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  Home > SCOP hierarchy > Immunoglobulin superfamily


Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)

Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346

 Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002802Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4639Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002555Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04885Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06151Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09692Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1232Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9713Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000001097InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003094InformativeDirect
Disease Ontology (DO)alopecia0.000428InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1601InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.26InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7839InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004893Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002574Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.0001293Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.01751Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.6774Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.1801Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4184Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7387Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.8629Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.8959Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.07647Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3604Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4559Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.6795Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.6992Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.00001413InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.0009024InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.002745InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.08166InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3466InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.6142InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.6813InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.6872InformativeInherited
Phenotypic Abnormality (PA)Diabetes insipidus0.0001591Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.0006393Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0008163Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.2232Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.3727Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.756Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001289Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000002707Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2599Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06775Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5645Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003186InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006094InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.545InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9392InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9864InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002543Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004408Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0001393Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001645Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0146Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.22Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.7138Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9824Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.00000000001641Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000005249Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000005633Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.00007864Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0005491Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0007295Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.001326Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.1266Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2053Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000000002829InformativeDirect
Worm Phenotype (WP)body posture variant0.000007419InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000008741InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00003386InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0000922InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0002604InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.0003915InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008878InformativeDirect
Worm Phenotype (WP)neuron migration variant0.6322InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7231InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000002603Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.000004668Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00004782Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0001246Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004557Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001411Highly InformativeInherited
Worm Phenotype (WP)synaptic transmission variant0.1094Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.0002821Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.0008534Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.00107Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.01452Least InformativeInherited
Fly Anatomy (FA)adult0.05449Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1149Least InformativeInherited
Fly Anatomy (FA)cell0.25Least InformativeInherited
Fly Anatomy (FA)larva0.3081Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000001438Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.0007172Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.004227Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02297Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.03106Moderately InformativeInherited
Fly Anatomy (FA)neuron0.05823Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.285Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.3368Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.413Moderately InformativeInherited
Fly Anatomy (FA)head0.6084Moderately InformativeInherited
Fly Anatomy (FA)embryo0.7206Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.00001426InformativeDirect
Fly Anatomy (FA)adult brain0.0003249InformativeDirect
Fly Anatomy (FA)nerve0.0005508InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.001712InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.002112InformativeInherited
Fly Anatomy (FA)primordium0.006646InformativeInherited
Fly Anatomy (FA)larval segment0.008037InformativeInherited
Fly Anatomy (FA)central brain0.01683InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.02652InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.02858InformativeInherited
Fly Anatomy (FA)syncytium0.03603InformativeInherited
Fly Anatomy (FA)sensory organ cell0.05368InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.06696InformativeInherited
Fly Anatomy (FA)muscle system0.0692InformativeInherited
Fly Anatomy (FA)labral segment0.07616InformativeInherited
Fly Anatomy (FA)abdominal segment0.07663InformativeInherited
Fly Anatomy (FA)chemosensory system0.1335InformativeInherited
Fly Anatomy (FA)neuromere0.2646InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.4072InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.495InformativeInherited
Fly Anatomy (FA)tract0.5979InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.0000003117Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.00004848Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.00006499Highly InformativeDirect
Fly Anatomy (FA)commissure0.00007032Highly InformativeDirect
Fly Anatomy (FA)connective0.0001733Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.0004258Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.000476Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.0005197Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0006408Highly InformativeDirect
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.0006439Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.0008143Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.06963Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.1289Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7228Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.4866InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008369Highly InformativeDirect
Zebrafish Anatomy (ZA)olfactory system0.2157Highly InformativeInherited
Zebrafish Anatomy (ZA)telencephalon0.3834Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.00000101Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)adult frog stage0.0003505Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases2.574e-16Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.02447Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00003335InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.