C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: C2 domain-like [ 49561] (5)
• Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
• Families:
  • PLC-like (P variant) [ 49563] (11)
  • Synaptotagmin-like (S variant) [ 49575] (10)

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Superfamily statistics

	Genomes (514)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	47,971	127,967	37
Proteins	31,885	86,310	35

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Functional annotation

• General category: Regulation
• Detailed category: Signal transduction

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4-bisphosphate 4-phosphatas	0	2.56	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4,5-trisphosphate 3-phospha	0.0000000000001879	2.259	--	DIRECT
Enzyme Commission (EC)	Transferases	0.002451	0	--	INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol-4-phosphate 3-kinase || Protein-serine/threonine kinases || Phosphatidylinositol 3-kinase || Transferring phosphorous-containing groups || Protein kinase C
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.162	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	0.9165	Moderately Informative	INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 3-phospha || Phosphatidylinositol-3,4-bisphosphate 4-phosphatas
Enzyme Commission (EC)	Carboxylic ester hydrolases	1	1.217	Moderately Informative	INHERITED FROM: Phospholipase A(2) || Lysophospholipase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.005268	0.8195	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase || Phosphatidylinositol-4-phosphate 3-kinase
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol 3-kinase	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Phospholipase A(2)	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein kinase C	0	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	2.368e-16	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Lysophospholipase	0.000000000002869	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Phospholipase D	0.0002652	2.083	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Thyroiditis	0.00009487	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the tongue	0.0001402	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Thyroid adenoma	0.0002793	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Molar tooth sign on MRI	0.0007312	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of midbrain morphology	0.004928	2.407	--	INHERITED FROM: Molar tooth sign on MRI
Phenotypic Abnormality (PA)	Abnormality of thyroid morphology	0.02796	1.561	--	INHERITED FROM: Thyroiditis || Thyroid adenoma
Phenotypic Abnormality (PA)	Abnormality of the face	0.1673	0.5614	--	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Neoplasm of the thyroid gland	0.181	1.628	--	INHERITED FROM: Thyroid adenoma
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.2291	1.151	--	INHERITED FROM: Thyroid adenoma
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2523	0.2543	--	INHERITED FROM: Molar tooth sign on MRI
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3691	0.472	--	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.4011	0.8268	--	INHERITED FROM: Thyroiditis
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.4453	0.8625	--	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.5077	0.8383	--	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.5085	0.6284	--	INHERITED FROM: Molar tooth sign on MRI
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.5521	0.7731	--	INHERITED FROM: Molar tooth sign on MRI
Phenotypic Abnormality (PA)	Abnormal inflammatory response	0.7866	1.176	--	INHERITED FROM: Thyroiditis
Phenotypic Abnormality (PA)	Increased inflammatory response	1	1.23	--	INHERITED FROM: Thyroiditis
Phenotypic Abnormality (PA)	Abnormality of the head	0.35	0.4771	Least Informative	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.8671	0.5677	Least Informative	INHERITED FROM: Molar tooth sign on MRI
Phenotypic Abnormality (PA)	Neoplasm	0.2721	1.106	Moderately Informative	INHERITED FROM: Thyroid adenoma
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.4972	0.9594	Moderately Informative	INHERITED FROM: Thyroid adenoma || Thyroiditis
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.7087	0.9441	Moderately Informative	INHERITED FROM: Thyroiditis
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.9594	Moderately Informative	INHERITED FROM: Abnormality of the tongue
Phenotypic Abnormality (PA)	Neoplasm of the endocrine system	0.1096	1.628	Informative	INHERITED FROM: Thyroid adenoma
Phenotypic Abnormality (PA)	Abnormality of the thyroid gland	0.1254	1.503	Informative	INHERITED FROM: Thyroid adenoma || Thyroiditis

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal platelet aggregation	0.0000007318	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet activation	0.000001169	1.809	--	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic vesicle number	0.000001536	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet physiology	0.00004382	1.809	--	DIRECT
Mammalian Phenotype (MP)	increased skin hamartoma incidence	0.0004913	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytotoxic T cell cytolysis	0.0007905	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic vesicle morphology	0.0008082	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal hemostasis	0.005256	1.394	--	INHERITED FROM: abnormal platelet activation || abnormal platelet aggregation || abnormal platelet physiology
Mammalian Phenotype (MP)	abnormal CD8-positive, alpha-beta T cell physiology	0.01497	2.031	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	increased integument system tumor incidence	0.02151	1.906	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.08439	0.9281	--	INHERITED FROM: abnormal platelet physiology || abnormal cytotoxic T cell cytolysis || abnormal platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal tumor incidence	0.1108	1.11	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.116	1.186	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1197	0.737	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	altered tumor susceptibility	0.1212	1.11	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.1324	0.9168	--	INHERITED FROM: abnormal platelet activation || abnormal platelet aggregation || abnormal cytotoxic T cell cytolysis || abnormal platelet physiology
Mammalian Phenotype (MP)	abnormal skin morphology	0.2623	1.229	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.277	1.186	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.463	0.9638	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.5052	0.9516	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.5206	1.207	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.5647	0.9638	--	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.6098	0.7085	--	INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || abnormal platelet activation
Mammalian Phenotype (MP)	increased classified tumor incidence	0.65	1.207	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.6933	1.186	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	increased tumor incidence	0.8399	1.11	--	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.847	0.3617	--	INHERITED FROM: abnormal platelet physiology || abnormal platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal nervous system morphology	1	0.627	--	INHERITED FROM: abnormal synaptic vesicle number || abnormal synaptic vesicle morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.02473	0.5166	Least Informative	INHERITED FROM: abnormal synaptic vesicle number || abnormal synaptic vesicle morphology
Mammalian Phenotype (MP)	immune system phenotype	0.1593	0.627	Least Informative	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.477	0.6505	Least Informative	INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || abnormal platelet activation || abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal homeostasis	0.7965	0.495	Least Informative	INHERITED FROM: abnormal platelet aggregation || abnormal platelet physiology || abnormal platelet activation
Mammalian Phenotype (MP)	neoplasm	0.1934	1.003	Moderately Informative	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.5903	0.9764	Moderately Informative	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	abnormal neuron morphology	0.5923	0.9516	Moderately Informative	INHERITED FROM: abnormal synaptic vesicle number || abnormal synaptic vesicle morphology
Mammalian Phenotype (MP)	integument phenotype	0.6068	0.8451	Moderately Informative	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal blood coagulation	0.004982	1.394	Informative	INHERITED FROM: abnormal platelet physiology || abnormal platelet aggregation || abnormal platelet activation
Mammalian Phenotype (MP)	abnormal T cell physiology	0.8119	1.605	Informative	INHERITED FROM: abnormal cytotoxic T cell cytolysis
Mammalian Phenotype (MP)	increased hamartoma incidence	0.001436	2.207	Highly Informative	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal synapse morphology	0.001848	2.031	Highly Informative	INHERITED FROM: abnormal synaptic vesicle number || abnormal synaptic vesicle morphology
Mammalian Phenotype (MP)	increased skin tumor incidence	0.002821	2.031	Highly Informative	INHERITED FROM: increased skin hamartoma incidence
Mammalian Phenotype (MP)	abnormal cytotoxic T cell physiology	0.3116	2.031	Highly Informative	INHERITED FROM: abnormal cytotoxic T cell cytolysis

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	gonad sheath contraction rate reduced	0.0000000001132	2.23	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.000000002285	1.708	--	DIRECT
Worm Phenotype (WP)	somatic gonad physiology variant	0.00000001593	2.106	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.00000004153	1.276	--	DIRECT
Worm Phenotype (WP)	presynaptic region physiology variant	0.0000001197	2.23	--	DIRECT
Worm Phenotype (WP)	somatic sheath physiology variant	0.0000001409	2.106	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.0000001418	1.407	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.00001366	1.385	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.00002697	0.632	--	DIRECT
Worm Phenotype (WP)	locomotor coordination variant	0.0001342	1.452	--	DIRECT
Worm Phenotype (WP)	nose movement decreased	0.0001477	2.708	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.0002397	1.594	--	DIRECT
Worm Phenotype (WP)	aging variant	0.0002559	2.708	--	DIRECT
Worm Phenotype (WP)	pathogen induced antimicrobial gene expression variant	0.0005296	1.804	--	DIRECT
Worm Phenotype (WP)	chemical response variant	0.0007667	0.8045	--	DIRECT
Worm Phenotype (WP)	antimicrobial gene expression variant	0.00219	1.804	--	INHERITED FROM: pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	pathogen induced gene expression variant	0.002879	1.804	--	INHERITED FROM: pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	cell type morphology variant	0.004894	0.8211	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes
Worm Phenotype (WP)	muscle cell morphology variant	0.006187	1.346	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	locomotion variant	0.01867	1.045	--	INHERITED FROM: locomotor coordination variant
Worm Phenotype (WP)	transmission of nerve impulse variant	0.04073	1.929	--	INHERITED FROM: presynaptic region physiology variant
Worm Phenotype (WP)	copulation variant	0.08227	1.594	--	INHERITED FROM: male mating defective
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.08347	1.594	--	INHERITED FROM: male mating defective
Worm Phenotype (WP)	nose movement variant	0.09711	1.708	--	INHERITED FROM: nose movement decreased
Worm Phenotype (WP)	hermaphrodite physiology variant	0.09832	1.365	--	INHERITED FROM: somatic sheath physiology variant || gonad sheath contraction rate reduced || gonad sheath contractions variant
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.1036	1.31	--	INHERITED FROM: somatic sheath physiology variant || gonad sheath contraction rate reduced || gonad sheath contractions variant
Worm Phenotype (WP)	mitochondria spacing variant	0.1971	1.594	--	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	neuronal outgrowth variant	0.2149	1.407	--	INHERITED FROM: axon outgrowth variant
Worm Phenotype (WP)	innate immune response variant	0.2915	1.804	--	INHERITED FROM: pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	cell component morphology variant	0.3293	0.7833	--	INHERITED FROM: mitochondria alignment variant || mitochondria morphology variant
Worm Phenotype (WP)	morphology variant	0.3439	0.06117	--	INHERITED FROM: body wall muscle sarcomere morphology variant || mitochondria morphology variant || endomitotic oocytes || mitochondria alignment variant || cell morphology variant || muscle system morphology variant || striated muscle morphology variant
Worm Phenotype (WP)	growth variant	0.4146	0.4022	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	gene expression variant	0.4942	0.6038	--	INHERITED FROM: protein subcellular localization variant || pathogen induced antimicrobial gene expression variant || protein expression variant || drug induced gene expression variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.577	0.1501	--	INHERITED FROM: cell stress response variant || pathogen induced antimicrobial gene expression variant || protein subcellular localization variant || protein expression variant || organism environmental stimulus response variant || growth rate variant || drug induced gene expression variant || drug resistant || chemical response variant || response to injury variant || chemical resistant || organism osmotic stress response variant || cellular osmotic stress response variant || RNAi response variant
Worm Phenotype (WP)	organism physiology variant	0.6146	0.1405	--	INHERITED FROM: protein expression variant || organism environmental stimulus response variant || somatic sheath physiology variant || pathogen induced antimicrobial gene expression variant || protein subcellular localization variant || cell stress response variant || chemical response variant || response to injury variant || drug resistant || drug induced gene expression variant || aging variant || growth rate variant || chemical resistant || gonad sheath contractions variant || cellular osmotic stress response variant || RNAi response variant || organism osmotic stress response variant || gonad sheath contraction rate reduced
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || chemical resistant || male mating defective || RNAi response variant || ovulation variant || gonad sheath contraction rate reduced || organism osmotic stress response variant || reproductive system physiology variant || presynaptic region physiology variant || chemical response variant || growth rate variant || lethal || cellular osmotic stress response variant || somatic sheath physiology variant || muscle cell physiology variant || nose movement decreased || protein subcellular localization variant || aging variant || electrophysiology variant || development variant || somatic gonad physiology variant || defecation contraction variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || axon outgrowth variant || nervous system physiology variant || embryonic development variant || embryonic lethal || fertility variant || behavior variant || muscle system physiology variant || gonad sheath contractions variant || locomotor coordination variant || organ system physiology variant || protein expression variant || organism behavior variant || maternal sterile || cell stress response variant || coelomic system physiology variant || pathogen induced antimicrobial gene expression variant || organism development variant || drug resistant || response to injury variant || defecation variant || fertility reduced || drug induced gene expression variant
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	male behavior variant	1	1.594	--	INHERITED FROM: male mating defective
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.429	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	cell physiology variant	0.00001177	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00001669	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.00002327	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0006223	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.003753	0.7119	Least Informative	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle system morphology variant
Worm Phenotype (WP)	cell development variant	0.02758	0.632	Least Informative	INHERITED FROM: presynaptic region physiology variant || axon outgrowth variant
Worm Phenotype (WP)	organism metabolism processing variant	0.06286	0.4572	Least Informative	INHERITED FROM: protein subcellular localization variant || pathogen induced antimicrobial gene expression variant || drug induced gene expression variant || protein expression variant
Worm Phenotype (WP)	protein expression variant	0.00000003429	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	neuron development variant	0.001762	1.245	Moderately Informative	INHERITED FROM: presynaptic region physiology variant || axon outgrowth variant
Worm Phenotype (WP)	drug response variant	0.006921	1.017	Moderately Informative	INHERITED FROM: drug resistant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.01913	0.9294	Moderately Informative	INHERITED FROM: response to injury variant || cellular osmotic stress response variant || cell stress response variant
Worm Phenotype (WP)	organism stress response variant	0.1101	0.8325	Moderately Informative	INHERITED FROM: response to injury variant || cellular osmotic stress response variant || cell stress response variant || organism osmotic stress response variant || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	movement variant	0.9354	1.026	Moderately Informative	INHERITED FROM: locomotor coordination variant || nose movement decreased
Worm Phenotype (WP)	germ cell morphology variant	0.9468	1.064	Moderately Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	defecation variant	0.0000000005906	1.628	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0000000692	1.429	Informative	DIRECT
Worm Phenotype (WP)	nervous system physiology variant	0.000004735	1.666	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.00004271	1.477	Informative	DIRECT
Worm Phenotype (WP)	cell stress response variant	0.00004616	1.407	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0.00006297	1.385	Informative	DIRECT
Worm Phenotype (WP)	coelomic system physiology variant	0.00007464	1.708	Informative	DIRECT
Worm Phenotype (WP)	organism osmotic stress response variant	0.000216	1.708	Informative	DIRECT
Worm Phenotype (WP)	drug resistant	0.0002826	1.503	Informative	DIRECT
Worm Phenotype (WP)	chemical resistant	0.0003444	1.477	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.0003914	1.407	Informative	DIRECT
Worm Phenotype (WP)	electrophysiology variant	0.0009171	1.708	Informative	DIRECT
Worm Phenotype (WP)	male mating variant	0.004028	1.594	Informative	INHERITED FROM: male mating defective
Worm Phenotype (WP)	pattern protein expression variant	0.006398	1.628	Informative	INHERITED FROM: protein subcellular localization variant
Worm Phenotype (WP)	organism pathogen response variant	0.006979	1.365	Informative	INHERITED FROM: pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	localized movement variant	0.05238	1.594	Informative	INHERITED FROM: nose movement decreased
Worm Phenotype (WP)	foraging behavior variant	0.2322	1.594	Informative	INHERITED FROM: nose movement decreased
Worm Phenotype (WP)	cell component localization variant	0.2783	1.365	Informative	INHERITED FROM: mitochondria alignment variant
Worm Phenotype (WP)	oocyte morphology variant	0.7132	1.276	Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	defecation contraction variant	0	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	gonad sheath contractions variant	0.000000001485	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	drug induced gene expression variant	0.000000002005	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	response to injury variant	0.0000001525	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	endomitotic oocytes	0.000000554	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	ovulation variant	0.000003028	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	cellular osmotic stress response variant	0.000009955	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	growth rate variant	0.00006096	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	male mating defective	0.0006109	1.753	Highly Informative	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.0009147	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	synaptic transmission variant	0.00146	1.929	Highly Informative	INHERITED FROM: presynaptic region physiology variant

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.2332	0.05522	--	INHERITED FROM: neurophysiology defective
Fly Phenotype (FP)	neurophysiology defective	0.0001194	1.525	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0.04376	0.1489	--	INHERITED FROM: pollen tube cell
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || pollen tube cell
Plant ANatomical entity (PAN)	pollen tube cell	0.00007221	1.339	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0.0001085	1.135	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0.03747	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0.03747	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0.03747	0.0937	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	plant organ development stage	0.0563	0.08108	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0.2761	0.05008	--	INHERITED FROM: pollen development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0.3362	0.03771	--	INHERITED FROM: androecium development stage || pollen development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: pollen development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: pollen development stage || androecium development stage
Plant structure DEvelopment stage (PDE)	pollen development stage	0.00003936	1.135	Moderately Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphatidylinositol 3-kinase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	2.253	--	DIRECT
Enzyme Commission (EC)	Protein kinase C	0	2.253	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.7559	--	DIRECT
Enzyme Commission (EC)	Phospholipase A(2)	0	2.253	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Phosphatidylserine decarboxylase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	2.574e-16	2.253	--	DIRECT
Enzyme Commission (EC)	Lysophospholipase	0.00000000000007109	2.253	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000002019	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.00001347	0.8446	--	DIRECT
Enzyme Commission (EC)	Phospholipase D	0.000284	2.475	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.6918	Least Informative	INHERITED FROM: Phosphatidylserine decarboxylase
Enzyme Commission (EC)	Aminoacyltransferases	0	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.003161	1.119	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase
Enzyme Commission (EC)	Carbon-carbon lyases	0.9191	1.101	Moderately Informative	INHERITED FROM: Phosphatidylserine decarboxylase
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	1.174	Moderately Informative	INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase || Phosphatidylinositol-3,4-bisphosphate 4-phosphatase || Protein-tyrosine-phosphatase
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.46	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.00005675	1.63	Informative	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0.2217	1.537	Informative	INHERITED FROM: Non-specific protein-tyrosine kinase
Enzyme Commission (EC)	Carboxy-lyases	0.4997	1.253	Informative	INHERITED FROM: Phosphatidylserine decarboxylase
Enzyme Commission (EC)	Carboxylic ester hydrolases	1	1.408	Informative	INHERITED FROM: Lysophospholipase || Phospholipase A(2)
Enzyme Commission (EC)	HECT-type E3 ubiquitin transferase	0	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0.0006409	1.873	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR008973 SSF49562 Protein matches
• Abstract:

  The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [9665851].

InterPro database

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