I set domains family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Immunoglobulin [ 48726] (4)
• Family: I set domains [ 49159] (38)

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Family statistics

	Genomes (81)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,969	13,306	162
Proteins	3,085	8,095	101

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.361	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	[Myosin light-chain] kinase	0.000000000002292	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0.00001517	1.7	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.88	0.01852	--	INHERITED FROM: Phosphoric monoester hydrolases || Acting on ester bonds || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Acting on ester bonds	0.0000006059	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	1	0.3212	Least Informative	INHERITED FROM: Peroxidases || Acting on a peroxide as acceptor || Peroxidase
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	0.9703	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.002937	1.042	Moderately Informative	INHERITED FROM: [Myosin light-chain] kinase
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	1.595	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.537	Informative	DIRECT
Enzyme Commission (EC)	Peroxidases	0.00001477	1.7	Informative	DIRECT
Enzyme Commission (EC)	Peroxidase	0.00000000003677	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	dengue hemorrhagic fever	0.00012	2.513	--	DIRECT
Disease Ontology (DO)	acute kidney failure	0.0001263	2.212	--	DIRECT
Disease Ontology (DO)	immune system disease	0.0002352	0.8411	--	DIRECT
Disease Ontology (DO)	bullous pemphigoid	0.0002435	1.61	--	DIRECT
Disease Ontology (DO)	craniosynostosis	0.0003347	2.513	--	DIRECT
Disease Ontology (DO)	dengue disease	0.003107	2.513	--	INHERITED FROM: dengue hemorrhagic fever
Disease Ontology (DO)	immune system cancer	0.003934	0.89	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	dysostosis	0.004824	2.212	--	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	disease of anatomical entity	0.007999	0.2414	--	INHERITED FROM: craniosynostosis || acute kidney failure || bullous pemphigoid || immune system disease
Disease Ontology (DO)	musculoskeletal system disease	0.0172	0.89	--	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	kidney disease	0.0396	1.066	--	INHERITED FROM: acute kidney failure
Disease Ontology (DO)	non-Hodgkin lymphoma	0.1099	1.814	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	bone development disease	0.127	2.212	--	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	hypersensitivity reaction disease	0.1353	0.8505	--	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	viral infectious disease	0.1741	1.212	--	INHERITED FROM: dengue hemorrhagic fever
Disease Ontology (DO)	disease of cellular proliferation	0.1979	0.2322	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	bone disease	0.4136	1.171	--	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	cancer	0.4343	0.2555	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	organ system cancer	0.4727	0.4879	Least Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	disease by infectious agent	0.04039	0.8142	Moderately Informative	INHERITED FROM: dengue hemorrhagic fever
Disease Ontology (DO)	urinary system disease	0.1456	1.051	Moderately Informative	INHERITED FROM: acute kidney failure
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.3092	0.8797	Moderately Informative	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	connective tissue disease	0.7992	1.022	Moderately Informative	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	hematologic cancer	0.853	0.89	Moderately Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.01989	1.472	Informative	INHERITED FROM: bullous pemphigoid
Disease Ontology (DO)	lymphoma	0.1161	1.668	Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	mature T-cell and NK-cell lymphoma	0.0007087	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	synostosis	0.002116	2.212	Highly Informative	INHERITED FROM: craniosynostosis
Disease Ontology (DO)	kidney failure	0.1286	1.814	Highly Informative	INHERITED FROM: acute kidney failure

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Cloverleaf skull	0.00005396	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Recurrent corneal erosions	0.0001513	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia of the phalanges of the hand	0.0002274	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia involving bones of the upper limbs	0.0002274	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the middle phalanges of the toes	0.0002274	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia involving bones of the extremities	0.0006068	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the tarsal bones	0.0006682	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Short middle phalanx of toe	0.0007291	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Short toe	0.02308	2.462	--	INHERITED FROM: Short middle phalanx of toe
Phenotypic Abnormality (PA)	Abnormal corneal epithelium morphology	0.1015	1.763	--	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Abnormality of finger	0.2488	1.258	--	INHERITED FROM: Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.2714	0.9183	--	INHERITED FROM: Aplasia of the phalanges of the hand || Aplasia involving bones of the upper limbs
Phenotypic Abnormality (PA)	Abnormality of the foot	0.2891	1.082	--	INHERITED FROM: Short middle phalanx of toe || Abnormality of the middle phalanges of the toes || Abnormality of the tarsal bones
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.2943	1.14	--	INHERITED FROM: Abnormality of the middle phalanges of the toes || Short middle phalanx of toe || Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving bones of the feet	0.3133	1.86	--	INHERITED FROM: Short middle phalanx of toe
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.3901	1.383	--	INHERITED FROM: Aplasia involving bones of the extremities || Short middle phalanx of toe || Aplasia involving bones of the upper limbs || Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.4379	1.462	--	INHERITED FROM: Aplasia involving bones of the upper limbs || Aplasia of the phalanges of the hand || Short middle phalanx of toe || Aplasia involving bones of the extremities
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the lower limbs	0.4508	1.763	--	INHERITED FROM: Short middle phalanx of toe
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.4585	0.6771	--	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.4922	0.9572	--	INHERITED FROM: Short middle phalanx of toe || Aplasia involving bones of the upper limbs || Aplasia involving bones of the extremities || Abnormality of the tarsal bones || Abnormality of the middle phalanges of the toes || Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the upper limbs	0.5228	1.559	--	INHERITED FROM: Aplasia of the phalanges of the hand || Aplasia involving bones of the upper limbs
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.621	0.8826	--	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.6303	0.8289	--	INHERITED FROM: Aplasia of the phalanges of the hand || Abnormality of the middle phalanges of the toes || Abnormality of the tarsal bones || Aplasia involving bones of the extremities || Aplasia involving bones of the upper limbs || Short middle phalanx of toe
Phenotypic Abnormality (PA)	Abnormality of the calvaria	0.668	1.286	--	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.7518	0.4712	--	INHERITED FROM: Abnormality of the tarsal bones || Abnormality of the middle phalanges of the toes || Cloverleaf skull || Aplasia of the phalanges of the hand || Short middle phalanx of toe || Aplasia involving bones of the upper limbs || Aplasia involving bones of the extremities
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.7959	0.7812	--	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.9295	0.4454	--	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Abnormality of the head	0.9587	0.4538	--	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Abnormality of limbs	0.5882	0.6429	Least Informative	INHERITED FROM: Abnormality of the middle phalanges of the toes || Abnormality of the tarsal bones || Aplasia of the phalanges of the hand || Short middle phalanx of toe || Aplasia involving bones of the extremities || Aplasia involving bones of the upper limbs
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.6469	0.513	Least Informative	INHERITED FROM: Aplasia involving bones of the upper limbs || Aplasia involving bones of the extremities || Short middle phalanx of toe || Aplasia of the phalanges of the hand || Abnormality of the tarsal bones || Cloverleaf skull || Abnormality of the middle phalanges of the toes
Phenotypic Abnormality (PA)	Abnormality of the eye	0.7473	0.5703	Least Informative	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Abnormality of the hand	0.4141	1.031	Moderately Informative	INHERITED FROM: Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.4236	1.12	Moderately Informative	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.4494	0.9309	Moderately Informative	INHERITED FROM: Abnormality of the tarsal bones || Short middle phalanx of toe || Abnormality of the middle phalanges of the toes
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.4922	0.9572	Moderately Informative	INHERITED FROM: Abnormality of the tarsal bones || Abnormality of the middle phalanges of the toes || Aplasia of the phalanges of the hand || Short middle phalanx of toe || Aplasia involving bones of the upper limbs || Aplasia involving bones of the extremities
Phenotypic Abnormality (PA)	Abnormal lower limb bone morphology	0.2877	1.508	Informative	INHERITED FROM: Short middle phalanx of toe || Abnormality of the tarsal bones
Phenotypic Abnormality (PA)	Abnormal cornea morphology	0.367	1.383	Informative	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Abnormality of toe	0.3805	1.617	Informative	INHERITED FROM: Abnormality of the middle phalanges of the toes || Short middle phalanx of toe
Phenotypic Abnormality (PA)	Abnormality of calvarial morphology	0.4803	1.508	Informative	INHERITED FROM: Cloverleaf skull
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.5559	1.508	Informative	INHERITED FROM: Aplasia of the phalanges of the hand || Aplasia involving bones of the upper limbs || Short middle phalanx of toe || Aplasia involving bones of the extremities
Phenotypic Abnormality (PA)	Abnormal finger phalanx morphology	0.8235	1.508	Informative	INHERITED FROM: Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Corneal erosion	0.009397	2.161	Highly Informative	INHERITED FROM: Recurrent corneal erosions
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of toe	0.05317	1.985	Highly Informative	INHERITED FROM: Short middle phalanx of toe
Phenotypic Abnormality (PA)	Abnormality of the phalanges of the toes	0.1281	1.86	Highly Informative	INHERITED FROM: Abnormality of the middle phalanges of the toes || Short middle phalanx of toe
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the phalanges of the hand	0.2046	1.86	Highly Informative	INHERITED FROM: Aplasia of the phalanges of the hand
Phenotypic Abnormality (PA)	Short digit	0.6263	1.86	Highly Informative	INHERITED FROM: Short middle phalanx of toe

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	small endometrial glands	0.00001065	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased Sertoli cell phagocytosis	0.00001065	2.126	--	DIRECT
Mammalian Phenotype (MP)	increased granulosa cell apoptosis	0.0000235	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal Sertoli cell phagocytosis	0.00007494	2.126	--	DIRECT
Mammalian Phenotype (MP)	axial skeleton hypoplasia	0.0001497	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased abdominal fat pad weight	0.0001754	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal diaphragm morphology	0.0003692	2.302	--	DIRECT
Mammalian Phenotype (MP)	midface hypoplasia	0.000518	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased kidney cell proliferation	0.0005801	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased IgG1 level	0.0007291	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal paranode morphology	0.000906	2.603	--	DIRECT
Mammalian Phenotype (MP)	vision/eye phenotype	0.002003	0.8789	--	INHERITED FROM: abnormal eye morphology
Mammalian Phenotype (MP)	abnormal endometrial gland morphology	0.004919	2.603	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal kidney cell proliferation	0.006755	2.603	--	INHERITED FROM: decreased kidney cell proliferation
Mammalian Phenotype (MP)	increased IgG level	0.01109	1.904	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.01396	0.8789	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	skeleton phenotype	0.01632	0.8038	--	INHERITED FROM: axial skeleton hypoplasia
Mammalian Phenotype (MP)	abnormal mucous gland morphology	0.02087	2.603	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal endometrium morphology	0.02133	2.603	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	muscle phenotype	0.02578	0.8473	--	INHERITED FROM: abnormal diaphragm morphology
Mammalian Phenotype (MP)	abnormal IgG1 level	0.03311	2.302	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal facial morphology	0.03728	1.348	--	INHERITED FROM: midface hypoplasia
Mammalian Phenotype (MP)	abnormal immune system physiology	0.04549	0.6789	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.0664	0.9219	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	craniofacial phenotype	0.06939	1.047	--	INHERITED FROM: midface hypoplasia
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.07335	0.9219	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.08987	0.9219	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal humoral immune response	0.1569	1.457	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.1859	1.112	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal cell physiology	0.2089	0.6209	--	INHERITED FROM: increased granulosa cell apoptosis || decreased kidney cell proliferation
Mammalian Phenotype (MP)	abnormal B cell physiology	0.2099	1.172	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.212	0.5861	--	INHERITED FROM: abnormal paranode morphology || abnormal innervation
Mammalian Phenotype (MP)	abnormal exocrine gland morphology	0.2423	1.261	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.2615	0.8789	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	increased apoptosis	0.3017	1.241	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	increased cell death	0.305	1.241	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	increased immunoglobulin level	0.3286	1.825	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.4917	0.931	--	INHERITED FROM: decreased kidney cell proliferation || abnormal urothelium morphology
Mammalian Phenotype (MP)	abnormal female reproductive gland morphology	0.4922	1.427	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal female reproductive system physiology	0.5629	1.223	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal apoptosis	0.5648	1.023	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0.6774	1.281	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0.6955	1.261	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0.6997	1.261	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal renal/urinary system physiology	0.7811	1.281	--	INHERITED FROM: decreased kidney cell proliferation
Mammalian Phenotype (MP)	abnormal cell proliferation	0.807	1.324	--	INHERITED FROM: decreased kidney cell proliferation
Mammalian Phenotype (MP)	abnormal IgG level	0.8601	1.562	--	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.8632	1.141	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.8971	1.223	--	INHERITED FROM: increased abdominal fat pad weight
Mammalian Phenotype (MP)	reproductive system phenotype	0.9065	0.8397	--	INHERITED FROM: abnormal Sertoli cell phagocytosis || increased granulosa cell apoptosis || small endometrial glands || decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal gametogenesis	0.956	1.324	--	INHERITED FROM: abnormal Sertoli cell phagocytosis || decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal gland morphology	0.9975	0.7519	--	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal skeleton morphology	1	0.8323	--	INHERITED FROM: axial skeleton hypoplasia
Mammalian Phenotype (MP)	nervous system phenotype	0.01609	0.4959	Least Informative	INHERITED FROM: abnormal paranode morphology || abnormal innervation
Mammalian Phenotype (MP)	immune system phenotype	0.05843	0.5462	Least Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.1227	0.5945	Least Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	cellular phenotype	0.442	0.5387	Least Informative	INHERITED FROM: decreased kidney cell proliferation || increased granulosa cell apoptosis
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.7513	0.6947	Least Informative	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.9233	0.6254	Least Informative	INHERITED FROM: midface hypoplasia
Mammalian Phenotype (MP)	abnormal eye morphology	0.000595	0.9129	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron morphology	0.03806	0.8323	Moderately Informative	INHERITED FROM: abnormal paranode morphology
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.03974	1.098	Moderately Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal head morphology	0.03977	1.241	Moderately Informative	INHERITED FROM: midface hypoplasia
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.06754	1.047	Moderately Informative	INHERITED FROM: midface hypoplasia
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.1197	1.001	Moderately Informative	INHERITED FROM: axial skeleton hypoplasia
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.2106	0.9219	Moderately Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal muscle morphology	0.2508	1.112	Moderately Informative	INHERITED FROM: abnormal diaphragm morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.383	1.047	Moderately Informative	INHERITED FROM: abnormal urothelium morphology
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.3878	1.001	Moderately Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	adipose tissue phenotype	0.8149	1.205	Moderately Informative	INHERITED FROM: increased abdominal fat pad weight
Mammalian Phenotype (MP)	abnormal cell death	0.8711	0.9904	Moderately Informative	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.8738	1.012	Moderately Informative	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.9519	0.9404	Moderately Informative	INHERITED FROM: decreased Sertoli cell phagocytosis || abnormal Sertoli cell phagocytosis || small endometrial glands
Mammalian Phenotype (MP)	abnormal innervation	0.000963	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.03374	1.427	Informative	INHERITED FROM: abnormal diaphragm morphology
Mammalian Phenotype (MP)	abnormal neurite morphology	0.2119	1.649	Informative	INHERITED FROM: abnormal paranode morphology
Mammalian Phenotype (MP)	abnormal immunoglobulin level	0.3514	1.524	Informative	INHERITED FROM: increased IgG1 level
Mammalian Phenotype (MP)	abnormal kidney physiology	0.3613	1.427	Informative	INHERITED FROM: decreased kidney cell proliferation
Mammalian Phenotype (MP)	abnormal fat pad morphology	0.5281	1.524	Informative	INHERITED FROM: increased abdominal fat pad weight
Mammalian Phenotype (MP)	decreased cell proliferation	0.7	1.603	Informative	INHERITED FROM: decreased kidney cell proliferation
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.8588	1.489	Informative	INHERITED FROM: abnormal Sertoli cell phagocytosis || decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal urothelium morphology	0.0006877	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermiogenesis	0.06127	2.001	Highly Informative	INHERITED FROM: abnormal Sertoli cell phagocytosis || decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal hypaxial muscle morphology	0.1877	1.825	Highly Informative	INHERITED FROM: abnormal diaphragm morphology
Mammalian Phenotype (MP)	abnormal axon morphology	0.3397	2.001	Highly Informative	INHERITED FROM: abnormal paranode morphology
Mammalian Phenotype (MP)	abnormal uterus morphology	0.3401	2.001	Highly Informative	INHERITED FROM: small endometrial glands
Mammalian Phenotype (MP)	abnormal abdominal fat pad morphology	0.4036	1.825	Highly Informative	INHERITED FROM: increased abdominal fat pad weight

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	muscle arm development variant	0.000000007867	1.866	--	DIRECT
Worm Phenotype (WP)	body wall cell development variant	0.00000001572	1.814	--	DIRECT
Worm Phenotype (WP)	ALM migration variant	0.00000004556	2.468	--	DIRECT
Worm Phenotype (WP)	axon fasciculation variant	0.0000005654	2.468	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.000001427	0.7558	--	DIRECT
Worm Phenotype (WP)	neuron development variant	0.000001952	1.321	--	DIRECT
Worm Phenotype (WP)	muscle cell development variant	0.000003181	1.814	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0.000006363	1.866	--	DIRECT
Worm Phenotype (WP)	pausing increased	0.000008405	2.769	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.00001112	0.7516	--	DIRECT
Worm Phenotype (WP)	path curvature increased	0.00003982	2.468	--	DIRECT
Worm Phenotype (WP)	loss of asymmetry ASE	0.00005823	2.292	--	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.00007468	1.655	--	DIRECT
Worm Phenotype (WP)	protruding vulva	0.0001299	1.623	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.0002868	1.337	--	DIRECT
Worm Phenotype (WP)	posterior cell migration variant	0.0003503	2.468	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.0005305	1.407	--	DIRECT
Worm Phenotype (WP)	posterior neuron migration variant	0.0005805	2.468	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.0007436	1.623	--	DIRECT
Worm Phenotype (WP)	neurite morphology variant	0.0009457	1.866	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.003669	1.306	--	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	neuron morphology variant	0.004248	1.866	--	INHERITED FROM: neurite morphology variant
Worm Phenotype (WP)	reproductive system development variant	0.006562	1.156	--	INHERITED FROM: anchor cell invasion variant || vulva uterus connection defective
Worm Phenotype (WP)	metabolic pathway variant	0.008424	1.263	--	INHERITED FROM: protein degradation variant
Worm Phenotype (WP)	behavior variant	0.008734	0.6859	--	INHERITED FROM: body posture variant || movement variant || forward locomotion decreased || path curvature increased || locomotion reduced || pausing increased
Worm Phenotype (WP)	activity level variant	0.01671	1.337	--	INHERITED FROM: pausing increased || locomotion reduced
Worm Phenotype (WP)	drug response variant	0.0184	1.135	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	nervous system morphology variant	0.02222	1.321	--	INHERITED FROM: neurite morphology variant || synapse morphology variant
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.0571	1.426	--	INHERITED FROM: protruding vulva || vulva morphology variant
Worm Phenotype (WP)	cell component morphology variant	0.1167	0.8392	--	INHERITED FROM: synapse morphology variant || mitochondria alignment variant || neurite morphology variant
Worm Phenotype (WP)	neuron migration variant	0.1189	1.623	--	INHERITED FROM: posterior neuron migration variant || ALM migration variant
Worm Phenotype (WP)	neuronal outgrowth variant	0.1252	1.565	--	INHERITED FROM: axon outgrowth variant || axon guidance variant
Worm Phenotype (WP)	mitochondria spacing variant	0.2006	1.623	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	axon development variant	0.2415	2.167	--	INHERITED FROM: axon fasciculation variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.4916	0.1444	--	INHERITED FROM: growth rate variant || protein degradation variant || aldicarb response variant
Worm Phenotype (WP)	organism physiology variant	0.5198	0.1342	--	INHERITED FROM: growth rate variant || protein degradation variant || aldicarb response variant
Worm Phenotype (WP)	growth variant	1	0.3438	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || axon fasciculation variant || forward locomotion decreased || muscle arm development variant || pausing increased || reproductive system physiology variant || organ system development variant || growth rate variant || axon guidance variant || body posture variant || nervous system development variant || protein degradation variant || movement variant || lethal || aldicarb response variant || posterior cell migration variant || anchor cell invasion variant || posterior neuron migration variant || muscle arm development defective || development variant || exploded through vulva || muscle cell development variant || hermaphrodite sterile || muscle cell attachment variant || hermaphrodite fertility reduced || axon outgrowth variant || embryonic development variant || embryonic lethal || locomotion reduced || vulva uterus connection defective || fertility variant || loss of asymmetry ASE || body wall cell development variant || path curvature increased || organ system physiology variant || maternal sterile || neuron development variant || organism development variant || ALM migration variant || fertility reduced || cell development variant
Worm Phenotype (WP)	locomotion variant	1	1.053	--	INHERITED FROM: locomotion reduced || path curvature increased || forward locomotion decreased || pausing increased
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	striated muscle morphology variant	1	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	cell development variant	0.0001617	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.003776	0.6614	Least Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	organism behavior variant	0.008422	0.6859	Least Informative	INHERITED FROM: forward locomotion decreased || movement variant || body posture variant || pausing increased || path curvature increased || locomotion reduced
Worm Phenotype (WP)	cell physiology variant	0.01858	0.5955	Least Informative	INHERITED FROM: protein degradation variant || muscle cell attachment variant
Worm Phenotype (WP)	organism metabolism processing variant	0.3526	0.4899	Least Informative	INHERITED FROM: protein degradation variant
Worm Phenotype (WP)	organ system development variant	0.00007889	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0.00009656	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0001978	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.0002033	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.01002	1.036	Moderately Informative	INHERITED FROM: protein degradation variant
Worm Phenotype (WP)	chemical response variant	0.03294	0.9053	Moderately Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell type morphology variant	0.1949	0.8878	Moderately Informative	INHERITED FROM: body wall muscle sarcomere morphology variant || neurite morphology variant || muscle cell morphology variant
Worm Phenotype (WP)	reproductive system morphology variant	0.5063	1.078	Moderately Informative	INHERITED FROM: protruding vulva || vulva morphology variant
Worm Phenotype (WP)	axon outgrowth variant	0.00000006627	1.565	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.00000153	1.446	Informative	DIRECT
Worm Phenotype (WP)	body posture variant	0.00003768	1.513	Informative	DIRECT
Worm Phenotype (WP)	locomotion reduced	0.0001209	1.49	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.0002998	1.426	Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0.001406	1.407	Informative	INHERITED FROM: posterior cell migration variant || posterior neuron migration variant || ALM migration variant
Worm Phenotype (WP)	mitochondria morphology variant	0.003217	1.513	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	locomotor coordination variant	0.003803	1.446	Informative	INHERITED FROM: path curvature increased
Worm Phenotype (WP)	cell fate specification variant	0.008379	1.513	Informative	INHERITED FROM: loss of asymmetry ASE
Worm Phenotype (WP)	muscle cell physiology variant	0.01289	1.426	Informative	INHERITED FROM: muscle cell attachment variant
Worm Phenotype (WP)	forward locomotion variant	0.02093	1.623	Informative	INHERITED FROM: forward locomotion decreased
Worm Phenotype (WP)	epithelial system development variant	0.04458	1.655	Informative	INHERITED FROM: exploded through vulva
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.04989	1.623	Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	protein metabolism variant	0.1393	1.354	Informative	INHERITED FROM: protein degradation variant
Worm Phenotype (WP)	cell component localization variant	0.3204	1.388	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	anchor cell invasion variant	0.0000000001214	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	axon guidance variant	0.000000002793	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle arm development defective	0.000000004117	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	protein degradation variant	0.00001237	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	nervous system development variant	0.00001675	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	growth rate variant	0.00001804	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	exploded through vulva	0.00005031	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	forward locomotion decreased	0.00006179	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle cell attachment variant	0.0005146	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	synapse morphology variant	0.0006206	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	loss of left right asymmetry	0.03881	1.99	Highly Informative	INHERITED FROM: loss of asymmetry ASE
Worm Phenotype (WP)	neuronal cell fate specification variant	0.1258	1.99	Highly Informative	INHERITED FROM: loss of asymmetry ASE
Worm Phenotype (WP)	neurite development variant	0.1827	1.866	Highly Informative	INHERITED FROM: axon fasciculation variant
Worm Phenotype (WP)	pausing variant	0.1889	1.866	Highly Informative	INHERITED FROM: pausing increased
Worm Phenotype (WP)	path curvature variant	0.3043	1.99	Highly Informative	INHERITED FROM: path curvature increased

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.06292	0.06546	--	INHERITED FROM: cell migration defective
Fly Phenotype (FP)	cell migration defective	0.00004415	1.908	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	interface glial cell	0.0000002721	2.389	--	DIRECT
Fly Anatomy (FA)	leg taste bristle chemosensory neuron	0.0000008128	2.389	--	DIRECT
Fly Anatomy (FA)	adult cerebral ganglion	0.000001044	1.69	--	DIRECT
Fly Anatomy (FA)	embryonic heart cardioblast	0.000001241	2.088	--	DIRECT
Fly Anatomy (FA)	neuron projection bundle	0.000002472	1.243	--	DIRECT
Fly Anatomy (FA)	gustatory system neuron	0.000005127	2.088	--	DIRECT
Fly Anatomy (FA)	adult pacemaker neuron	0.00001494	2.088	--	DIRECT
Fly Anatomy (FA)	synaptic neuropil	0.00001672	1.435	--	DIRECT
Fly Anatomy (FA)	ganglionic branch primordium	0.00004416	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval lateral glial cell	0.00004663	2.389	--	DIRECT
Fly Anatomy (FA)	pacemaker neuron	0.00006392	2.088	--	DIRECT
Fly Anatomy (FA)	procephalic segment	0.00006656	1.31	--	DIRECT
Fly Anatomy (FA)	embryonic cardioblast	0.00007425	2.088	--	DIRECT
Fly Anatomy (FA)	heart primordium	0.00008153	2.389	--	DIRECT
Fly Anatomy (FA)	gustatory system	0.00009152	2.088	--	DIRECT
Fly Anatomy (FA)	head segment	0.0001297	1.31	--	DIRECT
Fly Anatomy (FA)	larval abdominal sensory neuron	0.0001588	2.389	--	DIRECT
Fly Anatomy (FA)	LNv neuron	0.0001622	2.088	--	DIRECT
Fly Anatomy (FA)	lobe system of adult mushroom body	0.0002386	2.088	--	DIRECT
Fly Anatomy (FA)	larval abdomen	0.0002673	1.389	--	DIRECT
Fly Anatomy (FA)	adult head segment	0.0002688	1.435	--	DIRECT
Fly Anatomy (FA)	visceral muscle fiber	0.0003276	2.389	--	DIRECT
Fly Anatomy (FA)	adult descending neuron	0.0003525	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic somatic muscle	0.0003805	2.389	--	DIRECT
Fly Anatomy (FA)	tract neuropil	0.0004909	1.486	--	DIRECT
Fly Anatomy (FA)	visceral mesoderm derivative	0.0006543	2.088	--	DIRECT
Fly Anatomy (FA)	segmental subdivision of organ system	0.0006676	1.486	--	DIRECT
Fly Anatomy (FA)	embryonic/larval thoracic/abdominal lateral sensory cluster	0.0009561	2.389	--	DIRECT
Fly Anatomy (FA)	adult central nervous system	0.000965	1.69	--	DIRECT
Fly Anatomy (FA)	LN period neuron	0.001956	2.088	--	INHERITED FROM: LNv neuron || s-LNv neuron
Fly Anatomy (FA)	primary segmental branch primordium	0.002437	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	somatic muscle	0.002551	1.544	--	INHERITED FROM: embryonic somatic muscle
Fly Anatomy (FA)	trunk mesoderm derivative	0.002703	2.088	--	INHERITED FROM: visceral mesoderm derivative
Fly Anatomy (FA)	tracheal pit	0.0029	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	brain	0.00352	1.544	--	INHERITED FROM: LNv neuron || adult cerebral ganglion || s-LNv neuron || antennal lobe glomerulus || lobe system of adult mushroom body || adult brain
Fly Anatomy (FA)	larval neuropil glial cell	0.004368	2.088	--	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	dorsal ectoderm derivative	0.004644	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	circulatory system primordium	0.004889	1.912	--	INHERITED FROM: embryonic cardioblast || embryonic heart cardioblast || dorsal vessel primordium || heart primordium
Fly Anatomy (FA)	glial cell	0.005795	1.912	--	INHERITED FROM: interface glial cell || embryonic/larval lateral glial cell
Fly Anatomy (FA)	adult cerebrum	0.006233	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	muscle system	0.00786	1.435	--	INHERITED FROM: visceral muscle fiber || embryonic somatic muscle
Fly Anatomy (FA)	neuropil	0.008848	1.243	--	INHERITED FROM: lobe system of adult mushroom body || antennal lobe glomerulus || synaptic neuropil || synaptic neuropil block || commissure || tract neuropil || connective || synaptic neuropil subdomain
Fly Anatomy (FA)	late extended germ band embryo	0.009253	1.611	--	INHERITED FROM: ganglionic branch primordium || visceral mesoderm derivative
Fly Anatomy (FA)	chemosensory neuron	0.01302	1.787	--	INHERITED FROM: leg taste bristle chemosensory neuron || gustatory receptor neuron
Fly Anatomy (FA)	chemosensory system neuron	0.0134	1.787	--	INHERITED FROM: gustatory system neuron || gustatory receptor neuron || leg taste bristle chemosensory neuron
Fly Anatomy (FA)	eo neuron	0.01494	1.787	--	INHERITED FROM: leg taste bristle chemosensory neuron
Fly Anatomy (FA)	larval VNC neuropil glial cell	0.01562	2.088	--	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	sensory neuron	0.0195	1.213	--	INHERITED FROM: gustatory receptor neuron || leg taste bristle chemosensory neuron || larval abdominal sensory neuron
Fly Anatomy (FA)	antennal lobe	0.02033	1.912	--	INHERITED FROM: antennal lobe glomerulus
Fly Anatomy (FA)	tracheal primordium	0.02455	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	adult segment	0.02486	0.821	--	INHERITED FROM: adult head segment || lobe system of adult mushroom body
Fly Anatomy (FA)	adult labral segment	0.03086	1.912	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	developing embryonic structure	0.03699	1.243	--	INHERITED FROM: embryonic cardioblast || visceral mesoderm derivative || ganglionic branch primordium || embryonic heart cardioblast || heart primordium || dorsal vessel primordium
Fly Anatomy (FA)	organism subdivision	0.03961	0.5027	--	INHERITED FROM: head segment || adult cerebral ganglion || LNv neuron || lobe system of adult mushroom body || procephalic segment || adult brain || adult head segment || s-LNv neuron || larval abdomen
Fly Anatomy (FA)	embryonic/larval central nervous system	0.04166	1.275	--	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	non-connected developing system	0.04616	1.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	mesodermal derivative	0.05531	2.088	--	INHERITED FROM: visceral mesoderm derivative
Fly Anatomy (FA)	sensory system neuron	0.07341	1.213	--	INHERITED FROM: mechanosensory system neuron || leg taste bristle chemosensory neuron || larval abdominal sensory neuron || gustatory system neuron || gustatory receptor neuron
Fly Anatomy (FA)	presumptive embryonic/larval tracheal system	0.07555	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	visceral muscle	0.08821	2.389	--	INHERITED FROM: visceral muscle fiber
Fly Anatomy (FA)	tracheal branch primordium	0.09834	2.389	--	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	sensory system	0.1007	0.8577	--	INHERITED FROM: gustatory system || gustatory system neuron || leg taste bristle chemosensory neuron || mechanosensory system neuron || gustatory receptor neuron || larval abdominal sensory neuron
Fly Anatomy (FA)	embryonic/larval nervous system	0.1102	0.7171	--	INHERITED FROM: larval abdominal sensory neuron || s-LNv neuron || gustatory receptor neuron || adult pacemaker neuron || leg taste bristle chemosensory neuron || interface glial cell || embryonic/larval lateral glial cell || LNv neuron || gustatory system neuron || mechanosensory system neuron || pacemaker neuron || adult descending neuron
Fly Anatomy (FA)	adult tagma	0.1463	0.6649	--	INHERITED FROM: adult cerebral ganglion || adult head segment || LNv neuron || lobe system of adult mushroom body || s-LNv neuron || adult brain
Fly Anatomy (FA)	neuropil associated CNS glial cell	0.1475	2.088	--	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	organ system	0.1665	0.1823	--	INHERITED FROM: tract neuropil || leg taste bristle chemosensory neuron || adult pacemaker neuron || neuron projection bundle || adult central nervous system || pacemaker neuron || adult descending neuron || gustatory system neuron || LNv neuron || synaptic neuropil block || commissure || embryonic/larval lateral glial cell || synaptic neuropil subdomain || antennal lobe glomerulus || synaptic neuropil || adult brain || embryonic somatic muscle || gustatory receptor neuron || s-LNv neuron || larval abdominal sensory neuron || visceral muscle fiber || neuropil glial sheath || connective || mechanosensory system neuron || adult cerebral ganglion || lobe system of adult mushroom body || interface glial cell
Fly Anatomy (FA)	lobe system of mushroom body	0.1793	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	adult nervous system	0.2075	0.7764	--	INHERITED FROM: adult pacemaker neuron || gustatory receptor neuron || s-LNv neuron || larval abdominal sensory neuron || adult brain || leg taste bristle chemosensory neuron || LNv neuron || adult cerebral ganglion || lobe system of adult mushroom body || adult central nervous system || pacemaker neuron || adult descending neuron || mechanosensory system neuron || gustatory system neuron
Fly Anatomy (FA)	cell	0.2324	0.4069	--	INHERITED FROM: gustatory system neuron || mechanosensory system neuron || pacemaker neuron || adult descending neuron || visceral muscle fiber || interface glial cell || embryonic/larval lateral glial cell || cardioblast || LNv neuron || leg taste bristle chemosensory neuron || embryonic somatic muscle || embryonic cardioblast || larval abdominal sensory neuron || s-LNv neuron || gustatory receptor neuron || embryonic heart cardioblast || adult pacemaker neuron
Fly Anatomy (FA)	glomerulus	0.2441	1.912	--	INHERITED FROM: antennal lobe glomerulus
Fly Anatomy (FA)	somatic precursor cell	0.2801	1.185	--	INHERITED FROM: embryonic cardioblast || cardioblast || embryonic heart cardioblast
Fly Anatomy (FA)	midline crossing tract	0.309	1.69	--	INHERITED FROM: commissure
Fly Anatomy (FA)	adult central brain	0.3143	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	head	0.3153	0.912	--	INHERITED FROM: adult brain || head segment || procephalic segment || LNv neuron || adult cerebral ganglion || adult head segment || s-LNv neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	ipsilateral tract	0.3409	1.787	--	INHERITED FROM: connective
Fly Anatomy (FA)	adult mushroom body	0.3749	2.088	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	protocerebrum	0.3931	1.611	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	portion of tissue	0.4079	0.7764	--	INHERITED FROM: interface glial cell || neuropil glial sheath
Fly Anatomy (FA)	mushroom body	0.6557	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	embryo	0.6634	0.8978	--	INHERITED FROM: ganglionic branch primordium || visceral mesoderm derivative || embryonic somatic muscle || dorsal vessel primordium || heart primordium || embryonic heart cardioblast || embryonic cardioblast
Fly Anatomy (FA)	organism	0.68	0.06695	--	INHERITED FROM: ganglionic branch primordium || embryonic somatic muscle || procephalic segment || embryonic cardioblast || adult brain || larval abdominal sensory neuron || visceral mesoderm derivative || larval abdomen || s-LNv neuron || gustatory receptor neuron || heart primordium || embryonic heart cardioblast || mechanosensory system neuron || connective || neuropil glial sheath || visceral muscle fiber || interface glial cell || lobe system of adult mushroom body || dorsal vessel primordium || adult cerebral ganglion || leg taste bristle chemosensory neuron || embryonic/larval thoracic/abdominal lateral sensory cluster || tract neuropil || neuron projection bundle || adult head segment || adult pacemaker neuron || gustatory system neuron || head segment || pacemaker neuron || adult descending neuron || adult central nervous system || antennal lobe glomerulus || synaptic neuropil || embryonic/larval lateral glial cell || synaptic neuropil subdomain || commissure || synaptic neuropil block || LNv neuron
Fly Anatomy (FA)	non-connected functional system	0.9024	0.8451	--	INHERITED FROM: larval abdominal sensory neuron || gustatory receptor neuron || gustatory system neuron || leg taste bristle chemosensory neuron || mechanosensory system neuron || gustatory system
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: dorsal vessel primordium || adult cerebral ganglion || cardioblast || interface glial cell || lobe system of adult mushroom body || neuropil glial sheath || connective || visceral muscle fiber || mechanosensory system neuron || heart primordium || gustatory receptor neuron || embryonic heart cardioblast || larval abdominal sensory neuron || s-LNv neuron || larval abdomen || visceral mesoderm derivative || procephalic segment || adult brain || embryonic cardioblast || ganglionic branch primordium || embryonic somatic muscle || synaptic neuropil subdomain || embryonic/larval lateral glial cell || synaptic neuropil block || commissure || LNv neuron || segmental subdivision of organ system || synaptic neuropil || antennal lobe glomerulus || head segment || adult descending neuron || pacemaker neuron || adult central nervous system || gustatory system neuron || multi-cell-component structure || adult head segment || adult pacemaker neuron || neuron projection bundle || embryonic/larval thoracic/abdominal lateral sensory cluster || tract neuropil || multicellular structure || leg taste bristle chemosensory neuron
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: embryonic/larval thoracic/abdominal lateral sensory cluster || tract neuropil || multicellular structure || leg taste bristle chemosensory neuron || adult head segment || adult pacemaker neuron || neuron projection bundle || head segment || adult descending neuron || pacemaker neuron || adult central nervous system || gustatory system neuron || multi-cell-component structure || embryonic/larval lateral glial cell || synaptic neuropil subdomain || synaptic neuropil block || commissure || LNv neuron || segmental subdivision of organ system || synaptic neuropil || antennal lobe glomerulus || procephalic segment || gustatory system || adult brain || embryonic cardioblast || ganglionic branch primordium || embryonic somatic muscle || gustatory receptor neuron || heart primordium || embryonic heart cardioblast || larval abdominal sensory neuron || s-LNv neuron || larval abdomen || visceral mesoderm derivative || neuropil glial sheath || connective || visceral muscle fiber || mechanosensory system neuron || dorsal vessel primordium || adult cerebral ganglion || cardioblast || interface glial cell || lobe system of adult mushroom body
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: lobe system of adult mushroom body || adult cerebral ganglion || LNv neuron || head segment || larval abdomen || s-LNv neuron || adult head segment || procephalic segment || adult brain
Fly Anatomy (FA)	anatomical group	0.00804	0.6816	Least Informative	INHERITED FROM: tract neuropil || gustatory system || embryonic/larval thoracic/abdominal lateral sensory cluster || connective || gustatory system neuron || ganglionic branch primordium || leg taste bristle chemosensory neuron || mechanosensory system neuron || synaptic neuropil block || commissure || gustatory receptor neuron || larval abdominal sensory neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	tagma	0.03102	0.5027	Least Informative	INHERITED FROM: head segment || lobe system of adult mushroom body || adult cerebral ganglion || LNv neuron || procephalic segment || adult brain || larval abdomen || s-LNv neuron || adult head segment
Fly Anatomy (FA)	nervous system	0.05314	0.6333	Least Informative	INHERITED FROM: larval abdominal sensory neuron || s-LNv neuron || neuron projection bundle || gustatory receptor neuron || adult pacemaker neuron || leg taste bristle chemosensory neuron || tract neuropil || adult brain || interface glial cell || antennal lobe glomerulus || lobe system of adult mushroom body || synaptic neuropil || synaptic neuropil subdomain || embryonic/larval lateral glial cell || adult cerebral ganglion || synaptic neuropil block || commissure || LNv neuron || gustatory system neuron || mechanosensory system neuron || neuropil glial sheath || connective || pacemaker neuron || adult descending neuron || adult central nervous system
Fly Anatomy (FA)	organ system subdivision	0.06878	0.4301	Least Informative	INHERITED FROM: interface glial cell || segmental subdivision of organ system || synaptic neuropil || lobe system of adult mushroom body || antennal lobe glomerulus || synaptic neuropil subdomain || commissure || adult cerebral ganglion || synaptic neuropil block || LNv neuron || connective || neuropil glial sheath || adult central nervous system || s-LNv neuron || gustatory receptor neuron || leg taste bristle chemosensory neuron || tract neuropil || adult brain
Fly Anatomy (FA)	adult	0.1077	0.4496	Least Informative	INHERITED FROM: adult cerebral ganglion || LNv neuron || lobe system of adult mushroom body || adult descending neuron || pacemaker neuron || adult central nervous system || gustatory system neuron || mechanosensory system neuron || adult head segment || gustatory receptor neuron || adult pacemaker neuron || larval abdominal sensory neuron || s-LNv neuron || adult brain || leg taste bristle chemosensory neuron
Fly Anatomy (FA)	multi-tissue structure	0.1083	0.6038	Least Informative	INHERITED FROM: adult cerebral ganglion || LNv neuron || interface glial cell || lobe system of adult mushroom body || antennal lobe glomerulus || s-LNv neuron || adult brain
Fly Anatomy (FA)	somatic cell	0.1238	0.4861	Least Informative	INHERITED FROM: cardioblast || LNv neuron || embryonic/larval lateral glial cell || interface glial cell || visceral muscle fiber || adult descending neuron || pacemaker neuron || mechanosensory system neuron || gustatory system neuron || adult pacemaker neuron || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron || larval abdominal sensory neuron || embryonic cardioblast || embryonic somatic muscle || leg taste bristle chemosensory neuron
Fly Anatomy (FA)	segment	0.2029	0.6568	Least Informative	INHERITED FROM: lobe system of adult mushroom body || head segment || adult head segment || procephalic segment
Fly Anatomy (FA)	larva	0.274	0.3763	Least Informative	INHERITED FROM: interface glial cell || LNv neuron || embryonic/larval lateral glial cell || mechanosensory system neuron || gustatory system neuron || pacemaker neuron || adult descending neuron || larval abdomen || s-LNv neuron || larval abdominal sensory neuron || adult pacemaker neuron || gustatory receptor neuron || leg taste bristle chemosensory neuron || embryonic/larval thoracic/abdominal lateral sensory cluster
Fly Anatomy (FA)	multi-cell-component structure	0.00002387	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	central nervous system	0.001525	1.009	Moderately Informative	INHERITED FROM: adult central nervous system || adult brain || neuropil glial sheath || connective || tract neuropil || LNv neuron || synaptic neuropil subdomain || synaptic neuropil block || adult cerebral ganglion || commissure || s-LNv neuron || synaptic neuropil || antennal lobe glomerulus || lobe system of adult mushroom body || interface glial cell
Fly Anatomy (FA)	larval tagma	0.001572	1.159	Moderately Informative	INHERITED FROM: larval abdomen
Fly Anatomy (FA)	abdomen	0.006301	1.185	Moderately Informative	INHERITED FROM: larval abdomen
Fly Anatomy (FA)	ganglion	0.006454	1.185	Moderately Informative	INHERITED FROM: interface glial cell || lobe system of adult mushroom body || adult cerebral ganglion
Fly Anatomy (FA)	peripheral nervous system	0.01164	0.8978	Moderately Informative	INHERITED FROM: gustatory receptor neuron || leg taste bristle chemosensory neuron
Fly Anatomy (FA)	neuron	0.0883	0.8451	Moderately Informative	INHERITED FROM: adult pacemaker neuron || LNv neuron || gustatory receptor neuron || s-LNv neuron || larval abdominal sensory neuron || adult descending neuron || pacemaker neuron || mechanosensory system neuron || leg taste bristle chemosensory neuron || gustatory system neuron
Fly Anatomy (FA)	adult head	0.1034	1.009	Moderately Informative	INHERITED FROM: adult brain || adult cerebral ganglion || adult head segment || LNv neuron || lobe system of adult mushroom body || s-LNv neuron
Fly Anatomy (FA)	developing material anatomical entity	0.3065	0.8329	Moderately Informative	INHERITED FROM: embryonic cardioblast || cardioblast || embryonic heart cardioblast || dorsal vessel primordium || heart primordium || visceral mesoderm derivative || ganglionic branch primordium
Fly Anatomy (FA)	adult brain	0.00003378	1.69	Informative	DIRECT
Fly Anatomy (FA)	synaptic neuropil block	0.0005478	1.69	Informative	DIRECT
Fly Anatomy (FA)	synaptic neuropil subdomain	0.000919	1.69	Informative	DIRECT
Fly Anatomy (FA)	supraesophageal ganglion	0.001421	1.544	Informative	INHERITED FROM: lobe system of adult mushroom body || adult cerebral ganglion
Fly Anatomy (FA)	primordium	0.001462	1.435	Informative	INHERITED FROM: embryonic cardioblast || ganglionic branch primordium || embryonic heart cardioblast || heart primordium || dorsal vessel primordium
Fly Anatomy (FA)	dorsal closure embryo	0.002683	1.611	Informative	INHERITED FROM: embryonic cardioblast || ganglionic branch primordium || embryonic heart cardioblast || dorsal vessel primordium || heart primordium
Fly Anatomy (FA)	syncytium	0.003749	1.544	Informative	INHERITED FROM: embryonic somatic muscle
Fly Anatomy (FA)	muscle cell	0.008099	1.486	Informative	INHERITED FROM: visceral muscle fiber || embryonic somatic muscle
Fly Anatomy (FA)	central brain	0.01046	1.69	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	sensory organ cell	0.01104	1.31	Informative	INHERITED FROM: leg taste bristle chemosensory neuron
Fly Anatomy (FA)	presumptive embryonic/larval system	0.01538	1.389	Informative	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	embryonic/larval neuron	0.01595	1.389	Informative	INHERITED FROM: larval abdominal sensory neuron
Fly Anatomy (FA)	chemosensory system	0.01908	1.69	Informative	INHERITED FROM: leg taste bristle chemosensory neuron || gustatory system neuron || gustatory system || gustatory receptor neuron
Fly Anatomy (FA)	neuromere	0.02868	1.486	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	labral segment	0.05035	1.611	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	adult optic lobe neuron	0.05046	1.486	Informative	INHERITED FROM: LNv neuron || s-LNv neuron
Fly Anatomy (FA)	extended germ band embryo	0.05228	1.435	Informative	INHERITED FROM: visceral mesoderm derivative || ganglionic branch primordium
Fly Anatomy (FA)	ventral nerve cord	0.05536	1.31	Informative	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	synaptic neuropil domain	0.05621	1.544	Informative	INHERITED FROM: lobe system of adult mushroom body || antennal lobe glomerulus
Fly Anatomy (FA)	anatomical cluster	0.07438	1.69	Informative	INHERITED FROM: embryonic/larval thoracic/abdominal lateral sensory cluster
Fly Anatomy (FA)	adult procephalic segment	0.1058	1.435	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	mechanosensory system	0.2952	1.611	Informative	INHERITED FROM: mechanosensory system neuron
Fly Anatomy (FA)	tract	0.3288	1.486	Informative	INHERITED FROM: commissure || connective
Fly Anatomy (FA)	s-LNv neuron	0.0000001011	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	connective	0.00003773	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	gustatory receptor neuron	0.00006314	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	dorsal vessel primordium	0.000226	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	antennal lobe glomerulus	0.0002386	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	commissure	0.0002558	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	cardioblast	0.0002611	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	neuropil glial sheath	0.0004899	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	mechanosensory system neuron	0.000851	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval glial cell	0.009707	2.088	Highly Informative	INHERITED FROM: embryonic/larval lateral glial cell || interface glial cell
Fly Anatomy (FA)	sensory cluster	0.01028	1.787	Highly Informative	INHERITED FROM: embryonic/larval thoracic/abdominal lateral sensory cluster
Fly Anatomy (FA)	CNS glial cell	0.01277	1.912	Highly Informative	INHERITED FROM: interface glial cell
Fly Anatomy (FA)	early extended germ band embryo	0.03102	2.088	Highly Informative	INHERITED FROM: ganglionic branch primordium
Fly Anatomy (FA)	adult protocerebrum	0.06974	1.912	Highly Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	germ layer derivative	0.07799	1.912	Highly Informative	INHERITED FROM: visceral mesoderm derivative

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	medial longitudinal fasciculus	0.00004526	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	brainstem and spinal white matter	0.02502	2.17	--	INHERITED FROM: medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	anatomical system	0.068	0.1857	--	INHERITED FROM: medial longitudinal fasciculus || synencephalon || white matter
Zebrafish Anatomy (ZA)	anatomical group	0.09374	0.1532	--	INHERITED FROM: medial longitudinal fasciculus || white matter || synencephalon
Zebrafish Anatomy (ZA)	forebrain	0.2382	1.471	--	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	compound organ	0.2674	0.4299	--	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	brain	0.5	1.193	--	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	whole organism	0.949	0.00147	--	INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: medial longitudinal fasciculus || synencephalon || white matter
Zebrafish Anatomy (ZA)	multi-tissue structure	0.02583	0.5848	Least Informative	INHERITED FROM: synencephalon || medial longitudinal fasciculus || white matter
Zebrafish Anatomy (ZA)	cavitated compound organ	0.7049	0.5123	Least Informative	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	nervous system	0.7433	0.7079	Least Informative	INHERITED FROM: synencephalon || white matter || medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	central nervous system	0.146	1.04	Moderately Informative	INHERITED FROM: synencephalon || white matter || medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	diencephalon	0.1362	1.471	Informative	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	white matter	0.00001297	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	synencephalon	0.0001054	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	brainstem	0.008375	2.17	Highly Informative	INHERITED FROM: medial longitudinal fasciculus

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	wound epidermis	0.00005724	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal mesenchyme	0.0005103	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	regenerating hindlimb	0.0006181	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	regenerating limb	0.001963	2.263	--	INHERITED FROM: regenerating hindlimb
Xenopus ANatomical entity (XAN)	retinal neural layer	0.02642	1.824	--	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	regenerating tissue	0.04094	1.962	--	INHERITED FROM: wound epidermis || regenerating hindlimb
Xenopus ANatomical entity (XAN)	anatomical group	0.07237	0.1408	--	INHERITED FROM: retinal ganglion cell layer || spinal cord || retinal inner nuclear layer || optic vesicle
Xenopus ANatomical entity (XAN)	retina	0.07264	1.689	--	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.1835	0.1131	--	INHERITED FROM: regenerating hindlimb || pharyngeal mesenchyme || spinal cord || retinal ganglion cell layer || retinal inner nuclear layer || wound epidermis
Xenopus ANatomical entity (XAN)	head region	0.3841	0.4759	--	INHERITED FROM: pharyngeal mesenchyme || retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	compound organ	0.482	0.2177	--	INHERITED FROM: spinal cord || retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	anatomical region	0.5051	0.1803	--	INHERITED FROM: retinal inner nuclear layer || pharyngeal mesenchyme || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	visual system	0.5274	1.321	--	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer || optic vesicle
Xenopus ANatomical entity (XAN)	organism subdivision	0.7284	0.1679	--	INHERITED FROM: retinal inner nuclear layer || pharyngeal mesenchyme || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	central nervous system	0.9227	0.5841	--	INHERITED FROM: spinal cord || retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: retinal ganglion cell layer || spinal cord || retinal inner nuclear layer || optic vesicle
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: retinal inner nuclear layer || regenerating hindlimb || pharyngeal mesenchyme || spinal cord || retinal ganglion cell layer || optic vesicle || wound epidermis
Xenopus ANatomical entity (XAN)	tissue	0.3395	0.4672	Least Informative	INHERITED FROM: retinal inner nuclear layer || regenerating hindlimb || pharyngeal mesenchyme || wound epidermis || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	head	0.4321	0.4777	Least Informative	INHERITED FROM: pharyngeal mesenchyme || retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	nervous system	0.4875	0.5619	Least Informative	INHERITED FROM: spinal cord || retinal ganglion cell layer || retinal inner nuclear layer || optic vesicle
Xenopus ANatomical entity (XAN)	embryo	0.4901	0.5979	Least Informative	INHERITED FROM: optic vesicle
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.9021	0.2685	Least Informative	INHERITED FROM: spinal cord || retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.00316	1.066	Moderately Informative	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
Xenopus ANatomical entity (XAN)	sensory system	0.01213	1.158	Moderately Informative	INHERITED FROM: retinal inner nuclear layer || optic vesicle || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	embryonic structure	0.7438	1.149	Moderately Informative	INHERITED FROM: optic vesicle
Xenopus ANatomical entity (XAN)	spinal cord	0.00008306	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.00466	1.467	Informative	INHERITED FROM: pharyngeal mesenchyme
Xenopus ANatomical entity (XAN)	eye	0.004797	1.403	Informative	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	mesenchyme	0.005593	1.586	Informative	INHERITED FROM: pharyngeal mesenchyme
Xenopus ANatomical entity (XAN)	retinal ganglion cell layer	0.00001578	1.962	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	retinal inner nuclear layer	0.00003511	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	optic vesicle	0.0007994	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	blastema	0.03195	1.962	Highly Informative	INHERITED FROM: regenerating hindlimb || wound epidermis

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.767	--	DIRECT
Enzyme Commission (EC)	[Myosin light-chain] kinase	0.00000000001568	2.929	--	DIRECT
Enzyme Commission (EC)	Peroxidase	0.00000000004858	2.452	--	DIRECT
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0.00001935	1.951	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.7423	0.4043	Least Informative	INHERITED FROM: Phosphoric monoester hydrolases || Acting on ester bonds || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Oxidoreductases	1	0.7328	Least Informative	INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase
Enzyme Commission (EC)	Acting on ester bonds	0.0000004823	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	1.338	Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.0002304	1.437	Informative	DIRECT
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.868	Highly Informative	DIRECT
Enzyme Commission (EC)	Peroxidases	0.00001865	1.951	Highly Informative	DIRECT

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