FHA domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SMAD/FHA domain [ 49878]
• Superfamily: SMAD/FHA domain [ 49879] (4)
• Family: FHA domain [ 49885] (11)

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Family statistics

	Genomes (365)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,226	3,947	21
Proteins	1,189	3,874	21

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Zeaxanthin epoxidase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.000000000854	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0.0004105	0	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.09997	0.3212	Least Informative	INHERITED FROM: With NADH or NADPH as one donor, and incorporation || Acting on paired donors, with incorporation or red || Zeaxanthin epoxidase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.00000000000001563	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.000000001588	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.279	Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0.0000000000001689	1.741	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	retinal cancer	0.0005914	1.668	--	DIRECT
Disease Ontology (DO)	autosomal dominant disease	0.002332	1.399	--	INHERITED FROM: hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	autosomal genetic disease	0.0182	1.133	--	INHERITED FROM: hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	monogenic disease	0.02117	1.115	--	INHERITED FROM: hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	sensory system cancer	0.03378	1.668	--	INHERITED FROM: retinal cell cancer || retinal cancer
Disease Ontology (DO)	disease of cellular proliferation	0.2268	0.2322	--	INHERITED FROM: retinal cancer || retinal cell cancer
Disease Ontology (DO)	cancer	0.9459	0.2555	--	INHERITED FROM: retinal cancer || retinal cell cancer
Disease Ontology (DO)	ocular cancer	1	1.668	--	INHERITED FROM: retinal cancer || retinal cell cancer
Disease Ontology (DO)	organ system cancer	0.0902	0.4879	Least Informative	INHERITED FROM: retinal cell cancer || retinal cancer
Disease Ontology (DO)	nervous system cancer	0.006076	1.191	Moderately Informative	INHERITED FROM: retinal cell cancer || retinal cancer
Disease Ontology (DO)	genetic disease	0.03391	1.066	Moderately Informative	INHERITED FROM: hereditary breast ovarian cancer syndrome
Disease Ontology (DO)	hereditary breast ovarian cancer syndrome	0.0004942	1.513	Informative	DIRECT
Disease Ontology (DO)	retinal cell cancer	0.0005714	1.668	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal saccadic eye movements	0.00003923	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neuroepithelial neoplasm	0.0002523	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Nervous tissue neoplasm	0.0002689	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Sloping forehead	0.0008926	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal myelination	0.00682	1.763	--	INHERITED FROM: Abnormal peripheral myelination
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.008053	0.533	--	INHERITED FROM: Malignant neoplasm of the central nervous system
Phenotypic Abnormality (PA)	Neoplasm of the central nervous system	0.01048	1.684	--	INHERITED FROM: Malignant neoplasm of the central nervous system
Phenotypic Abnormality (PA)	Neoplasm of the nervous system	0.01081	1.684	--	INHERITED FROM: Malignant neoplasm of the central nervous system
Phenotypic Abnormality (PA)	Abnormality of eye movement	0.04237	1.286	--	INHERITED FROM: Abnormal saccadic eye movements
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.08301	1.184	--	INHERITED FROM: Malignant neoplasm of the central nervous system
Phenotypic Abnormality (PA)	Abnormality of the head	0.1255	0.4538	--	INHERITED FROM: Sloping forehead
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.1304	0.4454	--	INHERITED FROM: Sloping forehead
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.1322	0.2371	--	INHERITED FROM: Malignant neoplasm of the central nervous system || Areflexia || Abnormal peripheral myelination
Phenotypic Abnormality (PA)	Reduced tendon reflexes	0.166	1.985	--	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Neuroectodermal neoplasm	1	1.684	--	INHERITED FROM: Neuroepithelial neoplasm
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.0172	0.4756	Least Informative	INHERITED FROM: Malignant neoplasm of the central nervous system || Abnormal peripheral myelination
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.07876	0.3869	Least Informative	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.179	0.5433	Least Informative	INHERITED FROM: Skeletal muscle atrophy
Phenotypic Abnormality (PA)	Abnormality of the eye	0.245	0.5703	Least Informative	INHERITED FROM: Abnormal saccadic eye movements
Phenotypic Abnormality (PA)	Abnormality of the face	0.6134	0.533	Least Informative	INHERITED FROM: Sloping forehead
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.01987	0.9061	Moderately Informative	INHERITED FROM: Skeletal muscle atrophy
Phenotypic Abnormality (PA)	Neoplasm	0.09554	1.14	Moderately Informative	INHERITED FROM: Neuroepithelial neoplasm || Malignant neoplasm of the central nervous system || Nervous tissue neoplasm
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.1084	1.232	Moderately Informative	INHERITED FROM: Abnormal peripheral myelination
Phenotypic Abnormality (PA)	Abnormality of movement	0.1236	1.064	Moderately Informative	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.3417	0.7903	Moderately Informative	INHERITED FROM: Abnormal saccadic eye movements
Phenotypic Abnormality (PA)	Malignant neoplasm of the central nervous system	0.0002869	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of muscle size	0.009676	1.684	Informative	INHERITED FROM: Skeletal muscle atrophy
Phenotypic Abnormality (PA)	Neoplasm by histology	0.05599	1.617	Informative	INHERITED FROM: Neuroepithelial neoplasm || Nervous tissue neoplasm
Phenotypic Abnormality (PA)	Abnormal reflex	0.07175	1.508	Informative	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Abnormality of the forehead	0.2891	1.684	Informative	INHERITED FROM: Sloping forehead
Phenotypic Abnormality (PA)	Abnormal peripheral myelination	0.00006996	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Skeletal muscle atrophy	0.0001798	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Areflexia	0.0007444	1.985	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal mortality induced by ionizing radiation	0.000004973	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal chromosome stability	0.000009029	1.825	--	DIRECT
Mammalian Phenotype (MP)	increased mammary adenocarcinoma incidence	0.0003296	2.126	--	DIRECT
Mammalian Phenotype (MP)	increased cellular sensitivity to ionizing radiation	0.0004877	2.603	--	DIRECT
Mammalian Phenotype (MP)	microcephaly	0.0007485	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal class switch recombination	0.00078	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal response to radiation	0.0009935	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal induced cell death	0.005952	1.825	--	INHERITED FROM: increased cellular sensitivity to ionizing radiation
Mammalian Phenotype (MP)	abnormal head size	0.008408	2.302	--	INHERITED FROM: microcephaly
Mammalian Phenotype (MP)	abnormal apocrine gland morphology	0.02195	1.427	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased carcinoma incidence	0.02927	1.649	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0.02941	1.302	--	INHERITED FROM: abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	increased integument system tumor incidence	0.02965	1.758	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased classified tumor incidence	0.04786	1.324	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.04944	1.324	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.05767	1.223	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.06178	1.223	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal B cell physiology	0.06654	1.172	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.06904	1.205	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	increased tumor incidence	0.08986	1.172	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.09504	1.156	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal tumor incidence	0.1259	1.141	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.1314	1.141	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal cell physiology	0.1779	0.6209	--	INHERITED FROM: abnormal DNA repair || abnormal chromosome stability || chromosomal instability || increased cellular sensitivity to ionizing radiation
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.1789	1.072	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.2046	0.3626	--	INHERITED FROM: abnormal DNA repair || abnormal response to radiation || abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.2077	0.9404	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.2211	1.112	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal exocrine gland morphology	0.2313	1.261	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.2817	1.072	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.3326	0.8473	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	integument phenotype	0.4041	0.797	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.4223	0.9219	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.4277	0.9219	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.4388	0.9219	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.4465	0.8108	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.4539	0.8038	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.4729	0.8789	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.522	0.8789	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.5293	0.7167	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal immune system physiology	0.6354	0.6789	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal immune system morphology	0.6382	0.7223	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.6475	0.6686	--	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal gland morphology	0.7723	0.7519	--	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	cellular phenotype	0.2979	0.5387	Least Informative	INHERITED FROM: increased cellular sensitivity to ionizing radiation || chromosomal instability || abnormal chromosome stability || abnormal DNA repair
Mammalian Phenotype (MP)	mortality/aging	0.4186	0.5424	Least Informative	INHERITED FROM: abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.4274	0.6254	Least Informative	INHERITED FROM: microcephaly
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.5737	0.6947	Least Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.7836	0.5945	Least Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	immune system phenotype	0.8024	0.5462	Least Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal B cell morphology	0.02347	1.156	Moderately Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal head morphology	0.051	1.241	Moderately Informative	INHERITED FROM: microcephaly
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0.06151	1.241	Moderately Informative	INHERITED FROM: abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.1233	1.059	Moderately Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	neoplasm	0.1678	1.035	Moderately Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.1909	1.098	Moderately Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal cell death	0.2363	0.9904	Moderately Informative	INHERITED FROM: increased cellular sensitivity to ionizing radiation
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.395	0.9129	Moderately Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.4077	0.9219	Moderately Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.4093	1.156	Moderately Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal metabolism	0.00147	1.281	Informative	INHERITED FROM: abnormal DNA repair || abnormal mortality induced by ionizing radiation || abnormal response to radiation
Mammalian Phenotype (MP)	abnormal mammary gland morphology	0.02195	1.427	Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased gland tumor incidence	0.02543	1.649	Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.03496	1.373	Informative	INHERITED FROM: abnormal class switch recombination
Mammalian Phenotype (MP)	increased malignant tumor incidence	0.3155	1.562	Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	chromosomal instability	0.000004205	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal DNA repair	0.0001003	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased mammary gland tumor incidence	0.001696	2.126	Highly Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased adenocarcinoma incidence	0.006424	2.001	Highly Informative	INHERITED FROM: increased mammary adenocarcinoma incidence
Mammalian Phenotype (MP)	increased sensitivity to induced cell death	0.3527	2.126	Highly Informative	INHERITED FROM: increased cellular sensitivity to ionizing radiation

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	axon branching variant	0.000007394	2.292	--	DIRECT
Worm Phenotype (WP)	neurite morphology variant	0.0005623	1.866	--	DIRECT
Worm Phenotype (WP)	neuronal outgrowth variant	0.0009485	1.565	--	DIRECT
Worm Phenotype (WP)	neuron morphology variant	0.001584	1.866	--	INHERITED FROM: neurite morphology variant || axon branching variant || axon morphology variant
Worm Phenotype (WP)	neuron development variant	0.01984	1.321	--	INHERITED FROM: axon branching variant || neuronal outgrowth variant || axon outgrowth variant
Worm Phenotype (WP)	nervous system morphology variant	0.02776	1.321	--	INHERITED FROM: axon morphology variant || axon branching variant || neurite morphology variant
Worm Phenotype (WP)	cell component morphology variant	0.1316	0.8392	--	INHERITED FROM: axon morphology variant || axon branching variant || neurite morphology variant
Worm Phenotype (WP)	organ system morphology variant	0.2398	0.7516	--	INHERITED FROM: axon morphology variant || axon branching variant || neurite morphology variant
Worm Phenotype (WP)	cell morphology variant	0.2513	0.7558	--	INHERITED FROM: neurite morphology variant || axon branching variant || axon morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || axon branching variant || hermaphrodite fertility reduced || axon outgrowth variant || embryonic development variant || embryonic lethal || fertility variant || neuronal outgrowth variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0.1194	0.6752	Least Informative	INHERITED FROM: axon branching variant || axon outgrowth variant || neuronal outgrowth variant
Worm Phenotype (WP)	cell type morphology variant	0.1018	0.8878	Moderately Informative	INHERITED FROM: axon morphology variant || neurite morphology variant || axon branching variant
Worm Phenotype (WP)	axon outgrowth variant	0.000835	1.565	Informative	DIRECT
Worm Phenotype (WP)	axon morphology variant	0.0004056	1.924	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || tagma || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || organism subdivision || multicellular structure || developing material anatomical entity || tagma || larva || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: tagma
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	gamete	0.0001529	1.333	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant sperm cell || plant cell || gamete
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant ANatomical entity (PAN)	plant sperm cell	0.00003632	1.396	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	0	2.452	--	DIRECT
Enzyme Commission (EC)	Zeaxanthin epoxidase	0	2.929	--	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	1.617	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonucleases producing 5'-phosphomonoesters	0	2.327	--	DIRECT
Enzyme Commission (EC)	Adenosine-5'-diphospho-5'-(DNA) diphosphatase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonucleases producing 3'-phosphomonoesters	0	3.23	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	3.693e-16	1.639	--	DIRECT
Enzyme Commission (EC)	DNA-(apurinic or apyrimidinic site) lyase	0.00004533	2.151	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.1469	0.7021	--	INHERITED FROM: Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Carbon-oxygen lyases	0.4542	1.208	--	INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases
Enzyme Commission (EC)	Transferases	0.00003283	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0958	0.4043	Least Informative	INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Acting on ester bonds || Adenosine-5'-diphospho-5'-(DNA) diphosphatase || Exodeoxyribonucleases producing 3'-phosphomonoesters
Enzyme Commission (EC)	Oxidoreductases	0.6136	0.7328	Least Informative	INHERITED FROM: Zeaxanthin epoxidase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Enzyme Commission (EC)	Acyltransferases	0.00000001286	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.00000005402	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.8775	Moderately Informative	INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase
Enzyme Commission (EC)	Aminoacyltransferases	0	1.391	Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000000002195	1.437	Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.0000001024	1.514	Informative	DIRECT
Enzyme Commission (EC)	Other carbon-oxygen lyases	0.00006781	2.084	Highly Informative	DIRECT

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