SH3-domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SH3-like barrel [ 50036] (21)
• Superfamily: SH3-domain [ 50044]
• Families: SH3-domain [ 50045] (39)

---

Superfamily statistics

	Genomes (733)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	39,669	125,642	127
Proteins	30,833	97,806	122

---

Functional annotation

• General category: Regulation
• Detailed category: Signal transduction

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.281	--	DIRECT
Enzyme Commission (EC)	Glycoprotein 6-alpha-L-fucosyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.00006343	1.217	--	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.04271	--	INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases
Enzyme Commission (EC)	Acting on ester bonds	0.4052	0.4665	Least Informative	INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.00000006272	1.162	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.0001767	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	1	0.9165	Moderately Informative	INHERITED FROM: Glycoprotein 6-alpha-L-fucosyltransferase || Hexosyltransferases
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0.000000000000003251	1.715	Informative	DIRECT
Enzyme Commission (EC)	Mitogen-activated protein kinase kinase kinase	0.0000000000002472	2.083	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Liver abscess	0.00004223	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Pyloric stenosis	0.000459	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the pylorus	0.0008787	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abscess	0.02468	2.407	--	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Abnormal immune system morphology	0.02774	1.365	--	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.1125	1.293	--	INHERITED FROM: Pyloric stenosis || Abnormality of the pylorus
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.1895	1.293	--	INHERITED FROM: Pyloric stenosis || Abnormality of the pylorus
Phenotypic Abnormality (PA)	Abnormality of the stomach	0.3563	1.804	--	INHERITED FROM: Abnormality of the pylorus || Pyloric stenosis
Phenotypic Abnormality (PA)	Abnormal liver morphology	0.4679	1.293	--	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.4864	0.8268	--	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Abnormality of the liver	0.506	1.176	--	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.7052	0.5805	Least Informative	INHERITED FROM: Liver abscess || Abnormality of the pylorus || Pyloric stenosis
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.2107	1.026	Moderately Informative	INHERITED FROM: Pyloric stenosis || Abnormality of the pylorus
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.2938	1.128	Moderately Informative	INHERITED FROM: Cellulitis
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.6211	0.9752	Moderately Informative	INHERITED FROM: Liver abscess
Phenotypic Abnormality (PA)	Cellulitis	0.000273	2.106	Highly Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased interleukin-2 secretion	0.0000000007744	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal neutrophil physiology	0.00004231	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal angiotensin I-converting enzyme activity	0.00007639	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.0001584	0.9638	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.0002072	0.9638	--	DIRECT
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.0003569	0.9516	--	DIRECT
Mammalian Phenotype (MP)	abnormal CD8-positive, alpha-beta T cell differentiation	0.0004876	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal vascular endothelial cell development	0.0008302	2.508	--	DIRECT
Mammalian Phenotype (MP)	short cochlear hair cell stereocilia	0.0009081	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0.003964	0.737	--	INHERITED FROM: abnormal cell-mediated immunity || decreased interleukin-2 secretion || abnormal interleukin-2 secretion || abnormal B cell proliferation || abnormal neutrophil physiology || abnormal adaptive immunity || abnormal immune cell physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.004087	0.9168	--	INHERITED FROM: abnormal B cell proliferation || abnormal neutrophil physiology
Mammalian Phenotype (MP)	abnormal excitatory postsynaptic current amplitude	0.02394	1.906	--	INHERITED FROM: decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.06478	0.9281	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal B cell activation	0.07161	1.663	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal hippocampus morphology	0.07318	1.663	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.08704	1.229	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.1058	1.128	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal forebrain morphology	0.1111	1.253	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal hippocampus layer morphology	0.124	1.906	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.1283	0.8177	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.1298	0.9281	--	INHERITED FROM: abnormal neutrophil physiology || abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.1332	1.061	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.1418	1.229	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal excitatory postsynaptic currents	0.1445	1.809	--	INHERITED FROM: decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal telencephalon morphology	0.1476	1.332	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.1526	1.146	--	INHERITED FROM: decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal temporal lobe morphology	0.154	1.663	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.1545	0.627	--	INHERITED FROM: abnormal hippocampus pyramidal cell layer || short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.1784	1.277	--	INHERITED FROM: abnormal interleukin-2 secretion || decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal vascular development	0.1865	1.394	--	INHERITED FROM: abnormal vascular endothelial cell development
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.2238	1.186	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.2552	1.11	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.3386	1.304	--	INHERITED FROM: abnormal vascular endothelial cell development
Mammalian Phenotype (MP)	abnormal T cell morphology	0.3928	1.362	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal hair cell morphology	0.4034	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal cochlear sensory epithelium morphology	0.4034	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal organ of Corti morphology	0.4079	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal B cell physiology	0.4109	1.229	--	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal membranous labyrinth morphology	0.4343	1.466	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal scala media morphology	0.496	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal mechanoreceptor morphology	0.511	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal ear morphology	0.5448	1.304	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.5706	0.9397	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal cochlea morphology	0.5903	1.429	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.5991	0.8266	--	INHERITED FROM: abnormal vascular endothelial cell development
Mammalian Phenotype (MP)	abnormal innate immunity	0.6502	1.277	--	INHERITED FROM: abnormal neutrophil physiology
Mammalian Phenotype (MP)	abnormal cochlear labyrinth morphology	0.6626	1.508	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal immune system morphology	0.7986	0.8003	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal inner ear morphology	0.8581	1.394	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.8818	1.093	--	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.9776	0.3617	--	INHERITED FROM: abnormal angiotensin I-converting enzyme activity
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	1	0.7444	--	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.01011	0.6505	Least Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation || abnormal B cell proliferation || abnormal neutrophil physiology
Mammalian Phenotype (MP)	immune system phenotype	0.04097	0.627	Least Informative	INHERITED FROM: abnormal interleukin-2 secretion || abnormal B cell proliferation || abnormal CD8-positive, alpha-beta T cell differentiation || decreased interleukin-2 secretion || abnormal immune cell physiology || abnormal cell-mediated immunity || abnormal adaptive immunity || abnormal neutrophil physiology
Mammalian Phenotype (MP)	nervous system phenotype	0.05965	0.5166	Least Informative	INHERITED FROM: abnormal hippocampus pyramidal cell layer || short cochlear hair cell stereocilia || decreased excitatory postsynaptic current amplitude || abnormal synaptic vesicle recycling
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.7616	0.6818	Least Informative	INHERITED FROM: abnormal vascular endothelial cell development
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.07178	1.11	Moderately Informative	INHERITED FROM: decreased interleukin-2 secretion || abnormal interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.08773	0.8744	Moderately Informative	INHERITED FROM: abnormal synaptic vesicle recycling || decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.1455	0.9764	Moderately Informative	INHERITED FROM: abnormal neutrophil physiology || abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.1671	0.9764	Moderately Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	hearing/vestibular/ear phenotype	0.1956	1.207	Moderately Informative	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.2772	1.093	Moderately Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.4816	1.016	Moderately Informative	INHERITED FROM: abnormal vascular endothelial cell development
Mammalian Phenotype (MP)	abnormal brain morphology	0.5853	1.11	Moderately Informative	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.7998	1.016	Moderately Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.8118	1.11	Moderately Informative	INHERITED FROM: abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.8126	0.9764	Moderately Informative	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal metabolism	0.9629	1.093	Moderately Informative	INHERITED FROM: abnormal angiotensin I-converting enzyme activity
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.0002684	1.663	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cerebral hemisphere morphology	0.08867	1.605	Informative	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal limbic system morphology	0.1104	1.663	Informative	INHERITED FROM: abnormal hippocampus pyramidal cell layer
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme activity	0.2852	1.605	Informative	INHERITED FROM: abnormal angiotensin I-converting enzyme activity
Mammalian Phenotype (MP)	abnormal neuron physiology	0.2893	1.605	Informative	INHERITED FROM: abnormal synaptic vesicle recycling
Mammalian Phenotype (MP)	abnormal CNS synaptic transmission	0.3472	1.253	Informative	INHERITED FROM: decreased excitatory postsynaptic current amplitude
Mammalian Phenotype (MP)	abnormal cochlear hair cell morphology	0.3784	1.508	Informative	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.3934	1.394	Informative	INHERITED FROM: abnormal interleukin-2 secretion || decreased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.401	1.605	Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal effector T cell morphology	0.4637	1.663	Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal alpha-beta T cell morphology	0.5172	1.663	Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation
Mammalian Phenotype (MP)	abnormal synaptic vesicle recycling	0.000008205	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.0004401	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased excitatory postsynaptic current amplitude	0.0005036	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal hippocampus pyramidal cell layer	0.0009464	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal granulocyte physiology	0.05874	2.031	Highly Informative	INHERITED FROM: abnormal neutrophil physiology
Mammalian Phenotype (MP)	abnormal cochlear hair cell stereociliary bundle morphology	0.08477	1.809	Highly Informative	INHERITED FROM: short cochlear hair cell stereocilia
Mammalian Phenotype (MP)	abnormal CD8-positive, alpha beta T cell morphology	0.2822	2.031	Highly Informative	INHERITED FROM: abnormal CD8-positive, alpha-beta T cell differentiation

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	mitochondria alignment variant	0.00000000000002413	1.594	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.0000000000008485	1.276	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.00000000002704	1.407	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.0000005294	1.385	--	DIRECT
Worm Phenotype (WP)	mitochondria spacing variant	0.0000005438	1.594	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0.000001751	1.327	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.00002444	1.346	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.0001026	0.9594	--	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0006372	1.23	--	DIRECT
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.01358	1.503	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell corpse number variant	0.01512	1.245	--	INHERITED FROM: accumulated cell corpses
Worm Phenotype (WP)	behavior variant	0.03064	0.632	--	INHERITED FROM: ovulation variant
Worm Phenotype (WP)	gene expression variant	0.03197	0.6038	--	INHERITED FROM: protein expression variant || protein phosphorylation variant || protein expression reduced
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.03991	0.1501	--	INHERITED FROM: protein expression variant || protein phosphorylation variant || protein expression reduced || aldicarb response variant || protein metabolism variant
Worm Phenotype (WP)	cell type morphology variant	0.04749	0.8211	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant
Worm Phenotype (WP)	organism physiology variant	0.04851	0.1405	--	INHERITED FROM: protein expression variant || protein expression reduced || protein phosphorylation variant || protein metabolism variant || aldicarb response variant
Worm Phenotype (WP)	cell death variant	0.05556	0.9441	--	INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant
Worm Phenotype (WP)	chemical response variant	0.1112	0.8045	--	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.2401	1.23	--	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	cell component morphology variant	0.3883	0.7833	--	INHERITED FROM: mitochondria spacing variant || actin organization biogenesis variant || mitochondria alignment variant || mitochondria morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || ovulation variant || reproductive system physiology variant || apoptosis variant || lethal || aldicarb response variant || muscle cell physiology variant || actin organization biogenesis variant || protein phosphorylation variant || development variant || cell physiology variant || accumulated cell corpses || embryonic development variant || embryonic lethal || fertility variant || protein expression reduced || muscle system physiology variant || protein metabolism variant || body elongation variant || organ system physiology variant || protein expression variant || coelomic system physiology variant || organism development variant || programmed cell death variant || fertility reduced
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.429	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	cell morphology variant	0.000002652	0.6905	Least Informative	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.00002196	0.7119	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.00003307	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.02718	0.5677	Least Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	organism behavior variant	0.02821	0.632	Least Informative	INHERITED FROM: ovulation variant
Worm Phenotype (WP)	organism metabolism processing variant	0.09964	0.4572	Least Informative	INHERITED FROM: protein phosphorylation variant || protein metabolism variant || protein expression reduced || protein expression variant
Worm Phenotype (WP)	protein expression variant	0.000000006948	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.00005179	1	Moderately Informative	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.01422	1.117	Moderately Informative	INHERITED FROM: protein phosphorylation variant || protein metabolism variant
Worm Phenotype (WP)	drug response variant	0.1043	1.017	Moderately Informative	INHERITED FROM: aldicarb response variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.5881	1.106	Moderately Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.9209	0.9294	Moderately Informative	INHERITED FROM: protein metabolism variant || protein phosphorylation variant
Worm Phenotype (WP)	germ cell morphology variant	0.9872	1.064	Moderately Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.000000000009738	1.429	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0.0000000003423	1.385	Informative	DIRECT
Worm Phenotype (WP)	mitochondria morphology variant	0.0000003152	1.477	Informative	DIRECT
Worm Phenotype (WP)	cell component localization variant	0.00002954	1.365	Informative	DIRECT
Worm Phenotype (WP)	aldicarb response variant	0.0001217	1.503	Informative	DIRECT
Worm Phenotype (WP)	coelomic system physiology variant	0.0002376	1.708	Informative	DIRECT
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.005956	1.561	Informative	INHERITED FROM: actin organization biogenesis variant
Worm Phenotype (WP)	level of protein expression variant	0.008832	1.666	Informative	INHERITED FROM: protein expression reduced
Worm Phenotype (WP)	protein modification variant	0.4289	1.594	Informative	INHERITED FROM: protein phosphorylation variant
Worm Phenotype (WP)	oocyte morphology variant	0.9778	1.276	Informative	INHERITED FROM: endomitotic oocytes
Worm Phenotype (WP)	protein expression reduced	0.00000000001619	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	actin organization biogenesis variant	0.00006661	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	body elongation variant	0.0002911	2.23	Highly Informative	DIRECT
Worm Phenotype (WP)	ovulation variant	0.0005149	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	endomitotic oocytes	0.0005919	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	protein phosphorylation variant	0.0007248	1.929	Highly Informative	DIRECT

---

Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	cell wall morphology	0.003457	2.17	--	INHERITED FROM: chitin deposition
Yeast Phenotype (YP)	cellular morphology	0.03456	1.216	--	INHERITED FROM: chitin deposition
Yeast Phenotype (YP)	cellular processes	0.6407	0.1328	--	INHERITED FROM: intracellular transport
Yeast Phenotype (YP)	morphology	0.1488	1.11	Moderately Informative	INHERITED FROM: chitin deposition
Yeast Phenotype (YP)	intracellular transport	0.00002112	1.693	Informative	DIRECT
Yeast Phenotype (YP)	subcellular morphology	0.3133	1.392	Informative	INHERITED FROM: chitin deposition
Yeast Phenotype (YP)	chitin deposition	0.0003534	2.17	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.0001039	0.05522	--	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: cell component || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || cell component
Fly Anatomy (FA)	cell component	0.0009574	1.535	Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	root	0	0.5579	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.6838	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.5346	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.7789	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.7615	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.586	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Glycoprotein 6-alpha-L-fucosyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Mitogen-activated protein kinase kinase kinase	0.00000000000001242	2.475	--	DIRECT
Enzyme Commission (EC)	Type I protein arginine methyltransferase	0.00000000267	2.952	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.4781	0.7559	--	INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases
Enzyme Commission (EC)	Methyltransferases	1	1.181	--	INHERITED FROM: Type I protein arginine methyltransferase
Enzyme Commission (EC)	Acyltransferases	1	0.8446	--	INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C
Enzyme Commission (EC)	Aminoacyltransferases	0.00000003751	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.00003455	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	1.054	Moderately Informative	INHERITED FROM: Type I protein arginine methyltransferase
Enzyme Commission (EC)	Glycosyltransferases	1	1.204	Moderately Informative	INHERITED FROM: Hexosyltransferases || Glycoprotein 6-alpha-L-fucosyltransferase
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.537	Informative	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.0000000000245	1.384	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.0000000006559	1.46	Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.000111	1.572	Informative	DIRECT
Enzyme Commission (EC)	Non-specific protein-tyrosine kinase	0	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.998	Highly Informative	DIRECT

---

InterPro annotation

• Cross references: IPR001452 SSF50044 Protein matches
• Abstract: SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [15335710, 11256992]. They are found in a great variety of intracellular or membrane-associated proteins [1639195, 14731533, 7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

  The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [7953536].

InterPro database

---