Lipoxigenase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Lipoxigenase [ 48483]
• Superfamily: Lipoxigenase [ 48484] (2)
• Families:
  • Plant lipoxigenases [ 48485]
  • Animal lipoxigenases [ 48489]

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Superfamily statistics

	Genomes (264)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,298	5,243	14
Proteins	2,184	5,095	14

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Functional annotation

• General category: Metabolism
• Detailed category: Coenzyme metabolism and transport

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0	1.715	--	DIRECT
Enzyme Commission (EC)	Linoleate 9S-lipoxygenase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Linoleate 13S-lipoxygenase	0.000000000002421	2.259	--	DIRECT
Enzyme Commission (EC)	Arachidonate 12-lipoxygenase	0.0000004338	2.259	--	DIRECT
Enzyme Commission (EC)	Arachidonate 15-lipoxygenase	0.000001849	2.259	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.2975	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of mole	0	1.481	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	adenoma	0.00002639	2.371	--	DIRECT
Disease Ontology (DO)	integumentary system disease	0.0007506	0.8939	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0.09532	0.2157	--	INHERITED FROM: integumentary system disease || ichthyosis || skin disease
Disease Ontology (DO)	disease of cellular proliferation	0.214	0.2812	--	INHERITED FROM: adenoma || cell type benign neoplasm || benign neoplasm
Disease Ontology (DO)	skin disease	0.0002358	0.9397	Moderately Informative	DIRECT
Disease Ontology (DO)	benign neoplasm	0.000288	1.225	Moderately Informative	DIRECT
Disease Ontology (DO)	cell type benign neoplasm	0.0001433	1.417	Informative	DIRECT
Disease Ontology (DO)	ichthyosis	0.00007241	2.07	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the immune system	0	0.8268	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0	0.9294	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0	0.9441	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3617	--	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.495	Least Informative	DIRECT
Mammalian Phenotype (MP)	integument phenotype	0.01491	0.8451	Moderately Informative	INHERITED FROM: impaired skin barrier function || abnormal skin physiology
Mammalian Phenotype (MP)	abnormal skin physiology	0.00002211	1.73	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fluid regulation	0.07422	1.554	Informative	INHERITED FROM: impaired skin barrier function
Mammalian Phenotype (MP)	impaired skin barrier function	0.0009585	2.207	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	root primordium	0.00000001925	1.992	--	DIRECT
Plant ANatomical entity (PAN)	root	0.6759	0.5579	--	INHERITED FROM: lateral root primordium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || primordium || sporophyll || calyx || inflorescence axis || root primordium || flower || collective plant structure || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || reproductive shoot system || shoot apex || leaf apex || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || stem || whole plant || epidermis || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || shoot epidermis || lateral root primordium || phyllome apex || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || pollen || microsporophyll || pollen sac || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || stamen || stem internode || inflorescence branch || shoot axis || shoot system || lateral root primordium || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0.2679	0.6838	Least Informative	INHERITED FROM: primordium || root primordium || lateral root primordium
Plant ANatomical entity (PAN)	root system	0.3034	0.5346	Least Informative	INHERITED FROM: lateral root primordium
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	primordium	0.000001951	1.691	Informative	DIRECT
Plant ANatomical entity (PAN)	lateral root primordium	0.00000002396	1.992	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.02 two leaves visible stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.06 six leaves visible stage || sporophyte vegetative stage || leaf production stage || 1 main shoot growth stage || LP.04 four leaves visible stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Linoleate 9S-lipoxygenase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Linoleate 13S-lipoxygenase	0.000000000000008975	2.651	--	DIRECT
Enzyme Commission (EC)	Hydroperoxy icosatetraenoate isomerase	0.0000000000004896	2.651	--	DIRECT
Enzyme Commission (EC)	Arachidonate 15-lipoxygenase	0.000000000404	2.651	--	DIRECT
Enzyme Commission (EC)	Transferring hydroxy groups	0.0000000005732	2.253	--	DIRECT
Enzyme Commission (EC)	Arachidonate 12-lipoxygenase	0.000000001764	2.651	--	DIRECT
Enzyme Commission (EC)	Hydroperoxy icosatetraenoate dehydratase	0.000000002005	2.475	--	DIRECT
Enzyme Commission (EC)	Linoleate 11-lipoxygenase	0.000009379	2.952	--	DIRECT
Enzyme Commission (EC)	Arachidonate 5-lipoxygenase	0.0001502	2.651	--	DIRECT
Enzyme Commission (EC)	Hydro-lyases	0.1607	1.166	--	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	Carbon-oxygen lyases	0.3599	1.012	Moderately Informative	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	Isomerases	0.7964	0.8446	Moderately Informative	INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0	1.673	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular transferases	0.07781	1.408	Informative	INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0	1.91	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR013819 SSF48484 Protein matches
• Abstract:

  This entry represents the C-terminal region of these proteins.

InterPro database

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