Lipoxigenase N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Lipase/lipooxygenase domain (PLAT/LH2 domain) [ 49722]
• Superfamily: Lipase/lipooxygenase domain (PLAT/LH2 domain) [ 49723] (3)
• Family: Lipoxigenase N-terminal domain [ 49724] (2)

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Family statistics

	Genomes (92)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	450	1,042	14
Proteins	448	1,035	14

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0	1.627	--	DIRECT
Enzyme Commission (EC)	Linoleate 9S-lipoxygenase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Linoleate 13S-lipoxygenase	0.0000000000003285	2.44	--	DIRECT
Enzyme Commission (EC)	Arachidonate 12-lipoxygenase	0.0000001517	2.44	--	DIRECT
Enzyme Commission (EC)	Arachidonate 15-lipoxygenase	0.000008994	2.44	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of mole	0	1.537	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	skin disease	0.001356	1.022	--	INHERITED FROM: ichthyosis
Disease Ontology (DO)	disease of anatomical entity	0.1297	0.2414	--	INHERITED FROM: ichthyosis
Disease Ontology (DO)	disease of cellular proliferation	0.2505	0.2322	--	INHERITED FROM: adenoma || cell type benign neoplasm
Disease Ontology (DO)	benign neoplasm	0.001376	1.191	Moderately Informative	INHERITED FROM: cell type benign neoplasm || adenoma
Disease Ontology (DO)	integumentary system disease	0.002663	0.9817	Moderately Informative	INHERITED FROM: ichthyosis
Disease Ontology (DO)	cell type benign neoplasm	0.0009	1.337	Informative	DIRECT
Disease Ontology (DO)	ichthyosis	0.000000009519	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	adenoma	0.0002537	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear morphology	0	1.047	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear physiology	0	1.462	--	DIRECT
Phenotypic Abnormality (PA)	Hearing abnormality	1	1.462	--	INHERITED FROM: Hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the ear	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Hearing impairment	0	1.462	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	integument phenotype	0.01143	0.797	--	INHERITED FROM: impaired skin barrier function || abnormal skin physiology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.05513	0.3626	--	INHERITED FROM: impaired skin barrier function
Mammalian Phenotype (MP)	abnormal homeostasis	0.03125	0.4926	Least Informative	INHERITED FROM: impaired skin barrier function
Mammalian Phenotype (MP)	abnormal skin physiology	0.00001479	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fluid regulation	0.03123	1.373	Informative	INHERITED FROM: impaired skin barrier function
Mammalian Phenotype (MP)	impaired skin barrier function	0.000577	2.126	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6447	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7127	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5593	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.6385	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	root primordium	0.00000002487	2.123	--	DIRECT
Plant ANatomical entity (PAN)	primordium	0.000001928	1.822	--	DIRECT
Plant ANatomical entity (PAN)	root system	0.2985	0.4584	--	INHERITED FROM: lateral root primordium
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || primordium || sporophyll || calyx || inflorescence axis || root primordium || flower || collective plant structure || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || reproductive shoot system || shoot apex || leaf apex || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || stem || whole plant || epidermis || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || shoot epidermis || lateral root primordium || phyllome apex || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || pollen || microsporophyll || pollen sac || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || stamen || stem internode || inflorescence branch || shoot axis || shoot system || lateral root primordium || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.6176	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0.2612	0.5892	Least Informative	INHERITED FROM: primordium || root primordium || lateral root primordium
Plant ANatomical entity (PAN)	root	0.6623	0.4679	Least Informative	INHERITED FROM: lateral root primordium
Plant ANatomical entity (PAN)	lateral root primordium	0.00000002927	2.123	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.02 two leaves visible stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.06 six leaves visible stage || sporophyte vegetative stage || 1 main shoot growth stage || LP.04 four leaves visible stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0	1.907	--	DIRECT
Enzyme Commission (EC)	Linoleate 9S-lipoxygenase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Linoleate 13S-lipoxygenase	0.000000000000001463	2.929	--	DIRECT
Enzyme Commission (EC)	Hydroperoxy icosatetraenoate isomerase	0.0000000000002076	2.929	--	DIRECT
Enzyme Commission (EC)	Arachidonate 12-lipoxygenase	0.0000000001182	2.929	--	DIRECT
Enzyme Commission (EC)	Transferring hydroxy groups	0.0000000002503	2.531	--	DIRECT
Enzyme Commission (EC)	Arachidonate 15-lipoxygenase	0.0000000003089	2.929	--	DIRECT
Enzyme Commission (EC)	Hydroperoxy icosatetraenoate dehydratase	0.0000000008819	2.753	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	0.4143	1.208	--	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.6124	1.026	Moderately Informative	INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	Lyases	0.9829	0.8775	Moderately Informative	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	Intramolecular transferases	0.04256	1.606	Informative	INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups
Enzyme Commission (EC)	Hydro-lyases	0.2158	1.385	Informative	INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase
Enzyme Commission (EC)	With incorporation of two atoms of oxygen	0	1.974	Highly Informative	DIRECT

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