SUPERFAMILY 1.75 HMM library and genome assignments server

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C2 set domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   C2 set domains [ 49142] (8)

Family statistics
Genomes (39) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 290 826 29
Proteins 238 645 27

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0007402Least InformativeDirect
Disease Ontology (DO)organ system cancer0.2371Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0001274Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.0001382Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001562Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.000471Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0007126Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.003105Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.5965Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.000009417InformativeDirect
Disease Ontology (DO)arthritis0.0004295InformativeDirect
Disease Ontology (DO)rheumatoid arthritis0.0001273Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04993Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0544Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2004Least InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4904Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.002398InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.02221InformativeInherited

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]