14-3-3 protein family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: alpha-alpha superhelix [ 48370] (24)
• Superfamily: 14-3-3 protein [ 48445]
• Family: 14-3-3 protein [ 48446] (4)

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Family statistics

	Genomes (500)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,675	7,011	8
Proteins	2,647	6,930	8

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	central nervous system cancer	0	1.668	--	DIRECT
Disease Ontology (DO)	psychotic disorder	0.00005036	1.399	--	DIRECT
Disease Ontology (DO)	cognitive disorder	0.0001603	1.151	--	DIRECT
Disease Ontology (DO)	organ system cancer	0	0.4879	Least Informative	DIRECT
Disease Ontology (DO)	nervous system cancer	0	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	disease of mental health	0.001295	1.036	Moderately Informative	INHERITED FROM: cognitive disorder || schizophrenia || psychotic disorder
Disease Ontology (DO)	meningioma	0	1.668	Informative	DIRECT
Disease Ontology (DO)	schizophrenia	0.00004946	1.399	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	dauer development variant	0	1.769	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0	1.513	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	enzyme activity variant	0	1.99	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0	1.013	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0	1.426	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	larval physiology variant	0	1.593	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0	1.078	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0	1.354	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	0	1.593	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0	1.689	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0	1.354	--	DIRECT
Worm Phenotype (WP)	glutathione levels variant	0	2.769	--	DIRECT
Worm Phenotype (WP)	reduced levels of reduced glutathione	0	2.769	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || protein protein interaction variant || larval lethal || reproductive system physiology variant || transgene expression variant || gene expression variant || endocytic transport variant || glutathione levels variant || pattern protein expression variant || organ system development variant || organism homeostasis metabolism variant || transgene expression reduced || lethal || larval development variant || sterile progeny || protein interaction variant || germ cell physiology variant || organism physiology variant || transgene subcellular localization variant || progeny variant || protein subcellular localization variant || germ cell development variant || oocyte physiology variant || germ cell differentiation variant || sexually dimorphic physiology variant || life span variant || endocytic transport defect || development variant || developmental timing variant || larval physiology variant || enzyme activity reduced || cell physiology variant || organism environmental stimulus response variant || growth variant || hermaphrodite fertility reduced || enzyme activity variant || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || pattern of transgene expression variant || gametogenesis variant || dauer development variant || shortened life span || postembryonic development variant || larval arrest || organ system physiology variant || protein expression variant || reduced levels of reduced glutathione || organism development variant || vesicle trafficking variant || level of transgene expression variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || fertility reduced || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: sterile progeny
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	life span variant	0	1.321	Informative	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0	1.446	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0	1.49	Informative	DIRECT
Worm Phenotype (WP)	transgene expression reduced	0	1.623	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0	1.49	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	dauer larva physiology variant	1	1.593	Informative	INHERITED FROM: dauer development variant
Worm Phenotype (WP)	enzyme activity reduced	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	shortened life span	0	1.814	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	skin	0	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	visual system	0	1.321	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.0000004291	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	cranial ganglion	0.000005672	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	early embryonic cell	0.00001578	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	blastomere	0.00001636	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	larval alimentary system	0.00005457	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	immune system	0.0005908	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	muscular system	0.02315	1.263	--	INHERITED FROM: somite
Xenopus ANatomical entity (XAN)	cell	0.04781	0.8608	--	INHERITED FROM: blastomere || early embryonic cell
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: larval alimentary system || spinal cord || thymus || immune system || endocrine system || nervous system || brain || sensory system || cranial ganglion || peripheral nervous system || central nervous system || dermal system || ganglion || skin || eye || somite || visual system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: surface structure || immune system || head region || brain || blastomere || endocrine system || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || fin || larval alimentary system || thymus || ectoderm || compound organ || spinal cord || tissue || anatomical region || central nervous system || dermal system || peripheral nervous system || pharyngeal region || visual system || anatomical space || pronephric mesenchyme || somite || skin || eye || ganglion || early embryonic cell || sensory system || multi-tissue structure || organism subdivision || embryonic structure || head || cranial ganglion || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0	1.158	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.08196	1.087	Moderately Informative	INHERITED FROM: somite
Xenopus ANatomical entity (XAN)	alimentary system	0.09403	0.8739	Moderately Informative	INHERITED FROM: larval alimentary system
Xenopus ANatomical entity (XAN)	dermal system	0	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	eye	0	1.403	Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0	1.418	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	spinal cord	0.00002618	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical space	0.0002968	1.503	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endocrine system	0.0009356	1.719	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesenchyme	0.001293	1.586	Informative	INHERITED FROM: pronephric mesenchyme
Xenopus ANatomical entity (XAN)	mesoderm	0.002104	1.285	Informative	INHERITED FROM: somite
Xenopus ANatomical entity (XAN)	ganglion	0.00000263	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	pronephric mesenchyme	0.00002543	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	fin	0.0003452	1.962	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	thymus	0.0007211	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	somite	0.0009298	1.824	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: plant organ development stage
Plant structure DEvelopment stage (PDE)	seed development stage	0.0000003016	1.304	Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Cellular component	Cytoplasm	0	0.1597	--	DIRECT

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