Neurophysin II superfamily
|General category ||Processes_EC|
|Detailed category ||Toxins/defense|
Document: Function annotation of SCOP domain superfamilies
|Cross references ||IPR000981 SSF49606 Protein matches|
|Abstract ||Oxytocin and vasopressin are nine-residue, structurally and functionally related neurohypophysial peptide
hormones. Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while
vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels
. In common with most active peptides, both hormones are synthesised as larger protein
precursors that are enzymatically converted to their mature forms. Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), Locusta migratoria (Migratory locust) (locupressin or neuropeptide
F1/F2) and in molluscs (conopressins G and S) .|
PDBeMotif information about ligands, sequence and structure motifs
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Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 2 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a Neurophysin II domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 2 hidden Markov models representing the Neurophysin II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]