SUPERFAMILY 1.75 HMM library and genome assignments server

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Crystallins/Ca-binding development proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   gamma-Crystallin-like [ 49694]
Superfamily:   gamma-Crystallin-like [ 49695] (6)
Family:   Crystallins/Ca-binding development proteins [ 49696] (4)

Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,303 2,528 24
Proteins 1,249 2,460 23

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.00001212Least InformativeDirect
Disease Ontology (DO)eye disease0.0000000001483InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.774Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.05245InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.63InformativeInherited
Phenotypic Abnormality (PA)Cataract0Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.0000000803Highly InformativeDirect
Phenotypic Abnormality (PA)Myopia0.00001092Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.00003248Highly InformativeDirect
Phenotypic Abnormality (PA)Ocular anterior segment dysgenesis0.0001503Highly InformativeDirect
Phenotypic Abnormality (PA)Coloboma0.001234Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality iris morphology0.1409Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye morphology0.0000004777Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.00000000001051InformativeDirect
Mammalian Phenotype (MP)abnormal lens morphology0.000000000000055Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.000002528Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.1179Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.6461Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8294Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.06509Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1072Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.05496InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.2878Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.161Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.07921InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00002156Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a gamma-Crystallin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]