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PDZ domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PDZ domain-like [ 50155]
Superfamily:   PDZ domain-like [ 50156] (6)
Family:   PDZ domain [ 50157] (46)

Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,386 24,255 98
Proteins 5,100 16,127 95

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000269Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.02756Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000002457Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000242Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000007814Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.746e-16InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000000009221InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.3227Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.08148InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.4673Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5337Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8276Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.2031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.4175Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.4671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.5712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.05245InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.1339InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.2992InformativeInherited
Phenotypic Abnormality (PA)Abnormal size of the palpebral fissures0.0307Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality iris morphology0.05169Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.05493Highly InformativeInherited
Phenotypic Abnormality (PA)Visual field defect0.06622Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.1341Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00002349Least InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic transmission0.00003383Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.4289Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.5952Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.001074InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.01546InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.2789InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.5723InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.00002268Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0002716Highly InformativeDirect
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.0006359Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0002924Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0006318Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.02375Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1062Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2879Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0001062Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0003716Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.08871Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.09179Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.5273Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6794Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.9241Moderately InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.000002004InformativeDirect
Worm Phenotype (WP)chemical resistant0.000351InformativeDirect
Worm Phenotype (WP)brood size variant0.0006401InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002506InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.003461InformativeInherited
Worm Phenotype (WP)nervous system physiology variant0.008145InformativeInherited
Worm Phenotype (WP)vulva development variant0.03046InformativeInherited
Worm Phenotype (WP)cell number increased0.05989InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.06875InformativeInherited
Worm Phenotype (WP)egg laying variant0.07673InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.3864InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.63InformativeInherited
Worm Phenotype (WP)cell polarity variant0.0000001758Highly InformativeDirect
Worm Phenotype (WP)actin organization biogenesis variant0.0000003753Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000008706Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0001118Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.0002666Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0002763Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.006437Highly InformativeInherited
Worm Phenotype (WP)epithelial development variant0.00772Highly InformativeInherited
Worm Phenotype (WP)egg laying response to drug variant0.01344Highly InformativeInherited
Worm Phenotype (WP)serotonin response variant0.02064Highly InformativeInherited
Worm Phenotype (WP)synaptic transmission variant0.02285Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.000135InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.1579Least InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.05916Moderately InformativeInherited
Fly Anatomy (FA)gonad0.08826Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.03915InformativeInherited
Fly Anatomy (FA)somatic cell of ovariole0.0007356Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.07545Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3067Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.4237Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5459Moderately InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.003708Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.08107Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.08659Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.0875Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.00003956Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0001387Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000003305InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000003813InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000006651InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000006263InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000000000001826Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000001151Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.
   
Superfamily level     Family level

Alignments of sequences to 176 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PDZ domain-like domain.
   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.