C2 set domains family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Immunoglobulin [ 48726] (4)
• Family: C2 set domains [ 49142] (8)

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Family statistics

	Genomes (39)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	290	826	29
Proteins	238	645	27

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	demyelinating disease	0.00001003	1.367	--	DIRECT
Disease Ontology (DO)	hemorrhagic fever with renal syndrome	0.00002143	2.513	--	DIRECT
Disease Ontology (DO)	nephritis	0.00004543	1.309	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0.00008415	0.8698	--	DIRECT
Disease Ontology (DO)	immune system cancer	0.0001342	0.89	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	0.0005714	1.309	--	DIRECT
Disease Ontology (DO)	kidney disease	0.001239	1.066	--	INHERITED FROM: nephritis
Disease Ontology (DO)	hypersensitivity reaction disease	0.001361	0.8505	--	INHERITED FROM: hypersensitivity reaction type II disease
Disease Ontology (DO)	musculoskeletal system disease	0.00175	0.89	--	INHERITED FROM: arthritis || connective tissue disease || bone inflammation disease || rheumatoid arthritis
Disease Ontology (DO)	immune system disease	0.006409	0.8411	--	INHERITED FROM: hypersensitivity reaction type II disease
Disease Ontology (DO)	viral infectious disease	0.07529	1.212	--	INHERITED FROM: hemorrhagic fever with renal syndrome
Disease Ontology (DO)	disease of anatomical entity	0.114	0.2414	--	INHERITED FROM: arthritis || demyelinating disease || hematopoietic system disease || connective tissue disease || nervous system disease || rheumatoid arthritis || bone inflammation disease || central nervous system disease || multiple sclerosis || nephritis || hypersensitivity reaction type II disease
Disease Ontology (DO)	bone disease	0.3892	1.171	--	INHERITED FROM: bone inflammation disease || arthritis || rheumatoid arthritis
Disease Ontology (DO)	nervous system disease	0.0007402	0.7279	Least Informative	DIRECT
Disease Ontology (DO)	organ system cancer	0.2371	0.4879	Least Informative	INHERITED FROM: hematologic cancer || immune system cancer
Disease Ontology (DO)	hematologic cancer	0.0001274	0.89	Moderately Informative	DIRECT
Disease Ontology (DO)	hematopoietic system disease	0.0001382	1.051	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	0.0001562	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	connective tissue disease	0.000471	1.022	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.0007126	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	urinary system disease	0.003105	1.051	Moderately Informative	INHERITED FROM: nephritis
Disease Ontology (DO)	neurodegenerative disease	0.5965	1.022	Moderately Informative	INHERITED FROM: multiple sclerosis || demyelinating disease
Disease Ontology (DO)	multiple sclerosis	0.000009417	1.399	Informative	DIRECT
Disease Ontology (DO)	arthritis	0.0004295	1.472	Informative	DIRECT
Disease Ontology (DO)	rheumatoid arthritis	0.0001273	1.814	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased susceptibility to autoimmune diabetes	0.000003203	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell chemotaxis	0.0001355	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to autoimmune disorder	0.0005523	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal monocyte morphology	0.000803	2.302	--	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.004773	1.324	--	INHERITED FROM: decreased susceptibility to autoimmune disorder || decreased susceptibility to autoimmune diabetes
Mammalian Phenotype (MP)	abnormal self tolerance	0.004857	1.324	--	INHERITED FROM: decreased susceptibility to autoimmune diabetes || decreased susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	abnormal immune system physiology	0.01199	0.6789	--	INHERITED FROM: decreased susceptibility to autoimmune disorder || decreased susceptibility to autoimmune diabetes
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.01338	0.8473	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.01629	0.7167	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.02405	0.8038	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.02721	0.6686	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0.0279	1.281	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal immune tolerance	0.05026	1.324	--	INHERITED FROM: decreased susceptibility to autoimmune diabetes || decreased susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	abnormal cell physiology	0.1349	0.6209	--	INHERITED FROM: abnormal cell chemotaxis
Mammalian Phenotype (MP)	abnormal mononuclear phagocyte morphology	0.1453	1.457	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.2615	0.7223	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.2912	1.223	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.334	0.8108	--	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.04993	0.5945	Least Informative	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	immune system phenotype	0.0544	0.5462	Least Informative	INHERITED FROM: decreased susceptibility to autoimmune disorder || decreased susceptibility to autoimmune diabetes || abnormal monocyte morphology
Mammalian Phenotype (MP)	cellular phenotype	0.2004	0.5387	Least Informative	INHERITED FROM: abnormal cell chemotaxis
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.4904	0.9904	Moderately Informative	INHERITED FROM: abnormal monocyte morphology
Mammalian Phenotype (MP)	altered susceptibility to autoimmune disorder	0.002398	1.649	Informative	INHERITED FROM: decreased susceptibility to autoimmune disorder || decreased susceptibility to autoimmune diabetes
Mammalian Phenotype (MP)	abnormal cell migration	0.02221	1.399	Informative	INHERITED FROM: abnormal cell chemotaxis

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