Ankyrin repeat superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: beta-hairpin-alpha-hairpin repeat [ 74651] (2)
• Superfamily: Ankyrin repeat [ 48403]
• Families: Ankyrin repeat [ 48404] (17)

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Superfamily statistics

	Genomes (1,789)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	80,489	276,064	42
Proteins	69,282	232,456	42

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Functional annotation

• General category: General
• Detailed category: Protein interaction

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.145	--	DIRECT
Enzyme Commission (EC)	NAD(+) diphosphatase	0.000000000002158	2.259	--	DIRECT
Enzyme Commission (EC)	Glutaminase	0.00000005564	2.259	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.000000156	0.2175	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000004976	0	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0.000795	0.8195	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.006521	0.04271	--	INHERITED FROM: Carboxylic ester hydrolases || Glutaminase || NAD(+) diphosphatase || In linear amides || Acting on carbon-nitrogen bonds, other than peptid
Enzyme Commission (EC)	Pentosyltransferases	0.006892	1.238	--	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	Acting on acid anhydrides	0.4016	0.6408	Least Informative	INHERITED FROM: NAD(+) diphosphatase
Enzyme Commission (EC)	Acting on ester bonds	0.1213	0.4665	Least Informative	INHERITED FROM: Carboxylic ester hydrolases
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	In linear amides	0.000000001232	1.083	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0.0008122	1.217	Moderately Informative	DIRECT
Enzyme Commission (EC)	In phosphorous-containing anhydrides	0.001342	1.016	Moderately Informative	INHERITED FROM: NAD(+) diphosphatase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	0.8195	Moderately Informative	INHERITED FROM: Diacylglycerol kinase
Enzyme Commission (EC)	Glycosyltransferases	0.3822	0.9165	Moderately Informative	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0.000000000000344	1.657	Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase	0.0000000000002201	1.782	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	skeletal muscle cancer	0.0008462	1.894	--	DIRECT
Disease Ontology (DO)	muscle cancer	0.01033	1.894	--	INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer
Disease Ontology (DO)	integumentary system benign neoplasm	0.01307	1.894	--	INHERITED FROM: skin hemangioma
Disease Ontology (DO)	musculoskeletal system cancer	0.0964	1.292	--	INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer
Disease Ontology (DO)	disease of cellular proliferation	0.4422	0.2812	--	INHERITED FROM: rhabdomyosarcoma || skin hemangioma || skeletal muscle cancer
Disease Ontology (DO)	cancer	0.9314	0.3104	--	INHERITED FROM: skeletal muscle cancer || rhabdomyosarcoma
Disease Ontology (DO)	skin benign neoplasm	1	1.894	--	INHERITED FROM: skin hemangioma
Disease Ontology (DO)	organ system cancer	0.4146	0.5515	Least Informative	INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer
Disease Ontology (DO)	benign neoplasm	0.02096	1.225	Moderately Informative	INHERITED FROM: skin hemangioma
Disease Ontology (DO)	organ system benign neoplasm	0.181	1.526	Informative	INHERITED FROM: skin hemangioma
Disease Ontology (DO)	skin hemangioma	0.000004287	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	rhabdomyosarcoma	0.0006412	1.894	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal Peyer's patch T cell area morphology	0.0006325	2.508	--	DIRECT
Mammalian Phenotype (MP)	impaired somite development	0.0109	2.031	--	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal Peyer's patch follicle morphology	0.06144	2.508	--	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	abnormal gut-associated lymphoid tissue morphology	0.07986	1.73	--	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	abnormal somite development	0.1646	2.031	--	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.2999	1.128	--	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.3264	1.11	--	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.3505	1.277	--	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal embryo morphology	0.381	1.146	--	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal immune system morphology	0.4338	0.8003	--	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.4773	0.7444	--	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.5644	0.8177	--	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	immune system phenotype	0.4033	0.627	Least Informative	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.5574	0.6505	Least Informative	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.4101	1.186	Moderately Informative	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.5688	1.093	Moderately Informative	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.6281	1.016	Moderately Informative	INHERITED FROM: extramedullary hematopoiesis
Mammalian Phenotype (MP)	embryo phenotype	0.7215	0.9058	Moderately Informative	INHERITED FROM: incomplete somite formation
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.04956	1.73	Informative	INHERITED FROM: abnormal Peyer's patch T cell area morphology
Mammalian Phenotype (MP)	incomplete somite formation	0.000286	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	extramedullary hematopoiesis	0.0005196	2.207	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	octanol chemotaxis defective	0.00000147	2.23	--	DIRECT
Worm Phenotype (WP)	excretory secretory system development variant	0.000009442	1.929	--	DIRECT
Worm Phenotype (WP)	sinusoidal movement variant	0.00003487	1.708	--	DIRECT
Worm Phenotype (WP)	turning frequency variant	0.00005145	1.628	--	DIRECT
Worm Phenotype (WP)	tail bend angle variant	0.00006684	1.708	--	DIRECT
Worm Phenotype (WP)	turning variant	0.00006684	1.628	--	DIRECT
Worm Phenotype (WP)	tail movement variant	0.00007278	1.708	--	DIRECT
Worm Phenotype (WP)	body posture wavelength decreased	0.00008455	2.407	--	DIRECT
Worm Phenotype (WP)	nose movement variant	0.0001275	1.708	--	DIRECT
Worm Phenotype (WP)	head bend angle variant	0.0001325	1.628	--	DIRECT
Worm Phenotype (WP)	backward locomotion variant	0.00016	1.666	--	DIRECT
Worm Phenotype (WP)	head movement variant	0.0001661	1.628	--	DIRECT
Worm Phenotype (WP)	reversal variant	0.0001919	1.561	--	DIRECT
Worm Phenotype (WP)	chemosensory response variant	0.0009606	1.407	--	DIRECT
Worm Phenotype (WP)	chemosensory behavior variant	0.00125	1.407	--	INHERITED FROM: chemosensory response variant || octanol chemotaxis variant || chemotaxis variant || odorant negative chemotaxis defective || octanol chemotaxis defective
Worm Phenotype (WP)	locomotor coordination variant	0.001347	1.452	--	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || turning frequency variant
Worm Phenotype (WP)	organism morphology variant	0.0128	0.2011	--	INHERITED FROM: fat
Worm Phenotype (WP)	odorant negative chemotaxis variant	0.02291	2.106	--	INHERITED FROM: octanol chemotaxis defective || odorant negative chemotaxis defective || octanol chemotaxis variant
Worm Phenotype (WP)	negative chemotaxis variant	0.04299	1.804	--	INHERITED FROM: octanol chemotaxis variant || odorant negative chemotaxis defective || octanol chemotaxis defective
Worm Phenotype (WP)	organ system development variant	0.09001	0.8099	--	INHERITED FROM: excretory secretory system development variant
Worm Phenotype (WP)	morphology variant	0.145	0.06117	--	INHERITED FROM: fat
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1826	0.1501	--	INHERITED FROM: organism heat response variant || chemosensory response variant || chemotaxis variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant
Worm Phenotype (WP)	organism physiology variant	0.2154	0.1405	--	INHERITED FROM: organism heat response variant || chemotaxis variant || chemosensory response variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant
Worm Phenotype (WP)	locomotion variant	0.2611	1.045	--	INHERITED FROM: turning frequency variant || forward locomotion variant || sinusoidal movement variant || backward locomotion variant || turning variant || body bend variant || reversal variant
Worm Phenotype (WP)	body morphology variant	0.3068	1.164	--	INHERITED FROM: fat
Worm Phenotype (WP)	body width variant	0.3257	1.245	--	INHERITED FROM: fat
Worm Phenotype (WP)	body size variant	0.4211	1.202	--	INHERITED FROM: fat
Worm Phenotype (WP)	behavior variant	0.4982	0.632	--	INHERITED FROM: body bend variant || odorant negative chemotaxis defective || body posture wavelength decreased || backward locomotion variant || sinusoidal movement variant || body posture variant || head bend angle variant || localized movement variant || turning frequency variant || forward locomotion variant || chemotaxis variant || reversal variant || tail bend angle variant || octanol chemotaxis variant || nose movement variant || octanol chemotaxis defective || turning variant || chemosensory response variant || tail movement variant || head movement variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: localized movement variant || octanol chemotaxis defective || turning frequency variant || nose movement variant || body bend variant || sinusoidal movement variant || body posture variant || head bend angle variant || lethal || forward locomotion variant || excretory secretory system development variant || turning variant || odorant negative chemotaxis defective || development variant || backward locomotion variant || chemotaxis variant || tail bend angle variant || chemosensory response variant || head movement variant || tail movement variant || octanol chemotaxis variant || body posture wavelength decreased || organism heat response variant || organism development variant || reversal variant
Worm Phenotype (WP)	chemical response variant	1	0.8045	--	INHERITED FROM: odorant negative chemotaxis defective || chemosensory response variant || octanol chemotaxis variant || octanol chemotaxis defective || chemotaxis variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.04065	0.5677	Least Informative	INHERITED FROM: odorant negative chemotaxis defective || organism heat response variant || chemotaxis variant || octanol chemotaxis variant || octanol chemotaxis defective || chemosensory response variant
Worm Phenotype (WP)	organism behavior variant	0.4816	0.632	Least Informative	INHERITED FROM: head bend angle variant || localized movement variant || turning frequency variant || forward locomotion variant || body posture wavelength decreased || odorant negative chemotaxis defective || body bend variant || backward locomotion variant || sinusoidal movement variant || body posture variant || octanol chemotaxis variant || nose movement variant || octanol chemotaxis defective || chemosensory response variant || turning variant || head movement variant || tail movement variant || chemotaxis variant || reversal variant || tail bend angle variant
Worm Phenotype (WP)	organism segment morphology variant	0.0272	1.064	Moderately Informative	INHERITED FROM: fat
Worm Phenotype (WP)	body region morphology variant	0.02807	1.045	Moderately Informative	INHERITED FROM: fat
Worm Phenotype (WP)	organism stress response variant	0.1164	0.8325	Moderately Informative	INHERITED FROM: organism heat response variant
Worm Phenotype (WP)	movement variant	0.2968	1.026	Moderately Informative	INHERITED FROM: nose movement variant || body bend variant || reversal variant || head bend angle variant || turning frequency variant || forward locomotion variant || head movement variant || tail bend angle variant || tail movement variant || backward locomotion variant || localized movement variant || turning variant || sinusoidal movement variant
Worm Phenotype (WP)	body bend variant	0.00003023	1.708	Informative	DIRECT
Worm Phenotype (WP)	localized movement variant	0.0001919	1.594	Informative	DIRECT
Worm Phenotype (WP)	forward locomotion variant	0.000214	1.628	Informative	DIRECT
Worm Phenotype (WP)	body posture variant	0.0004271	1.531	Informative	DIRECT
Worm Phenotype (WP)	chemotaxis variant	0.0006131	1.407	Informative	DIRECT
Worm Phenotype (WP)	organism temperature response variant	0.001444	1.477	Informative	INHERITED FROM: organism heat response variant
Worm Phenotype (WP)	foraging behavior variant	0.00636	1.594	Informative	INHERITED FROM: nose movement variant
Worm Phenotype (WP)	directionality variant	0.07116	1.531	Informative	INHERITED FROM: reversal variant || backward locomotion variant || turning frequency variant || turning variant
Worm Phenotype (WP)	odorant chemosensory response variant	0.3083	1.708	Informative	INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant
Worm Phenotype (WP)	odorant negative chemotaxis defective	0.000007585	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	octanol chemotaxis variant	0.00003874	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	fat	0.0003157	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	organism heat response variant	0.0005059	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	body posture wavelength variant	0.3883	2.106	Highly Informative	INHERITED FROM: body posture wavelength decreased

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	cell cycle progression through the G2/M phase transition	0.0002366	2.471	--	DIRECT
Yeast Phenotype (YP)	mitotic cell cycle	0.07625	1.471	--	INHERITED FROM: cell cycle progression through the G2/M phase transition
Yeast Phenotype (YP)	cellular processes	0.3641	0.1328	--	INHERITED FROM: cell cycle progression through the G2/M phase transition
Yeast Phenotype (YP)	cell cycle progression	0.05809	1.471	Informative	INHERITED FROM: cell cycle progression through the G2/M phase transition

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	thermotaxis behavior defective	0.000575	2.303	--	DIRECT
Fly Phenotype (FP)	courtship behavior defective	0.0008375	2.303	--	DIRECT
Fly Phenotype (FP)	temperature response defective	0.0008505	2.303	--	DIRECT
Fly Phenotype (FP)	mating behavior defective	0.05097	2.303	--	INHERITED FROM: courtship behavior defective
Fly Phenotype (FP)	phenotype	0.3104	0.05522	--	INHERITED FROM: temperature response defective || thermotaxis behavior defective || behavior defective || courtship behavior defective || sensory perception defective || neurophysiology defective
Fly Phenotype (FP)	behavior defective	0.00039	1.189	Moderately Informative	DIRECT
Fly Phenotype (FP)	sensory perception defective	0.00000001877	1.701	Informative	DIRECT
Fly Phenotype (FP)	neurophysiology defective	0.0000001103	1.525	Informative	DIRECT
Fly Phenotype (FP)	mating defective	0.005485	1.826	Highly Informative	INHERITED FROM: courtship behavior defective

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	Johnston organ neuron	0.00005277	2.38	--	DIRECT
Fly Anatomy (FA)	sensory neuron	0.007523	1.234	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	sensory system neuron	0.01531	1.234	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	adult nervous system	0.01846	0.8487	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	anatomical group	0.0189	0.7891	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	mechanosensory system neuron	0.09322	2.38	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	embryonic/larval nervous system	0.1037	0.812	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	scolopidial neuron	0.1218	2.38	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	mechanosensory neuron	0.1337	2.38	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	organ system	0.2803	0.2279	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	somatic cell	0.3714	0.5607	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	organism	0.5507	0.07918	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	multicellular structure	0.5854	0.009143	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	non-connected functional system	0.8942	0.9652	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	cell	0.01209	0.4937	Least Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	nervous system	0.08337	0.7467	Least Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	adult	0.1547	0.5607	Least Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	larva	0.4862	0.4611	Least Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	sensory system	0.1012	0.9652	Moderately Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	neuron	0.2388	0.9031	Moderately Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	sensory organ cell	0.01768	1.301	Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	mechanosensory system	0.3198	1.681	Informative	INHERITED FROM: Johnston organ neuron
Fly Anatomy (FA)	cholinergic neuron	0.03102	2.079	Highly Informative	INHERITED FROM: Johnston organ neuron

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	radial glial cell	0.0005547	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	neuroblast (sensu Vertebrata)	0.001375	2.439	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	neuroblast	0.002762	2.439	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	neuronal stem cell	0.01001	2.439	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	multi fate stem cell	0.1941	2.439	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	somatic stem cell	0.2203	2.439	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	whole organism	0.9513	0.004764	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: radial glial cell
Zebrafish Anatomy (ZA)	cell	0.4353	0.7491	Least Informative	INHERITED FROM: radial glial cell

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Protein S-acyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	NAD(+) diphosphatase	0.00000004849	2.651	--	DIRECT
Enzyme Commission (EC)	Asparaginase	0.000000128	2.475	--	DIRECT
Enzyme Commission (EC)	1-alkyl-2-acetylglycerophosphocholine esterase	0.000000129	2.475	--	DIRECT
Enzyme Commission (EC)	Lysophospholipase	0.0000213	2.253	--	DIRECT
Enzyme Commission (EC)	Glutaminase	0.0001192	2.35	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.4107	0.7559	--	INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase || Phosphoric diester hydrolases
Enzyme Commission (EC)	Hydrolases	0.3555	0.3541	Least Informative	INHERITED FROM: Adenosinetriphosphatase || Phosphoric diester hydrolases || In linear amides || Glutaminase || 1-alkyl-2-acetylglycerophosphocholine esterase || NAD(+) diphosphatase || Lysophospholipase || Asparaginase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.5453	Least Informative	INHERITED FROM: Diacylglycerol kinase (ATP) || Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0.00000000647	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0.003949	0.9562	Moderately Informative	INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0.02728	1.094	Moderately Informative	INHERITED FROM: In linear amides || Asparaginase || Glutaminase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	1	1.119	Moderately Informative	INHERITED FROM: Protein S-acyltransferase
Enzyme Commission (EC)	Glycosyltransferases	1	1.204	Moderately Informative	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.119	Moderately Informative	INHERITED FROM: Diacylglycerol kinase (ATP)
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.42	Informative	DIRECT
Enzyme Commission (EC)	In linear amides	0.00002494	1.372	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.00004974	1.46	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.009471	1.28	Informative	INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase
Enzyme Commission (EC)	Carboxylic ester hydrolases	0.01418	1.408	Informative	INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase
Enzyme Commission (EC)	Pentosyltransferases	0.05786	1.447	Informative	INHERITED FROM: NAD(+) ADP-ribosyltransferase
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0.000000000000002018	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase (ATP)	0.00000000002682	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	HECT-type E3 ubiquitin transferase	0.00000006764	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Adenosinetriphosphatase	0.000001356	2.174	Highly Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Domain	ANK repeat	0	0.9542	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR002110 SSF48403 Protein matches
• Abstract:

  The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

  The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [8875926, 9353127, 9461436, 9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90^o angle. The repeats stack together to form an L-shaped structure [8875926, 12461176].

InterPro database

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