SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.
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Cna protein B-type domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Processes_EC |
| Detailed category | Cell adhesion |
Document: Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR008970 SSF49478 Protein matches |
| Abstract | This entry represents a repeated B region domain found in the collagen-binding surface protein Cna in Staphylococcus aureus, which has a prealbumin-like beta-sandwich fold of seven strands in two sheets with a Greek key topology [ 10673425]. However, this domain does not mediate collagen binding, the region carries out that function; instead it appears to form a stalk that presents the ligand binding domain away from the bacterial cell surface. Cna is a collagen-binding MSCRAMM (Microbial Surface Component Recognizing Adhesive Matrix Molecules), and is necessary and sufficient for S. aureus cells to adhere to cartilage.
Other proteins contain domains with a similar fold, although they can have an additional 1-2 strands. Such proteins include the C-terminal domain of the beta subunit of transhydroxylase, a molybdenum-containing enzyme from Pelobacter acidigallici that catalyses the conversion of pyrogallol to phoroglucinol, an important building block of plant polymers [15284442]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 7 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Cna protein B-type domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 7 hidden Markov models representing the Cna protein B-type domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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