Cell growth inhibitor/plasmid maintenance toxic component superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SH3-like barrel [ 50036] (21)
• Superfamily: Cell growth inhibitor/plasmid maintenance toxic component [ 50118] (3)
• Families:
  • CcdB [ 50119]
  • Kid/PemK [ 82075] (3)
  • Rv2302-like [ 141248]

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Superfamily statistics

	Genomes (1,361)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,865	23,346	5
Proteins	2,864	23,333	5

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Functional annotation

• General category: Other
• Detailed category: Unknown function

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InterPro annotation

• Cross references: IPR011067 SSF50118 Protein matches
• Abstract:

  Bacterial cells remove plasmid-free segregants by the use of toxin/antitoxin systems, where cells that lack plasmids cannot produce the antitoxin required for survival. Several of the toxin components have similar structures, which consists of an SH3-like barrel fold, and contains an inserted beta-sheet subdomain and a C-terminal helix, despite often low sequence identities. Toxins that have this structural fold include CcdB from Escherichia coli, a topoisomerase poison that interferes with DNA gyrase activity [9917404], PemK-like YdcE from Bacillus subtilis, Kid toxin (Kis antitoxin) from the E. coli R1 plasmid [12377128], and the MazF toxin (MazE antitoxin) from E. coli [12718874].

InterPro database

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