Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Galactose-binding domain-like [ 49784]
• Superfamily: Galactose-binding domain-like [ 49785] (32)
• Family: Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)

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Family statistics

	Genomes (70)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,261	3,458	11
Proteins	762	2,058	8

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.361	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	1.595	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal bleeding	0.002063	1.286	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Subcutaneous hemorrhage	0.04646	1.763	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.09112	1.383	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.2602	0.7142	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.404	0.7722	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of the skin	0.6086	0.722	--	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1543	0.5179	Least Informative	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of the integument	0.362	0.6235	Least Informative	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.07114	0.9183	Moderately Informative	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Vascular skin abnormality	0.02776	1.462	Informative	INHERITED FROM: Bruising susceptibility
Phenotypic Abnormality (PA)	Bruising susceptibility	0.0004236	2.161	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	lethality, incomplete penetrance	0.0006173	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0.731	0.6441	--	INHERITED FROM: lethality, incomplete penetrance || decreased survivor rate
Mammalian Phenotype (MP)	mortality/aging	0.6161	0.5424	Least Informative	INHERITED FROM: lethality, incomplete penetrance || decreased survivor rate
Mammalian Phenotype (MP)	decreased survivor rate	0.0002891	1.904	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || multicellular structure || sensory system || non-connected functional system || larva || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.767	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	2.084	Highly Informative	DIRECT

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