Myeloperoxidase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Heme-dependent peroxidases [ 48112]
• Superfamily: Heme-dependent peroxidases [ 48113] (3)
• Family: Myeloperoxidase-like [ 48132] (2)

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Family statistics

	Genomes (318)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,144	9,102	14
Proteins	2,037	8,666	14

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0	1.7	--	DIRECT
Enzyme Commission (EC)	With a oxygen as acceptor	0	2.264	--	DIRECT
Enzyme Commission (EC)	Prostaglandin-endoperoxide synthase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Iodide peroxidase	0.00000000205	2.44	--	DIRECT
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0.00000005416	1.627	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0.007541	1.31	--	INHERITED FROM: With a oxygen as acceptor
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.00000000148	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of mole	0.003667	1.537	Informative	INHERITED FROM: With incorporation of two atoms of oxygen
Enzyme Commission (EC)	Peroxidases	1	1.7	Informative	INHERITED FROM: Peroxidase || Iodide peroxidase
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Peroxidase	0.000000000004349	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	stomach disease	0.00001994	1.814	--	DIRECT
Disease Ontology (DO)	endocrine system disease	0.0001297	1.309	--	DIRECT
Disease Ontology (DO)	respiratory system disease	0.0003498	0.9334	--	DIRECT
Disease Ontology (DO)	nephritis	0.0005235	1.309	--	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.0007202	1.212	--	DIRECT
Disease Ontology (DO)	kidney disease	0.006579	1.066	--	INHERITED FROM: nephritis
Disease Ontology (DO)	autosomal genetic disease	0.01207	1.133	--	INHERITED FROM: cystic fibrosis
Disease Ontology (DO)	monogenic disease	0.01381	1.115	--	INHERITED FROM: cystic fibrosis
Disease Ontology (DO)	bacterial infectious disease	0.04979	1.191	--	INHERITED FROM: primary bacterial infectious disease
Disease Ontology (DO)	disease of cellular proliferation	0.3427	0.2322	--	INHERITED FROM: cell type benign neoplasm
Disease Ontology (DO)	disease by infectious agent	0.0005749	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	benign neoplasm	0.001141	1.191	Moderately Informative	INHERITED FROM: cell type benign neoplasm
Disease Ontology (DO)	genetic disease	0.02053	1.066	Moderately Informative	INHERITED FROM: cystic fibrosis
Disease Ontology (DO)	urinary system disease	0.03534	1.051	Moderately Informative	INHERITED FROM: nephritis
Disease Ontology (DO)	gastrointestinal system disease	0.2314	0.8797	Moderately Informative	INHERITED FROM: peptic ulcer disease || stomach disease
Disease Ontology (DO)	cell type benign neoplasm	0.0006766	1.337	Informative	DIRECT
Disease Ontology (DO)	autosomal recessive disease	0.001625	1.472	Informative	INHERITED FROM: cystic fibrosis
Disease Ontology (DO)	peptic ulcer disease	0.000005544	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	cystic fibrosis	0.0001178	2.212	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased circulating pituitary hormone level	0.00004986	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased pituitary hormone level	0.00007516	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased physiological sensitivity to xenobiotic	0.0007203	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.003532	1.241	--	INHERITED FROM: increased circulating pituitary hormone level
Mammalian Phenotype (MP)	abnormal pituitary hormone level	0.01555	1.758	--	INHERITED FROM: increased pituitary hormone level || increased circulating pituitary hormone level
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.1736	0.6893	--	INHERITED FROM: increased circulating pituitary hormone level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.2682	0.3626	--	INHERITED FROM: increased pituitary hormone level || increased circulating pituitary hormone level || increased physiological sensitivity to xenobiotic
Mammalian Phenotype (MP)	abnormal homeostasis	0.6476	0.4926	Least Informative	INHERITED FROM: increased circulating pituitary hormone level || increased pituitary hormone level
Mammalian Phenotype (MP)	abnormal hormone level	0.005564	1.141	Moderately Informative	INHERITED FROM: increased pituitary hormone level || increased circulating pituitary hormone level
Mammalian Phenotype (MP)	abnormal physiological response to xenobiotic	0.01157	1.825	Highly Informative	INHERITED FROM: increased physiological sensitivity to xenobiotic
Mammalian Phenotype (MP)	abnormal circulating pituitary hormone level	0.01415	1.904	Highly Informative	INHERITED FROM: increased circulating pituitary hormone level

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	blistered	0.000000007378	2.769	--	DIRECT
Worm Phenotype (WP)	pericellular component morphology variant	0.000007482	1.99	--	DIRECT
Worm Phenotype (WP)	body length variant	0.007939	1.292	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	body width variant	0.01167	1.237	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	body size variant	0.0187	1.189	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	body morphology variant	0.02507	1.145	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || larval lethal || reproductive system physiology variant || pathogen susceptibility increased || organism homeostasis metabolism variant || lethal || larval development variant || organism physiology variant || development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.3045	0.6614	Least Informative	INHERITED FROM: pathogen susceptibility increased
Worm Phenotype (WP)	organism segment morphology variant	0.04702	1.087	Moderately Informative	INHERITED FROM: dumpy
Worm Phenotype (WP)	body region morphology variant	0.0476	1.087	Moderately Informative	INHERITED FROM: dumpy
Worm Phenotype (WP)	organism stress response variant	0.1223	0.9693	Moderately Informative	INHERITED FROM: pathogen susceptibility increased
Worm Phenotype (WP)	organism pathogen response variant	0.05085	1.468	Informative	INHERITED FROM: pathogen susceptibility increased
Worm Phenotype (WP)	cuticle morphology variant	0.000004477	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	dumpy	0.0002007	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	pathogen susceptibility increased	0.0003044	2.07	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || anatomical system || anatomical group || whole organism || endocrine system
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	endocrine system	0.000886	1.693	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0	1.951	--	DIRECT
Enzyme Commission (EC)	Miscellaneous	0	2.385	--	DIRECT
Enzyme Commission (EC)	Prostaglandin-endoperoxide synthase	0	2.929	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	2.753	--	DIRECT
Enzyme Commission (EC)	NAD(P)H oxidase (H(2)O(2)-forming)	0	2.753	--	DIRECT
Enzyme Commission (EC)	Peroxidase	0.000000000000004356	2.452	--	DIRECT
Enzyme Commission (EC)	Transferring hydroxy groups	0.0000000000004846	2.531	--	DIRECT
Enzyme Commission (EC)	Linoleate 8R-lipoxygenase	0.0000000000259	2.929	--	DIRECT
Enzyme Commission (EC)	Iodide peroxidase	0.00000000444	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0.000002354	1.783	--	DIRECT
Enzyme Commission (EC)	9,12-octadecadienoate 8-hydroperoxide 8R-isomerase	0.0003056	3.23	--	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0.006348	1.907	--	INHERITED FROM: Linoleate 8R-lipoxygenase || With incorporation of two atoms of oxygen
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.4241	1.026	Moderately Informative	INHERITED FROM: 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.00000005325	1.514	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular transferases	0.01134	1.606	Informative	INHERITED FROM: 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0.00000008594	1.974	Highly Informative	DIRECT
Enzyme Commission (EC)	Peroxidases	1	1.951	Highly Informative	INHERITED FROM: Iodide peroxidase || Peroxidase

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