p53-like transcription factors superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
• Superfamily: p53-like transcription factors [ 49417] (7)
• Families:
  • p53 DNA-binding domain-like [ 81314] (2)
  • Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  • T-box [ 81316] (2)
  • STAT DNA-binding domain [ 81317] (3)
  • RUNT domain [ 81318]
  • DNA-binding domain from NDT80 [ 81992]
  • DNA-binding protein LAG-1 (CSL) [ 110080]

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Superfamily statistics

	Genomes (367)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,320	19,251	53
Proteins	6,210	18,948	53

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Functional annotation

• General category: Regulation
• Detailed category: DNA-binding

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cheilitis	0.0000002723	2.371	--	DIRECT
Disease Ontology (DO)	mammary Paget's disease	0.0000004254	2.371	--	DIRECT
Disease Ontology (DO)	head and neck cancer	0.000001676	1.672	--	DIRECT
Disease Ontology (DO)	B-cell lymphoma	0.00005515	2.07	--	DIRECT
Disease Ontology (DO)	breast adenocarcinoma	0.000065	2.371	--	DIRECT
Disease Ontology (DO)	microcephaly	0.000208	2.371	--	DIRECT
Disease Ontology (DO)	lip disease	0.000253	2.371	--	DIRECT
Disease Ontology (DO)	intestinal disease	0.0006925	1.33	--	DIRECT
Disease Ontology (DO)	colon cancer	0.0008151	2.371	--	DIRECT
Disease Ontology (DO)	musculoskeletal system cancer	0.001493	1.292	--	INHERITED FROM: connective tissue cancer
Disease Ontology (DO)	larynx cancer	0.004697	1.769	--	INHERITED FROM: laryngeal carcinoma
Disease Ontology (DO)	immune system cancer	0.005552	0.8797	--	INHERITED FROM: Burkitt lymphoma || chronic leukemia || B-cell lymphoma
Disease Ontology (DO)	stomach disease	0.009066	1.894	--	INHERITED FROM: gastritis
Disease Ontology (DO)	esophageal disease	0.009359	1.769	--	INHERITED FROM: Barrett's esophagus
Disease Ontology (DO)	oral cavity cancer	0.01012	1.769	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	commensal bacterial infectious disease	0.01824	1.894	--	INHERITED FROM: pertussis
Disease Ontology (DO)	gastrointestinal system cancer	0.01839	1.292	--	INHERITED FROM: colon cancer || salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	thoracic cancer	0.02862	1.371	--	INHERITED FROM: mammary Paget's disease || breast adenocarcinoma
Disease Ontology (DO)	mouth disease	0.04629	1.257	--	INHERITED FROM: cheilitis || lip disease
Disease Ontology (DO)	congenital nervous system abnormality	0.1089	2.371	--	INHERITED FROM: microcephaly
Disease Ontology (DO)	bacterial infectious disease	0.1214	1.225	--	INHERITED FROM: pertussis
Disease Ontology (DO)	disease of anatomical entity	0.1605	0.2157	--	INHERITED FROM: cheilitis || colitis || lip disease || gastritis || Barrett's esophagus || intestinal disease || inflammatory bowel disease
Disease Ontology (DO)	leukemia	0.1858	1.225	--	INHERITED FROM: chronic leukemia
Disease Ontology (DO)	intestinal cancer	0.2566	1.894	--	INHERITED FROM: colon cancer
Disease Ontology (DO)	cancer	0.2964	0.3104	--	INHERITED FROM: head and neck cancer || connective tissue cancer || salivary gland adenoid cystic carcinoma || mammary Paget's disease || head and neck carcinoma || colon cancer || chronic leukemia || B-cell lymphoma || laryngeal carcinoma || breast adenocarcinoma || Burkitt lymphoma
Disease Ontology (DO)	breast carcinoma	0.3094	1.672	--	INHERITED FROM: mammary Paget's disease || breast adenocarcinoma
Disease Ontology (DO)	disease of cellular proliferation	0.3367	0.2812	--	INHERITED FROM: chronic leukemia || colon cancer || mammary Paget's disease || hemangioma || connective tissue cancer || head and neck cancer || breast adenocarcinoma || Burkitt lymphoma || head and neck carcinoma || salivary gland adenoid cystic carcinoma || laryngeal carcinoma || B-cell lymphoma
Disease Ontology (DO)	non-Hodgkin lymphoma	0.4573	1.593	--	INHERITED FROM: Burkitt lymphoma || B-cell lymphoma
Disease Ontology (DO)	salivary gland carcinoma	1	1.769	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	mature B-cell neoplasm	1	2.07	--	INHERITED FROM: Burkitt lymphoma
Disease Ontology (DO)	salivary gland cancer	1	1.769	--	INHERITED FROM: salivary gland adenoid cystic carcinoma
Disease Ontology (DO)	organ system cancer	0.1041	0.5515	Least Informative	INHERITED FROM: Burkitt lymphoma || breast adenocarcinoma || laryngeal carcinoma || B-cell lymphoma || chronic leukemia || colon cancer || head and neck carcinoma || mammary Paget's disease || salivary gland adenoid cystic carcinoma || head and neck cancer || connective tissue cancer
Disease Ontology (DO)	hematologic cancer	0.001442	0.8939	Moderately Informative	INHERITED FROM: chronic leukemia || B-cell lymphoma || Burkitt lymphoma
Disease Ontology (DO)	disease by infectious agent	0.004839	0.8029	Moderately Informative	INHERITED FROM: mumps || progressive multifocal leukoencephalopathy || pertussis
Disease Ontology (DO)	gastrointestinal system disease	0.01041	0.8526	Moderately Informative	INHERITED FROM: lip disease || Barrett's esophagus || gastritis || inflammatory bowel disease || intestinal disease || colitis || cheilitis
Disease Ontology (DO)	benign neoplasm	0.0246	1.225	Moderately Informative	INHERITED FROM: hemangioma
Disease Ontology (DO)	head and neck carcinoma	0.0000002789	1.672	Informative	DIRECT
Disease Ontology (DO)	inflammatory bowel disease	0.000002655	1.468	Informative	DIRECT
Disease Ontology (DO)	connective tissue cancer	0.00009375	1.417	Informative	DIRECT
Disease Ontology (DO)	physical disorder	0.001156	1.672	Informative	INHERITED FROM: microcephaly
Disease Ontology (DO)	lymphoma	0.007302	1.468	Informative	INHERITED FROM: B-cell lymphoma || Burkitt lymphoma
Disease Ontology (DO)	breast cancer	0.008714	1.371	Informative	INHERITED FROM: breast adenocarcinoma || mammary Paget's disease
Disease Ontology (DO)	cell type benign neoplasm	0.01092	1.417	Informative	INHERITED FROM: hemangioma
Disease Ontology (DO)	respiratory system cancer	0.1016	1.468	Informative	INHERITED FROM: laryngeal carcinoma
Disease Ontology (DO)	viral infectious disease	0.2672	1.257	Informative	INHERITED FROM: progressive multifocal leukoencephalopathy || mumps
Disease Ontology (DO)	colitis	0.000000088	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	Burkitt lymphoma	0.00002723	2.07	Highly Informative	DIRECT
Disease Ontology (DO)	mumps	0.00006612	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	Barrett's esophagus	0.00007312	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	gastritis	0.0002504	2.07	Highly Informative	DIRECT
Disease Ontology (DO)	chronic leukemia	0.0004027	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	pertussis	0.0004157	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	progressive multifocal leukoencephalopathy	0.000514	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	laryngeal carcinoma	0.0005401	1.769	Highly Informative	DIRECT
Disease Ontology (DO)	hemangioma	0.0005585	2.07	Highly Informative	DIRECT
Disease Ontology (DO)	salivary gland adenoid cystic carcinoma	0.0007397	1.769	Highly Informative	DIRECT
Disease Ontology (DO)	large intestine cancer	0.007613	1.894	Highly Informative	INHERITED FROM: colon cancer

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Absent hand	0.0002232	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Hypoplastic scapulae	0.000436	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.0009305	1.23	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.009081	0.8268	--	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Abnormality of the pituitary gland	0.009249	1.628	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormality of the scapula	0.01058	1.708	--	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Abnormal cellular immune system morphology	0.01451	1.407	--	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Abnormality of the hypothalamus-pituitary axis	0.01511	1.628	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the scapulae	0.01535	2.407	--	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.04168	1.561	--	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Hypopituitarism	0.08843	2.106	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.09225	0.7344	--	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1405	0.4621	--	INHERITED FROM: Hypoplastic scapulae || Absent hand
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.1443	1.293	--	INHERITED FROM: Hypoplastic scapulae || Absent hand
Phenotypic Abnormality (PA)	Abnormal immune system morphology	0.1644	1.365	--	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Aplasia/hypoplasia affecting bones of the axial skeleton	0.1887	1.804	--	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the upper limbs	0.2212	1.929	--	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.2803	0.6284	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormal leukocyte count	0.2822	1.804	--	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Abnormality of the hand	0.3129	1.064	--	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.4783	0.9441	--	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.5194	0.2543	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.5759	0.7731	--	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.6569	0.8625	--	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.15	0.5677	Least Informative	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.159	0.6284	Least Informative	INHERITED FROM: Abnormal vascular morphology
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.6078	0.472	Least Informative	INHERITED FROM: Hypoplastic scapulae || Absent hand
Phenotypic Abnormality (PA)	Abnormality of limbs	0.7513	0.6431	Least Informative	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.0001419	0.9294	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.01523	0.9441	Moderately Informative	INHERITED FROM: Abnormal vascular morphology
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.1936	0.9594	Moderately Informative	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.2245	1.026	Moderately Informative	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.2261	0.8625	Moderately Informative	INHERITED FROM: Abnormal vascular morphology
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.2971	0.9441	Moderately Informative	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.4031	0.9441	Moderately Informative	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of the anterior pituitary	0.002433	1.628	Informative	INHERITED FROM: Anterior hypopituitarism
Phenotypic Abnormality (PA)	Abnormal leukocyte morphology	0.01451	1.503	Informative	INHERITED FROM: Leukopenia
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.05465	1.503	Informative	INHERITED FROM: Absent hand
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.2836	1.293	Informative	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Anterior hypopituitarism	0.0006479	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Leukopenia	0.0007182	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving bones of the thorax	0.02197	2.106	Highly Informative	INHERITED FROM: Hypoplastic scapulae
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the hand	0.2284	1.929	Highly Informative	INHERITED FROM: Absent hand

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.000000001415	1.128	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell morphology	0.000000001753	1.362	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.00000001254	0.9281	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.00000004717	1.076	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.0000009579	1.061	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.0000009882	1.229	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.00000137	1.429	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.000002173	0.9281	--	DIRECT
Mammalian Phenotype (MP)	skeleton phenotype	0.000002797	0.8451	--	DIRECT
Mammalian Phenotype (MP)	increased chronic myelocytic leukemia incidence	0.000002912	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal spinal cord dorsal column morphology	0.000002912	2.207	--	DIRECT
Mammalian Phenotype (MP)	craniofacial phenotype	0.00001009	1.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating interferon-gamma level	0.00001033	1.73	--	DIRECT
Mammalian Phenotype (MP)	absent sternum	0.00001137	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0.00001288	0.6214	--	DIRECT
Mammalian Phenotype (MP)	abnormal cranium morphology	0.00001422	1.304	--	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.00002643	1.466	--	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.00003809	0.8003	--	DIRECT
Mammalian Phenotype (MP)	small Peyer's patches	0.00004636	2.207	--	DIRECT
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.00005733	1.253	--	DIRECT
Mammalian Phenotype (MP)	no abnormal phenotype detected	0.00006503	1.663	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality during organogenesis, complete penetrance	0.00007101	2.508	--	DIRECT
Mammalian Phenotype (MP)	muscle phenotype	0.0001108	0.8177	--	DIRECT
Mammalian Phenotype (MP)	acanthosis	0.0001409	2.207	--	DIRECT
Mammalian Phenotype (MP)	epidermis stratum spinosum hyperplasia	0.0001704	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal dendritic cell number	0.0001914	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.0002378	0.9397	--	DIRECT
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.0002459	1.11	--	DIRECT
Mammalian Phenotype (MP)	abnormal inguinal lymph node morphology	0.0002749	2.207	--	DIRECT
Mammalian Phenotype (MP)	decreased Peyer's patch number	0.0003156	2.508	--	DIRECT
Mammalian Phenotype (MP)	impaired natural killer cell mediated cytotoxicity	0.0003572	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal zygomatic arch morphology	0.0003704	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.0003734	0.9168	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.0004286	1.229	--	DIRECT
Mammalian Phenotype (MP)	abnormal dendritic cell morphology	0.0006294	2.207	--	DIRECT
Mammalian Phenotype (MP)	decreased erythroid progenitor cell number	0.0007459	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal insulin-like growth factor I level	0.0007552	1.809	--	DIRECT
Mammalian Phenotype (MP)	abnormal vascular development	0.0007641	1.394	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.00078	0.3617	--	DIRECT
Mammalian Phenotype (MP)	increased IgG2a level	0.0007898	2.508	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality, incomplete penetrance	0.0008782	2.508	--	DIRECT
Mammalian Phenotype (MP)	head tilt	0.0009429	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal stomach mucosa morphology	0.001212	2.207	--	INHERITED FROM: abnormal stomach epithelium morphology
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.00123	1.304	--	INHERITED FROM: abnormal heart development || abnormal vascular development
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.001545	1.429	--	INHERITED FROM: increased leukocyte cell number
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.001598	1.186	--	INHERITED FROM: abnormal mammary gland alveolus morphology || abnormal coat appearance
Mammalian Phenotype (MP)	abnormal granulocyte morphology	0.00167	1.906	--	INHERITED FROM: abnormal granulocyte number
Mammalian Phenotype (MP)	abnormal response to infection	0.001708	1.253	--	INHERITED FROM: increased susceptibility to infection
Mammalian Phenotype (MP)	abnormal immune system physiology	0.002552	0.737	--	INHERITED FROM: increased susceptibility to infection || abnormal level of surface class II molecules || increased IgG2a level || decreased B cell proliferation || abnormal B cell proliferation || respiratory system inflammation || impaired natural killer cell mediated cytotoxicity || abnormal interleukin level || abnormal circulating interferon-gamma level || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.003053	0.9638	--	INHERITED FROM: abnormal leukocyte physiology || impaired natural killer cell mediated cytotoxicity || abnormal B cell proliferation || decreased B cell proliferation || increased IgG2a level || abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.003463	0.9638	--	INHERITED FROM: abnormal B cell proliferation || impaired natural killer cell mediated cytotoxicity || abnormal leukocyte physiology || abnormal level of surface class II molecules || decreased B cell proliferation || increased IgG2a level
Mammalian Phenotype (MP)	abnormal immune system morphology	0.003644	0.8003	--	INHERITED FROM: decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal thymus morphology || abnormal dendritic cell morphology || abnormal granulocyte number || small Peyer's patches || abnormal T cell morphology || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal myeloid leukocyte morphology || abnormal inguinal lymph node morphology || abnormal lymphopoiesis || abnormal T cell differentiation || increased leukocyte cell number || decreased Peyer's patch number || abnormal lymphocyte morphology || abnormal leukopoiesis || abnormal dendritic cell number
Mammalian Phenotype (MP)	abnormal palate development	0.003786	2.031	--	INHERITED FROM: abnormal secondary palate development
Mammalian Phenotype (MP)	abnormal hepatobiliary system physiology	0.003952	1.304	--	INHERITED FROM: abnormal liver physiology
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.004461	0.9516	--	INHERITED FROM: abnormal leukocyte physiology || abnormal B cell proliferation || impaired natural killer cell mediated cytotoxicity || increased IgG2a level || decreased B cell proliferation || abnormal level of surface class II molecules
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.004547	0.9281	--	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	abnormal apocrine gland morphology	0.004959	1.466	--	INHERITED FROM: abnormal mammary gland alveolus morphology
Mammalian Phenotype (MP)	abnormal gut-associated lymphoid tissue morphology	0.00586	1.73	--	INHERITED FROM: small Peyer's patches || decreased Peyer's patch number
Mammalian Phenotype (MP)	increased malignant tumor incidence	0.007093	1.663	--	INHERITED FROM: increased adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal endocrine gland morphology	0.008116	1.304	--	INHERITED FROM: abnormal thymus medulla morphology || abnormal thymus morphology
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.01039	1.186	--	INHERITED FROM: decreased B cell proliferation || increased IgG2a level || abnormal B cell proliferation || impaired natural killer cell mediated cytotoxicity || abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal antigen presentation	0.01334	1.663	--	INHERITED FROM: abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal respiratory system physiology	0.01529	1.332	--	INHERITED FROM: respiratory system inflammation
Mammalian Phenotype (MP)	abnormal erythroid progenitor cell morphology	0.02311	2.508	--	INHERITED FROM: decreased erythroid progenitor cell number
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.02785	1.186	--	INHERITED FROM: decreased dendritic cell number
Mammalian Phenotype (MP)	abnormal NK cell physiology	0.03019	1.663	--	INHERITED FROM: impaired natural killer cell mediated cytotoxicity
Mammalian Phenotype (MP)	abnormal cytokine level	0.03446	1.466	--	INHERITED FROM: abnormal interleukin level || abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.03942	1.045	--	INHERITED FROM: abnormal dendritic cell number || increased leukocyte cell number || abnormal granulocyte number || decreased dendritic cell number
Mammalian Phenotype (MP)	lethality throughout fetal growth and development	0.04688	1.809	--	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	increased tumor incidence	0.04772	1.11	--	INHERITED FROM: increased chronic myelocytic leukemia incidence || increased adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal circulating interferon level	0.04948	1.663	--	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal immunoglobulin level	0.05515	1.605	--	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0.06303	1.229	--	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.06506	1.277	--	INHERITED FROM: decreased dendritic cell number || abnormal dendritic cell morphology || abnormal dendritic cell number
Mammalian Phenotype (MP)	abnormal antigen presentation via MHC class II	0.06662	1.809	--	INHERITED FROM: abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.06706	1.304	--	INHERITED FROM: abnormal cranium morphology || abnormal zygomatic arch morphology
Mammalian Phenotype (MP)	abnormal innate immunity	0.08759	1.277	--	INHERITED FROM: impaired natural killer cell mediated cytotoxicity
Mammalian Phenotype (MP)	abnormal cervical vertebrae morphology	0.09247	2.031	--	INHERITED FROM: abnormal cervical atlas morphology
Mammalian Phenotype (MP)	abnormal circulating protein level	0.09786	1.253	--	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal B cell physiology	0.09874	1.229	--	INHERITED FROM: abnormal level of surface class II molecules || decreased B cell proliferation || increased IgG2a level || abnormal B cell proliferation
Mammalian Phenotype (MP)	increased immunoglobulin level	0.1047	2.207	--	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal stomach wall morphology	0.106	2.207	--	INHERITED FROM: abnormal stomach epithelium morphology
Mammalian Phenotype (MP)	abnormal Peyer's patch number	0.1105	2.508	--	INHERITED FROM: decreased Peyer's patch number
Mammalian Phenotype (MP)	abnormal presacral vertebrae morphology	0.1186	1.663	--	INHERITED FROM: abnormal cervical atlas morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.1187	0.7444	--	INHERITED FROM: abnormal hemopoiesis || abnormal blood cell morphology || decreased erythroid progenitor cell number || abnormal T cell morphology || decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal dendritic cell morphology || abnormal thymus morphology || abnormal granulocyte number || increased leukocyte cell number || abnormal T cell differentiation || abnormal dendritic cell number || abnormal leukopoiesis || abnormal lymphocyte morphology || abnormal definitive hematopoiesis || abnormal myeloid leukocyte morphology || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal lymphopoiesis || abnormal blood cell morphology/development
Mammalian Phenotype (MP)	abnormal skin adnexa physiology	0.1448	1.809	--	INHERITED FROM: abnormal mammary gland epithelium physiology
Mammalian Phenotype (MP)	abnormal mammary gland physiology	0.1542	1.906	--	INHERITED FROM: abnormal mammary gland epithelium physiology
Mammalian Phenotype (MP)	abnormal exocrine gland morphology	0.1543	1.253	--	INHERITED FROM: abnormal mammary gland alveolus morphology
Mammalian Phenotype (MP)	abnormal B cell activation	0.1588	1.663	--	INHERITED FROM: decreased B cell proliferation || abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal mammary gland lobule morphology	0.1616	1.906	--	INHERITED FROM: abnormal mammary gland alveolus morphology
Mammalian Phenotype (MP)	increased IgG2 level	0.177	2.508	--	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.1856	1.207	--	INHERITED FROM: increased adenocarcinoma incidence || increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal mouth morphology	0.2423	1.73	--	INHERITED FROM: abnormal secondary palate development || cleft palate
Mammalian Phenotype (MP)	abnormal apocrine gland physiology	0.2487	1.906	--	INHERITED FROM: abnormal mammary gland epithelium physiology
Mammalian Phenotype (MP)	abnormal exocrine gland physiology	0.2645	1.906	--	INHERITED FROM: abnormal mammary gland epithelium physiology
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.2724	1.186	--	INHERITED FROM: increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal facial morphology	0.2748	1.605	--	INHERITED FROM: abnormal secondary palate development || cleft palate
Mammalian Phenotype (MP)	abnormal palate morphology	0.2782	1.906	--	INHERITED FROM: abnormal secondary palate development || cleft palate
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.2796	1.128	--	INHERITED FROM: abnormal circulating insulin-like growth factor I level
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.2965	1.128	--	INHERITED FROM: abnormal vertebral arch morphology || absent sternum || abnormal zygomatic arch morphology || abnormal intervertebral disk morphology || abnormal cervical atlas morphology || abnormal cranium morphology
Mammalian Phenotype (MP)	abnormal skin morphology	0.2974	1.229	--	INHERITED FROM: epidermis stratum spinosum hyperplasia || acanthosis
Mammalian Phenotype (MP)	increased inflammatory response	0.2994	1.146	--	INHERITED FROM: respiratory system inflammation
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.3153	0.9281	--	INHERITED FROM: abnormal leukopoiesis || abnormal dendritic cell number || abnormal T cell morphology || abnormal lymphocyte morphology || increased leukocyte cell number || abnormal T cell differentiation || abnormal granulocyte number || abnormal lymphopoiesis || abnormal dendritic cell morphology || abnormal myeloid leukocyte morphology || decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal leukocyte morphology
Mammalian Phenotype (MP)	preweaning lethality	0.3205	0.8266	--	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance || embryonic lethality, incomplete penetrance || lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	increased classified tumor incidence	0.3206	1.207	--	INHERITED FROM: increased adenocarcinoma incidence || increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal blood circulation	0.3286	1.277	--	INHERITED FROM: hemorrhage
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.3412	0.627	--	INHERITED FROM: abnormal spinal cord dorsal column morphology
Mammalian Phenotype (MP)	abnormal stationary movement	0.3555	2.031	--	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	abnormal IgG level	0.3686	1.73	--	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal thymus lobule morphology	0.4124	1.906	--	INHERITED FROM: abnormal thymus medulla morphology
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.4289	1.186	--	INHERITED FROM: increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal craniofacial development	0.4369	2.031	--	INHERITED FROM: abnormal secondary palate development
Mammalian Phenotype (MP)	abnormal survival	0.4648	0.7297	--	INHERITED FROM: embryonic lethality, incomplete penetrance || lethality throughout fetal growth and development, complete penetrance || embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.5069	0.8266	--	INHERITED FROM: abnormal vascular development || abnormal heart development
Mammalian Phenotype (MP)	altered susceptibility to infection	0.5326	1.253	--	INHERITED FROM: increased susceptibility to infection
Mammalian Phenotype (MP)	altered tumor susceptibility	0.5518	1.11	--	INHERITED FROM: increased chronic myelocytic leukemia incidence || increased adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal pectoral girdle bone morphology	0.5878	1.73	--	INHERITED FROM: absent sternum
Mammalian Phenotype (MP)	abnormal coat/ hair morphology	0.6379	1.605	--	INHERITED FROM: abnormal coat appearance
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.6541	0.8177	--	INHERITED FROM: abnormal granulocyte number || abnormal dendritic cell morphology || decreased dendritic cell number || abnormal mononuclear cell morphology || abnormal T cell morphology || decreased erythroid progenitor cell number || abnormal blood cell morphology || abnormal hemopoiesis || abnormal lymphopoiesis || abnormal myeloid leukocyte morphology || abnormal definitive hematopoiesis || abnormal leukocyte morphology || abnormal dendritic cell number || abnormal leukopoiesis || abnormal lymphocyte morphology || increased leukocyte cell number || abnormal T cell differentiation
Mammalian Phenotype (MP)	embryonic lethality	0.724	1.304	--	INHERITED FROM: embryonic lethality, incomplete penetrance || embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.8011	1.362	--	INHERITED FROM: abnormal cervical atlas morphology || abnormal vertebral arch morphology || abnormal intervertebral disk morphology
Mammalian Phenotype (MP)	abnormal IgG2 level	0.8113	1.906	--	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal tumor incidence	0.9317	1.11	--	INHERITED FROM: increased chronic myelocytic leukemia incidence || increased adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal blood homeostasis	1	0.7085	--	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.000001613	0.7017	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0.000002072	0.5888	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0.0001991	0.5301	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0003387	0.6818	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.006084	0.6505	Least Informative	INHERITED FROM: increased leukocyte cell number || abnormal T cell differentiation || abnormal leukopoiesis || abnormal dendritic cell number || abnormal lymphocyte morphology || abnormal blood cell physiology || abnormal myeloid leukocyte morphology || abnormal definitive hematopoiesis || abnormal thymus medulla morphology || abnormal leukocyte morphology || abnormal B cell proliferation || abnormal blood cell morphology/development || decreased B cell proliferation || increased IgG2a level || abnormal lymphopoiesis || abnormal level of surface class II molecules || abnormal blood cell morphology || abnormal hemopoiesis || impaired natural killer cell mediated cytotoxicity || abnormal T cell morphology || decreased erythroid progenitor cell number || abnormal leukocyte physiology || abnormal thymus morphology || abnormal dendritic cell morphology || abnormal mononuclear cell morphology || decreased dendritic cell number || abnormal granulocyte number || abnormal hematopoietic system physiology
Mammalian Phenotype (MP)	immune system phenotype	0.00757	0.627	Least Informative	INHERITED FROM: decreased B cell proliferation || increased IgG2a level || abnormal lymphopoiesis || abnormal level of surface class II molecules || abnormal myeloid leukocyte morphology || abnormal B cell proliferation || respiratory system inflammation || increased susceptibility to infection || decreased dendritic cell number || abnormal leukocyte physiology || abnormal thymus morphology || abnormal circulating interferon-gamma level || small Peyer's patches || impaired natural killer cell mediated cytotoxicity || abnormal inguinal lymph node morphology || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal leukopoiesis || abnormal dendritic cell number || decreased Peyer's patch number || abnormal lymphocyte morphology || increased leukocyte cell number || abnormal T cell differentiation || abnormal granulocyte number || abnormal mononuclear cell morphology || abnormal dendritic cell morphology || abnormal T cell morphology || abnormal interleukin level
Mammalian Phenotype (MP)	nervous system phenotype	0.027	0.5166	Least Informative	INHERITED FROM: abnormal spinal cord dorsal column morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.1983	0.495	Least Informative	INHERITED FROM: abnormal fluid regulation || abnormal interleukin level || abnormal intercellular signaling peptide or protein level || abnormal circulating interferon-gamma level || abnormal circulating insulin-like growth factor I level || impaired adaptive thermogenesis || abnormal insulin-like growth factor I level
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.000000009842	1.093	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.0000004954	0.9764	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.0000008399	0.8951	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	integument phenotype	0.00000123	0.8451	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	embryo phenotype	0.000001871	0.9058	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	respiratory system phenotype	0.000005384	0.9893	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal gland morphology	0.000009362	0.8644	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.000009631	1.207	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.00002864	0.9764	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.00008684	1.016	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.0008506	0.9397	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal inflammatory response	0.001434	1.076	Moderately Informative	INHERITED FROM: respiratory system inflammation
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.003571	1.11	Moderately Informative	INHERITED FROM: abnormal interleukin level || abnormal circulating interferon-gamma level || increased IgG2a level
Mammalian Phenotype (MP)	abnormal cell death	0.005867	1.045	Moderately Informative	INHERITED FROM: abnormal apoptosis
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.01525	0.9168	Moderately Informative	INHERITED FROM: hemorrhage
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.01999	1.186	Moderately Informative	INHERITED FROM: abnormal thymus morphology || abnormal thymus medulla morphology || small Peyer's patches || abnormal inguinal lymph node morphology || decreased Peyer's patch number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.03041	0.9764	Moderately Informative	INHERITED FROM: abnormal granulocyte number || decreased dendritic cell number || abnormal dendritic cell number || increased leukocyte cell number
Mammalian Phenotype (MP)	neoplasm	0.03167	1.003	Moderately Informative	INHERITED FROM: increased adenocarcinoma incidence || altered tumor pathology || increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.03407	1.016	Moderately Informative	INHERITED FROM: abnormal vascular development
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.0484	1.229	Moderately Informative	INHERITED FROM: abnormal myeloid leukocyte morphology || abnormal granulocyte number || decreased erythroid progenitor cell number
Mammalian Phenotype (MP)	abnormal heart morphology	0.0545	1.076	Moderately Informative	INHERITED FROM: abnormal heart development
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.0582	1.229	Moderately Informative	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	prenatal lethality	0.08255	1.076	Moderately Informative	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance || embryonic lethality, incomplete penetrance || lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.1005	1.031	Moderately Informative	INHERITED FROM: abnormal stomach epithelium morphology || abnormal secondary palate development || cleft palate
Mammalian Phenotype (MP)	abnormal protein level	0.1339	1.146	Moderately Informative	INHERITED FROM: abnormal circulating interferon-gamma level || abnormal intercellular signaling peptide or protein level || abnormal interleukin level
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.4805	1.11	Moderately Informative	INHERITED FROM: increased IgG2a level || decreased B cell proliferation || abnormal B cell proliferation || abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal hormone level	0.7243	1.076	Moderately Informative	INHERITED FROM: abnormal insulin-like growth factor I level || abnormal circulating insulin-like growth factor I level
Mammalian Phenotype (MP)	abnormal behavior	1	0.9397	Moderately Informative	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	abnormal interleukin level	0.00000001067	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	increased susceptibility to infection	0.0000003063	1.466	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal liver physiology	0.000003189	1.394	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal thymus morphology	0.00001343	1.508	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal coat appearance	0.00002017	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.00002985	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fluid regulation	0.00004723	1.554	Informative	DIRECT
Mammalian Phenotype (MP)	normal phenotype	0.00006634	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.0001193	1.663	Informative	DIRECT
Mammalian Phenotype (MP)	hemorrhage	0.0001351	1.394	Informative	DIRECT
Mammalian Phenotype (MP)	altered tumor pathology	0.0003112	1.554	Informative	DIRECT
Mammalian Phenotype (MP)	increased leukocyte cell number	0.0004405	1.554	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cartilage morphology	0.002027	1.605	Informative	INHERITED FROM: abnormal intervertebral disk morphology
Mammalian Phenotype (MP)	abnormal humoral immune response	0.003854	1.508	Informative	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal adaptive thermogenesis	0.004057	1.73	Informative	INHERITED FROM: impaired adaptive thermogenesis
Mammalian Phenotype (MP)	abnormal spinal cord morphology	0.008815	1.663	Informative	INHERITED FROM: abnormal spinal cord dorsal column morphology
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.01021	1.554	Informative	INHERITED FROM: epidermis stratum spinosum hyperplasia || acanthosis
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.01213	1.508	Informative	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal gland physiology	0.02284	1.554	Informative	INHERITED FROM: abnormal mammary gland epithelium physiology
Mammalian Phenotype (MP)	abnormal B lymphocyte antigen presentation	0.02882	1.663	Informative	INHERITED FROM: abnormal level of surface class II molecules
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.04135	1.508	Informative	INHERITED FROM: abnormal inguinal lymph node morphology
Mammalian Phenotype (MP)	abnormal head morphology	0.04153	1.429	Informative	INHERITED FROM: cleft palate || abnormal secondary palate development
Mammalian Phenotype (MP)	abnormal interferon level	0.07086	1.663	Informative	INHERITED FROM: abnormal circulating interferon-gamma level
Mammalian Phenotype (MP)	abnormal mammary gland morphology	0.07522	1.466	Informative	INHERITED FROM: abnormal mammary gland alveolus morphology
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0.07944	1.429	Informative	INHERITED FROM: absent sternum
Mammalian Phenotype (MP)	abnormal thoracic cage morphology	0.241	1.73	Informative	INHERITED FROM: absent sternum
Mammalian Phenotype (MP)	abnormal natural killer cell mediated cytotoxicity	0.2425	1.663	Informative	INHERITED FROM: impaired natural killer cell mediated cytotoxicity
Mammalian Phenotype (MP)	abnormal stomach morphology	0.3273	1.73	Informative	INHERITED FROM: abnormal stomach epithelium morphology
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.3512	1.508	Informative	INHERITED FROM: increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	increased carcinoma incidence	0.3811	1.663	Informative	INHERITED FROM: increased adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal voluntary movement	0.4831	1.429	Informative	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	abnormal erythroid lineage cell morphology	0.5382	1.605	Informative	INHERITED FROM: decreased erythroid progenitor cell number
Mammalian Phenotype (MP)	abnormal vertebrae morphology	0.6989	1.508	Informative	INHERITED FROM: abnormal vertebral arch morphology || abnormal cervical atlas morphology
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.8938	1.73	Informative	INHERITED FROM: small Peyer's patches || decreased Peyer's patch number
Mammalian Phenotype (MP)	decreased B cell proliferation	0.000006213	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mammary gland epithelium physiology	0.000009099	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	respiratory system inflammation	0.000009657	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	lethality throughout fetal growth and development, complete penetrance	0.00002637	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal secondary palate development	0.00006071	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal intervertebral disk morphology	0.0001097	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased dendritic cell number	0.00012	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	impaired adaptive thermogenesis	0.0001287	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cervical atlas morphology	0.0001553	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal stomach epithelium morphology	0.0001704	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	cleft palate	0.0002123	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal level of surface class II molecules	0.0002749	1.809	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal thymus medulla morphology	0.0003089	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart development	0.0003219	1.809	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating insulin-like growth factor I level	0.0005441	1.809	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased adenocarcinoma incidence	0.0006211	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal granulocyte number	0.0006533	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mammary gland alveolus morphology	0.0008596	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal vertebral arch morphology	0.0008597	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spinal cord white matter morphology	0.008997	2.031	Highly Informative	INHERITED FROM: abnormal spinal cord dorsal column morphology
Mammalian Phenotype (MP)	abnormal IgG2a level	0.01023	1.906	Highly Informative	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal head movements	0.01327	2.031	Highly Informative	INHERITED FROM: head tilt
Mammalian Phenotype (MP)	increased leukemia incidence	0.01366	2.031	Highly Informative	INHERITED FROM: increased chronic myelocytic leukemia incidence
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.01868	2.031	Highly Informative	INHERITED FROM: decreased erythroid progenitor cell number
Mammalian Phenotype (MP)	embryonic lethality during organogenesis	0.0599	1.906	Highly Informative	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	abnormal Peyer's patch size	0.1245	1.906	Highly Informative	INHERITED FROM: small Peyer's patches
Mammalian Phenotype (MP)	abnormal peripheral lymph node morphology	0.1485	2.031	Highly Informative	INHERITED FROM: abnormal inguinal lymph node morphology
Mammalian Phenotype (MP)	abnormal epidermis stratum spinosum morphology	0.2192	2.031	Highly Informative	INHERITED FROM: acanthosis || epidermis stratum spinosum hyperplasia
Mammalian Phenotype (MP)	abnormal neurocranium morphology	0.2649	1.809	Highly Informative	INHERITED FROM: abnormal zygomatic arch morphology
Mammalian Phenotype (MP)	increased IgG level	0.356	2.207	Highly Informative	INHERITED FROM: increased IgG2a level
Mammalian Phenotype (MP)	abnormal sternum morphology	0.8426	1.906	Highly Informative	INHERITED FROM: absent sternum

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	epithelial morphology variant	0.000004325	2.407	--	DIRECT
Worm Phenotype (WP)	epithelial system morphology variant	0.00003666	2.407	--	DIRECT
Worm Phenotype (WP)	lineage variant	0.0005445	1.804	--	DIRECT
Worm Phenotype (WP)	sister cell division timing asynchrony reduced	0.000752	2.407	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.02593	0.6038	--	INHERITED FROM: ectopic expression transgene || gene expression level reduced
Worm Phenotype (WP)	transgene expression variant	0.2312	0.7938	--	INHERITED FROM: ectopic expression transgene
Worm Phenotype (WP)	organism morphology variant	0.2812	0.2011	--	INHERITED FROM: developmental morphology variant
Worm Phenotype (WP)	morphology variant	0.5813	0.06117	--	INHERITED FROM: developmental morphology variant || alimentary system morphology variant || epithelial system morphology variant || epithelial morphology variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.8914	0.1501	--	INHERITED FROM: ectopic expression transgene || gene expression level reduced
Worm Phenotype (WP)	organism physiology variant	0.9113	0.1405	--	INHERITED FROM: gene expression level reduced || ectopic expression transgene
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: gene expression level reduced || hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || ectopic expression transgene || sister cell division timing asynchrony reduced || lineage variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organ system morphology variant	0.02242	0.7119	Least Informative	INHERITED FROM: epithelial system morphology variant || epithelial morphology variant || alimentary system morphology variant
Worm Phenotype (WP)	cell development variant	0.04947	0.632	Least Informative	INHERITED FROM: lineage variant
Worm Phenotype (WP)	organism metabolism processing variant	0.08677	0.4572	Least Informative	INHERITED FROM: ectopic expression transgene || gene expression level reduced
Worm Phenotype (WP)	cell physiology variant	0.131	0.5344	Least Informative	INHERITED FROM: sister cell division timing asynchrony reduced
Worm Phenotype (WP)	cell division variant	0.08251	1	Moderately Informative	INHERITED FROM: sister cell division timing asynchrony reduced
Worm Phenotype (WP)	pattern of transgene expression variant	1	1.017	Moderately Informative	INHERITED FROM: ectopic expression transgene
Worm Phenotype (WP)	developmental morphology variant	0.0006114	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	gene expression level reduced	0.0007862	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	alimentary system morphology variant	0.0008484	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	ectopic expression transgene	0.0008928	2.106	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.0731	0.05522	--	INHERITED FROM: size defective
Fly Phenotype (FP)	size defective	0.0007515	1.701	Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	integumentary system	0.00002903	0.8617	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0.00003309	1.204	--	DIRECT
Fly Anatomy (FA)	segment	0.00009214	0.812	--	DIRECT
Fly Anatomy (FA)	adult external thorax	0.00009939	1.234	--	DIRECT
Fly Anatomy (FA)	embryonic hemocoel	0.0002297	1.903	--	DIRECT
Fly Anatomy (FA)	embryonic hemocyte	0.0002297	1.903	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0.0002606	1.176	--	DIRECT
Fly Anatomy (FA)	circulatory system	0.001307	1.301	--	INHERITED FROM: embryonic/larval circulatory system || embryonic hemocoel || head mesoderm derived embryonic hemocyte || embryonic hemocyte
Fly Anatomy (FA)	immaterial anatomical entity	0.00204	1.681	--	INHERITED FROM: embryonic hemocoel || embryonic hemocyte || head mesoderm derived embryonic hemocyte
Fly Anatomy (FA)	mechanosensory sensory organ	0.005719	1.903	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	somatic cell	0.005912	0.5607	--	INHERITED FROM: embryonic hemocyte || head mesoderm derived embryonic hemocyte
Fly Anatomy (FA)	tagma	0.00629	0.6478	--	INHERITED FROM: mesothoracic segment || mesothoracic tergum || adult external thorax
Fly Anatomy (FA)	external sensillum	0.006301	1.301	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	sensillum	0.007558	1.301	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	cell cluster organ	0.01004	1.301	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	adult thorax	0.01254	1.125	--	INHERITED FROM: mesothoracic tergum || adult external thorax
Fly Anatomy (FA)	external sensory organ	0.01912	1.15	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	tergum	0.02004	2.079	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	dorsal mesothorax	0.02004	2.079	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	anatomical group	0.02216	0.7891	--	INHERITED FROM: mechanosensory system || mechanosensory chaeta
Fly Anatomy (FA)	hemocyte	0.02473	1.903	--	INHERITED FROM: head mesoderm derived embryonic hemocyte || embryonic hemocyte
Fly Anatomy (FA)	sense organ	0.02829	1.101	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	adult external mesothorax	0.03327	2.079	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	segmental subdivision of integument	0.08388	2.079	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	adult thoracic segment	0.09286	1.176	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	eo-type sensillum	0.1028	1.602	--	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	thoracic segment	0.1048	1.15	--	INHERITED FROM: mesothoracic tergum || mesothoracic segment
Fly Anatomy (FA)	late embryo	0.1487	1.15	--	INHERITED FROM: embryonic/larval circulatory system
Fly Anatomy (FA)	organ system	0.2354	0.2279	--	INHERITED FROM: embryonic hemocoel || integumentary system || tagmatic subdivision of integument || head mesoderm derived embryonic hemocyte || embryonic hemocyte || embryonic/larval circulatory system || adult external thorax || mesothoracic tergum
Fly Anatomy (FA)	non-connected functional system	0.2787	0.9652	--	INHERITED FROM: mechanosensory system || mechanosensory chaeta
Fly Anatomy (FA)	adult mesothoracic segment	0.3054	1.204	--	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	hemocoel	0.3763	1.778	--	INHERITED FROM: head mesoderm derived embryonic hemocyte || embryonic hemocyte || embryonic hemocoel
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: mesothoracic tergum || adult external thorax || organism || mesothoracic segment || embryonic/larval circulatory system || mechanosensory chaeta || segment || embryonic hemocyte || head mesoderm derived embryonic hemocyte || tagmatic subdivision of integument || embryonic hemocoel || integumentary system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: embryonic hemocoel || integumentary system || multicellular structure || mechanosensory system || tagmatic subdivision of integument || segment || embryonic hemocyte || head mesoderm derived embryonic hemocyte || embryonic/larval circulatory system || mechanosensory chaeta || mesothoracic tergum || adult external thorax || organism || mesothoracic segment
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.632	--	INHERITED FROM: mesothoracic segment || adult external thorax || mesothoracic tergum || segment
Fly Anatomy (FA)	organism subdivision	0.004231	0.6243	Least Informative	INHERITED FROM: adult external thorax || mesothoracic tergum || mesothoracic segment || segment
Fly Anatomy (FA)	organ system subdivision	0.008166	0.5673	Least Informative	INHERITED FROM: mesothoracic tergum || adult external thorax || tagmatic subdivision of integument
Fly Anatomy (FA)	adult	0.008401	0.5607	Least Informative	INHERITED FROM: adult external thorax || mesothoracic tergum
Fly Anatomy (FA)	cell	0.0168	0.4937	Least Informative	INHERITED FROM: embryonic hemocyte || head mesoderm derived embryonic hemocyte
Fly Anatomy (FA)	larva	0.0387	0.4611	Least Informative	INHERITED FROM: embryonic/larval circulatory system
Fly Anatomy (FA)	adult segment	0.005454	0.9652	Moderately Informative	INHERITED FROM: mesothoracic tergum
Fly Anatomy (FA)	adult integumentary system	0.007744	1.15	Moderately Informative	INHERITED FROM: adult external thorax || mesothoracic tergum
Fly Anatomy (FA)	thorax	0.008551	1.101	Moderately Informative	INHERITED FROM: mesothoracic segment || adult external thorax || mesothoracic tergum
Fly Anatomy (FA)	region of integument	0.01294	1.038	Moderately Informative	INHERITED FROM: adult external thorax || mesothoracic tergum || tagmatic subdivision of integument
Fly Anatomy (FA)	sensory system	0.01757	0.9652	Moderately Informative	INHERITED FROM: mechanosensory system || mechanosensory chaeta
Fly Anatomy (FA)	adult tagma	0.06063	0.7674	Moderately Informative	INHERITED FROM: adult external thorax || mesothoracic tergum
Fly Anatomy (FA)	embryo	0.09529	0.9178	Moderately Informative	INHERITED FROM: embryonic/larval circulatory system
Fly Anatomy (FA)	mechanosensory system	0.000251	1.681	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval circulatory system	0.0003048	1.681	Informative	DIRECT
Fly Anatomy (FA)	chaeta	0.001088	1.602	Informative	INHERITED FROM: mechanosensory chaeta
Fly Anatomy (FA)	anatomical space	0.001861	1.681	Informative	INHERITED FROM: embryonic hemocyte || head mesoderm derived embryonic hemocyte || embryonic hemocoel
Fly Anatomy (FA)	mechanosensory chaeta	0.00004374	1.903	Highly Informative	DIRECT
Fly Anatomy (FA)	head mesoderm derived embryonic hemocyte	0.0001682	1.903	Highly Informative	DIRECT
Fly Anatomy (FA)	mesothoracic tergum	0.0003916	2.079	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	mesenchyme	0.00005354	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	mesodermal cell	0.0001459	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	primordial vasculature	0.0001666	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	anterior lateral plate mesoderm	0.0004982	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	mesoderm	0.117	2.439	--	INHERITED FROM: anterior lateral plate mesoderm || mesodermal cell
Zebrafish Anatomy (ZA)	lateral plate mesoderm	0.553	2.439	--	INHERITED FROM: anterior lateral plate mesoderm
Zebrafish Anatomy (ZA)	anatomical system	0.5735	0.2245	--	INHERITED FROM: primordial vasculature
Zebrafish Anatomy (ZA)	anatomical group	0.6332	0.1889	--	INHERITED FROM: primordial vasculature
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: mesodermal cell || mesenchyme || primordial vasculature || anterior lateral plate mesoderm || whole organism || primary germ layer
Zebrafish Anatomy (ZA)	cell	0.06261	0.7491	Least Informative	INHERITED FROM: mesodermal cell
Zebrafish Anatomy (ZA)	cardiovascular system	0.01495	1.138	Moderately Informative	INHERITED FROM: primordial vasculature
Zebrafish Anatomy (ZA)	portion of tissue	0.054	0.8161	Moderately Informative	INHERITED FROM: primary germ layer || primordial vasculature || mesenchyme || anterior lateral plate mesoderm || mesodermal cell
Zebrafish Anatomy (ZA)	primary germ layer	0.0002565	1.661	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal subdivision	0.000001232	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	progenitor cell	0.000002201	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	cartilage element	0.000002815	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	involuted ventral mesoderm	0.00001069	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	lower jaw	0.00001262	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	appendage	0.00001761	2.062	--	DIRECT
Xenopus ANatomical entity (XAN)	cartilage tissue	0.00002594	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	lung bud	0.00002911	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	heart	0.00003499	1.647	--	DIRECT
Xenopus ANatomical entity (XAN)	ceratohyal	0.00005833	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0.0000844	1.647	--	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0.00009822	1.33	--	DIRECT
Xenopus ANatomical entity (XAN)	chondrocranium	0.0001749	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	primary heart field	0.0002003	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	lung primordium	0.0002534	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	Meckel's cartilage	0.0002765	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	lower blastopore lip	0.000284	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	hindlimb	0.0003316	2.159	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch skeleton	0.0005129	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	myocardium	0.0007305	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	lateral	0.0007474	2.46	--	DIRECT
Xenopus ANatomical entity (XAN)	regenerating tissue	0.0008542	1.916	--	DIRECT
Xenopus ANatomical entity (XAN)	facial nerve	0.0009543	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	respiratory system	0.001058	2.284	--	INHERITED FROM: lung bud || lung primordium
Xenopus ANatomical entity (XAN)	circumblastoporal collar	0.004023	1.858	--	INHERITED FROM: involuted ventral mesoderm
Xenopus ANatomical entity (XAN)	cephalic nerve	0.037	1.916	--	INHERITED FROM: facial nerve
Xenopus ANatomical entity (XAN)	nerve	0.04254	1.916	--	INHERITED FROM: facial nerve
Xenopus ANatomical entity (XAN)	skeleton	0.09689	1.647	--	INHERITED FROM: Meckel's cartilage || cartilage tissue || cartilage element || ceratohyal || branchial arch skeleton || skeletal subdivision
Xenopus ANatomical entity (XAN)	hyoid arch	0.2142	2.761	--	INHERITED FROM: ceratohyal
Xenopus ANatomical entity (XAN)	mandibular arch	0.2168	2.761	--	INHERITED FROM: Meckel's cartilage
Xenopus ANatomical entity (XAN)	muscular system	0.2402	1.314	--	INHERITED FROM: myocardium
Xenopus ANatomical entity (XAN)	endoskeleton	0.2557	2.46	--	INHERITED FROM: cartilage tissue
Xenopus ANatomical entity (XAN)	skeletal element	0.281	1.682	--	INHERITED FROM: cartilage element || cartilage tissue || ceratohyal || Meckel's cartilage
Xenopus ANatomical entity (XAN)	splanchnocranium	0.3913	2.284	--	INHERITED FROM: Meckel's cartilage || branchial arch skeleton
Xenopus ANatomical entity (XAN)	head region	0.4083	0.5108	--	INHERITED FROM: ceratohyal || branchial arch skeleton || Meckel's cartilage || facial nerve || pharyngeal arch || chondrocranium || lower jaw || pharyngeal region
Xenopus ANatomical entity (XAN)	anatomical cluster	0.5112	0.7974	--	INHERITED FROM: skeletal subdivision || ceratohyal || heart || branchial arch skeleton || cartilage element || cartilage tissue || myocardium || Meckel's cartilage || lower jaw || chondrocranium
Xenopus ANatomical entity (XAN)	primary germ layer	0.6518	0.7237	--	INHERITED FROM: neurogenic placode || cranial placode || neural plate || neuroectoderm || mesoderm
Xenopus ANatomical entity (XAN)	anatomical region	0.7149	0.193	--	INHERITED FROM: heart || branchial arch skeleton || myocardium || lower jaw || pharyngeal region || chondrocranium || ceratohyal || Meckel's cartilage || pharyngeal arch || facial nerve
Xenopus ANatomical entity (XAN)	compound organ	0.7557	0.24	--	INHERITED FROM: ceratohyal || heart || cartilage tissue || myocardium || Meckel's cartilage || cartilage element
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.7845	0.1217	--	INHERITED FROM: lung bud || ceratohyal || mesoderm || Meckel's cartilage || appendage || neural plate || lower jaw || limb bud || regenerating tissue || myocardium || primary heart field || hindlimb || cartilage element || facial nerve || mesenchyme || multi-tissue structure || neuroectoderm || pharyngeal arch || neurogenic placode || involuted ventral mesoderm || lung primordium || chondrocranium || cranial placode || pharyngeal region || notochord || blastema || branchial arch skeleton || heart || cartilage tissue
Xenopus ANatomical entity (XAN)	organism subdivision	0.7983	0.1871	--	INHERITED FROM: heart || branchial arch skeleton || hindlimb || myocardium || pharyngeal region || limb bud || lower jaw || chondrocranium || ceratohyal || appendage || Meckel's cartilage || pharyngeal arch || facial nerve
Xenopus ANatomical entity (XAN)	cell	0.8612	0.7974	--	INHERITED FROM: progenitor cell || neuron
Xenopus ANatomical entity (XAN)	blastopore	0.9161	2.284	--	INHERITED FROM: lower blastopore lip
Xenopus ANatomical entity (XAN)	vegetal yolk mass	0.9283	2.284	--	INHERITED FROM: lower blastopore lip
Xenopus ANatomical entity (XAN)	trunk region	1	0.4287	--	INHERITED FROM: heart || myocardium
Xenopus ANatomical entity (XAN)	blastopore lip	1	2.284	--	INHERITED FROM: lower blastopore lip
Xenopus ANatomical entity (XAN)	anatomical group	1	0.1442	--	INHERITED FROM: Meckel's cartilage || cardiovascular system || ceratohyal || lung bud || lower jaw || myocardium || primary heart field || cartilage element || facial nerve || sensory system || lung primordium || neuron || chondrocranium || cartilage tissue || skeletal subdivision || foregut || heart || branchial arch skeleton
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: Meckel's cartilage || ceratohyal || lung bud || cardiovascular system || lower jaw || cartilage element || primary heart field || myocardium || facial nerve || sensory system || lung primordium || neuron || chondrocranium || cartilage tissue || heart || branchial arch skeleton || skeletal subdivision || foregut
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: neural plate || lower blastopore lip || lower jaw || limb bud || regenerating tissue || myocardium || hindlimb || cartilage element || primary heart field || lung bud || ceratohyal || cardiovascular system || mesoderm || Meckel's cartilage || appendage || cranial placode || chondrocranium || pharyngeal region || blastema || branchial arch skeleton || heart || notochord || foregut || skeletal subdivision || cartilage tissue || mesenchyme || facial nerve || sensory system || pharyngeal arch || multi-tissue structure || neuroectoderm || neurogenic placode || progenitor cell || involuted ventral mesoderm || neuron || lung primordium
Xenopus ANatomical entity (XAN)	skeletal tissue	1	1.72	--	INHERITED FROM: cartilage tissue
Xenopus ANatomical entity (XAN)	paired appendage	1	2.062	--	INHERITED FROM: hindlimb
Xenopus ANatomical entity (XAN)	tissue	0.1348	0.5011	Least Informative	INHERITED FROM: neural plate || cranial placode || regenerating tissue || blastema || notochord || primary heart field || myocardium || cartilage tissue || neuroectoderm || mesenchyme || facial nerve || neurogenic placode || mesoderm || involuted ventral mesoderm
Xenopus ANatomical entity (XAN)	embryo	0.2751	0.6341	Least Informative	INHERITED FROM: neural plate || cranial placode || lower blastopore lip || neurogenic placode || neuroectoderm || lung primordium || mesoderm || lung bud || foregut || involuted ventral mesoderm
Xenopus ANatomical entity (XAN)	head	0.4019	0.5108	Least Informative	INHERITED FROM: facial nerve || pharyngeal arch || chondrocranium || pharyngeal region || lower jaw || ceratohyal || branchial arch skeleton || Meckel's cartilage
Xenopus ANatomical entity (XAN)	nervous system	0.6581	0.6341	Least Informative	INHERITED FROM: neuron || facial nerve || sensory system
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.7455	0.3033	Least Informative	INHERITED FROM: heart || myocardium
Xenopus ANatomical entity (XAN)	trunk	1	0.4308	Least Informative	INHERITED FROM: heart || myocardium
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.0001289	1.071	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0.000166	1.17	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0.003643	1.138	Moderately Informative	INHERITED FROM: lung bud || involuted ventral mesoderm || foregut || cranial placode || lung primordium || neurogenic placode || lower blastopore lip
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.03414	1.118	Moderately Informative	INHERITED FROM: lower jaw || chondrocranium || cartilage element || cartilage tissue || myocardium || Meckel's cartilage || skeletal subdivision || ceratohyal || branchial arch skeleton
Xenopus ANatomical entity (XAN)	viscus	0.7418	0.9618	Moderately Informative	INHERITED FROM: heart || myocardium
Xenopus ANatomical entity (XAN)	ectoderm	0.7579	0.9688	Moderately Informative	INHERITED FROM: neuroectoderm || neurogenic placode || neural plate || cranial placode
Xenopus ANatomical entity (XAN)	alimentary system	0.7688	0.955	Moderately Informative	INHERITED FROM: foregut || lung primordium || lung bud
Xenopus ANatomical entity (XAN)	mesenchyme	0.0000009581	1.647	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.000008425	1.482	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical direction	0.00001873	1.682	Informative	DIRECT
Xenopus ANatomical entity (XAN)	neural plate	0.00004513	1.482	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cranial placode	0.0002353	1.682	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0.0003196	1.314	Informative	DIRECT
Xenopus ANatomical entity (XAN)	notochord	0.000403	1.682	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.0005322	1.506	Informative	DIRECT
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.005021	1.682	Informative	INHERITED FROM: facial nerve
Xenopus ANatomical entity (XAN)	skeletal system	0.02864	1.531	Informative	INHERITED FROM: ceratohyal || branchial arch skeleton || skeletal subdivision || Meckel's cartilage || chondrocranium || cartilage tissue || cartilage element || lower jaw
Xenopus ANatomical entity (XAN)	surface structure	0.06342	1.419	Informative	INHERITED FROM: limb bud
Xenopus ANatomical entity (XAN)	connective tissue	0.6003	1.72	Informative	INHERITED FROM: cartilage tissue
Xenopus ANatomical entity (XAN)	limb	0.6248	1.615	Informative	INHERITED FROM: hindlimb
Xenopus ANatomical entity (XAN)	solid compound organ	0.808	1.399	Informative	INHERITED FROM: cartilage element || Meckel's cartilage || ceratohyal || cartilage tissue
Xenopus ANatomical entity (XAN)	muscle	0.952	1.46	Informative	INHERITED FROM: myocardium
Xenopus ANatomical entity (XAN)	neurogenic placode	0.00001116	1.807	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb bud	0.00002138	2.159	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	foregut	0.0003687	1.858	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	blastema	0.000456	1.916	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuron	0.0008531	1.761	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	cranium	0.001372	2.062	Highly Informative	INHERITED FROM: chondrocranium || Meckel's cartilage || branchial arch skeleton || lower jaw
Xenopus ANatomical entity (XAN)	gustatory system	0.02536	1.983	Highly Informative	INHERITED FROM: facial nerve
Xenopus ANatomical entity (XAN)	branchial arch	0.2188	2.159	Highly Informative	INHERITED FROM: branchial arch skeleton
Xenopus ANatomical entity (XAN)	pelvic appendage	0.9841	2.062	Highly Informative	INHERITED FROM: hindlimb
Xenopus ANatomical entity (XAN)	marginal zone	1	1.858	Highly Informative	INHERITED FROM: lower blastopore lip
Xenopus ANatomical entity (XAN)	cranial nerve	1	1.983	Highly Informative	INHERITED FROM: facial nerve
Xenopus DEvelopment stage (XDE)	NF stage 46	0.0000005951	2.362	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0.6288	0.02327	--	INHERITED FROM: NF stage 46
Xenopus DEvelopment stage (XDE)	tadpole stage	0.9238	0.5946	--	INHERITED FROM: NF stage 46
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.7782	0.5693	Least Informative	INHERITED FROM: NF stage 46
Xenopus DEvelopment stage (XDE)	premetamorphosis stage	0.01454	1.885	Highly Informative	INHERITED FROM: NF stage 46

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InterPro annotation

• Cross references: IPR008967 SSF49417 Protein matches
• Abstract:

  This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [12729611]; STAT-1 plays an important role in B lymphocyte growth and function [12855573]; and NFkappaB is involved in the inflammatory response [12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.

InterPro database

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