Synaptotagmin-like (S variant) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: C2 domain-like [ 49561] (5)
• Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
• Family: Synaptotagmin-like (S variant) [ 49575] (10)

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Family statistics

	Genomes (196)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,966	8,159	19
Proteins	2,256	6,247	17

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0.00000000000006328	0	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.6586	0.8381	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase
Enzyme Commission (EC)	Protein kinase C	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0	2.139	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal synaptic vesicle morphology	0.001199	2.126	--	INHERITED FROM: abnormal synaptic vesicle number
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.01336	0.825	--	INHERITED FROM: abnormal miniature endplate potential
Mammalian Phenotype (MP)	abnormal PNS synaptic transmission	0.01754	2.001	--	INHERITED FROM: abnormal miniature endplate potential
Mammalian Phenotype (MP)	abnormal synapse morphology	0.03102	1.825	--	INHERITED FROM: abnormal synaptic vesicle number
Mammalian Phenotype (MP)	abnormal nervous system morphology	1	0.5861	--	INHERITED FROM: abnormal synaptic vesicle number
Mammalian Phenotype (MP)	nervous system phenotype	0.23	0.4959	Least Informative	INHERITED FROM: abnormal synaptic vesicle number || abnormal miniature endplate potential
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.004644	1.156	Moderately Informative	INHERITED FROM: abnormal miniature endplate potential
Mammalian Phenotype (MP)	abnormal neuron morphology	0.9245	0.8323	Moderately Informative	INHERITED FROM: abnormal synaptic vesicle number
Mammalian Phenotype (MP)	abnormal miniature endplate potential	0.0001945	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic vesicle number	0.0008622	2.126	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	presynaptic region physiology variant	0.00000002856	2.468	--	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor resistant	0.0000001989	2.468	--	DIRECT
Worm Phenotype (WP)	pharyngeal pumping irregular	0.0000002717	2.769	--	DIRECT
Worm Phenotype (WP)	transmission of nerve impulse variant	0.000000451	2.07	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.00005859	1.513	--	DIRECT
Worm Phenotype (WP)	roller	0.0003217	2.292	--	DIRECT
Worm Phenotype (WP)	drug response variant	0.00094	1.135	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0009715	0.6859	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.001284	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	muscle system morphology variant	0.001413	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	neuron development variant	0.002871	1.321	--	INHERITED FROM: presynaptic region physiology variant || synaptic transmission variant
Worm Phenotype (WP)	muscle cell morphology variant	0.01598	1.337	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	body length variant	0.02024	1.292	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	body width variant	0.02909	1.237	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	cell morphology variant	0.03425	0.7558	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	eating variant	0.0417	1.769	--	INHERITED FROM: pharyngeal pumping rate variant || pharyngeal pumping irregular
Worm Phenotype (WP)	body size variant	0.04504	1.189	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	body morphology variant	0.05877	1.145	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	locomotion variant	0.1103	1.053	--	INHERITED FROM: roller
Worm Phenotype (WP)	feeding behavior variant	0.14	1.25	--	INHERITED FROM: pharyngeal pumping irregular || pharyngeal pumping rate variant
Worm Phenotype (WP)	organ system morphology variant	0.2165	0.7516	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	gene expression variant	0.4868	0.6256	--	INHERITED FROM: protein subcellular localization variant || pattern protein expression variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.5926	0.1444	--	INHERITED FROM: acetylcholinesterase inhibitor resistant || protein subcellular localization variant || drug response variant || pattern protein expression variant || drug resistant || acetylcholinesterase inhibitor response variant || chemical resistant
Worm Phenotype (WP)	organism physiology variant	0.619	0.1342	--	INHERITED FROM: drug response variant || protein subcellular localization variant || acetylcholinesterase inhibitor resistant || acetylcholinesterase inhibitor response variant || pattern protein expression variant || drug resistant || chemical resistant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || chemical resistant || roller || reproductive system physiology variant || presynaptic region physiology variant || transmission of nerve impulse variant || pattern protein expression variant || lethal || protein subcellular localization variant || synaptic transmission variant || development variant || pharyngeal pumping rate variant || defecation contraction variant || hermaphrodite sterile || drug response variant || hermaphrodite fertility reduced || pharyngeal pumping irregular || acetylcholinesterase inhibitor resistant || nervous system physiology variant || embryonic development variant || embryonic lethal || fertility variant || behavior variant || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || drug resistant || acetylcholinesterase inhibitor response variant || defecation variant || fertility reduced
Worm Phenotype (WP)	pharyngeal pumping variant	1	1.99	--	INHERITED FROM: pharyngeal pumping rate variant || pharyngeal pumping irregular
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	organism behavior variant	0.0009324	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.09554	0.6614	Least Informative	INHERITED FROM: chemical resistant || drug response variant || acetylcholinesterase inhibitor resistant || drug resistant || acetylcholinesterase inhibitor response variant
Worm Phenotype (WP)	cell development variant	0.2613	0.6752	Least Informative	INHERITED FROM: synaptic transmission variant || presynaptic region physiology variant
Worm Phenotype (WP)	organism metabolism processing variant	0.6802	0.4899	Least Informative	INHERITED FROM: protein subcellular localization variant || pattern protein expression variant
Worm Phenotype (WP)	protein expression variant	0.007478	1.125	Moderately Informative	INHERITED FROM: pattern protein expression variant || protein subcellular localization variant
Worm Phenotype (WP)	chemical response variant	0.03376	0.9053	Moderately Informative	INHERITED FROM: acetylcholinesterase inhibitor resistant || chemical resistant || drug response variant || acetylcholinesterase inhibitor response variant || drug resistant
Worm Phenotype (WP)	organism segment morphology variant	0.1034	1.087	Moderately Informative	INHERITED FROM: dumpy
Worm Phenotype (WP)	body region morphology variant	0.1045	1.087	Moderately Informative	INHERITED FROM: dumpy
Worm Phenotype (WP)	cell type morphology variant	0.232	0.8878	Moderately Informative	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	movement variant	0.9142	1.02	Moderately Informative	INHERITED FROM: roller
Worm Phenotype (WP)	defecation variant	0.0000001254	1.689	Informative	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.000001443	1.623	Informative	DIRECT
Worm Phenotype (WP)	drug resistant	0.00001064	1.689	Informative	DIRECT
Worm Phenotype (WP)	nervous system physiology variant	0.00003341	1.727	Informative	DIRECT
Worm Phenotype (WP)	chemical resistant	0.00005538	1.593	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0.00009228	1.49	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0009515	1.446	Informative	DIRECT
Worm Phenotype (WP)	locomotor coordination variant	0.03371	1.446	Informative	INHERITED FROM: roller
Worm Phenotype (WP)	defecation contraction variant	6.263e-16	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	synaptic transmission variant	0.000000451	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	dumpy	0.0005934	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	pharyngeal pumping rate variant	0.0006954	1.99	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || organism
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Protein kinase C	0	2.452	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0000000000007611	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.5197	1.238	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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