Fibronectin type III family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: Fibronectin type III [ 49265]
• Family: Fibronectin type III [ 49266] (44)

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Family statistics

	Genomes (178)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,788	25,820	172
Proteins	5,142	15,784	117

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.361	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0.000000000000003089	0	--	DIRECT
Enzyme Commission (EC)	[Myosin light-chain] kinase	0.000000002477	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.000001549	0.01852	--	DIRECT
Enzyme Commission (EC)	Glycosylases	0.00001016	0.8221	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.000000000000001381	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	0.9703	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-gl	0.00000000004123	0.8899	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.2382	1.042	Moderately Informative	INHERITED FROM: [Myosin light-chain] kinase
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	1.595	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.537	Informative	DIRECT
Enzyme Commission (EC)	Chitinase	0.0002342	1.963	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	acute kidney failure	0.000001509	2.212	--	DIRECT
Disease Ontology (DO)	lepromatous leprosy	0.0002475	2.513	--	DIRECT
Disease Ontology (DO)	demyelinating disease	0.0008558	1.367	--	DIRECT
Disease Ontology (DO)	leprosy	0.02888	2.513	--	INHERITED FROM: lepromatous leprosy
Disease Ontology (DO)	disease of anatomical entity	0.04496	0.2414	--	INHERITED FROM: demyelinating disease || acute kidney failure
Disease Ontology (DO)	kidney disease	0.1054	1.066	--	INHERITED FROM: acute kidney failure
Disease Ontology (DO)	bacterial infectious disease	0.5723	1.191	--	INHERITED FROM: lepromatous leprosy
Disease Ontology (DO)	central nervous system disease	0.6215	0.8698	--	INHERITED FROM: demyelinating disease
Disease Ontology (DO)	primary bacterial infectious disease	0.6547	1.212	--	INHERITED FROM: lepromatous leprosy
Disease Ontology (DO)	nervous system disease	0.5427	0.7279	Least Informative	INHERITED FROM: demyelinating disease
Disease Ontology (DO)	urinary system disease	0.2379	1.051	Moderately Informative	INHERITED FROM: acute kidney failure
Disease Ontology (DO)	neurodegenerative disease	0.457	1.022	Moderately Informative	INHERITED FROM: demyelinating disease
Disease Ontology (DO)	disease by infectious agent	0.6443	0.8142	Moderately Informative	INHERITED FROM: lepromatous leprosy
Disease Ontology (DO)	kidney failure	0.01628	1.814	Highly Informative	INHERITED FROM: acute kidney failure

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.000002589	1.373	--	DIRECT
Mammalian Phenotype (MP)	increased subcutaneous adipose tissue amount	0.000006225	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased Sertoli cell phagocytosis	0.00004815	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal endocardium morphology	0.00007999	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased granulosa cell apoptosis	0.0001029	2.302	--	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.000151	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal self tolerance	0.0001632	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.0004712	1.324	--	DIRECT
Mammalian Phenotype (MP)	absent organized vascular network	0.0004807	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytokine level	0.001177	1.348	--	INHERITED FROM: abnormal circulating cytokine level || abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal Sertoli cell phagocytosis	0.001177	2.126	--	INHERITED FROM: decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal immune tolerance	0.002445	1.324	--	INHERITED FROM: autoimmune response || abnormal self tolerance
Mammalian Phenotype (MP)	abnormal cell differentiation	0.003969	1.373	--	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	abnormal circulating protein level	0.005649	1.205	--	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal vascular development	0.02449	1.223	--	INHERITED FROM: absent organized vascular network
Mammalian Phenotype (MP)	abnormal immune system physiology	0.02492	0.6789	--	INHERITED FROM: autoimmune response || abnormal circulating cytokine level || abnormal self tolerance || abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal vasculogenesis	0.0556	2.603	--	INHERITED FROM: absent organized vascular network
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.05765	0.5861	--	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	abnormal hypodermis fat layer morphology	0.06301	2.603	--	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal hypodermis morphology	0.09494	2.603	--	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal female reproductive system physiology	0.2317	1.223	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal white adipose tissue amount	0.2322	1.758	--	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	integument phenotype	0.2636	0.797	--	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal circulating interferon level	0.3381	1.825	--	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal interferon level	0.4055	1.825	--	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.4566	0.7902	--	INHERITED FROM: absent organized vascular network || abnormal endocardium morphology
Mammalian Phenotype (MP)	reproductive system phenotype	0.5354	0.8397	--	INHERITED FROM: increased granulosa cell apoptosis || decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal cell physiology	0.6659	0.6209	--	INHERITED FROM: increased granulosa cell apoptosis || abnormal axon guidance
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.809	0.6893	--	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.8111	0.3626	--	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	increased apoptosis	0.8217	1.241	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	increased cell death	0.8251	1.241	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal gametogenesis	0.8988	1.324	--	INHERITED FROM: decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.9227	1.223	--	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal apoptosis	0.9988	1.023	--	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	nervous system phenotype	0.01017	0.4959	Least Informative	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	immune system phenotype	0.2513	0.5462	Least Informative	INHERITED FROM: abnormal circulating cytokine level || abnormal circulating interferon-gamma level || autoimmune response || abnormal self tolerance
Mammalian Phenotype (MP)	cellular phenotype	0.6641	0.5387	Least Informative	INHERITED FROM: abnormal axon guidance || increased granulosa cell apoptosis
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.6914	0.6737	Least Informative	INHERITED FROM: abnormal endocardium morphology || absent organized vascular network
Mammalian Phenotype (MP)	abnormal homeostasis	0.912	0.4926	Least Informative	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal protein level	0.004857	1.112	Moderately Informative	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal intercellular signaling peptide or protein level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.01883	1.001	Moderately Informative	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.07524	1.059	Moderately Informative	INHERITED FROM: absent organized vascular network
Mammalian Phenotype (MP)	abnormal neuron morphology	0.1158	0.8323	Moderately Informative	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	abnormal nervous system development	0.1384	1.112	Moderately Informative	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.2282	1.023	Moderately Informative	INHERITED FROM: absent organized vascular network
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.2368	0.9404	Moderately Informative	INHERITED FROM: decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal heart morphology	0.7776	0.9597	Moderately Informative	INHERITED FROM: abnormal endocardium morphology
Mammalian Phenotype (MP)	adipose tissue phenotype	0.8871	1.205	Moderately Informative	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.9097	1.012	Moderately Informative	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.9165	1.156	Moderately Informative	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal cell death	1	0.9904	Moderately Informative	INHERITED FROM: increased granulosa cell apoptosis
Mammalian Phenotype (MP)	abnormal neuron differentiation	0.02879	1.562	Informative	INHERITED FROM: abnormal axon guidance
Mammalian Phenotype (MP)	abnormal heart layer morphology	0.1118	1.489	Informative	INHERITED FROM: abnormal endocardium morphology
Mammalian Phenotype (MP)	abnormal white adipose tissue morphology	0.3771	1.603	Informative	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.547	1.489	Informative	INHERITED FROM: decreased Sertoli cell phagocytosis
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0.8313	1.489	Informative	INHERITED FROM: increased subcutaneous adipose tissue amount
Mammalian Phenotype (MP)	abnormal axon guidance	0.0002533	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating interferon-gamma level	0.0003459	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermiogenesis	0.06434	2.001	Highly Informative	INHERITED FROM: decreased Sertoli cell phagocytosis

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	muscle arm development variant	0.00000005577	1.866	--	DIRECT
Worm Phenotype (WP)	neuron development variant	0.00000006031	1.321	--	DIRECT
Worm Phenotype (WP)	body wall cell development variant	0.0000001228	1.814	--	DIRECT
Worm Phenotype (WP)	neurite morphology variant	0.000004423	1.866	--	DIRECT
Worm Phenotype (WP)	muscle cell development variant	0.000004902	1.814	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0.00002686	1.866	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00005246	0.7558	--	DIRECT
Worm Phenotype (WP)	neuron morphology variant	0.00005733	1.866	--	DIRECT
Worm Phenotype (WP)	commissure absent	0.000512	2.769	--	DIRECT
Worm Phenotype (WP)	path curvature increased	0.0009727	2.468	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.002727	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	nervous system morphology variant	0.002817	1.321	--	INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || neurite morphology variant
Worm Phenotype (WP)	organ system morphology variant	0.003879	0.7516	--	INHERITED FROM: axon morphology variant || commissure absent || neuron morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant
Worm Phenotype (WP)	activity level variant	0.004116	1.337	--	INHERITED FROM: locomotion reduced
Worm Phenotype (WP)	neuronal outgrowth variant	0.01338	1.565	--	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	reproductive system development variant	0.02017	1.156	--	INHERITED FROM: anchor cell invasion variant || vulva uterus connection defective
Worm Phenotype (WP)	muscle cell morphology variant	0.02088	1.337	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	axon trajectory variant	0.05407	2.292	--	INHERITED FROM: commissure absent
Worm Phenotype (WP)	behavior variant	0.09075	0.6859	--	INHERITED FROM: body posture variant || forward locomotion decreased || path curvature increased || locomotion reduced
Worm Phenotype (WP)	locomotion variant	0.8024	1.053	--	INHERITED FROM: locomotion reduced || path curvature increased || forward locomotion decreased
Worm Phenotype (WP)	cell component morphology variant	0.8042	0.8392	--	INHERITED FROM: axon morphology variant || commissure absent || neurite morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || forward locomotion decreased || muscle arm development variant || reproductive system physiology variant || organ system development variant || body posture variant || lethal || anchor cell invasion variant || muscle arm development defective || development variant || muscle cell development variant || hermaphrodite sterile || hermaphrodite fertility reduced || axon outgrowth variant || embryonic development variant || embryonic lethal || locomotion reduced || vulva uterus connection defective || fertility variant || body wall cell development variant || path curvature increased || organ system physiology variant || maternal sterile || neuron development variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	striated muscle morphology variant	1	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	commissure variant	1	2.468	--	INHERITED FROM: commissure absent
Worm Phenotype (WP)	cell development variant	0.003011	0.6752	Least Informative	INHERITED FROM: body wall cell development variant || muscle arm development variant || muscle arm development defective || muscle cell development variant || axon outgrowth variant || neuron development variant
Worm Phenotype (WP)	organism behavior variant	0.0876	0.6859	Least Informative	INHERITED FROM: forward locomotion decreased || body posture variant || path curvature increased || locomotion reduced
Worm Phenotype (WP)	organ system development variant	0.000005464	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0.005001	1.02	Moderately Informative	INHERITED FROM: forward locomotion decreased || locomotion reduced || path curvature increased
Worm Phenotype (WP)	cell type morphology variant	0.03995	0.8878	Moderately Informative	INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant
Worm Phenotype (WP)	axon outgrowth variant	0.0000000003708	1.565	Informative	DIRECT
Worm Phenotype (WP)	locomotion reduced	0.00004925	1.49	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0001784	1.446	Informative	DIRECT
Worm Phenotype (WP)	body posture variant	0.0002628	1.513	Informative	DIRECT
Worm Phenotype (WP)	locomotor coordination variant	0.002557	1.446	Informative	INHERITED FROM: path curvature increased
Worm Phenotype (WP)	forward locomotion variant	0.03255	1.623	Informative	INHERITED FROM: forward locomotion decreased
Worm Phenotype (WP)	anchor cell invasion variant	0.0000000003796	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	axon morphology variant	0.000000009039	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle arm development defective	0.00000002659	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	forward locomotion decreased	0.000117	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	path curvature variant	0.7006	1.99	Highly Informative	INHERITED FROM: path curvature increased

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	cell adhesion defective	0.0002629	2.386	--	DIRECT
Fly Phenotype (FP)	phenotype	0.2245	0.06546	--	INHERITED FROM: cell adhesion defective

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	neuron projection bundle	0.00000001837	1.243	--	DIRECT
Fly Anatomy (FA)	adult pacemaker neuron	0.000002383	2.088	--	DIRECT
Fly Anatomy (FA)	pacemaker neuron	0.000005229	2.088	--	DIRECT
Fly Anatomy (FA)	LNv neuron	0.00001022	2.088	--	DIRECT
Fly Anatomy (FA)	lobe system of adult mushroom body	0.00001536	2.088	--	DIRECT
Fly Anatomy (FA)	synaptic neuropil	0.0000215	1.435	--	DIRECT
Fly Anatomy (FA)	tract neuropil	0.00003403	1.486	--	DIRECT
Fly Anatomy (FA)	embryonic heart cardioblast	0.00004484	2.088	--	DIRECT
Fly Anatomy (FA)	LN period neuron	0.00007518	2.088	--	DIRECT
Fly Anatomy (FA)	procephalic segment	0.0001017	1.31	--	DIRECT
Fly Anatomy (FA)	larval abdomen	0.0001615	1.389	--	DIRECT
Fly Anatomy (FA)	embryonic cardioblast	0.001143	2.088	--	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	adult cerebrum	0.001459	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	head segment	0.002323	1.31	--	INHERITED FROM: procephalic segment || lobe system of adult mushroom body
Fly Anatomy (FA)	neuropil	0.002967	1.243	--	INHERITED FROM: lobe system of adult mushroom body || synaptic neuropil || commissure || tract neuropil
Fly Anatomy (FA)	adult head segment	0.003446	1.435	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	gustatory system neuron	0.004386	2.088	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	organism subdivision	0.006983	0.5027	--	INHERITED FROM: LN period neuron || larval tagma || LNv neuron || lobe system of adult mushroom body || procephalic segment || s-LNv neuron || larval abdomen
Fly Anatomy (FA)	segmental subdivision of organ system	0.008658	1.486	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	chemosensory neuron	0.01207	1.787	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	chemosensory system neuron	0.01252	1.787	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	circulatory system primordium	0.01419	1.912	--	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	adult cerebral ganglion	0.01423	1.69	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	gustatory system	0.02006	2.088	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	organ system	0.02679	0.1823	--	INHERITED FROM: tract neuropil || adult pacemaker neuron || neuron projection bundle || pacemaker neuron || LNv neuron || commissure || nerve || synaptic neuropil || neuron projection bundle of ventral nerve cord || gustatory receptor neuron || s-LNv neuron || LN period neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	brain	0.03365	1.544	--	INHERITED FROM: LNv neuron || s-LNv neuron || lobe system of adult mushroom body || LN period neuron
Fly Anatomy (FA)	adult central nervous system	0.03924	1.69	--	INHERITED FROM: lobe system of adult mushroom body || s-LNv neuron || LNv neuron || LN period neuron
Fly Anatomy (FA)	sensory neuron	0.05088	1.213	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	adult labral segment	0.05091	1.912	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	embryonic/larval nervous system	0.05915	0.7171	--	INHERITED FROM: s-LNv neuron || gustatory receptor neuron || adult pacemaker neuron || neuron projection bundle of ventral nerve cord || LNv neuron || pacemaker neuron || LN period neuron
Fly Anatomy (FA)	developing embryonic structure	0.07087	1.243	--	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	adult central brain	0.08165	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	adult segment	0.08464	0.821	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	lobe system of mushroom body	0.1138	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	sensory system	0.1191	0.8577	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	protocerebrum	0.201	1.611	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	midline crossing tract	0.212	1.69	--	INHERITED FROM: commissure
Fly Anatomy (FA)	sensory system neuron	0.2138	1.213	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	adult mushroom body	0.2392	2.088	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	adult nervous system	0.3513	0.7764	--	INHERITED FROM: adult pacemaker neuron || gustatory receptor neuron || s-LNv neuron || LNv neuron || lobe system of adult mushroom body || LN period neuron || pacemaker neuron
Fly Anatomy (FA)	cell	0.374	0.4069	--	INHERITED FROM: pacemaker neuron || LN period neuron || LNv neuron || s-LNv neuron || gustatory receptor neuron || embryonic heart cardioblast || adult pacemaker neuron
Fly Anatomy (FA)	adult tagma	0.3947	0.6649	--	INHERITED FROM: LNv neuron || lobe system of adult mushroom body || s-LNv neuron || LN period neuron
Fly Anatomy (FA)	organism	0.4443	0.06695	--	INHERITED FROM: neuron projection bundle of ventral nerve cord || procephalic segment || larval abdomen || s-LNv neuron || gustatory receptor neuron || embryonic heart cardioblast || LN period neuron || lobe system of adult mushroom body || tract neuropil || neuron projection bundle || adult pacemaker neuron || pacemaker neuron || synaptic neuropil || nerve || commissure || larval tagma || LNv neuron
Fly Anatomy (FA)	mushroom body	0.4564	1.787	--	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	somatic precursor cell	0.4652	1.185	--	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	head	0.679	0.912	--	INHERITED FROM: LN period neuron || procephalic segment || LNv neuron || s-LNv neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	embryo	0.7861	0.8978	--	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: lobe system of adult mushroom body || LN period neuron || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron || larval abdomen || procephalic segment || neuron projection bundle of ventral nerve cord || nerve || larval tagma || commissure || LNv neuron || synaptic neuropil || pacemaker neuron || organ system subdivision || multi-cell-component structure || adult pacemaker neuron || neuron projection bundle || tract neuropil || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: tract neuropil || multicellular structure || adult pacemaker neuron || neuron projection bundle || pacemaker neuron || organ system subdivision || multi-cell-component structure || nerve || larval tagma || commissure || LNv neuron || synaptic neuropil || procephalic segment || neuron projection bundle of ventral nerve cord || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron || larval abdomen || LN period neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	non-connected functional system	1	0.8451	--	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: lobe system of adult mushroom body || larval tagma || LNv neuron || LN period neuron || larval abdomen || s-LNv neuron || procephalic segment
Fly Anatomy (FA)	organ system subdivision	0.000355	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0.001057	0.6816	Least Informative	INHERITED FROM: tract neuropil || commissure || gustatory receptor neuron || lobe system of adult mushroom body
Fly Anatomy (FA)	tagma	0.005253	0.5027	Least Informative	INHERITED FROM: LN period neuron || lobe system of adult mushroom body || larval tagma || LNv neuron || procephalic segment || larval abdomen || s-LNv neuron
Fly Anatomy (FA)	nervous system	0.00901	0.6333	Least Informative	INHERITED FROM: s-LNv neuron || neuron projection bundle || gustatory receptor neuron || adult pacemaker neuron || neuron projection bundle of ventral nerve cord || tract neuropil || lobe system of adult mushroom body || synaptic neuropil || nerve || commissure || LNv neuron || pacemaker neuron || LN period neuron
Fly Anatomy (FA)	adult	0.02462	0.4496	Least Informative	INHERITED FROM: LNv neuron || lobe system of adult mushroom body || pacemaker neuron || LN period neuron || gustatory receptor neuron || adult pacemaker neuron || s-LNv neuron
Fly Anatomy (FA)	multi-tissue structure	0.04397	0.6038	Least Informative	INHERITED FROM: LNv neuron || lobe system of adult mushroom body || LN period neuron || s-LNv neuron
Fly Anatomy (FA)	segment	0.05804	0.6568	Least Informative	INHERITED FROM: lobe system of adult mushroom body || procephalic segment
Fly Anatomy (FA)	larva	0.1548	0.3763	Least Informative	INHERITED FROM: LNv neuron || larval tagma || LN period neuron || pacemaker neuron || larval abdomen || s-LNv neuron || adult pacemaker neuron || gustatory receptor neuron || neuron projection bundle of ventral nerve cord
Fly Anatomy (FA)	somatic cell	0.2687	0.4861	Least Informative	INHERITED FROM: LNv neuron || LN period neuron || pacemaker neuron || adult pacemaker neuron || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron
Fly Anatomy (FA)	multi-cell-component structure	0.000000002149	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	larval tagma	0.0006706	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	ganglion	0.00227	1.185	Moderately Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	central nervous system	0.00676	1.009	Moderately Informative	INHERITED FROM: LN period neuron || tract neuropil || LNv neuron || commissure || s-LNv neuron || synaptic neuropil || lobe system of adult mushroom body
Fly Anatomy (FA)	abdomen	0.01584	1.185	Moderately Informative	INHERITED FROM: larval abdomen
Fly Anatomy (FA)	peripheral nervous system	0.03506	0.8978	Moderately Informative	INHERITED FROM: nerve || gustatory receptor neuron
Fly Anatomy (FA)	neuron	0.2355	0.8451	Moderately Informative	INHERITED FROM: adult pacemaker neuron || LNv neuron || gustatory receptor neuron || s-LNv neuron || LN period neuron || pacemaker neuron
Fly Anatomy (FA)	adult head	0.3148	1.009	Moderately Informative	INHERITED FROM: LN period neuron || LNv neuron || lobe system of adult mushroom body || s-LNv neuron
Fly Anatomy (FA)	developing material anatomical entity	0.4668	0.8329	Moderately Informative	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	nerve	0.0008824	1.389	Informative	DIRECT
Fly Anatomy (FA)	adult brain	0.001495	1.69	Informative	INHERITED FROM: LNv neuron || LN period neuron || lobe system of adult mushroom body || s-LNv neuron
Fly Anatomy (FA)	synaptic neuropil block	0.002048	1.69	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	central brain	0.00334	1.69	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	supraesophageal ganglion	0.02108	1.544	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	dorsal closure embryo	0.02161	1.611	Informative	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	primordium	0.02209	1.435	Informative	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	chemosensory system	0.03188	1.69	Informative	INHERITED FROM: gustatory receptor neuron
Fly Anatomy (FA)	labral segment	0.04784	1.611	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	adult optic lobe neuron	0.0517	1.486	Informative	INHERITED FROM: LNv neuron || s-LNv neuron
Fly Anatomy (FA)	neuromere	0.08197	1.486	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	synaptic neuropil domain	0.388	1.544	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	tract	0.4107	1.486	Informative	INHERITED FROM: commissure
Fly Anatomy (FA)	adult procephalic segment	0.4927	1.435	Informative	INHERITED FROM: lobe system of adult mushroom body
Fly Anatomy (FA)	s-LNv neuron	0.000000001651	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	commissure	0.000004583	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	neuron projection bundle of ventral nerve cord	0.0002337	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	gustatory receptor neuron	0.0007472	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	dorsal vessel primordium	0.003046	1.912	Highly Informative	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	cardioblast	0.005216	2.088	Highly Informative	INHERITED FROM: embryonic heart cardioblast
Fly Anatomy (FA)	adult protocerebrum	0.2102	1.912	Highly Informative	INHERITED FROM: lobe system of adult mushroom body

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	medial longitudinal fasciculus	0.000008435	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	glomerular layer	0.0003653	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	olfactory bulb	0.004997	2.471	--	INHERITED FROM: glomerular layer
Zebrafish Anatomy (ZA)	brainstem and spinal white matter	0.01955	2.17	--	INHERITED FROM: medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	forebrain	0.05096	1.471	--	INHERITED FROM: synencephalon || glomerular layer
Zebrafish Anatomy (ZA)	olfactory system	0.08338	2.471	--	INHERITED FROM: glomerular layer
Zebrafish Anatomy (ZA)	compound organ	0.1278	0.4299	--	INHERITED FROM: glomerular layer || synencephalon
Zebrafish Anatomy (ZA)	anatomical system	0.3291	0.1857	--	INHERITED FROM: glomerular layer || medial longitudinal fasciculus || synencephalon || white matter
Zebrafish Anatomy (ZA)	anatomical group	0.4207	0.1532	--	INHERITED FROM: medial longitudinal fasciculus || glomerular layer || white matter || synencephalon
Zebrafish Anatomy (ZA)	brain	0.4944	1.193	--	INHERITED FROM: synencephalon || glomerular layer
Zebrafish Anatomy (ZA)	whole organism	0.9019	0.00147	--	INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus || glomerular layer
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: glomerular layer || medial longitudinal fasciculus || synencephalon || white matter
Zebrafish Anatomy (ZA)	multi-tissue structure	0.1102	0.5848	Least Informative	INHERITED FROM: glomerular layer || synencephalon || medial longitudinal fasciculus || white matter
Zebrafish Anatomy (ZA)	nervous system	0.5605	0.7079	Least Informative	INHERITED FROM: synencephalon || white matter || medial longitudinal fasciculus || glomerular layer
Zebrafish Anatomy (ZA)	cavitated compound organ	0.6341	0.5123	Least Informative	INHERITED FROM: glomerular layer || synencephalon
Zebrafish Anatomy (ZA)	central nervous system	0.2723	1.04	Moderately Informative	INHERITED FROM: glomerular layer || synencephalon || white matter || medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	sensory system	0.7027	1.11	Moderately Informative	INHERITED FROM: glomerular layer
Zebrafish Anatomy (ZA)	diencephalon	0.06384	1.471	Informative	INHERITED FROM: synencephalon
Zebrafish Anatomy (ZA)	white matter	0.0000007574	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	synencephalon	0.0003653	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	brainstem	0.002076	2.17	Highly Informative	INHERITED FROM: medial longitudinal fasciculus
Zebrafish Anatomy (ZA)	telencephalon	0.214	2.17	Highly Informative	INHERITED FROM: glomerular layer

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	retinal neural layer	0.0006169	1.824	--	DIRECT
Xenopus ANatomical entity (XAN)	retina	0.003873	1.689	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	visual system	0.3978	1.321	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.5349	0.1131	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	central nervous system	0.5991	0.5841	--	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	organism subdivision	0.6612	0.1679	--	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	compound organ	0.7354	0.2177	--	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	anatomical region	0.7358	0.1803	--	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	head region	0.8286	0.4759	--	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	anatomical group	0.9629	0.1408	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	nervous system	0.6401	0.5619	Least Informative	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	head	0.8553	0.4777	Least Informative	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.9471	0.2685	Least Informative	INHERITED FROM: retinal neural layer || retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	tissue	1	0.4672	Least Informative	INHERITED FROM: retinal ganglion cell layer
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.1847	1.066	Moderately Informative	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	sensory system	0.4045	1.158	Moderately Informative	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	eye	0.4141	1.403	Informative	INHERITED FROM: retinal ganglion cell layer || retinal neural layer
Xenopus ANatomical entity (XAN)	retinal ganglion cell layer	0.0002191	1.962	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0.0000001994	1.006	Moderately Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: root || collective plant structure || cardinal organ part || multi-tissue plant structure || shoot apex || shoot system || plant organ || root system || cardinal part of multi-tissue plant structure || plant axis || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root system || root || shoot apex || shoot axis || shoot system
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein O-mannose beta-1,4-N-acetylglucosaminyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.767	--	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.00000000004736	1.617	--	DIRECT
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	0.00000000007162	1.225	--	DIRECT
Enzyme Commission (EC)	[Myosin light-chain] kinase	0.000000005098	2.929	--	DIRECT
Enzyme Commission (EC)	Pullulanase	0.000000005165	2.628	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.000003786	1.65	--	DIRECT
Enzyme Commission (EC)	Alpha-amylase	0.0002533	2.385	--	DIRECT
Enzyme Commission (EC)	Chitinase	0.0009271	2.452	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0000003997	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.00000000000001155	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosylases	0.00003361	1.154	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.9689	1.034	Moderately Informative	INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	1.338	Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0.0000001135	1.391	Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.2002	1.437	Informative	INHERITED FROM: [Myosin light-chain] kinase
Enzyme Commission (EC)	Glycosyltransferases	0.8261	1.378	Informative	INHERITED FROM: Protein O-mannose beta-1,4-N-acetylglucosaminyltransferase || Hexosyltransferases
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	2.084	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0	1.868	Highly Informative	DIRECT

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