Sm motif of small nuclear ribonucleoproteins, SNRNP family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Sm-like fold [ 50181] (5)
• Superfamily: Sm-like ribonucleoproteins [ 50182] (6)
• Family: Sm motif of small nuclear ribonucleoproteins, SNRNP [ 50183] (8)

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Family statistics

	Genomes (498)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,407	3,326	18
Proteins	1,405	3,323	18

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	P granule localization defective	0.000000000002039	2.468	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.00000000008337	1.371	--	DIRECT
Worm Phenotype (WP)	cell proliferation variant	0.00000000009954	1.99	--	DIRECT
Worm Phenotype (WP)	vulval cell induction increased	0.0000000003339	1.866	--	DIRECT
Worm Phenotype (WP)	vulval cell induction variant	0.000000001351	1.727	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.000000001975	1.156	--	DIRECT
Worm Phenotype (WP)	vulva cell fate specification variant	0.000000002232	1.689	--	DIRECT
Worm Phenotype (WP)	pachytene region organization variant	0.00000002286	1.727	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.000000461	1.407	--	DIRECT
Worm Phenotype (WP)	protein subcellular localization variant	0.0000006355	1.513	--	DIRECT
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.0000008034	1.866	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.000001286	1.321	--	DIRECT
Worm Phenotype (WP)	excess intestinal cells	0.000001382	2.292	--	DIRECT
Worm Phenotype (WP)	alimentary system development variant	0.00000368	1.814	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0.000008041	1.689	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.000008173	1.426	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	0.00001017	1.593	--	DIRECT
Worm Phenotype (WP)	recycling endosome localization variant	0.00001227	1.769	--	DIRECT
Worm Phenotype (WP)	endosome localization variant	0.00001308	1.769	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00001478	0.7558	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.00001568	1.426	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0.00003052	1.306	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0.00005901	1.727	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.00006894	1.354	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0.00007056	1.727	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.000105	1.689	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0002758	0.6859	--	DIRECT
Worm Phenotype (WP)	pigmentation variant	0.0002857	1.924	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.0003044	1.354	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0004142	1.087	--	DIRECT
Worm Phenotype (WP)	reduced brood size	0.0005636	1.593	--	DIRECT
Worm Phenotype (WP)	adult lethal	0.0007961	2.468	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.0009215	1.125	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.001271	1.087	--	INHERITED FROM: apoptosis variant
Worm Phenotype (WP)	P granule abnormal	0.001284	2.292	--	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	gametogenesis variant	0.002198	1.013	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || germ cell development variant || pachytene region organization variant || meiotic progression during oogenesis variant || no oocytes || chromosome condensation variant
Worm Phenotype (WP)	transgene expression variant	0.002463	0.773	--	INHERITED FROM: pattern of transgene expression variant
Worm Phenotype (WP)	protein interaction variant	0.004411	1.078	--	INHERITED FROM: protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	feeding behavior variant	0.004596	1.25	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	gene expression variant	0.007675	0.6256	--	INHERITED FROM: protein subcellular localization variant || pattern protein expression variant || pattern of transgene expression variant
Worm Phenotype (WP)	reproductive system development variant	0.01127	1.156	--	INHERITED FROM: vulva cell fate specification variant || vulval cell induction variant || vulval cell induction increased || multivulva
Worm Phenotype (WP)	organ system morphology variant	0.02908	0.7516	--	INHERITED FROM: rachis morphology variant || gonad morphology variant || pachytene region organization variant
Worm Phenotype (WP)	no differentiated gametes	0.06286	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	meiosis variant	0.07577	1.263	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant || chromosome condensation variant
Worm Phenotype (WP)	no germ line	0.08762	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	oogenesis variant	0.09396	1.237	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression during oogenesis variant || pachytene region organization variant || meiotic progression prophase variant
Worm Phenotype (WP)	growth variant	0.1699	0.3438	--	INHERITED FROM: sick
Worm Phenotype (WP)	germ cell compartment morphology variant	0.2067	1.354	--	INHERITED FROM: germ cell compartment expansion variant
Worm Phenotype (WP)	cell component morphology variant	0.2289	0.8392	--	INHERITED FROM: cell membrane organization biogenesis variant || recycling endosome morphology variant || P granule localization defective || endosome morphology variant || germ cell cytoplasmic morphology variant || vesicle organization variant || vesicle morphology variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.3191	0.1444	--	INHERITED FROM: protein subcellular localization variant || pattern protein expression variant || sick || response to bacteria variant || pattern of transgene expression variant || avoids bacterial lawn || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	organism physiology variant	0.3387	0.1342	--	INHERITED FROM: oocyte physiology variant || protein subcellular localization variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || pattern protein expression variant || sexually dimorphic physiology variant || sick || life span variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || avoids bacterial lawn || response to bacteria variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || meiotic progression during oogenesis variant || protein protein interaction variant || vesicle morphology variant || vulval cell induction increased || response to bacteria variant || reproductive system physiology variant || adult lethal || cell fate specification variant || early embryonic lethal || endocytic transport variant || no oocytes || pattern protein expression variant || organ system development variant || vulva cell fate specification variant || apoptosis variant || avoids bacterial lawn || lethal || chromosome condensation variant || germ cell physiology variant || protein subcellular localization variant || germ cell development variant || oocyte physiology variant || sexually dimorphic physiology variant || intestinal development variant || life span variant || cell secretion variant || cell proliferation increased || endocytic transport defect || development variant || alimentary system development variant || reduced brood size || hermaphrodite sterile || hermaphrodite fertility reduced || multivulva || sick || embryonic development variant || embryonic lethal || cell number variant || vesicle organization variant || fertility variant || behavior variant || cell number increased || vulval cell induction variant || embryonic arrest || cell proliferation variant || excess intestinal cells || pattern of transgene expression variant || protein aggregation variant || recycling endosome morphology variant || cell cycle variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || organ system physiology variant || organism behavior variant || maternal sterile || endosome morphology variant || organism development variant || vesicle trafficking variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || fertility reduced || pachytene region organization variant || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0.00002286	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0002648	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.02343	0.4899	Least Informative	INHERITED FROM: protein subcellular localization variant || pattern protein expression variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0271	0.6614	Least Informative	INHERITED FROM: avoids bacterial lawn || response to bacteria variant
Worm Phenotype (WP)	cell physiology variant	0.03144	0.5955	Least Informative	INHERITED FROM: endocytic transport defect || endocytic transport variant || apoptosis variant || oocyte physiology variant || cell secretion variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant || germ cell physiology variant || vesicle trafficking variant || cell cycle variant || receptor mediated endocytosis defective || chromosome condensation variant
Worm Phenotype (WP)	germ cell development variant	0.0000003771	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.0000007276	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.000004401	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0.0001401	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0.0002339	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.0004828	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0.0009652	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.001627	1.078	Moderately Informative	INHERITED FROM: pachytene region organization variant || rachis morphology variant || gonad morphology variant
Worm Phenotype (WP)	cell division variant	0.002657	1.036	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || pachytene region organization variant || chromosome condensation variant
Worm Phenotype (WP)	protein expression variant	0.005435	1.125	Moderately Informative	INHERITED FROM: pattern protein expression variant || protein subcellular localization variant
Worm Phenotype (WP)	cell death variant	0.01106	1.061	Moderately Informative	INHERITED FROM: apoptosis variant
Worm Phenotype (WP)	germ cell differentiation variant	0.4208	1.167	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || no oocytes || meiotic progression during oogenesis variant || pachytene progression during oogenesis variant || pachytene region organization variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.8081	1.135	Moderately Informative	INHERITED FROM: cell membrane organization biogenesis variant
Worm Phenotype (WP)	cell number increased	0.000000000006013	1.446	Informative	DIRECT
Worm Phenotype (WP)	sick	0.00000001951	1.727	Informative	DIRECT
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.00000005613	1.565	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.0000004847	1.468	Informative	DIRECT
Worm Phenotype (WP)	rachis morphology variant	0.0000005356	1.623	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.0000009657	1.49	Informative	DIRECT
Worm Phenotype (WP)	pattern protein expression variant	0.000001104	1.49	Informative	DIRECT
Worm Phenotype (WP)	life span variant	0.00001356	1.321	Informative	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0.00001414	1.446	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.00004419	1.49	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0.00006089	1.407	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0.0001205	1.655	Informative	DIRECT
Worm Phenotype (WP)	cell fate specification variant	0.0002031	1.513	Informative	DIRECT
Worm Phenotype (WP)	brood size variant	0.001061	1.538	Informative	INHERITED FROM: reduced brood size
Worm Phenotype (WP)	vulva development variant	0.001206	1.655	Informative	INHERITED FROM: multivulva || vulva cell fate specification variant || vulval cell induction increased || vulval cell induction variant
Worm Phenotype (WP)	cell component localization variant	0.03552	1.388	Informative	INHERITED FROM: endosome localization variant || recycling endosome localization variant || RAB-11 recycling endosome localization variant
Worm Phenotype (WP)	mitosis variant	0.06247	1.689	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	meiotic chromosome organization variant	0.5311	1.623	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	cell proliferation increased	0.000000000000007503	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	intestinal development variant	0.000000000009955	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic arrest	0.0000000001799	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	multivulva	0.000000000249	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	RAB-11 recycling endosome localization variant	0.00001188	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	no oocytes	0.00005637	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	organism pigmentation variant	0.0001939	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	cell secretion variant	0.000251	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	chromosome condensation variant	0.0002971	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	0.0008665	1.814	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || larva || organism
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0.000006736	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.0001447	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0.001411	1.202	--	INHERITED FROM: egg
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system || egg || genital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || egg || anatomical group || multicellular anatomical structure || tissue || anatomical region || germ cell || organism subdivision || cell || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	germ cell	0.00003214	1.08	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.00003203	1.347	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unfertilized egg stage	0.0009096	1.83	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || E expanded cotyledon stage || F mature embryo stage || D bilateral stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || C globular stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Ribonucleoprotein	2.434e-16	1.732	Informative	DIRECT

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