ARM repeat superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: alpha-alpha superhelix [ 48370] (24)
• Superfamily: ARM repeat [ 48371] (23)
• Families:
  • Armadillo repeat [ 48372] (6)
  • Clathrin adaptor core protein [ 74771] (2)
  • HEAT repeat [ 48385] (2)
  • MIF4G domain-like [ 100908] (5)
  • PHAT domain [ 89129]
  • Mo25 protein [ 101407]
  • Leukotriene A4 hydrolase C-terminal domain [ 63608]
  • Clathrin heavy chain proximal leg segment [ 48390]
  • Clathrin heavy-chain linker domain [ 48393]
  • Leucine-rich repeat variant [ 48396]
  • Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  • Pumilio repeat [ 63611]
  • Regulatory subunit H of the V-type ATPase [ 63614]
  • PBS lyase HEAT-like repeat [ 101410] (2)
  • BC3264-like [ 109965] (2)
  • Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  • Exportin HEAT-like repeat [ 117002]
  • B56-like [ 140819]
  • HspBP1 domain [ 140822]
  • GUN4-associated domain [ 140825] (2)
  • Diap1 N-terninal region-like [ 140830]
  • Plakophilin 1 helical region [ 140833]
  • RPA1889-like [ 158764]

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Superfamily statistics

	Genomes (2,503)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	147,501	479,904	107
Proteins	123,570	406,390	92

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Functional annotation

• General category: General
• Detailed category: General

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Ether hydrolases	0	1.861	--	DIRECT
Enzyme Commission (EC)	Deoxyhypusine monooxygenase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Transferases	0.000000000005204	0	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.0000000007319	1.238	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.000000001226	1.145	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.3047	0.04271	--	INHERITED FROM: Ether hydrolases || Leukotriene-A(4) hydrolase || Omega peptidases || Acting on ether bonds || Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.01346	0.5513	Least Informative	INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Oxidoreductases	0.05767	0.2975	Least Informative	INHERITED FROM: Acting on paired donors, with incorporation or red || Deoxyhypusine monooxygenase || Miscellaneous (requires further characterization)
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	1.016	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Omega peptidases	0.0000001704	1.145	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.00001023	0.8195	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ether bonds	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol 3-kinase	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Leukotriene-A(4) hydrolase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol 4-kinase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0.000000000000004166	1.861	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Peutz-Jeghers syndrome	0.0001097	2.371	--	DIRECT
Disease Ontology (DO)	intestinal disease	0.5913	1.33	--	INHERITED FROM: Peutz-Jeghers syndrome
Disease Ontology (DO)	disease of anatomical entity	1	0.2157	--	INHERITED FROM: Peutz-Jeghers syndrome
Disease Ontology (DO)	gastrointestinal system disease	0.5135	0.8526	Moderately Informative	INHERITED FROM: Peutz-Jeghers syndrome

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Monotonic speech	0.0002091	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0003598	1.009	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal speech prosody	0.000747	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.0008914	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.007162	0.6284	--	INHERITED FROM: Abnormality of the glial cells || Abnormal cerebellum morphology || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.01257	1.176	--	INHERITED FROM: Abnormal ocular adnexa morphology
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.02889	0.7731	--	INHERITED FROM: Abnormal cerebellum morphology || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormality of hindbrain morphology	0.03564	1.708	--	INHERITED FROM: Abnormal cerebellum morphology
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.1183	0.2543	--	INHERITED FROM: Abnormal cerebellum morphology || Abnormality of the glial cells || Abnormality of nervous system morphology || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.4917	1.176	--	INHERITED FROM: Abnormal ocular adnexa morphology
Phenotypic Abnormality (PA)	Abnormality of the face	0.9599	0.5614	--	INHERITED FROM: Abnormal ocular adnexa morphology
Phenotypic Abnormality (PA)	Abnormality of the metencephalon	1	1.708	--	INHERITED FROM: Abnormal cerebellum morphology
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.000413	0.5677	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0.0006398	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.0005834	1.176	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.6682	0.9916	Moderately Informative	INHERITED FROM: Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormal cerebellum morphology	0.00002593	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the glial cells	0.0008198	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the voice	0.3512	1.628	Informative	INHERITED FROM: Monotonic speech || Abnormal speech prosody

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased renal cystadenoma incidence	0.0000305	2.508	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality	0.00007545	1.304	--	DIRECT
Mammalian Phenotype (MP)	increased cystadenoma incidence	0.001361	2.508	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.09633	1.186	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.1032	1.186	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	abnormal survival	0.1079	0.7297	--	INHERITED FROM: embryonic lethality
Mammalian Phenotype (MP)	abnormal adenoma incidence	0.1221	2.031	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	abnormal tumor incidence	0.1486	1.11	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	preweaning lethality	0.1527	0.8266	--	INHERITED FROM: embryonic lethality
Mammalian Phenotype (MP)	increased tumor incidence	0.1688	1.11	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.2461	1.11	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.2605	0.8951	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	increased kidney tumor incidence	0.3217	2.508	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.3754	1.207	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	increased classified tumor incidence	0.5305	1.207	--	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	mortality/aging	0.006974	0.5888	Least Informative	INHERITED FROM: embryonic lethality
Mammalian Phenotype (MP)	prenatal lethality	0.001415	1.076	Moderately Informative	INHERITED FROM: embryonic lethality
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.06394	1.016	Moderately Informative	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	neoplasm	0.2128	1.003	Moderately Informative	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	increased urinary system tumor incidence	0.001516	2.207	Highly Informative	INHERITED FROM: increased renal cystadenoma incidence
Mammalian Phenotype (MP)	increased adenoma incidence	0.128	2.031	Highly Informative	INHERITED FROM: increased renal cystadenoma incidence

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.000000000000001794	1.26	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.000000000000004479	1.31	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0000000000001025	0.8099	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0000003995	0.632	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.0000007765	1.327	--	DIRECT
Worm Phenotype (WP)	microtubule organization biogenesis variant	0.000003641	1.753	--	DIRECT
Worm Phenotype (WP)	accumulated somatic cell corpses	0.00001333	2.407	--	DIRECT
Worm Phenotype (WP)	failure to hatch	0.00001868	2.23	--	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.00003686	1.365	--	DIRECT
Worm Phenotype (WP)	endoderm absent	0.00005957	2.407	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic development variant	0.00006305	1.862	--	DIRECT
Worm Phenotype (WP)	adult lethal	0.0001133	2.407	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.000212	0.6038	--	DIRECT
Worm Phenotype (WP)	P granule localization defective	0.0002365	2.407	--	DIRECT
Worm Phenotype (WP)	male mating efficiency reduced	0.0002535	2.407	--	DIRECT
Worm Phenotype (WP)	seam cell fusion variant	0.0002776	2.708	--	DIRECT
Worm Phenotype (WP)	V lineages variant	0.0003455	2.708	--	DIRECT
Worm Phenotype (WP)	masculinized	0.0003574	2.23	--	DIRECT
Worm Phenotype (WP)	EMS anterior extension fails early emb	0.0005345	2.708	--	DIRECT
Worm Phenotype (WP)	proximal germ cell proliferation variant	0.0006756	2.708	--	DIRECT
Worm Phenotype (WP)	amphid phasmid neuron morphology variant	0.0007401	1.862	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.003111	1.216	--	INHERITED FROM: endocytic transport variant
Worm Phenotype (WP)	morphology variant	0.01092	0.06117	--	INHERITED FROM: P granule localization defective || embryonic cell organization biogenesis variant || developmental morphology variant || vesicle organization variant || seam cell morphology variant || pigmentation variant || organ system morphology variant || vulva morphology variant || EMS anterior extension fails early emb || cell morphology variant || dye filling defect || amphid phasmid neuron morphology variant || microtubule organization biogenesis variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.01392	0.1501	--	INHERITED FROM: gene expression variant || protein expression variant || sick || organism metabolism processing variant || RNAi response variant
Worm Phenotype (WP)	embryonic cell physiology variant	0.01414	1.628	--	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	organism physiology variant	0.02104	0.1405	--	INHERITED FROM: protein expression variant || gene expression variant || sexually dimorphic physiology variant || sick || RNAi response variant || organism metabolism processing variant
Worm Phenotype (WP)	epithelial cell morphology variant	0.0572	1.929	--	INHERITED FROM: seam cell morphology variant
Worm Phenotype (WP)	cell position defective early emb	0.06364	2.708	--	INHERITED FROM: EMS anterior extension fails early emb
Worm Phenotype (WP)	fertility variant	0.06683	0.08329	--	INHERITED FROM: brood size variant
Worm Phenotype (WP)	reproductive system physiology variant	0.07504	0.07209	--	INHERITED FROM: brood size variant || germ cell physiology variant
Worm Phenotype (WP)	organ system physiology variant	0.0775	0.05921	--	INHERITED FROM: brood size variant || epithelial system physiology variant || germ cell physiology variant
Worm Phenotype (WP)	cell position defective	0.09251	2.708	--	INHERITED FROM: EMS anterior extension fails early emb
Worm Phenotype (WP)	embryonic development variant	0.09705	0.06709	--	INHERITED FROM: endoderm absent || gastrulation variant || cytokinesis variant emb || EMS anterior extension fails early emb || failure to hatch || embryonic arrest || embryonic cell organization biogenesis variant || hatching variant || early embryonic lethal
Worm Phenotype (WP)	cell death variant	0.0992	0.9441	--	INHERITED FROM: accumulated somatic cell corpses
Worm Phenotype (WP)	gametogenesis variant	0.101	0.9517	--	INHERITED FROM: proximal germ cell proliferation variant
Worm Phenotype (WP)	germ cell mitosis variant	0.1126	2.23	--	INHERITED FROM: proximal germ cell proliferation variant
Worm Phenotype (WP)	cytokinesis variant	0.1248	1.666	--	INHERITED FROM: cytokinesis variant emb
Worm Phenotype (WP)	programmed cell death variant	0.2262	0.9594	--	INHERITED FROM: accumulated somatic cell corpses
Worm Phenotype (WP)	cell corpse number variant	0.2333	1.245	--	INHERITED FROM: accumulated somatic cell corpses
Worm Phenotype (WP)	nuclear division variant	0.2568	1.862	--	INHERITED FROM: nuclear number variant
Worm Phenotype (WP)	cell component morphology variant	0.2587	0.7833	--	INHERITED FROM: microtubule organization biogenesis variant || P granule localization defective || vesicle organization variant || embryonic cell organization biogenesis variant
Worm Phenotype (WP)	cell type morphology variant	0.2964	0.8211	--	INHERITED FROM: P granule localization defective || seam cell morphology variant
Worm Phenotype (WP)	embryonic lethal	0.3368	0.07108	--	INHERITED FROM: early embryonic lethal || EMS anterior extension fails early emb || cytokinesis variant emb || failure to hatch
Worm Phenotype (WP)	copulation variant	0.3626	1.594	--	INHERITED FROM: male mating efficiency reduced
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.3674	1.594	--	INHERITED FROM: male mating efficiency reduced
Worm Phenotype (WP)	hermaphrodite fertility variant	0.3707	0.1278	--	INHERITED FROM: brood size variant
Worm Phenotype (WP)	hermaphrodite sexual development variant	0.3784	2.23	--	INHERITED FROM: masculinized
Worm Phenotype (WP)	lineage variant	0.3927	1.804	--	INHERITED FROM: V lineages variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.4479	1.23	--	INHERITED FROM: microtubule organization biogenesis variant
Worm Phenotype (WP)	accumulated cell corpses	0.5315	1.327	--	INHERITED FROM: accumulated somatic cell corpses
Worm Phenotype (WP)	amphid phasmid sensillum morphology variant	0.5338	1.708	--	INHERITED FROM: amphid phasmid neuron morphology variant || dye filling defect
Worm Phenotype (WP)	lethal	0.9088	0.01121	--	INHERITED FROM: failure to hatch || adult lethal || EMS anterior extension fails early emb || cytokinesis variant emb || early embryonic lethal
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.9172	1.365	--	INHERITED FROM: vulva morphology variant
Worm Phenotype (WP)	growth variant	1	0.4022	--	INHERITED FROM: sick
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: male mating efficiency reduced || organism metabolism processing variant || RNAi response variant || adult lethal || gene expression variant || early embryonic lethal || endocytic transport variant || embryonic cell organization biogenesis variant || organ system development variant || seam cell fusion variant || epithelial system physiology variant || EMS anterior extension fails early emb || hatching variant || V lineages variant || germ cell physiology variant || cytokinesis variant emb || masculinized || sexually dimorphic physiology variant || gastrulation variant || endoderm absent || development variant || cell physiology variant || sick || failure to hatch || brood size variant || cell number variant || vesicle organization variant || behavior variant || proximal germ cell proliferation variant || embryonic arrest || microtubule organization biogenesis variant || protein expression variant || organism behavior variant || sexually dimorphic development variant || nuclear number variant || organism development variant || cell polarity variant || accumulated somatic cell corpses || cell development variant
Worm Phenotype (WP)	organism morphology variant	1	0.2011	--	INHERITED FROM: developmental morphology variant
Worm Phenotype (WP)	male behavior variant	1	1.594	--	INHERITED FROM: male mating efficiency reduced
Worm Phenotype (WP)	cell morphology variant	0	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0000000000001642	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.000000000003181	0.4572	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.000000001658	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0000002876	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.000000000000003586	1.216	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0.0000000000002001	1.106	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.000000001134	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.01179	1	Moderately Informative	INHERITED FROM: cytokinesis variant emb
Worm Phenotype (WP)	cell organization biogenesis variant	0.02248	1.106	Moderately Informative	INHERITED FROM: embryonic cell organization biogenesis variant || microtubule organization biogenesis variant
Worm Phenotype (WP)	reproductive system morphology variant	0.02751	1.017	Moderately Informative	INHERITED FROM: vulva morphology variant
Worm Phenotype (WP)	germ cell morphology variant	0.0342	1.064	Moderately Informative	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	apoptosis variant	0.1362	1	Moderately Informative	INHERITED FROM: accumulated somatic cell corpses
Worm Phenotype (WP)	germ cell development variant	0.5459	0.9752	Moderately Informative	INHERITED FROM: proximal germ cell proliferation variant
Worm Phenotype (WP)	nervous system morphology variant	0.7901	1.216	Moderately Informative	INHERITED FROM: dye filling defect || amphid phasmid neuron morphology variant
Worm Phenotype (WP)	brood size variant	0.0000000001437	1.628	Informative	DIRECT
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.00000001179	1.628	Informative	DIRECT
Worm Phenotype (WP)	cytokinesis variant emb	0.000001243	1.666	Informative	DIRECT
Worm Phenotype (WP)	sick	0.00001519	1.561	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0.00001794	1.531	Informative	DIRECT
Worm Phenotype (WP)	pigmentation variant	0.00009454	1.531	Informative	DIRECT
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.01652	1.666	Informative	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	male mating variant	0.03485	1.594	Informative	INHERITED FROM: male mating efficiency reduced
Worm Phenotype (WP)	sensillum morphology variant	0.1411	1.477	Informative	INHERITED FROM: amphid phasmid neuron morphology variant || dye filling defect
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.2966	1.561	Informative	INHERITED FROM: microtubule organization biogenesis variant
Worm Phenotype (WP)	gastrulation variant	0.00001089	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic arrest	0.00001734	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	developmental morphology variant	0.00006844	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	seam cell morphology variant	0.00007073	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.0002022	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	hatching variant	0.000222	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	cell polarity variant	0.0003268	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	dye filling defect	0.0003573	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	epithelial system physiology variant	0.0008012	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	nuclear number variant	0.0008031	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	cell fusion variant	0.1034	2.009	Highly Informative	INHERITED FROM: seam cell fusion variant
Worm Phenotype (WP)	sex determination variant	0.1751	2.106	Highly Informative	INHERITED FROM: masculinized
Worm Phenotype (WP)	P granule abnormal	0.442	2.106	Highly Informative	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	postembryonic cell lineage variant	0.4785	2.009	Highly Informative	INHERITED FROM: V lineages variant
Worm Phenotype (WP)	germline proliferation variant	0.8295	1.929	Highly Informative	INHERITED FROM: proximal germ cell proliferation variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0.1885	0.1328	--	INHERITED FROM: protein transport
Yeast Phenotype (YP)	metabolism and growth	0.4541	0.5905	Least Informative	INHERITED FROM: protein/peptide distribution
Yeast Phenotype (YP)	intracellular transport	0.001582	1.693	Informative	INHERITED FROM: protein transport
Yeast Phenotype (YP)	protein transport	0.0004348	2.17	Highly Informative	DIRECT
Yeast Phenotype (YP)	protein/peptide distribution	0.0006663	2.17	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.00004337	0.05522	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0.00006895	1.349	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0.1074	1.303	--	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	increased mortality during development	0.2255	0.6799	--	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	increased mortality	0.02597	0.5628	Least Informative	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	lethal	0.3643	0.798	Moderately Informative	INHERITED FROM: lethal - all die before end of pupal stage

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	male organism	0.000000000000001546	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0.00000000002791	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0.00000000004768	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0.00004517	1.17	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0.00008237	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0.0001057	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0.0002218	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0.0002469	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.0007097	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0.003449	0.193	--	INHERITED FROM: trunk region || trunk || gonad || testis
Xenopus ANatomical entity (XAN)	organism subdivision	0.01589	0.1871	--	INHERITED FROM: trunk || gonad || testis
Xenopus ANatomical entity (XAN)	anatomical group	0.04341	0.1442	--	INHERITED FROM: testis || urogenital system || genital system || egg || central nervous system || male genitalia
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.1599	0.1217	--	INHERITED FROM: testis || gonad || compound organ || trunk
Xenopus ANatomical entity (XAN)	gamete	0.3642	1.17	--	INHERITED FROM: egg
Xenopus ANatomical entity (XAN)	anatomical structure	1	0	--	INHERITED FROM: genital system || egg || urogenital system || gonad || compound organ || trunk || testis || male organism || trunk region || central nervous system || male genitalia || cell
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || urogenital system || egg || genital system || male genitalia || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || genital system || egg || testis || gonad || compound organ || trunk || central nervous system || male genitalia || trunk region || male organism || cell
Xenopus ANatomical entity (XAN)	urogenital system	0.000000004775	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0.00002299	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.002867	0.3033	Least Informative	INHERITED FROM: gonad || testis
Xenopus ANatomical entity (XAN)	nervous system	0.003362	0.6341	Least Informative	INHERITED FROM: central nervous system
Xenopus ANatomical entity (XAN)	testis	0.000000000000001546	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0.008339	1.013	Moderately Informative	INHERITED FROM: egg
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.0004128	1.314	Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0.0000007573	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	flower bud	0.00002384	2.168	--	DIRECT
Plant ANatomical entity (PAN)	reproductive bud	0.00002839	2.168	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0.00006295	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0.000253	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0.0003509	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0.00117	0.1892	--	INHERITED FROM: guard cell || stomatal complex || shoot epidermis
Plant ANatomical entity (PAN)	pollen sac	0.001964	0.7531	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	epidermis	0.002681	0.2464	--	INHERITED FROM: shoot epidermis || stomatal complex || guard cell
Plant ANatomical entity (PAN)	microgametophyte	0.00311	0.7531	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	shoot system	0.09284	0.05747	--	INHERITED FROM: bud || flower bud || shoot epidermis || stomatal complex || pollen || guard cell || reproductive bud
Plant ANatomical entity (PAN)	sporophyll	0.09346	0.4713	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	epidermal cell	0.3128	0.2569	--	INHERITED FROM: guard cell
Plant ANatomical entity (PAN)	phyllome	0.3642	0.3809	--	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	shoot epidermal cell	0.4329	0.276	--	INHERITED FROM: guard cell
Plant ANatomical entity (PAN)	collective plant structure	0.7668	0.01577	--	INHERITED FROM: bud || flower bud || stomatal complex || shoot epidermis || guard cell || reproductive bud || pollen
Plant ANatomical entity (PAN)	reproductive shoot system	0.8063	0.4141	--	INHERITED FROM: reproductive bud || flower bud
Plant ANatomical entity (PAN)	plant organ	1	0.2816	--	INHERITED FROM: microsporangium || pollen || sporangium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: bud || guard cell || reproductive bud || sporangium || stomatal complex || flower bud || microsporangium || pollen || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: flower bud || bud || reproductive bud || guard cell || pollen || stomatal complex || shoot epidermis
Plant ANatomical entity (PAN)	multi-tissue plant structure	1	0.2691	--	INHERITED FROM: microsporangium || pollen || sporangium
Plant ANatomical entity (PAN)	guard cell	0.00006124	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0.0003798	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0.03804	0.4218	Least Informative	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	microsporophyll	0.09409	0.5029	Least Informative	INHERITED FROM: pollen
Plant ANatomical entity (PAN)	pollen	0.0002784	0.7531	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	bud	0.000122	2.071	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0.0004989	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0.001136	0.0937	--	INHERITED FROM: pollen development stage
Plant structure DEvelopment stage (PDE)	androecium development stage	0.002053	1.135	--	INHERITED FROM: pollen development stage
Plant structure DEvelopment stage (PDE)	plant embryo stage	0.02632	0.2833	--	INHERITED FROM: D bilateral stage || F mature embryo stage
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.3458	0.2036	--	INHERITED FROM: F mature embryo stage || D bilateral stage
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.3573	0.1968	--	INHERITED FROM: D bilateral stage || F mature embryo stage
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0.4473	0.0937	--	INHERITED FROM: pollen development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: pollen development stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: F mature embryo stage || D bilateral stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || pollen development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: D bilateral stage || F mature embryo stage
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0.0005929	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0.0009097	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	pollen development stage	0.0002554	1.135	Moderately Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Deoxyhypusine monooxygenase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol 3-kinase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	2.253	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol 4-kinase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Ether hydrolases	0	2.107	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0.000000000000005258	2.253	--	DIRECT
Enzyme Commission (EC)	Epoxyqueuosine reductase	0.0000000000009208	2.475	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000000000002495	2.253	--	DIRECT
Enzyme Commission (EC)	Aminopeptidase B	0.0000000001707	2.475	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.000000009223	1.59	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.000000000006522	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.4393	0.6234	Least Informative	INHERITED FROM: Deoxyhypusine monooxygenase || Miscellaneous || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With other acceptors || Epoxyqueuosine reductase
Enzyme Commission (EC)	Hydrolases	0.7723	0.3541	Least Informative	INHERITED FROM: Ether hydrolases || ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase || Aminopeptidase B || Omega peptidases || Ubiquitinyl hydrolase 1 || Acting on ether bonds
Enzyme Commission (EC)	Aminoacyltransferases	0	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.0000353	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.01301	0.8949	Moderately Informative	INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 || Aminopeptidase B
Enzyme Commission (EC)	Glycosylases	0.7277	1.094	Moderately Informative	INHERITED FROM: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.308	Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0000000001055	1.42	Informative	DIRECT
Enzyme Commission (EC)	Omega peptidases	0.000002692	1.447	Informative	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.0000317	1.384	Informative	DIRECT
Enzyme Commission (EC)	Hydrolyzing N-glycosyl compounds	0.004722	1.63	Informative	INHERITED FROM: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.006195	1.475	Informative	INHERITED FROM: With other acceptors || Epoxyqueuosine reductase
Enzyme Commission (EC)	Miscellaneous	0	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on ether bonds	0	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase	0.0000000000001691	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	HECT-type E3 ubiquitin transferase	0.0000000136	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Aminopeptidases	0.007381	1.806	Highly Informative	INHERITED FROM: Aminopeptidase B

---

UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Biological process	Virulence	0.000000000003948	0.9031	Moderately Informative	DIRECT
Cellular component	Phycobilisome	0.000000000002097	1.23	Moderately Informative	DIRECT

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