Regulator of G-protein signaling, RGS family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Regulator of G-protein signaling, RGS [ 48096]
• Superfamily: Regulator of G-protein signaling, RGS [ 48097]
• Family: Regulator of G-protein signaling, RGS [ 48098] (9)

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Family statistics

	Genomes (145)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,647	7,329	11
Proteins	2,645	7,318	11

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	[G-protein-coupled receptor] kinase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Rhodopsin kinase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal rod electrophysiology	0.0002062	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal pericardium morphology	0.1198	2.126	--	INHERITED FROM: enlarged pericardium
Mammalian Phenotype (MP)	vision/eye phenotype	0.3513	0.8789	--	INHERITED FROM: abnormal rod electrophysiology
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.5142	0.7902	--	INHERITED FROM: enlarged pericardium
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.02964	0.6737	Least Informative	INHERITED FROM: enlarged pericardium
Mammalian Phenotype (MP)	abnormal heart morphology	0.4893	0.9597	Moderately Informative	INHERITED FROM: enlarged pericardium
Mammalian Phenotype (MP)	abnormal eye physiology	0.0697	1.649	Informative	INHERITED FROM: abnormal rod electrophysiology
Mammalian Phenotype (MP)	enlarged pericardium	0.0007754	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal eye electrophysiology	0.004334	2.001	Highly Informative	INHERITED FROM: abnormal rod electrophysiology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	chemotaxis variant	0.0006046	1.513	--	DIRECT
Worm Phenotype (WP)	chemosensory behavior variant	0.001265	1.49	--	INHERITED FROM: negative chemotaxis variant || chemotaxis variant
Worm Phenotype (WP)	behavior variant	0.2182	0.6859	--	INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || negative chemotaxis variant || development variant || mechanosensation variant || hermaphrodite sterile || hermaphrodite fertility reduced || chemotaxis variant || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism behavior variant	0.2143	0.6859	Least Informative	INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.2376	0.6614	Least Informative	INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant
Worm Phenotype (WP)	chemical response variant	0.1213	0.9053	Moderately Informative	INHERITED FROM: negative chemotaxis variant || chemotaxis variant
Worm Phenotype (WP)	chemosensory response variant	0.003166	1.49	Informative	INHERITED FROM: negative chemotaxis variant || chemotaxis variant
Worm Phenotype (WP)	negative chemotaxis variant	0.0000112	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	mechanosensation variant	0.00002214	1.814	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	mating response	0	2.444	--	DIRECT
Yeast Phenotype (YP)	mating efficiency	0	2.444	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	development	0	1.143	Moderately Informative	DIRECT
Yeast Phenotype (YP)	sexual cycle	0	1.745	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	cell cycle defective	0.005048	1.541	Informative	INHERITED FROM: mitotic cell cycle defective
Fly Phenotype (FP)	mitotic cell cycle defective	0.0009205	1.784	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	embryonic/first instar larval cuticle	0.0002606	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval integumentary system	0.001605	1.787	--	INHERITED FROM: embryonic/first instar larval cuticle
Fly Anatomy (FA)	integumentary system	0.05804	0.8094	--	INHERITED FROM: embryonic/first instar larval cuticle
Fly Anatomy (FA)	cuticle	0.1058	1.31	--	INHERITED FROM: embryonic/first instar larval cuticle
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || embryonic/first instar larval cuticle || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism || embryonic/first instar larval cuticle
Fly Anatomy (FA)	larva	0.6524	0.3763	Least Informative	INHERITED FROM: embryonic/first instar larval cuticle
Fly Anatomy (FA)	acellular anatomical structure	0.02687	1.134	Moderately Informative	INHERITED FROM: embryonic/first instar larval cuticle
Fly Anatomy (FA)	embryonic/larval cuticle	0.001288	1.912	Highly Informative	INHERITED FROM: embryonic/first instar larval cuticle

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Rhodopsin kinase	0	3.23	--	DIRECT
Enzyme Commission (EC)	[Beta-adrenergic-receptor] kinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	[G-protein-coupled receptor] kinase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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