p120GAP domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: GTPase activation domain, GAP [ 48349]
• Superfamily: GTPase activation domain, GAP [ 48350] (2)
• Family: p120GAP domain-like [ 48360] (2)

---

Family statistics

	Genomes (324)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,411	4,902	2
Proteins	1,410	4,884	2

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.516	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Slanting of the palpebral fissure	0.001811	1.86	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.01479	1.232	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.0242	1.082	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.02614	1.082	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the head	0.2475	0.4538	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.2528	0.4454	--	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.5703	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0.1945	0.533	Least Informative	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormal eye physiology	0	0.7903	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.02309	1.082	Moderately Informative	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the palpebral fissures	0.003128	1.559	Informative	INHERITED FROM: Downslanted palpebral fissures
Phenotypic Abnormality (PA)	Downslanted palpebral fissures	0.0006998	1.985	Highly Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased hepatocellular carcinoma incidence	0.0000009123	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased hepatobiliary system tumor incidence	0.000007237	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating aspartate transaminase level	0.0001312	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased carcinoma incidence	0.0002218	1.649	--	DIRECT
Mammalian Phenotype (MP)	increased classified tumor incidence	0.002673	1.324	--	INHERITED FROM: increased carcinoma incidence || increased hepatocellular carcinoma incidence || increased malignant tumor incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.002786	1.324	--	INHERITED FROM: increased hepatocellular carcinoma incidence || increased carcinoma incidence || increased malignant tumor incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.003415	1.223	--	INHERITED FROM: increased liver tumor incidence || increased hepatobiliary system tumor incidence || increased hepatocellular carcinoma incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.003746	1.223	--	INHERITED FROM: increased hepatocellular carcinoma incidence || increased hepatobiliary system tumor incidence || increased liver tumor incidence
Mammalian Phenotype (MP)	increased tumor incidence	0.006066	1.172	--	INHERITED FROM: increased liver tumor incidence || increased malignant tumor incidence || increased hepatobiliary system tumor incidence || increased hepatocellular carcinoma incidence || increased carcinoma incidence
Mammalian Phenotype (MP)	abnormal tumor incidence	0.00961	1.141	--	INHERITED FROM: increased hepatobiliary system tumor incidence || increased carcinoma incidence || increased malignant tumor incidence || increased liver tumor incidence || increased hepatocellular carcinoma incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.01018	1.141	--	INHERITED FROM: increased hepatobiliary system tumor incidence || increased carcinoma incidence || increased malignant tumor incidence || increased liver tumor incidence || increased hepatocellular carcinoma incidence
Mammalian Phenotype (MP)	abnormal circulating enzyme level	0.01055	1.7	--	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0.02239	1.098	--	INHERITED FROM: increased hepatocellular carcinoma incidence || increased liver tumor incidence || increased hepatobiliary system tumor incidence
Mammalian Phenotype (MP)	abnormal circulating protein level	0.06106	1.205	--	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.2802	0.5861	--	INHERITED FROM: abnormal dendrite morphology
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.3273	0.6893	--	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.5215	0.3626	--	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	nervous system phenotype	0.4307	0.4959	Least Informative	INHERITED FROM: abnormal dendrite morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.6476	0.4926	Least Informative	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	neoplasm	0.01423	1.035	Moderately Informative	INHERITED FROM: increased hepatocellular carcinoma incidence || increased liver tumor incidence || increased malignant tumor incidence || increased carcinoma incidence || altered tumor pathology || increased hepatobiliary system tumor incidence
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.03208	1.012	Moderately Informative	INHERITED FROM: increased hepatobiliary system tumor incidence || increased liver tumor incidence || increased hepatocellular carcinoma incidence
Mammalian Phenotype (MP)	abnormal protein level	0.08156	1.112	Moderately Informative	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	abnormal neuron morphology	0.2334	0.8323	Moderately Informative	INHERITED FROM: abnormal dendrite morphology
Mammalian Phenotype (MP)	altered tumor pathology	0.0001873	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	increased malignant tumor incidence	0.0005327	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neurite morphology	0.007168	1.649	Informative	INHERITED FROM: abnormal dendrite morphology
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme level	0.0159	1.649	Informative	INHERITED FROM: abnormal circulating aspartate transaminase level
Mammalian Phenotype (MP)	increased liver tumor incidence	0.000006948	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal dendrite morphology	0.0007079	2.126	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || reproductive system physiology variant || transgene expression variant || gene expression variant || organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	head	0	0.912	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || adult || adult nervous system || segment || adult head || multi-tissue structure || adult tagma || adult segment || tagma || head || organ system subdivision || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || organism subdivision || multicellular structure || adult tagma || adult segment || tagma || head || organ system subdivision || multi-tissue structure || adult head || segment || adult || adult nervous system || organism || nervous system
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: head || tagma || adult segment || adult tagma || segment || adult head
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	adult head	0	1.009	Moderately Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---