FROM: clear
Worm Phenotype (WP)	cell morphology variant	0.02403	0.7558	--	INHERITED FROM: mitochondria alignment variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || striated muscle morphology variant
Worm Phenotype (WP)	mitochondria spacing variant	0.1191	1.623	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1925	0.1444	--	INHERITED FROM: pathogen resistance increased || organism environmental stimulus response variant || response to bacteria variant || aldicarb response variant || bacterially unswollen || organism pathogen response variant
Worm Phenotype (WP)	organism physiology variant	0.2094	0.1342	--	INHERITED FROM: organism environmental stimulus response variant || pathogen resistance increased || organism pathogen response variant || bacterially unswollen || response to bacteria variant || aldicarb response variant
Worm Phenotype (WP)	drug response variant	0.2326	1.135	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell component morphology variant	0.3177	0.8392	--	INHERITED FROM: mitochondria alignment variant || mitochondria morphology variant
Worm Phenotype (WP)	body length variant	0.3849	1.292	--	INHERITED FROM: short
Worm Phenotype (WP)	body width variant	0.9638	1.237	--	INHERITED FROM: short
Worm Phenotype (WP)	body morphology variant	1	1.145	--	INHERITED FROM: short
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || response to bacteria variant || reproductive system physiology variant || lethal || aldicarb response variant || pathogen resistance increased || development variant || organism pathogen response variant || hermaphrodite sterile || muscle cell attachment variant || organism environmental stimulus response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || bacterially unswollen || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00007065	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.01104	0.5955	Least Informative	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	organism segment morphology variant	0.000000006024	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.000000006293	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.02267	0.9693	Moderately Informative	INHERITED FROM: bacterially unswollen || organism pathogen response variant || pathogen resistance increased
Worm Phenotype (WP)	cell type morphology variant	0.1832	0.8878	Moderately Informative	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	chemical response variant	0.6006	0.9053	Moderately Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	organism pathogen response variant	0.0001439	1.468	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.000177	1.446	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.000974	1.513	Informative	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.0114	1.623	Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell component localization variant	0.01161	1.388	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	muscle cell physiology variant	0.01289	1.426	Informative	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	small	0.2397	1.623	Informative	INHERITED FROM: short
Worm Phenotype (WP)	tail morphology variant	0.0000001675	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	short	0.0004146	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle cell attachment variant	0.0004146	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	organism pigmentation variant	0.008486	1.924	Highly Informative	INHERITED FROM: clear

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || adult || organism
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	blood vessel endothelial cell	0.000341	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	blood vessel endothelium	0.0004455	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	vascular endothelium	0.0006165	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	simple squamous epithelium	0.0007149	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	squamous epithelial cell	0.00147	2.471	--	INHERITED FROM: blood vessel endothelial cell
Zebrafish Anatomy (ZA)	lining cell	0.00637	2.17	--	INHERITED FROM: blood vessel endothelial cell
Zebrafish Anatomy (ZA)	barrier cell	0.01027	2.17	--	INHERITED FROM: blood vessel endothelial cell
Zebrafish Anatomy (ZA)	unilaminar epithelium	0.01932	2.471	--	INHERITED FROM: vascular endothelium || blood vessel endothelium || simple squamous epithelium || blood vessel endothelial cell
Zebrafish Anatomy (ZA)	epithelium	0.07649	1.772	--	INHERITED FROM: blood vessel endothelial cell || blood vessel endothelium || simple squamous epithelium || vascular endothelium
Zebrafish Anatomy (ZA)	anatomical group	0.4309	0.1532	--	INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium
Zebrafish Anatomy (ZA)	anatomical system	0.7416	0.1857	--	INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || whole organism || simple squamous epithelium || vascular endothelium
Zebrafish Anatomy (ZA)	cell	0.4919	0.6388	Least Informative	INHERITED FROM: blood vessel endothelial cell
Zebrafish Anatomy (ZA)	multi-tissue structure	0.8305	0.5848	Least Informative	INHERITED FROM: vascular endothelium || blood vessel endothelium || blood vessel endothelial cell
Zebrafish Anatomy (ZA)	portion of tissue	0.3646	0.7637	Moderately Informative	INHERITED FROM: blood vessel endothelial cell || blood vessel endothelium || vascular endothelium || simple squamous epithelium
Zebrafish Anatomy (ZA)	cardiovascular system	0.3948	1.216	Moderately Informative	INHERITED FROM: blood vessel endothelium || vascular endothelium || blood vessel endothelial cell
Zebrafish Anatomy (ZA)	vasculature	0.2712	1.471	Informative	INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium
Zebrafish Anatomy (ZA)	endothelial cell	0.005895	2.17	Highly Informative	INHERITED FROM: blood vessel endothelial cell
Zebrafish Anatomy (ZA)	epithelial cell	0.04538	2.17	Highly Informative	INHERITED FROM: blood vessel endothelial cell

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.639	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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