SUPERFAMILY 1.75 HMM library and genome assignments server

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Cadherin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cadherin-like [ 49313] (2)
Family:   Cadherin [ 49314] (3)

Family statistics
Genomes (66) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,124 2,760 26
Proteins 513 1,242 13

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.01604Moderately InformativeInherited
Disease Ontology (DO)hypotrichosis0.0009003InformativeDirect
Disease Ontology (DO)bullous skin disease0.00352InformativeInherited
Disease Ontology (DO)pemphigus0.00002412Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6429Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.4938Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.7485Moderately InformativeInherited
Phenotypic Abnormality (PA)Anorectal anomaly0.0114InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.1357InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anus0.002172Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial skeleton0.4287Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2023Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7608Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.183Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.2076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.3516Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0008453InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.05784InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.2485InformativeInherited
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.00000116Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary system development0.0004676Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02377Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.1653Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.0005994InformativeDirect
Worm Phenotype (WP)cell polarity variant0.000001075Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00002832Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001303Highly InformativeDirect
Worm Phenotype (WP)neurite development variant0.03822Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0000003798InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.078Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2696Least InformativeInherited
Fly Anatomy (FA)tagma0.2785Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3326Least InformativeInherited
Fly Anatomy (FA)nervous system0.4588Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5903Least InformativeInherited
Fly Anatomy (FA)adult0.5912Least InformativeInherited
Fly Anatomy (FA)larva0.7827Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.004292Moderately InformativeInherited
Fly Anatomy (FA)adult head0.06894Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.08276Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1358Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1524Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1803Moderately InformativeInherited
Fly Anatomy (FA)neuron0.453Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.653Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.6916Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.02174InformativeInherited
Fly Anatomy (FA)sensory organ cell0.02966InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.03159InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.04139InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.06266InformativeInherited
Fly Anatomy (FA)cuticular specialization0.7527InformativeInherited
Fly Anatomy (FA)photoreceptor cell R40.0002456Highly InformativeDirect
Fly Anatomy (FA)wing hair0.0009925Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4027Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6859Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6942Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0114Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3642Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.01021InformativeInherited
Zebrafish Anatomy (ZA)white matter0.0002324Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.0009595Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.01997Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.2626InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0002393Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 33 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cadherin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]